Kan Kültürü
Özet
Kan kültürü, kan dolaşım enfeksiyonları, enfektif endokardit, sepsis ve septik şok tanısında önemli bir role sahiptir. Kan örneklerinden patojen mikroorganizmaların (bakteri veya mantar) üremesi için kullanılan bir tanı yöntemidir. Enfeksiyon etkenlerinin tanımlanması ve uygun tedavinin belirlenmesi açısından kritik bir öneme sahiptir. Özellikle antibiyotiklerin zamanında başlanmasının yaşamsal önem taşıdığı sepsis ve menenjit gibi durumlarda başvuru sonrasında en kısa zamanda kan kültürü için örnek alınması yaşam kurtarıcı olabilmektedir. Etkenin belirlenme süresinin uzaması mortalite ve morbidite artışına neden olabilmektedir.
Referanslar
Ullmann AJ, Cornely OA, Donnelly JP, Akova M, Arendrup MC,, Arikan-Akdagli S et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: developing European guidelines in clinical microbiology and infectious diseases. Clin Microbiol Infect 2012; 18 (Suppl. 7): 1–8.
Fabre V, Carroll KC, Cosgrove SE. Blood Culture Utilization in the Hospital Setting: a Call for Diagnostic Stewardship. J Clin Microbiol. 2022; 60(3): e0100521.
Lamy B, Dargère S, Arendrup MC, Parienti J-J, Tattevin P. How to optimize the use of blood cultures for the diagnosis of bloodstream infections? A state-of-the art. Frontiers in microbiology. 2016; 7: 697.
Klinik Mikrobiyoloji Uzmanlık Derneği (KLIMUD), Kan Dolaşımı Örneklerinin Laboratuvar İncelemesi Rehberi, 2022. Bölüm 1, Kan Kültürü Alınması Gerektiren Klinik Durumlar.S:1.
Lee A, Weinstein MP, Mirrett S, Reller LB. Detection of Bloodstream Infections in Adults: How Many Blood Cultures Are Needed ? J Clin Microbiol. 2007;45(11):3546-3548.
Başustaoğlu A. Kan Kültürü Uygulama Kılavuzu. 2013
Mermel LA, Maki DG. Detection of bacteremia in adults : consequences of culturing an inadequate volume of blood. Ann Intern Med. 1993;119(4):270-272.
Bouza E, Sousa D, Rodríguez-Créixems M, et al. Is the volume of blood cultured still a significant factor in the diagnosis of bloodstream infections? J Clin Microbiol. 2007;45(9):2765-2769.
CLSI. Principles and Procedures for Blood Cultures. 2nd ed. CLSI guideline M47. Clinical and Laboratory Standards Institute; 2022.
Baron EJ, Weinstein MP, Dunne Jr. WM, et al. Cumitech 1C, Blood Cultures IV. Coordinating ed., E.J. Baron. ASM Press, Washington, D.C. 2005.
Huber S, Hetzer B, Crazzolara R, Orth-Höller D. The correct blood volume for paediatric blood cultures: a conundrum? Clin Microbiol Infect. 2020;26(2):168-173.
Carroll KC, Pfaller MA, Landry ML, et al. Manual of Clinical Microbiology, 12th Edition, 2019.
Hall KK and Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev.2006;19(4):788-802.
Bard JD. Blood Culture. A key investigation for the diagnosis of bloodstream infection.2022
Wilson ML, Mirrett S, Reller LB, et al. Recovery of clinically important microorganisms from the BacT/ALERT blood culture system does not require testing for 7 days. Diagn Microbiol Infect Dis.1993;16(1):31-34.
Cockerill FR III, Wilson JW, Vetter EA, et al. Optimal testing parameters for blood cultures. Clin Infect Dis. 2004;38 :1724-1730.
Dellinger RP, Levy MM, Carlet JM et al. International guidelines for management of severe sepsis and septic shock, Crit Care Med 2008;36(1): 296-327.
Karakoç AE. Güncel Rehberler Işığında Sepsis, Klasik ve Hızlı Tanı Yöntemleri, Ulusal Hemokültür Rehberi. Ankem Derg 2014;28(Ek 2):46-51.
Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589-1596.
Beekmann SE, Diekama DJ, Chapin KC, Goern GV. Effects of rapid detection of bloodstream infections on length of hospitalization and hospital charges. J Clin Microbiol. 2003;41(7):3119-3125.
Munson E, Diekema DJ, Beekmann SE, et al. Detection and treatment of bloodstream infection: laboratory reporting and antimicrobial management. J Clin Microbiol. 2003;41(1):495-497.
Barenfanger J, Graham DR, Kolluri L, et al. Decreased Mortality Associated With Prompt Gram Staining of Blood Cultures. Am J Clin Pathol. 2008;130(6):870-876.
CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 32nd ed. CLSI supplement M100. Clinical and Laboratory Standards Institute; 2022.
Fowler Jr VG, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis AL, et al. The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clinical InfectiousDiseases.2023;77(4):518-526. https://doi.org/10.1093/cid/ciad271
Chamat-Hedemand S, Dahl A, Ostergaard L, et al. Prevalence of infective endocarditis in streptococcal bloodstream infections is dependent on streptococcal Species. Circulation 2020; 142:720–30.
Aldman MH, Rasmussen M, Olaison L, Påhlman LI. Endocarditis due to Staphylococcus lugdunensis-a retrospective national registry-based study. Eur J Clin Microbiol Infect Dis 2021; 40:1103–6.
Dahl A, Fowler VG, Miro JM, Bruun NE. Sign of the times: updating infective endocarditis diagnostic criteria to recognize Enterococcus faecalis as a typical endocarditis bacterium. Clin Infect Dis 2022; 75:1097–102.
Berge A, Kronberg K, Sunnerhagen T, Nilson BHK, Giske CG, Rasmussen M. Risk for endocarditis in bacteremia with Streptococcus-like bacteria: a retrospective population-based cohort study. Open Forum Infect Dis 2019; 6:ofz437.
Chirouze C, Athan E, Alla F, et al. Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-prospective cohort study. Clin Microbiol Infect 2013; 19:1140–7.
Wang A, Athan E, Pappas PA, et al. Contemporary clinical profile and outcome of prosthetic valve endocarditis. JAMA 2007; 297:1354–61.
Bläckberg A, Falk L, Oldberg K, Olaison L, Rasmussen M. Infective endocarditis due to Corynebacterium species: clinical features and antibiotic resistance. Open Forum Infect Dis 2021; 8:ofab055.
Maskarinec SA, Thaden JT, Cyr DD, Ruffin F, Souli M, Fowler VG. The risk of cardiac device-related infection in bacteremic patients is Species specific: results of a 12-year prospective cohort. Open Forum Infect Dis 2017; 4:ofx132.
Berisha B, Ragnarsson S, Olaison L, Rasmussen M. Microbiological etiology in prosthetic valve endocarditis: a nationwide registry study. J Intern Med 2022; 292:428–37.
Bouchiat C, Saison J, Boisset S, et al. Nontuberculous mycobacteria: an underestimated cause of bioprosthetic valve infective endocarditis. Open Forum Infect Dis 2015; 2:ofv047.
Fowler Jr VG, Durack DT, Selton-Suty C, Athan E, Bayer AS, Chamis AS et al.The 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis: Updating the Modified Duke Criteria. Clin Infect Dis. 2023 May 4;77(4):518–526.
