Tanısal İşlemlerde Bedel-Etkinlik
Özet
Acil servisin sınırlı kaynak kullanımının yanında hızlı, yüksek duyarlılıklı tanı araçlarına ihtiyaç duyması; bedel-etkinlik değerlendirilmesini zorunlu kılar. Bedel-etkin tanı stratejilerinde klinik karar kuralları ve risk skorlarının rolü önem kazanmaktadır. Canadian CT Head Rule (Kanada Kranial BT Kuralları), National Emergency X-Radiography Utilization Study Group (NEXUS, Ulusal Acil Radyografi Kullanım Çalışma Grubu) ve HEART (History, ECG, Age, Risk Factors, Troponin) skoru gibi algoritmalar, acil serviste ileri tetkik gereksinimini belirlemede klinisyenlere rehberlik etmektedir. Öncelikle direkt grafinin kullanıldığı ve tanı konulan hastalarda hem hızlıca tedavi basamağına geçilir hem de ek tetkik ihtiyacı bulunmaz, bedel-etkin bir yol izlenmiş olur. Direkt grafinin endike olmadığı, yetersiz kaldığı veya klinik şüphenin devam ettiği hastalarda bilgisayarlı tomografi (BT) veya ultrasonografi (USG) gibi araçların kullanımı düşünülmelidir. USG safra kesesi, nefro-ürolithiazis, ektopik gebelik, apandisit değerlendirmesinde; sıvı içeriği yüksek organların değerlendirilmesinde yüksek tanısal doğruluk sunar. İyonize radyasyon içermemesi, hızlı sonuç vermesi, uygun maliyeti avantajlarından olup kullanıcı bağımlı olması dezavantajlarındandır. BT ve manyetik rezonans görüntüleme (MR), maliyeti gereği bedel-etkinlik analizinde geride kalsa da gerekli ve uygun klinik koşullarda kullanımı vazgeçilmezdir. Klinisyenin uygun sırayla ve endikasyonla hangi aracı kullanacağına karar vermesi önem arz etmektedir.
Referanslar
Korley FK, Pham JC, Kirsch TD. Use of advanced radiology during visits to US emergency departments for injury-related conditions, 1998-2007. Jama. 2010;304(13):1465-71.
Schuur JD, Venkatesh AK. The growing role of emergency departments in hospital admissions. N Engl J Med. 2012;367(5):391-3.
Bate A, Mitton C. Application of economic principles in healthcare priority setting. Expert Rev Pharmacoecon Outcomes Res. 2006;6(3):275-84.
Arrow KJ. Uncertainty and the welfare economics of medical care. 1963. Bull World Health Organ. 2004;82(2):141-9.
Newhouse JP. Why is there a quality chasm? Health Aff (Millwood). 2002;21(4):13-25.
Sox HC, Greenfield S. Comparative effectiveness research: a report from the Institute of Medicine. Ann Intern Med. 2009;151(3):203-5.
Weinstein MC, Skinner JA. Comparative effectiveness and health care spending--implications for reform. N Engl J Med. 2010;362(5):460-5.
Neumann PJ, Sanders GD, Russell LB, Siegel JE, Ganiats TG. Cost-effectiveness in health and medicine: Oxford University Press; 2016.
Khare RK, Courtney DM, Powell ES, Venkatesh AK, Lee TA. Sixty-four-slice computed tomography of the coronary arteries: cost-effectiveness analysis of patients presenting to the emergency department with low-risk chest pain. Acad Emerg Med. 2008;15(7):623-32.
April MD, Murray BP. Cost-effectiveness Analysis Appraisal and Application: An Emergency Medicine Perspective. Academic Emergency Medicine. 2017;24(6):754-68.
Weinstein MC, Siegel JE, Gold MR, Kamlet MS, Russell LB. Recommendations of the Panel on Cost-effectiveness in Health and Medicine. Jama. 1996;276(15):1253-8.
Adam T, Koopmanschap MA, Evans DB. Cost-effectiveness analysis: can we reduce variability in costing methods? Int J Technol Assess Health Care. 2003;19(2):407-20.
Welch HG, Black WC. Overdiagnosis in cancer. J Natl Cancer Inst. 2010;102(9):605-13.
