Egzersiz ve Kolorektal Kanser Epidemiyolojisi: 1985-2025 Dönemine Ait Bibliyometrik Bir İnceleme
Özet
Bu bibliyometrik inceleme, egzersiz ve kolorektal kanser (KRK) ilişkisine dair bilimsel üretimi sistematik olarak haritalamak amacıyla 1985–2025 döneminde Web of Science Core Collection’dan elde edilen en alakalı 500 yayını analiz etmiştir. Kayıtların tam metaverileri dışa aktarılmış, R (4.4.2) ve Bibliometrix/Biblioshiny ile yıllara göre üretim eğilimleri, yazar/ülke/kurum üretkenliği, atıf örüntüleri, anahtar kelime eş görünümü ve tematik haritalama yapılmıştır. Yıllık yayın artış hızı %9,3 olup, belgelerin ortalama yaşı 9,14 yıldır. Çalışmaların çoğu özgün makale (n=406) ve derlemedir (n=77). Toplam 3.232 yazar yer almakta, belge başına ortalama yazar sayısı 8,16 ve uluslararası ortak yazarlık oranı %25,4’tür. En çok yayın Supportive Care in Cancer ve Cancer Causes & Control dergilerinde, en çok atıf ABD, Birleşik Krallık ve Çin kaynaklı yayınlarda toplanmıştır. Tematik analiz, iki ana ekseni öne çıkarmaktadır: (i) risk/önleme odaklı epidemiyolojik çalışmalar ve (ii) tedavi sonrası yaşam kalitesi ve müdahale temelli klinik araştırmalar. Bulgular, fiziksel aktivitenin KRK’nin önlenmesi ve sağ kalımı üzerindeki rolüne ilişkin kanıt birikiminin güçlü olduğunu göstermektedir. Bununla birlikte, egzersizin türü, dozu ve zamanlamasına ilişkin metodolojik standartların yetersizliği ve düşük-orta gelirli ülkelerin sınırlı temsili önemli boşluklardır. Gelecek çalışmaların çok disiplinli tasarlanması, rastgele kontrollü denemelerin artırılması ve standart raporlama ile kanıtların klinik ve halk sağlığı kılavuzlarına daha güçlü entegrasyonu önerilmektedir.
Referanslar
Allen, J. M., Mailing, L. J., Niemiro, G. M., Moore, R., Cook, M. D., White, B. A., Holscher, H. D., & Woods, J. A. (2018). Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans. Medicine and Science in Sports and Exercise, 50(4), 747–757. https://doi.org/10.1249/MSS.0000000000001495
Aria, M., & Cuccurullo, C. (2017). bibliometrix: An R-tool for comprehensive science mapping analysis. Journal of Informetrics, 11(4), 959–975. https://doi.org/10.1016/J.JOI.2017.08.007
Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 74(3), 229–263. https://doi.org/10.3322/caac.21834
Colditz, G. A., Cannuscio, C. C., & Frazier, A. L. (1997a). Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes & Control : CCC, 8(4), 649–667. https://doi.org/10.1023/A:1018458700185
Colditz, G. A., Cannuscio, C. C., & Frazier, A. L. (1997b). Physical activity and reduced risk of colon cancer: implications for prevention. Cancer Causes & Control : CCC, 8(4), 649–667. https://doi.org/10.1023/A:1018458700185
Courneya, K. S., Vardy, J. L., O’Callaghan, C. J., Gill, S., Friedenreich, C. M., Wong, R. K. S., Dhillon, H. M., Coyle, V., Chua, N. S., Jonker, D. J., Beale, P. J., Haider, K., Tang, P. A., Bonaventura, T., Wong, R., Lim, H. J., Burge, M. E., Hubay, S., Sanatani, M., … Booth, C. M. (2025). Structured Exercise after Adjuvant Chemotherapy for Colon Cancer. The New England Journal of Medicine, 393(1), 13–25. https://doi.org/10.1056/NEJMOA2502760
Duvivier, B. M. F. M., Schaper, N. C., Bremers, M. A., van Crombrugge, G., Menheere, P. P. C. A., Kars, M., & Savelberg, H. H. C. M. (2013). Minimal intensity physical activity (standing and walking) of longer duration improves insulin action and plasma lipids more than shorter periods of moderate to vigorous exercise (cycling) in sedentary subjects when energy expenditure is comparable. PloS One, 8(2). https://doi.org/10.1371/JOURNAL.PONE.0055542
Giovannucci, E. (2001). Insulin, insulin-like growth factors and colon cancer: A review of the evidence. Journal of Nutrition, 131(11 SUPPL.). https://doi.org/10.1093/jn/131.11.3109s
Johnson, C. M., Wei, C., Ensor, J. E., Smolenski, D. J., Amos, C. I., Levin, B., & Berry, D. A. (2013). Meta-analyses of colorectal cancer risk factors. Cancer Causes & Control : CCC, 24(6), 1207–1222. https://doi.org/10.1007/S10552-013-0201-5
