Kanama Durdurucular
Özet
Kanama durdurucu ajanlar (hemostatik ajanlar), travma, cerrahi girişimler veya spontan kanama durumlarında hemostazı sağlamak amacıyla kullanılan farmakolojik veya biyolojik maddelerdir. Bu ajanlar, primer ve sekonder hemostazın çeşitli basamaklarına etki ederek pıhtı oluşumunu destekler, kan kaybını azaltır ve hastanın prognozunu olumlu yönde etkiler. Traneksamik asit kullanılması son zamanlarda özellikle travma hastalarında yeniden önerilmiştir. Protrombin kompleks konsantreleri, vitamin K antagonistlerine bağlı kanamalarda taze donmuş plazmaya alternatif olarak ortaya çıkmış olsalar da yapılan çalışmalarla kullanım alanları giderek artmaktadır. Taze donmuş plazma, olası komplikasyonları nedeni ile daralan endikasyonlarda, alternatif tedavi seçeneklerinin yokluğunda önerilmeye başlanmıştır. İlk üretildiğinde birden fazla endikasyon için önerilen Ankaferd ile yapılan çalışmalar sonucunda kullanım alanları lokal uygulamalar ile sınırlı kalmıştır. Sık kullanılan bu ajanlardan başka klinik pratikte çok kullanılmayan hemostatik tozlar, fibrin yapıştırıcılar da özellikli hastalar için önerilmektedir.
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