Endodontik İrrigasyonda Bitkisel Ajanlar: Antimikrobiyal Etkinlikler ve Klinik Potansiyel
Özet
Endodontik tedavinin başarısı kök kanalındaki bakterilerin etkin bir şekilde uzaklaştırılmasına bağlıdır. Geleneksel irrigasyon solüsyonları yüksek antimikrobiyal etkinlik göstermelerine rağmen, toksisite ve biyouyumluluk sorunları nedeniyle sınırlı klinik güvenilirliğe sahiptir. Son yıllarda yapılan çalışmalarda propolis, triphala, neem, yeşil çay, zencefil, sarımsak, papatya ve nar gibi birçok bitkisel ürünün antimikrobiyal etkinlik, biyouyumluluk ve düşük toksisite gibi avantajları gözlenmiştir. Doğal ürünler bu özellikleriyle öne çıkarken biyofilmlere karşı da önemli etkiler göstermektedir. Bitkisel ajanlar daha güvenli ve alternatif irrigantlar olma yolunda klinik olarak umut vadedicidir.
Referanslar
Erik CE, Maden M, Çelik G. Endodontide Kullanılan İrrigasyon Solüsyonları. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2018 Dec 6;9(3):31–8.
Küçük M, Kermeoğlu F, Kalender A. Endodontide Kullanılan Güncel İrrigasyon Solüsyonları, Sistem ve Cihazları Contemporary Irrigation Solutions, System and Devices Used in Endodontics. İnönü Üniversitesi Sağlık Bilimleri Dergisi. 2016;5(1):29–37.
Canavar T, Eren İ, Melike Bayram H, et al. HERBAL ALTERNATIVES USED AS IRRIGATION SOLUTIONS IN ENDODONTICS ENDODONTİDE İRRİGASYON SOLÜSYONU OLARAK KULLANILAN BİTKİSEL ALTERNATİFLER Corresponding Author [Internet]. Vol. 2, DENTAL AND MEDICAL JOURNAL-REVIEW. 2020. Available from: http://www.dergipark.org.tr/dmj
Alexander AK, Paulaian B, Tamilarasan SP, et al. Comparing the efficacy of herbal irrigants using laser activation in removing endodontic pathogens: An in vitro analysis. Journal of Conservative Dentistry and Endodontics. 2025 Mar;28(3):237–41.
Haapasalo M, Shen Y, Wang Z, et al. Irrigation in endodontics. Br Dent J. 2014 Mar 21;216(6):299–303.
Haapasalo M, Shen Y, Wang Z, et al. Irrigation in endodontics. Br Dent J. 2014 Mar 21;216(6):299–303.
Akgun SE, Arslan I, Aydinoglu S, et al. Can herbal products be alternative root canal irrigation solutions in primary teeth? An in vitro study. Pediatric Dental Journal. 2022 Dec;32(3):193–203.
Haapasalo M, Shen Y, Wang Z, et al. Irrigation in endodontics. Br Dent J. 2014 Mar 21;216(6):299–303.
Ballal NV, Rao BN, Mala K, et al. Assessment of genotoxic effect of maleic acid and EDTA: a comparative in vitro experimental study. Clin Oral Investig. 2013 Jun 15;17(5):1319–27.
Amaral KF, Rogero MM, Fock RA, et al. Cytotoxicity analysis of EDTA and citric acid applied on murine resident macrophages culture. Int Endod J. 2007 May 2;40(5):338–43.
Tewari R, Kapoor B, Mishra S, et al. Role of herbs in endodontics. Journal of Oral Research and Review. 2016;8(2):95.
Sedigh-Shams M, Badiee P, Adl A, et al. In vitro comparison of antimicrobial effect of sodium hypochlorite solution and Zataria multiflora essential oil as irrigants in root canals contaminated with Candida albicans. Journal of Conservative Dentistry. 2016;19(1):101.
Babaji P, Jagtap K, Lau H, et al. Comparative evaluation of antimicrobial effect of herbal root canal irrigants (Morinda citrifolia, Azadirachta indica, Aloe vera) with sodium hypochlorite: An in vitro study. J Int Soc Prev Community Dent. 2016;6(3):196.
Vitali FC, Andrada AC, Cardoso HC da L, et al. Does the use of natural products for endodontic therapy in primary teeth have sufficient evidence for clinical practice? A scoping review. Clin Oral Investig. 2022 Jul 19;26(10):6043–60.
Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs. 2010 Oct 13;19(10):1297–307.
