Eye Diseases And Treatment: Novel Ophthalmic Drug Delivery Systems

Willoughby CE, Ponzin D, Ferrari S, Lobo A, Landau K, Omidi Y. Anatomy and physiology of the human eye: effects of mucopolysaccharidoses disease on structure and function - a review. Clinical and Experimental Ophthalmology, 2010, 38: 2-11.

Bhattacharjee A, Das PJ, Adhikari P, Marbaniang D, Pal P, Ray S, Mazumder B. Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery. European journal of ophthalmology, 2019, 29: 113-126.

Bergin RB, Geetha P. Refractive Errors in Children: A Short Review. International Journal of Health Sciences: 7291-7297.

Watson S, Cabrera-Aguas M, Khoo P. Common eye infections. Aust Prescr, 2018, 41: 67-72.

Zhang J, Tuo J, Wang Z, Zhu A, Machalińska A, Long Q. Pathogenesis of common ocular diseases. 2015, 2015.

Alshammari F, Shaikh S, Hussain A, Alafnan A, Almuzaini I, Alshammari B. In: Public Awareness of Common Eye Diseases and the Role of Pharmacists in Raising This Awareness in Saudi Arabia: A Cross-Sectional Study, Healthcare. Multidisciplinary Digital Publishing Institute: 2021; 692.

Lam D, Rao SK, Ratra V, Liu Y, Mitchell P, King J, Tassignon MJ, Jonas J, Pang CP, Chang DF. Cataract. Nat Rev Dis Primers, 2015, 1: 15014.

Raja H, Akram MU, Hassan T, Ramzan A, Aziz A, Raja H. Glaucoma Detection Using Optical Coherence Tomography Images: A Systematic Review of Clinical and Automated Studies. IETE Journal of Research, 2022: 1-21.

Nayak K, Misra M. A review on recent drug delivery systems for posterior segment of eye. Biomed Pharmacother, 2018, 107: 1564-1582.

Ahmed, S., Amin, M.M. & Sayed, S. Ocular Drug Delivery: a Comprehensive Review. AAPS PharmSciTech 24, 66 (2023). https://doi.org/10.1208/s12249-023-02516-9.

Agrawal H, Sharma P, Malviya R. Applications, Model Study and Commercial Utilization (Patents) of Ophthalmic Route as Drug Delivery Site. Pharm Anal Acta, 2019, 9: 607.

Patel A, Cholkar K, Agrahari V, Mitra AK. Ocular drug delivery systems: An overview. World J Pharmacol, 2013, 2: 47-64.

Gote V, Sikder S, Sicotte J, Pal D. Ocular Drug Delivery: Present Innovations and Future Challenges. J Pharmacol Exp Ther, 2019, 370: 602-624.

Zignani M, Tabatabay C, Gurny R. Topical semi-solid drug delivery: kinetics and tolerance of ophthalmic hydrogels. Advanced drug delivery reviews, 1995, 16: 51-60.

Baranowski P, Karolewicz B, Gajda M, Pluta J. Ophthalmic drug dosage forms: characterisation and research methods. ScientificWorldJournal, 2014, 2014: 861904.

Akhter MH, Ahmad I, Alshahrani MY, Al-Harbi AI, Khalilullah H, Afzal O, Altamimi AS, Najib Ullah SNM, Ojha A, Karim S. Drug Delivery Challenges and Current Progress in Nanocarrier-Based Ocular Therapeutic System. Gels, 2022, 8: 82.

Jervis L. A Summary of Recent Advances in Ocular Inserts and Implants. Journal of Bioequivalence & Bioavailability, 2016, 09.

Kumar K, Bhowmik D, Harish G, SD, Kumar P. Ocular Inserts: A novel controlled drug delivery system. Pharma Innov. J, 2012, 1.

Tiwari R, Pandey V, Asati S, Soni V, Jain D. Therapeutic challenges in ocular delivery of lipid based emulsion. Egyptian Journal of Basic and Applied Sciences, 2018, 5: 121-129.

Maulvi FA, Soni TG, Shah DO. A review on therapeutic contact lenses for ocular drug delivery. Drug Deliv, 2016, 23: 3017-3026.

Farandos NM, Yetisen AK, Monteiro MJ, Lowe CR, Yun SH. Contact lens sensors in ocular diagnostics. Adv Healthc Mater, 2015, 4: 792-810.

Hsu K-H, Gause S, Chauhan A. Review of ophthalmic drug delivery by contact lenses. Journal of Drug Delivery Science and Technology, 2014, 24: 123-135.

Gade, S., So, Y., Mishra, D., Baviskar, S. M., Assiri, A. A., Glover, K., Sheshala, R., Vora, L. K., & Thakur, R. R. S. (2025). Ocular Drug Delivery: Emerging Approaches and Advances. Pharmaceutics, 17(5), 599. https://doi.org/10.3390/pharmaceutics17050599.

Dhyani A, Kumar G. A New Vision To Eye: Novel Ocular Drug Delivery System. Pharmacophore, 2019, 10: 13-20.

Wang X, Wang S, Zhang Y. Advance of the application of nano-controlled release system in ophthalmic drug delivery. Drug Delivery, 2016, 23: 2897-2901.