Welch HG. Overdiagnosis and mammography screening. Bmj. 2009;339:b1425.
Ferrante di Ruffano L, Hyde CJ, McCaffery KJ, Bossuyt PMM, Deeks JJ. Assessing the value of diagnostic tests: a framework for designing and evaluating trials. BMJ. 2012;344:e686.
Bossuyt PM, Irwig L, Craig J, Glasziou P. Comparative accuracy: assessing new tests against existing diagnostic pathways. Bmj. 2006;332(7549):1089-92.
Gluud C, Gluud LL. Evidence based diagnostics. Bmj. 2005;330(7493):724-6.
Biesheuvel CJ, Grobbee DE, Moons KGM. Distraction From Randomization in Diagnostic Research. Annals of Epidemiology. 2006;16(7):540-4.
Cannoodt L, Mock C, Bucagu M. Identifying barriers to emergency care services. Int J Health Plann Manage. 2012;27(2):e104-20.
Onah MN, Govender V. Out-of-pocket payments, health care access and utilisation in south-eastern Nigeria: a gender perspective. PLoS One. 2014;9(4):e93887.
Ro YS, Shin SD, Jeong J, Kim MJ, Jung YH, Kamgno J, et al. Evaluation of demands, usage and unmet needs for emergency care in Yaoundé, Cameroon: a cross-sectional study. BMJ Open. 2017;7(2):e014573.
Richard F, Ouédraogo C, Compaoré J, Dubourg D, De Brouwere V. Reducing financial barriers to emergency obstetric care: experience of cost-sharing mechanism in a district hospital in Burkina Faso. Trop Med Int Health. 2007;12(8):972-81.
Monaghan TF, Rahman SN, Agudelo CW, Wein AJ, Lazar JM, Everaert K, et al. Foundational Statistical Principles in Medical Research: Sensitivity, Specificity, Positive Predictive Value, and Negative Predictive Value. Medicina (Kaunas). 2021;57(5).
Versi E. "Gold standard" is an appropriate term. Bmj. 1992;305(6846):187.
Zègre-Hemsey J, Sommargren CE, Drew BJ. Initial ECG acquisition within 10 minutes of arrival at the emergency department in persons with chest pain: time and gender differences. J Emerg Nurs. 2011;37(1):109-12.
Kim JS, Dong JZ, Brener S, Coyte PC, Rampersaud YR. Cost-effectiveness analysis of a reduction in diagnostic imaging in degenerative spinal disorders. Healthc Policy. 2011;7(2):e105-21.
Kır Karluka P, Oguz AB, Polat O, Yüksel Haliloğlu E, Günalp M, Genc S, et al. Direct and Indirect Cost Analysis for Emergency Department Patients. Journal of Ankara University Faculty of Medicine. 2021;74:43-51.
Al Nhdi N, Al Asmari H, Al Thobaity A. Investigating Indicators of Waiting Time and Length of Stay in Emergency Departments. Open Access Emerg Med. 2021;13:311-8.
Lentz B, Fong T, Rhyne R, Risko N. A systematic review of the cost-effectiveness of ultrasound in emergency care settings. Ultrasound J. 2021;13(1):16.
Buchberger B, Scholl K, Krabbe L, Spiller L, Lux B. Radiation exposure by medical X-ray applications. Ger Med Sci. 2022;20:Doc06.
Treskes K, Sierink JC, Edwards MJR, Beuker BJA, Van Lieshout EMM, Hohmann J, et al. Cost-effectiveness of immediate total-body CT in patients with severe trauma (REACT-2 trial). Br J Surg. 2021;108(3):277-85.
Runde D. Calculated decisions:NEXUS criteria for c-spine imaging. Emerg Med Pract. 2020(Suppl 8):Cd1-cd3.
Sampalli A, Kang J, Campbell SG, LeBlanc CH. Adherence to the Canadian CT Head Rule in a Nova Scotian Emergency and Trauma Center. Cureus. 2023;15(5):e39484.
Riley RF, Miller CD, Russell GB, Harper EN, Hiestand BC, Hoekstra JW, et al. Cost analysis of the History, ECG, Age, Risk factors, and initial Troponin (HEART) Pathway randomized control trial. Am J Emerg Med. 2017;35(1):77-81.