Arayne MS, Sultana N, Bahadur SS. The berberis story: Berberis vulgaris in therapeutics. Pak J Pharm Sci. 2007 Jan;20(1):83–92.
Xie Q, Johnson BR, Wenckus CS, et al. Efficacy of Berberine, an Antimicrobial Plant Alkaloid, as an Endodontic Irrigant against a Mixed-culture Biofilm in an In Vitro Tooth Model. J Endod. 2012 Aug;38(8):1114–7.
Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opin Investig Drugs. 2010 Oct 13;19(10):1297–307.
Xie Q, Johnson BR, Wenckus CS, et al. Efficacy of Berberine, an Antimicrobial Plant Alkaloid, as an Endodontic Irrigant against a Mixed-culture Biofilm in an In Vitro Tooth Model. J Endod. 2012 Aug;38(8):1114–7.
Donyavi Z, Arabestani MR, Dastan D, et al. Comparison of Antimicrobial Effect of Berberine as an Endodontic Irrigant with that of Other Common Root Canal Irrigants on Three Microorganisms Involved in Persistent Endodontic Infections. J Mol Biol Res. 2018 Oct 15;8(1):153.
de Andrade Ferreira FB, Torres SA, da Silva Rosa OP, et al. Antimicrobial effect of propolis and other substances against selected endodontic pathogens. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2007 Nov;104(5):709–16.
Khurshid Z, Naseem M, Zafar MS, et al. Propolis: A natural biomaterial for dental and oral healthcare. J Dent Res Dent Clin Dent Prospects [Internet]. 2017;11(4):265–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29354255
Pujar M, Makandar S. Herbal Usage In Endodontics-A Review. 2011.
Silva FB da, Almeida JM de, Sousa SMG de. Natural medicaments in endodontics: a comparative study of the anti-inflammatory action. Braz Oral Res. 2004 Jun;18(2):174–9.
Verma M, Pandey R, Khanna R, Agarwal J. The antimicrobial effectiveness of 25% propolis extract in root canal irrigation of primary teeth. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2014;32(2):120.
Garg P, Tyagi S, Sinha D, et al. Comparison of antimicrobial efficacy of propolis, Morinda citrifolia, Azadirachta indica, triphala, green tea polyphenols and 5.25% sodium hypochlorite against Enterococcus fecalis biofilm. Saudi Endodontic Journal. 2014;4(3):122.
Peterson CT, Denniston K, Chopra D. Therapeutic Uses of Triphala in Ayurvedic Medicine. The Journal of Alternative and Complementary Medicine. 2017 Aug;23(8):607–14.
Prakash S, Shelke A. Role of Triphala in dentistry. J Indian Soc Periodontol. 2014;18(2):132.
Durga Bhavani G, Rathod T, Parveen N, et al. Assessment of the Antimicrobial Effectiveness of Herbal Root Canal Irrigants (Propolis, Triphala, and Aloe Vera) and Chlorhexidine Against Enterococcus Faecalis. Cureus. 2023 Jul 10;
Açar Dn, Aktören O. Diş Hekimliğinde Aromaterapi. Selcuk Dental Journal. 2023 Apr 27;10(1):118–23.
Alghutaimel H. Endodontic Applications of Propolis in Primary and Permanent Teeth: A Scoping Review of Clinical Studies. Eur Endod J [Internet]. 2024;167–79. Available from: https://eurendodj.com/jvi.aspx?un=EEJ-65487&volume=
Saxena D, Saha S, Saha M, et al. An in vitro evaluation of antimicrobial activity of five herbal extracts and comparison of their activity with 2.5% sodium hypochlorite against Enterococcus faecalis. Indian Journal of Dental Research. 2015;26(5):524.
Divia AR, Nair MG, Mary Varughese J, et al. Dental Research Journal A comparative evaluation of Morinda citrifolia, green tea polyphenols, and Triphala with 5% sodium hypochlorite as an endodontic irrigant against Enterococcus faecalis: An in vitro study [Internet]. 2018. Available from: www.ncbi.nlm.nih.gov/pmc/journals/1480
Shakouie S, Eskandarinezhad M, Gasemi N, et al. An In Vitro Comparison of the Antibacterial Efficacy of Triphala with Different Concentrations of Sodium Hypochlorite. Vol. 9, IEJ Iranian Endodontic Journal. 2014.