Lee, I. M. (2003). Physical activity and cancer prevention--data from epidemiologic studies. Medicine and Science in Sports and Exercise, 35(11), 1823–1827. https://doi.org/10.1249/01.MSS.0000093620.27893.23
Lee, I. M., Paffenbarger, R. S., & Hsieh, C. cheng. (1991). Physical activity and risk of developing colorectal cancer among college alumni. Journal of the National Cancer Institute, 83(18), 1324–1329. https://doi.org/10.1093/JNCI/83.18.1324
Malats, N., & Castaño-Vinyals, G. (2007). Cancer epidemiology: study designs and data analysis. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 9(5), 290–297. https://doi.org/10.1007/S12094-007-0056-X
Markozannes, G., Becerra-Tomás, N., Cariolou, M., Balducci, K., Vieira, R., Kiss, S., Aune, D., Greenwood, D. C., Gunter, M. J., Copson, E., Renehan, A. G., Bours, M., Demark-Wahnefried, W., Hudson, M. M., May, A. M., Odedina, F. T., Skinner, R., Steindorf, K., Tjønneland, A., … Chan, D. S. M. (2024). Post-diagnosis physical activity and sedentary behaviour and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis. International Journal of Cancer, 155(3), 426–444. https://doi.org/10.1002/IJC.34903
Mattiuzzi, C., & Lippi, G. (2019). Current Cancer Epidemiology. Journal of Epidemiology and Global Health, 9(4), 217. https://doi.org/10.2991/JEGH.K.191008.001
Meyerhardt, J. A., Giovannucci, E. L., Holmes, M. D., Chan, A. T., Chan, J. A., Colditz, G. A., & Fuchs, C. S. (2006a). Physical activity and survival after colorectal cancer diagnosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 24(22), 3527–3534. https://doi.org/10.1200/JCO.2006.06.0855
Meyerhardt, J. A., Giovannucci, E. L., Holmes, M. D., Chan, A. T., Chan, J. A., Colditz, G. A., & Fuchs, C. S. (2006b). Physical activity and survival after colorectal cancer diagnosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 24(22), 3527–3534. https://doi.org/10.1200/JCO.2006.06.0855
Meyerhardt, J. A., Giovannucci, E. L., Ogino, S., Kirkner, G. J., Chan, A. T., Willett, W., & Fuchs, C. S. (2009a). Physical activity and male colorectal cancer survival. Archives of Internal Medicine, 169(22), 2102–2108. https://doi.org/10.1001/ARCHINTERNMED.2009.412
Meyerhardt, J. A., Giovannucci, E. L., Ogino, S., Kirkner, G. J., Chan, A. T., Willett, W., & Fuchs, C. S. (2009b). Physical activity and male colorectal cancer survival. Archives of Internal Medicine, 169(22), 2102–2108. https://doi.org/10.1001/ARCHINTERNMED.2009.412
Paschke, S., Jafarov, S., Staib, L., Kreuser, E. D., Maulbecker-Armstrong, C., Roitman, M., Holm, T., Harris, C. C., Link, K. H., & Kornmann, M. (2018). Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer. International Journal of Molecular Sciences, 19(9). https://doi.org/10.3390/IJMS19092577
Patel, A. V., Friedenreich, C. M., Moore, S. C., Hayes, S. C., Silver, J. K., Campbell, K. L., Winters-Stone, K., Gerber, L. H., George, S. M., Fulton, J. E., Denlinger, C., Morris, G. S., Hue, T., Schmitz, K. H., & Matthews, C. E. (2019). American College of Sports Medicine Roundtable Report on Physical Activity, Sedentary Behavior, and Cancer Prevention and Control. Medicine and Science in Sports and Exercise, 51(11), 2391–2402. https://doi.org/10.1249/MSS.0000000000002117
Samad, A. K. A., Taylor, R. S., Marshall, T., & Chapman, M. A. S. (2005a). A meta-analysis of the association of physical activity with reduced risk of colorectal cancer. Colorectal Disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, 7(3), 204–213. https://doi.org/10.1111/J.1463-1318.2005.00747.X
Samad, A. K. A., Taylor, R. S., Marshall, T., & Chapman, M. A. S. (2005b). A meta-analysis of the association of physical activity with reduced risk of colorectal cancer. Colorectal Disease : The Official Journal of the Association of Coloproctology of Great Britain and Ireland, 7(3), 204–213. https://doi.org/10.1111/J.1463-1318.2005.00747.X