Shende PK, Godbole R. Current and novel techniques in the ophthalmic drug delivery systems. Int J Pharm Sci Res, 2016, 7: 3557-3566.

Joseph RR, Venkatraman SS. Drug delivery to the eye: what benefits do nanocarriers offer? Nanomedicine (Lond), 2017, 12: 683-702.

Rawas-Qalaji M, Williams CA. Advances in ocular drug delivery. Curr Eye Res, 2012, 37: 345-56.

Bairagi, R.D., Reon, R.R., Hasan, M.M. et al. Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases. Discover Nano 20, 75 (2025). https://doi.org/10.1186/s11671-025-04234-6.

Dymek M, Sikora E. Liposomes as biocompatible and smart delivery systems–The current state. Advances in Colloid and Interface Science, 2022: 102757.

Mehrandish S, Mirzaeei S. A review on ocular novel drug delivery systems of antifungal drugs: functional evaluation and comparison of conventional and novel dosage forms. Advanced Pharmaceutical Bulletin, 2021, 11: 28.

Wang Y, Wang C. Novel Eye Drop Delivery Systems: Advance on Formulation Design Strategies Targeting Anterior and Posterior Segments of the Eye. Pharmaceutics, 2022, 14: 1150.

Kaiser JM, Imai H, Haakenson JK, Brucklacher RM, Fox TE, Shanmugavelandy SS, Unrath KA, Pedersen MM, Dai P, Freeman WM. Nanoliposomal minocycline for ocular drug delivery. Nanomedicine: Nanotechnology, Biology and Medicine, 2013, 9: 130-140.

Nicolosi D, Cupri S, Genovese C, Tempera G, Mattina R, Pignatello R. Nanotechnology approaches for antibacterial drug delivery: preparation and microbiological evaluation of fusogenic liposomes carrying fusidic acid. International journal of antimicrobial agents, 2015, 45: 622-626.

Sharma R, Dua J, Parsad D. An overview on Niosomes: Novel Pharmaceutical drug delivery system. Journal of Drug Delivery and Therapeutics, 2022, 12: 171-177.

Badri S, Sailaja P, Annagowni NR, Lunjala RS, Seshu D. A review on niosomes as novel drug delivary system. International Journal of Indigenous Herbs and Drugs, 2022: 87.

Fetih G. Fluconazole-loaded niosomal gels as a topical ocular drug delivery system for corneal fungal infections. Journal of Drug Delivery Science and Technology, 2016, 35: 8-15.

Jayswal MG, Majaz Q. A comprehensive review on dendrimers drug delivery system.

Corrales DG, Rojas NF, Vindas GS, Muñoz MS, Rojas MC, Brenes DM, Salas MFR, Redondo GM. Dendrimers and their applications. Journal of Drug Delivery and Therapeutics, 2022, 12: 151-158.

López-Cano J, González-Cela-Casamayor M, Andrés-Guerrero V, Vicario-de-la-Torre M, Del Castillo JB, Herrero-Vanrell R, Molina-Martínez I. Development of an osmoprotective microemulsion as a therapeutic platform for ocular surface protection. International Journal of Pharmaceutics, 2022, 623: 121948.

Tiwari N, Sivakumar A. Biomedical application of microemulsion delivery systems: A review. 2022.

Morrison PW, Khutoryanskiy VV. Advances in ophthalmic drug delivery. Therapeutic delivery, 2014, 5: 1297-1315.

Rozi MF, Sabere ASM. A Review on Conventional and Novel Topical Ocular Drug Delivery System. Journal of Pharmacy, 2021, 1: 19-26.

Ramesh Y, Kothapalli CB, Reddigari JRP. A novel approaches on Ocular drug delivery system. Journal of Drug Delivery and Therapeutics, 2017, 7: 117-124.

Torres-Luna C, Fan X, Domszy R, Hu N, Wang NS, Yang A. Hydrogel-based ocular drug delivery systems for hydrophobic drugs. European Journal of Pharmaceutical Sciences, 2020, 154: 105503.

Aghamirsalim M, Mobaraki M, Soltani M, Kiani Shahvandi M, Jabbarvand M, Afzali E, Raahemifar K. 3D Printed Hydrogels for Ocular Wound Healing. Biomedicines, 2022, 10: 1562.

Lynch CR, Kondiah PP, Choonara YE, Du Toit LC, Ally N, Pillay V. Hydrogel biomaterials for application in ocular drug delivery. Frontiers in Bioengineering and Biotechnology, 2020, 8: 228.

Tyagi P, Barros M, Stansbury JW, Kompella UB. Light-activated, in situ forming gel for sustained suprachoroidal delivery of bevacizumab. Molecular pharmaceutics, 2013, 10: 2858-2867.

Rauck BM, Friberg TR, Mendez CAM, Park D, Shah V, Bilonick RA, Wang Y. Biocompatible reverse thermal gel sustains the release of intravitreal bevacizumab in vivo. Investigative ophthalmology & visual science, 2014, 55: 469-476.

Li S, Dong S, Xu W, Tu S, Yan L, Zhao C, Ding J, Chen X. Antibacterial hydrogels. Advanced science, 2018, 5: 1700527.