Reshma Raj V, Varma Rb, Sureshkumar J, et al. Comparison of cytotoxicity and smear layer removal efficacy of triphala (an Indian ayurvedic herbal formulation) and 5.25% sodium hypochlorite as root canal irrigants: An in vitro study. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2020;38(4):343.
Shakouie S, Eskandarinezhad M, Gasemi N, et al. An In Vitro Comparison of the Antibacterial Efficacy of Triphala with Different Concentrations of Sodium Hypochlorite. Vol. 9, IEJ Iranian Endodontic Journal. 2014.
Carson CF, Hammer KA, Riley T V. Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties. Clin Microbiol Rev. 2006 Jan;19(1):50–62.
Hammer KA, Dry L, Johnson M, et al. Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiol Immunol. 2003 Dec 24;18(6):389–92.
Prabhakar J, Senthilkumar M, Priya MS, et al. Evaluation of Antimicrobial Efficacy of Herbal Alternatives (Triphala and Green Tea Polyphenols), MTAD, and 5% Sodium Hypochlorite against Enterococcus faecalis Biofilm Formed on Tooth Substrate: An In Vitro Study. J Endod. 2010 Jan;36(1):83–6.
Cabrera C, Artacho R, Giménez R. Beneficial Effects of Green Tea—A Review. J Am Coll Nutr. 2006 Apr;25(2):79–99.
Pujar M, Patil C, Kadam A. Comparison of antimicrobial efficacy of Triphala, (GTP) Green tea polyphenols and 3% of sodium hypochlorite on Enterococcus faecalis biofilms formed on tooth substrate: in vitro [Internet]. Vol. 3, J. Int Oral Health. 2011. Available from: www.ispcd.org
Martina L, Ebenezar AR, Ghani M, et al. An in vitro comparative antibacterial study of different concentrations of green tea extracts and 2% chlorhexidine on Enterococcus faecalis. Saudi Endodontic Journal. 2013;3(3):120.
Mensudar R, Geethapriya N, Prabhakar J. Cleaning Efficacy of Triphala (An Indian Herbal Medicine) and Green Tea Polyphenol Used as Irrigants on Removal of Smear Layer: A Sem Study. Biomedical and Pharmacology Journal. 2015 Oct 25;8(october Spl Edition):303–7.
Biswas K, Chattopadhyay I, Banerjee RK, et al. (Biological activities and medicinal properties of neem) Azadirachta indica. Vol. 82. 2002.
Bohora A, Hegde V, Kokate S. Comparison of the antibacterial efficiency of neem leaf extract and 2% sodium hypochlorite against E. faecalis, C. albicans and mixed culture - An in vitro study. Endodontology. 2010;22(1):10.
Baswa M, Rath CC, Dash SK, et al. Antibacterial activity of Karanj (Pongamia pinnata) and Neem (Azadirachta indica) seed oil: a preliminary report. Microbios. 2001;105(412):183–9.
Dutta A, Kundabala M. Comparative anti-microbial efficacy of Azadirachta indica,/i> irrigant with standard endodontic irrigants: A preliminary study. Journal of Conservative Dentistry. 2014;17(2):133.
Dhull KS, Anasane NS, Singh S, et al. Evaluating the Efficacy of Chemical and Herbal Endodontic Irrigants in Smear Layer Removal: An In-vitro Analysis. J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S774–6.
Suraksha H, Shetty S, Jayalakshmi KB, et al. “Comparative evaluation of cytotoxicity of three herbal endodontic irrigants at three intervals of time” – An in vitro study. Journal of Conservative Dentistry and Endodontics. 2024 Nov;27(11):1126–30.
Lakshmi T, Krishnan V, Rajendran R, et al. Azadirachta indica : A herbal panacea in dentistry - An update. Pharmacogn Rev. 2015;9(17):41.
Lorente J, Vegara S, Martí N, et al. Chemical guide parameters for Spanish lemon (Citrus limon (L.) Burm.) juices. Food Chem. 2014 Nov;162:186–91.
Bolhari B, Sharifian MR, Aminsobhani M, et al. Assessing the efficacy of citrus aurantifolia extract on smear layer removal with scanning electron microscope. Iran Endod J. 2012;7(2):88–97.
