Efüzyonlu Otitis Media
Özet
Efüzyonlu otitis media (EOM), akut enfeksiyon bulgusu olmaksızın orta kulakta sıvı birikimiyle karakterizedir ve çocukluk çağında işitme kaybının en sık nedenlerinden biridir. Genellikle 1–6 yaş arasında görülür ve temel nedenler arasında Östaki tüpü disfonksiyonu, kronik inflamasyon, bakteriyel biyofilm oluşumu ve mukosilier temizlenme bozukluğu yer alır. Klinik olarak iletim tipi işitme kaybı, kulakta dolgunluk hissi ve konuşma gelişiminde gecikme ile seyreder. Tanıda otoskopi, pnömatik otoskopi, timpanometri ve odyometri gibi objektif yöntemler kullanılır. Hafif olgular kendiliğinden düzelebilse de, üç aydan uzun süren ya da belirgin işitme kaybı bulunan hastalarda ventilasyon tüpü uygulaması ve adenoidektomi temel tedavi seçenekleridir. Östaki tüpü balon dilatasyonu ve probiyotik destekli yaklaşımlar yeni ve minimal invaziv alternatifler olarak öne çıkmaktadır. Erken tanı ve bireyselleştirilmiş tedavi planlaması, EOM’un çocukların bilişsel, dilsel ve sosyal gelişimi üzerindeki olumsuz etkilerini azaltmada kilit rol oynar.
Referanslar
R. M. Rosenfeld et al., “Clinical Practice Guideline: Otitis Media with Effusion (Update),” Otolaryngology–Head and Neck Surgery, vol. 154, no. S1, 2016, doi: 10.1177/0194599815623467.
F. Martines, D. Bentivegna, E. Maira, V. Sciacca, and E. Martines, “Risk factors for otitis media with effusion: Case-control study in Sicilian schoolchildren,” Int J Pediatr Otorhinolaryngol, vol. 75, no. 6, 2011, doi: 10.1016/j.ijporl.2011.01.031.
G. A. Zielhuis, E. W. Heuvelmans-Heinen, G. H. Rach, and P. Van Den Broek, “Environmental risk factors for otitis media with effusion in preschool children,” Scand J Prim Health Care, vol. 7, no. 1, 1989, doi: 10.3109/02813438909103668.
V. D. Udagatti, R. Dinesh Kumar, V. Kumbar, and K. P. John, “High Resolution Computed Tomography Study of the Length, Width & Angle of Eustachian Tube in Normal Ear and in Chronic Otitis Media,” Indian Journal of Otolaryngology and Head & Neck Surgery, vol. 76, no. 6, pp. 5386–5392, Dec. 2024, doi: 10.1007/s12070-024-04984-2.
N. A. Stoler, B. R. Crovetti, A. M. Rosas Herrera, M. F. Musso, and Y.-C. C. Liu, “Rate and management of tympanic membrane perforations in children with Down syndrome and middle ear disorder,” Int J Pediatr Otorhinolaryngol, vol. 180, p. 111954, May 2024, doi: 10.1016/j.ijporl.2024.111954.
E. A. MacIntyre et al., “Otitis media incidence and risk factors in a population-based birth cohort,” Paediatr Child Health, vol. 15, no. 7, 2010, doi: 10.1093/pch/15.7.437.
R. G. Campbell, C. S. Birman, and L. Morgan, “Management of otitis media with effusion in children with primary ciliary dyskinesia: A literature review,” 2009. doi: 10.1016/j.ijporl.2009.08.024.
L. Dong et al., “Trends in the incidence and burden of otitis media in children: a global analysis from 1990 to 2021,” European Archives of Oto-Rhino-Laryngology, Dec. 2024, doi: 10.1007/s00405-024-09165-z.
F. Martines, D. Bentivegna, F. Di Piazza, G. Martinciglio, V. Sciacca, and E. Martines, “The point prevalence of otitis media with effusion among primary school children in Western Sicily,” European Archives of Oto-Rhino-Laryngology, vol. 267, no. 5, 2010, doi: 10.1007/s00405-009-1131-4.
A. Y. Gunduz, M. T. Kalcioglu, O. Yigit, and H. Kubba, “Otitis Media with Effusion,” 2024, pp. 347–365. doi: 10.1007/978-3-031-76173-7_17.
W. Liu, L. Shi, and Y. Feng, “Advance in the pathogenesis of otitis media with effusion induced by platelet-activating factor,” Sci Prog, vol. 107, no. 4, Oct. 2024, doi: 10.1177/00368504241265171.
H. A. Joo et al., “A trend of otologic diseases during the coronavirus disease 2019 pandemic period,” Acta Otolaryngol, pp. 1–6, Feb. 2025, doi: 10.1080/00016489.2025.2459343.