Duriseti RS, Brandeau ML. Cost-effectiveness of strategies for diagnosing pulmonary embolism among emergency department patients presenting with undifferentiated symptoms. Ann Emerg Med. 2010;56(4):321-32.e10.
Ghazal F, Theobald H, Rosenqvist M, Al-Khalili F. Feasibility and outcomes of atrial fibrillation screening using intermittent electrocardiography in a primary healthcare setting: A cross-sectional study. PLoS One. 2018;13(5):e0198069.
Gach O, El HZ, Lancellotti P. [Acute coronary syndrome]. Rev Med Liege. 2018;73(5-6):243-50.
Vallabhajosyula S, Verghese D, Bell MR, Murphree DH, Cheungpasitporn W, Miller PE, et al. Fibrinolysis vs. primary percutaneous coronary intervention for ST-segment elevation myocardial infarction cardiogenic shock. ESC Heart Fail. 2021;8(3):2025-35.
Christiansen NM, Brabrand M, Fløjstrup M, Bech M, Lassen AT, Mogensen CB, et al. Utilisation and time to performance of diagnostic imaging in patients admitted to Danish emergency departments: a nationwide register-based study from 2007 to 2017. BMJ Open. 2023;13(5):e070943.
Self WH, Courtney DM, McNaughton CD, Wunderink RG, Kline JA. High discordance of chest x-ray and computed tomography for detection of pulmonary opacities in ED patients: implications for diagnosing pneumonia. Am J Emerg Med. 2013;31(2):401-5.
Ct versus X-ray for Cervical Spine Blunt Trauma Washington University School of Medicine 2007 [cited 2025 May 10]. Available from: https://emergencymedicine.wustl.edu/items/1977/#:~:text=Bottom%20Line.
Gibbs V, Cole D, Sassano A. Ultrasound physics and technology: how, why and when: Elsevier Health Sciences; 2011.
Lamperti M, Bodenham AR, Pittiruti M, Blaivas M, Augoustides JG, Elbarbary M, et al. International evidence-based recommendations on ultrasound-guided vascular access. Intensive Care Med. 2012;38(7):1105-17.
Bierig SM, Jones A. Accuracy and cost comparison of ultrasound versus alternative imaging modalities, including CT, MR, PET, and angiography. Journal of Diagnostic Medical Sonography. 2009;25(3):138-44.
Fowlkes JB. American Institute of Ultrasound in Medicine consensus report on potential bioeffects of diagnostic ultrasound: executive summary. Journal of ultrasound in medicine: official journal of the American Institute of Ultrasound in Medicine. 2008;27(4):503-15.
Radiology ACo. American College of Radiology (2020) ACR Appropriateness Criteria 2020 [cited 2025 May 8]. Available from: https://acsearch.acr.org/list.
American Board of Internal Medicine Foundation (2020) Choosing Wisely Initiative American Board of Internal Medicine Foundation 2020 [cited 2025 May 8]. Available from: https://www.choosingwisely.org.
American Institute of Ultrasound in Medicine (2020) Ultrasound First American Institute of Ultrasound in Medicine2020 [cited 2025 May 8]. Available from: http://www.ultrasoundfirst.org.
Sistrom CL, McKay NL. Costs, charges, and revenues for hospital diagnostic imaging procedures: differences by modality and hospital characteristics. J Am Coll Radiol. 2005;2(6):511-9.
Lentz B, Fong T, Rhyne R, Risko N. A systematic review of the cost-effectiveness of ultrasound in emergency care settings. The Ultrasound Journal. 2021;13(1):16.
van Atta AJ, Baskin HJ, Maves CK, Rollins MD, Bolte RG, Mundorff MB, et al. Implementing an ultrasound-based protocol for diagnosing appendicitis while maintaining diagnostic accuracy. Pediatr Radiol. 2015;45(5):678-85.
Gregory S, Kuntz K, Sainfort F, Kharbanda A. Cost-Effectiveness of Integrating a Clinical Decision Rule and Staged Imaging Protocol for Diagnosis of Appendicitis. Value Health. 2016;19(1):28-35.