Meyappan N, Mahadevan M, Manimaran ND, et al. Scanning Electron Microscopy Analysis of Smear Layer Removal Ability of Conventional Endodontic Irrigation Regimen, MTAD, and QMixTM Versus a Mixture of Azadirachta indica and Citrus limon: An In Vitro Study. Cureus. 2023 Aug 2;
Bolhari B, Reza Sharifian M, Aminsobhani M, et al. Archive of SID Assessing the Efficacy of Citrus Aurantifolia Extract on Smear Layer Removal with Scanning Electron Microscope [Internet]. Vol. 7, Iranian Endodontic Journal. 2012. Available from: www.SID.ir
Penna SC, Medeiros MV, Aimbire FSC, et al. Anti-inflammatory effect of the hydralcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema. Phytomedicine. 2003 Jan;10(5):381–5.
Ahmed N, Karobari MI, Yousaf A, et al. The Antimicrobial Efficacy Against Selective Oral Microbes, Antioxidant Activity and Preliminary Phytochemical Screening of Zingiber officinale. Infect Drug Resist. 2022 May;Volume 15:2773–85.
Abdollahi-Mansoorkhani HR, Soleimani F, Mahmoudi F. A Multi-Criteria Approach for Comparison of Ginger Extract and Conventional Irrigants in Root Canal Treatment. Cureus. 2022 Sep 19;
Valera MC, Maekawa LE, Oliveira LD de, et al. In vitro antimicrobial activity of auxiliary chemical substances and natural extracts on Candida albicans and Enterococcus faecalis in root canals. Journal of Applied Oral Science. 2013 Apr;21(2):118–23.
Frank N, Knauft J, Amelung F, et al. No prevention of liver and kidney tumors in Long–Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 2003 Feb;523–524:127–35.
Kunchandy E, Rao MNA. Oxygen radical scavenging activity of curcumin. Int J Pharm. 1990 Feb;58(3):237–40.
Chainani-Wu N. Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric ( Curcuma longa ). The Journal of Alternative and Complementary Medicine. 2003 Feb;9(1):161–8.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: Lessons learned from clinical trials. Vol. 15, AAPS Journal. 2013. p. 195–218.
Kaur S, Modi NH, Panda D, et al. Probing the binding site of curcumin in Escherichia coli and Bacillus subtilis FtsZ – A structural insight to unveil antibacterial activity of curcumin. Eur J Med Chem. 2010 Sep;45(9):4209–14.
Sotomil JM, Münchow EA, Pankajakshan D, et al. Curcumin—A Natural Medicament for Root Canal Disinfection: Effects of Irrigation, Drug Release, and Photoactivation. J Endod. 2019 Nov;45(11):1371–7.
Eskandarinezhad M, Barhaghi MS, Allameh K, et al. The comparison of calcium hydroxide, curcumin, and Aloe vera antibacterial effects on 6-week-old Enterococcus faecalis biofilm as an intracanal medicament: An in vitro study. Dent Res J (Isfahan). 2022;19(1):14.
Tyagi P, Singh M, Kumari H, et al. Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane. PLoS One. 2015 Mar 26;10(3):e0121313.
Iacobellis NS, Lo Cantore P, Capasso F, et al. Antibacterial Activity of Cuminum cyminum L. and Carum carvi L. Essential Oils. J Agric Food Chem. 2005 Jan 1;53(1):57–61.
Raana Mahmood, Itrat Jawed, Nosheen, et al. Study of Analgesic Activity of Methanolic Extracts of Cuminum Cyminum (L.) and Centratherum Anthelminticum (L.) in Mice. ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE. 2019 Jun 30;24(2):90–5.
Nadeem M, Riaz A. Cumin (Cuminum cyminum) as a potential source of antioxidants. Vol. 22, Pakistan Journal of Food Sciences. 2012.
Pai MithunBH, Prashant G, Murlikrishna K, et al. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: An in vitro study. Indian Journal of Dental Research. 2010;21(3):334.
Fancello F, Petretto GL, Marceddu S, et al. Antimicrobial activity of gaseous Citrus limon var pompia leaf essential oil against Listeria monocytogenes on ricotta salata cheese. Food Microbiol. 2020 May;87:103386.
Amalia R, Dewi SU, Margono A, et al. Antibacterial Effects of Cuminum cyminum Extract Against Enterococcus Faecalis Biofilms From Clinical Isolates. Pesqui Bras Odontopediatria Clin Integr. 2019;19(1):1–8.
Abbaszadegan A, Gholami A, Ghahramani Y, et al. Antimicrobial and cytotoxic activity of cuminum cyminum as an intracanal medicament compared to chlorhexidine gel. Iran Endod J. 2016 Dec 1;11(1):44–50.
Phenolic Composition and Antioxidant Pro.
