Kromofob Renal Hücreli Karsinom (Kromofob RCC)
Özet
Kromofob renal hücreli karsinom (Kromofob RCC), 1985 yılında tanımlanmış olup, renal hücreli karsinomların yaklaşık %6’sını oluşturur. Berrak hücreli RCC’ye göre daha az agresiftir ve çoğu zaman görüntülemelerde tesadüfen saptanır. Sarkomatoid değişim, vasküler invazyon ve tümör nekrozu kötü prognoz göstergeleridir. Mikroskopik olarak fibrovasküler septalarla ayrılmış, eozinofilik sitoplazmalı hücreler, perinükleer halo ve belirgin hücre membranı tipiktir. İmmünohistokimyada KIT ve keratin 7 diffüz pozitiftir, CA9 negatiftir. Genetik olarak 1, 2, 6, 10, 13, 17 ve 21 kromozom kayıpları ile karakterizedir. Genellikle iyi prognozlu olmakla birlikte, büyük tümör boyutu veya sarkomatoid farklılaşma kötü seyirle ilişkilidir.
Referanslar
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