Stations PS, Stations PS, Stations IA. Advanced Trauma Life Support®. 2016.
Van Schaik GWW, Van Schaik KD, Murphy MC. Point-of-Care Ultrasonography (POCUS) in a Community Emergency Department: An Analysis of Decision Making and Cost Savings Associated With POCUS. Journal of Ultrasound in Medicine. 2019;38(8):2133-40.
Zeina AR, Trachtengerts V, Abadi S, Jarchowsky J, Soimu U, Nachtigal A. Thoraco-abdominal Aorta Dissection: Look Again Before You Leap. J Radiol Case Rep. 2009;3(9):29-33.
Bellolio MF, Heien HC, Sangaralingham LR, Jeffery MM, Campbell RL, Cabrera D, et al. Increased Computed Tomography Utilization in the Emergency Department and Its Association with Hospital Admission. West J Emerg Med. 2017;18(5):835-45.
Abuqbeitah M, Demir M, Sonmezoglu K, Sayman H, Kabasakal L, Sager S, et al. Patients Undergoing Multiple 18F-FDG PET/CT Scans: 11-Year Study At A High-Capacity Center2021.
Raja AS, Wright C, Sodickson AD, Zane RD, Schiff GD, Hanson R, et al. Negative appendectomy rate in the era of CT: an 18-year perspective. Radiology. 2010;256(2):460-5.
Rao PM, Rhea JT, Novelline RA, Mostafavi AA, McCabe CJ. Effect of computed tomography of the appendix on treatment of patients and use of hospital resources. N Engl J Med. 1998;338(3):141-6.
Doty E, DiGiacomo S, Gunn B, Westafer L, Schoenfeld E. What are the clinical effects of the different emergency department imaging options for suspected renal colic? A scoping review. JACEP Open. 2021;2(3):e12446.
Jennings R, Guo H, Goldin A, Wright DR. Cost-effectiveness of Imaging Protocols for Suspected Appendicitis. Pediatrics. 2020;145(2).
Kepka S, Zarca K, Ohana M, Hoffmann A, Muller J, Le Borgne P, et al. A Real-World Cost-Effectiveness Study Evaluating Imaging Strategies for the Diagnostic Workup of Renal Colic in the Emergency Department. Medicina (Kaunas). 2023;59(3).
Kline JA, Mitchell AM, Kabrhel C, Richman PB, Courtney DM. Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism. J Thromb Haemost. 2004;2(8):1247-55.
Righini M, Van Es J, Den Exter PL, Roy PM, Verschuren F, Ghuysen A, et al. Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. Jama. 2014;311(11):1117-24.
Aujesky D, Obrosky DS, Stone RA, Auble TE, Perrier A, Cornuz J, et al. A prediction rule to identify low-risk patients with pulmonary embolism. Arch Intern Med. 2006;166(2):169-75.
Stein PD, Fowler SE, Goodman LR, Gottschalk A, Hales CA, Hull RD, et al. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006;354(22):2317-27.
Gupta S, Kumar A, Kaur T, Gamanagatti S, Kumar A, Gupta A, et al. Current updates in acute traumatic aortic injury: radiologic diagnosis and management. Clin Exp Emerg Med. 2022;9(2):73-83.
Flower L, Arrowsmith J, Bewley J, Cook S, Cooper G, Flower J, et al. Management of acute aortic dissection in critical care. Journal of the Intensive Care Society. 2023;24:175114372311622.
Hillal A, Ullberg T, Ramgren B, Wassélius J. Computed tomography in acute intracerebral hemorrhage: neuroimaging predictors of hematoma expansion and outcome. Insights into Imaging. 2022;13(1):180.
Martinez G, Katz JM, Pandya A, Wang JJ, Boltyenkov A, Malhotra A, et al. Cost-Effectiveness Study of Initial Imaging Selection in Acute Ischemic Stroke Care. J Am Coll Radiol. 2021;18(6):820-33.
Takala J, Peura H, Pirinen R, Väätäinen K, Terjajev S, Lin Z, et al. High Sensitivity in Spontaneous Intracranial Hemorrhage Detection from Emergency Head CT Scans Using Meta-Learning Approach. medRxiv. 2025:2024.05.28.24308084.