Schottenfeld, D. (1981). The epidemiology of cancer: an overview. Cancer, 47(5), 1095. https://pubmed.ncbi.nlm.nih.gov/7237366/
Schottenfeld, D., & Beebe-Dimmer, J. L. (2005a). Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. Annual Review of Public Health, 26, 37–60. https://doi.org/10.1146/ANNUREV.PUBLHEALTH.26.021304.144402
Schottenfeld, D., & Beebe-Dimmer, J. L. (2005b). Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. Annual Review of Public Health, 26, 37–60. https://doi.org/10.1146/ANNUREV.PUBLHEALTH.26.021304.144402
Slattery, M. L., Edwards, S., Curtin, K., Ma, K., Edwards, R., Holubkov, R., & Schaffer, D. (2003). Physical activity and colorectal cancer. American Journal of Epidemiology, 158(3), 214–224. https://doi.org/10.1093/AJE/KWG134
Stein, M. J., Baurecht, H., Bohmann, P., Fervers, B., Fontvieille, E., Freisling, H., Friedenreich, C. M., Konzok, J., Peruchet-Noray, L., Sedlmeier, A. M., Leitzmann, M. F., & Weber, A. (2024a). Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank. BMC Medicine, 22(1), 1–11. https://doi.org/10.1186/S12916-024-03632-4/TABLES/4
Stein, M. J., Baurecht, H., Bohmann, P., Fervers, B., Fontvieille, E., Freisling, H., Friedenreich, C. M., Konzok, J., Peruchet-Noray, L., Sedlmeier, A. M., Leitzmann, M. F., & Weber, A. (2024b). Diurnal timing of physical activity and risk of colorectal cancer in the UK Biobank. BMC Medicine, 22(1). https://doi.org/10.1186/S12916-024-03632-4
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/CAAC.21660
Tanik, F., Naz, İ., Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Fizyoterapi ve Rehabilitasyon Bölümü, İ., Yazar, S., Author, C., & Fzt İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Enstitüsü Fizyoterapi ve Rehabilitasyon Anabilim Dalı, U. (2022). Kanserde Fiziksel Aktivite ve Egzersiz - Koruyucu ve Tedavi Edici Etki. İzmir Katip Çelebi University Faculty of Health Science Journal, 7(1), 129–132. https://dergipark.org.tr/en/pub/ikcusbfd/issue/68428/979502
The Cancer Genome Atlas Program (TCGA). (n.d.). Retrieved September 15, 2025, from https://www.cancer.gov/ccg/research/genome-sequencing/tcga
Vena, J. E., Graham, S., Zielezny, M., Swanson, M. K., Barnes, R. E., & Nolan, J. (1985). Lifetime occupational exercise and colon cancer. American Journal of Epidemiology, 122(3), 357–365. https://doi.org/10.1093/OXFORDJOURNALS.AJE.A114116
Wei, E. K., Giovannucci, E., Wu, K., Rosner, B., Fuchs, C. S., Willett, W. C., & Colditz, G. A. (2004). Comparison of risk factors for colon and rectal cancer. International Journal of Cancer, 108(3), 433–442. https://doi.org/10.1002/IJC.11540
West, M. A., Loughney, L., Lythgoe, D., Barben, C. P., Sripadam, R., Kemp, G. J., Grocott, M. P. W., & Jack, S. (2015). Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: A blinded interventional pilot study. British Journal of Anaesthesia, 114(2), 244–251. https://doi.org/10.1093/bja/aeu318
Wolin, K. Y., Yan, Y., Colditz, G. A., & Lee, I. M. (2009a). Physical activity and colon cancer prevention: a meta-analysis. British Journal of Cancer, 100(4), 611–616. https://doi.org/10.1038/SJ.BJC.6604917
Wolin, K. Y., Yan, Y., Colditz, G. A., & Lee, I. M. (2009b). Physical activity and colon cancer prevention: a meta-analysis. British Journal of Cancer, 100(4), 611–616. https://doi.org/10.1038/SJ.BJC.6604917
Yin, Z., Yao, C., Zhang, L., & Qi, S. (2023). Application of artificial intelligence in diagnosis and treatment of colorectal cancer: A novel Prospect. Frontiers in Medicine, 10, 1128084. https://doi.org/10.3389/FMED.2023.1128084
Yuhara, H., Steinmaus, C., Cohen, S. E., Corley, D. A., Tei, Y., & Buffler, P. A. (2011). Is diabetes mellitus an independent risk factor for colon cancer and rectal cancer? The American Journal of Gastroenterology, 106(11), 1911–1921. https://doi.org/10.1038/AJG.2011.301