S. A. E.-S. Tawfik, A. A. Ibrahim, I. M. Talaat, S. S. A. E.-R. El-Alkamy, and A. Youssef, “Role of bacterial biofilm in development of middle ear effusion,” European Archives of Oto-Rhino-Laryngology, vol. 273, no. 11, pp. 4003–4009, Nov. 2016, doi: 10.1007/s00405-016-4094-2.
J. Bustamante, T. Tran, and C. R. Rodriguez, “Otitides,” Primary Care: Clinics in Office Practice, vol. 52, no. 1, pp. 1–14, Mar. 2025, doi: 10.1016/j.pop.2024.09.003.
M. Dzięgielewska and H. Skarżyński, “Hearing loss in Apert syndrome,” Nowa Audiofonologia, vol. 13, no. 1, pp. 77–82, Apr. 2024, doi: 10.17431/na/166254.
W. Liu, L. Shi, and Y. Feng, “Advance in the pathogenesis of otitis media with effusion induced by platelet-activating factor,” Sci Prog, vol. 107, no. 4, Oct. 2024, doi: 10.1177/00368504241265171.
M. Arslan, E. Ocak, and S. Tokgöz Yılmaz, “Wideband Absorption for Diagnosing Conductive Hearing Loss: Insights from Middle Ear Pathologies,” Journal of Academic Research in Medicine, vol. 14, no. 3, pp. 131–137, Jan. 2025, doi: 10.4274/jarem.galenos.2024.10327.
D. Savegnago et al., “Learning disabilities in children with hearing loss: A systematic review,” Am J Otolaryngol, vol. 45, no. 5, p. 104439, Sep. 2024, doi: 10.1016/j.amjoto.2024.104439.
A. Y. Gunduz, M. T. Kalcioglu, O. Yigit, and H. Kubba, “Otitis Media with Effusion,” 2024, pp. 347–365. doi: 10.1007/978-3-031-76173-7_17.
K. M. Harmes, R. A. Blackwood, H. L. Burrows, J. M. Cooke, R. Van Harrison, and P. P. Passamani, “Otitis media: Diagnosis and treatment,” Am Fam Physician, vol. 88, no. 7, 2013.
Y.-S. Cho, D.-K. Lee, C.-K. Lee, M. H. Ko, and H.-S. Lee, “Video pneumatic otoscopy for the diagnosis of otitis media with effusion: a quantitative approach,” European Archives of Oto-Rhino-Laryngology, vol. 266, no. 7, pp. 967–973, Jul. 2009, doi: 10.1007/s00405-008-0839-x.
A. L. P. K. de Araújo, F. P. Cordeiro, R. da Costa Monsanto, and N. de O. Penido, “Audiometric evaluation in different clinical presentations of otitis media,” Braz J Otorhinolaryngol, vol. 90, no. 1, p. 101359, Jan. 2024, doi: 10.1016/j.bjorl.2023.101359.
L. Li–min and D. Min–ming, “Management of Otitis Media with Effusion,” J Otol, vol. 3, no. 2, pp. 68–75, Dec. 2008, doi: 10.1016/S1672-2930(08)50017-1.
E. M. Mandel, H. E. Rockette, C. D. Bluestone, J. L. Paradise, and R. J. Nozza, “Myringotomy With and Without Tympanostomy Tubes for Chronic Otitis Media With Effusion,” Archives of Otolaryngology - Head and Neck Surgery, vol. 115, no. 10, pp. 1217–1224, Oct. 1989, doi: 10.1001/archotol.1989.01860340071020.
P. V. Vlastarakos, T. P. Nikolopoulos, S. Korres, E. Tavoulari, A. Tzagaroulakis, and E. Ferekidis, “Grommets in otitis media with effusion: the most frequent operation in children. But is it associated with significant complications?,” Eur J Pediatr, vol. 166, no. 5, pp. 385–391, Mar. 2007, doi: 10.1007/s00431-006-0367-x.
P. S. Mattila, “Adenoids provide a microenvironment for the generation of CD4+, CD45RO+, L-selectin-, CXCR4+, CCR5+ T lymphocytes, a lymphocyte phenotype found in the middle ear effusion,” Int Immunol, vol. 12, no. 9, pp. 1235–1243, Sep. 2000, doi: 10.1093/intimm/12.9.1235.
B. Demir and C. Batman, “Efficacy of balloon Eustachian tuboplasty as a first line treatment for otitis media with effusion in children,” J Laryngol Otol, vol. 134, no. 11, pp. 1018–1021, Nov. 2020, doi: 10.1017/S0022215120002340.