Macellari F, Paciaroni M, Agnelli G, Caso V. Neuroimaging in Intracerebral Hemorrhage. Stroke. 2014;45(3):903-8.
Holmes MW, Goodacre S, Stevenson MD, Pandor A, Pickering A. The cost-effectiveness of diagnostic management strategies for adults with minor head injury. Injury. 2012;43(9):1423-31.
Chardoli M, Hasan-Ghaliaee T, Akbari H, Rahimi-Movaghar V. Accuracy of chest radiography versus chest computed tomography in hemodynamically stable patients with blunt chest trauma. Chin J Traumatol. 2013;16(6):351-4.
Treskes K, Sierink J, Edwards M, Beuker B, Lieshout E, Hohmann J, et al. Cost-effectiveness of immediate total-body CT in patients with severe trauma (REACT-2 trial). British Journal of Surgery. 2021;108.
Abdel Hamid MA, Abd-erRazik MA, Nagy M, El-Shinawi M, Hirshon JM, El-Setouhy M. Computed tomography benefits and cost in hemodynamically stable patients with blunt abdominal trauma at an Egyptian University Hospital. Afr J Emerg Med. 2024;14(2):96-9.
Comparison of Efficacy of FAST and CT Scan in Patients with Blunt Abdominal Trauma Annals of Punjab Medical College2019 [cited 2025 May 10]. Available from: https://apmcfmu.com/index.php/apmc/article/view/34#:~:text=,of%20patients.
Huber-Wagner S, Lefering R, Qvick LM, Körner M, Kay MV, Pfeifer KJ, et al. Effect of whole-body CT during trauma resuscitation on survival: a retrospective, multicentre study. Lancet. 2009;373(9673):1455-61.
Blackmore CC, Ramsey SD, Mann FA, Deyo RA. Cervical spine screening with CT in trauma patients: a cost-effectiveness analysis. Radiology. 1999;212(1):117-25.
Avci M, Kozaci N. Comparison of X-Ray Imaging and Computed Tomography Scan in the Evaluation of Knee Trauma. Medicina (Kaunas). 2019;55(10).
Brian R, Bennett DJ, Kim WC, Stein DM. Computed tomography angiography is associated with low added utility for detecting clinically relevant vascular injuries among patients with extremity trauma. Trauma Surg Acute Care Open. 2021;6(1):e000828.
Gakhal MS, Sartip KA. CT Angiography Signs of Lower Extremity Vascular Trauma. American Journal of Roentgenology. 2009;193(1):W49-W57.
Penckofer M, Kazmi KS, Thon J, Tonetti DA, Ries C, Rajagopalan S. Neuro-imaging in intracerebral hemorrhage: updates and knowledge gaps. Frontiers in Neuroscience. 2024;Volume 18 - 2024.
Burke JF, Kerber KA, Iwashyna TJ, Morgenstern LB. Wide variation and rising utilization of stroke magnetic resonance imaging: data from 11 states. Ann Neurol. 2012;71(2):179-85.
Kidwell CS, Chalela JA, Saver JL, Starkman S, Hill MD, Demchuk AM, et al. Comparison of MRI and CT for detection of acute intracerebral hemorrhage. Jama. 2004;292(15):1823-30.
Grund B, Ebert A, Sandikci V, Neumaier-Probst E, Alonso A. Benefits of early MR-Imaging in patients with acute spontaneous intracerebral hemorrhage: a retrospective study. BMC Neurol. 2024;24(1):487.
Fandler-Höfler S, Ambler G, Goeldlin MB, Obergottsberger L, Wünsch G, Kneihsl M, et al. MRI-Based Prediction of Macrovascular Causes of Intracerebral Hemorrhage: The MACRO Score. Neurology. 2024;103(10):e209950.
Tu LH, Melnick E, Venkatesh AK, Sheth KN, Navaratnam D, Yaesoubi R, et al. Cost-Effectiveness of CT, CTA, MRI, and Specialized MRI for Evaluation of Patients Presenting to the Emergency Department With Dizziness. American Journal of Roentgenology. 2024;222(2):e2330060.
de Havenon A, Delic A, McNally S, Reddy V, Anzai Y, Majersik J, et al. Cost-effectiveness of Rapid MRI in the Emergency Department Evaluation of Suspected Stroke (2532). Neurology. 2020;94(15_supplement):2532.
Paszkowska E, Wasilewski G, Szalcunas-Olsztyn A, Jancewicz P, Stefanowicz E. The comparison of the value of ct imaging and selected MRI sequences (including DWI) in the evaluation of axonal injuries. Pol J Radiol. 2010;75(1):13-7.
Lee HJ, Sun, H. W., Lee, J. S., Choi, N. J., Jung, Y. J., Hong, S. K. . Clinical Outcomes of Diffuse Axonal Injury According to Radiological Grade. Journal of Trauma and Injury. 2018.
Lee H, Yang Y, Xu J, Ware JB, Liu B. Use of Magnetic Resonance Imaging in Acute Traumatic Brain Injury Patients is Associated with Lower Inpatient Mortality. J Clin Imaging Sci. 2021;11:53.
Earnshaw SR, Jackson D, Farkouh R, Schwamm L. Cost-Effectiveness of Patient Selection Using Penumbral-Based MRI for Intravenous Thrombolysis. Stroke. 2009;40(5):1710-20.
Newman-Toker DE, McDonald KM, Meltzer DO. How much diagnostic safety can we afford, and how should we decide? A health economics perspective. BMJ Qual Saf. 2013;22 Suppl 2(Suppl 2):ii11-ii20.
Nze Ossima A, Ngaleu Siaha BF, Mimouni M, Mezaour N, Darlington M, Berard L, et al. Cost-effectiveness of modified diagnostic strategy to safely rule-out pulmonary embolism in the emergency department: a non-inferiority cluster crossover randomized trial (MODIGLIA-NI). BMC Emergency Medicine. 2023;23(1):140.
Anand A, Lee KK, Chapman AR, Ferry AV, Adamson PD, Strachan FE, et al. High-Sensitivity Cardiac Troponin on Presentation to Rule Out Myocardial Infarction: A Stepped-Wedge Cluster Randomized Controlled Trial. Circulation. 2021;143(23):2214-24.
Chuang MA, Gnanamanickam ES, Karnon J, Lambrakis K, Horsfall M, Blyth A, et al. Cost effectiveness of a 1-hour high-sensitivity troponin-T protocol: An analysis of the RAPID-TnT trial. Int J Cardiol Heart Vasc. 2022;38:100933.
CADTH Optimal Use Reports. High-Sensitivity Cardiac Troponin for the Rapid Diagnosis of Acute Coronary Syndrome in the Emergency Department: A Clinical and Cost-Effectiveness Evaluation: Protocol. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health
Copyright © 2012 CADTH.; 2012.
Matthes A, Wolf F, Wilde E, Bleidorn J, Markwart R. Point-of-care measurement of C-reactive protein promotes de-escalation of treatment decisions and strengthens the perceived clinical confidence of physicians in out-of-hours outpatient emergency medical services. BMJ Open. 2023;13(5):e069453.
Holmes EAF, Harris SD, Hughes A, Craine N, Hughes DA. Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care. Antibiotics (Basel). 2018;7(4).
Westwood M, Ramaekers B, Whiting P, Tomini F, Joore M, Armstrong N, et al. Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis. Health Technol Assess. 2015;19(96):v-xxv, 1-236.
Ward MJ, Self WH, Singer A, Lazar D, Pines JM. Cost-effectiveness analysis of early point-of-care lactate testing in the emergency department. J Crit Care. 2016;36:69-75.
Siebert U, Milev S, Zou D, Litkiewicz M, Gaggin HK, Tirapelle L, et al. Economic Evaluation of an N-terminal Pro B-type Natriuretic Peptide-Supported Diagnostic Strategy Among Dyspneic Patients Suspected of Acute Heart Failure in the Emergency Department. Am J Cardiol. 2021;147:61-9.
Mueller C, Laule-Kilian K, Schindler C, Klima T, Frana B, Rodriguez D, et al. Cost-effectiveness of B-type natriuretic peptide testing in patients with acute dyspnea. Arch Intern Med. 2006;166(10):1081-7.