Subbiya A, Geethapriya N, Padmavathy K, et al. Efficacy of Herbal Extracts against Enterococcus faecalis on a Dentinal Biofilm. Journal of Operative Dentistry & Endodontics. 2019 Jun;4(1):22–6.
Nabavizade M, Sobhnamayan F, Bahrami H, et al. Evaluation of the wettability of a resin-based sealer in contact with some herbal irrigants. Dent Res J (Isfahan). 2018;15(2):130–5.
Rai Aneja K, Joshi R, Sharma C. In Vitro Antimicrobial Activity of Sapindus mukorossi and Emblica officinalis Against Dental Caries Pathogens. Vol. 14, Ethnobotanical Leaflets. 2010.
Ibrahim M, Khaja MN, Aara A, et al. Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies. World J Gastroenterol. 2008;14(16):2566.
Simbula G, Dettori C, Camboni T, et al. Comparison of Tetraacetylethylendiamine + Sodium Perborate and Sodium Hypochlorite Cytotoxicity on L929 Fibroblasts. J Endod. 2010 Sep;36(9):1516–20.
Talwar GP, Dar SA, Rai MK, et al. A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens. Int J Antimicrob Agents. 2008 Aug;32(2):180–5.
Güçlüer Ö, Akarsu E, Yavuz E, et al. Human pulp tissue dissolution ability of different extracts of Sapindus mukorossi: An in vitro study. Chin Herb Med. 2020 Apr;12(2):178–82.
Ghagi R. Study of functional properties of Sapindus mukorossi as a potential bio-surfactant. Indian J Sci Technol. 2011 May 20;4(5):530–3.
Holmberg K. Natural surfactants. Curr Opin Colloid Interface Sci. 2001 May;6(2):148–59.
Garsin DA, Lorenz MC. Candida albicans and Enterococcus faecalis in the gut. Gut Microbes. 2013 Sep 28;4(5):409–15.
Subasree S, Murthykumar K, Dhanraj. Effect of Aloe Vera in Oral Health-A Review. Res J Pharm Technol. 2016;9(5):609.
KumarS A. ETHNO-BOTANICAL APPROACH FOR ROOT CANAL TREATMENT-AN UPDATE.
Goud S, Aravelli S, Dronamraju S, et al. Comparative Evaluation of the Antibacterial Efficacy of Aloe Vera, 3% Sodium Hypochlorite, and 2% Chlorhexidine Gluconate Against Enterococcus faecalis: An In Vitro Study. Cureus. 2018 Oct 23;
Kurian B, Swapna D, Nadig R, et al. Efficacy of calcium hydroxide, mushroom, and Aloe vera as an intracanal medicament against Enterococcus faecalis: An in vitro study. Endodontology. 2016;28(2):137.
Varshini R, Subha A, Prabhakar V, et al. Antimicrobial efficacy of Aloe vera, lemon, Ricinus communis, and calcium hydroxide as intracanal medicament against Enterococcus faecalis: A confocal microscopic study. J Pharm Bioallied Sci. 2019;11(6):256.
Sabbar Dahham S, Naiman Ali M, Tabassum H, et al. Studies on Antibacterial and Antifungal Activity of Pomegranate (Punica granatum L.). J Agric & Environ Sci [Internet]. 2010;9(3):273–81. Available from: https://www.researchgate.net/publication/284580543
Cushnie TPT, Lamb AJ. Antimicrobial activity of flavonoids. Int J Antimicrob Agents. 2005 Nov;26(5):343–56.
Lakshmaiah D, Irudayaraj N, Ambeth N, et al. Comparative Evaluation of Microhardness, Smear Layer Removal Efficacy and Depth of Penetration Using Punica granatum, Emblica officinalis and Sodium Hypochlorite As Endodontic Irrigants: An In Vitro Study. Cureus. 2023 Sep 6;
Sharifani M, Akbarpour V, Hemmati K. Physical and Chemical Properties of Pomegranate (Punica granatum L.) Fruit in Maturation Stage. J Agric & Environ Sci [Internet]. 2009;6(4):411–6. Available from: https://www.researchgate.net/publication/239586980
singh A, Tejaswi S, Mruthunjaya K, et al. Comparative Evaluation of Microhardness and Color Change of Root dentin using Punica granatum (pomegranate extract), Sodium hypochlorite, Chlorhexidine and Normal saline as an Endodontic irrigant – An in vitro study. Pharmacognosy Journal. 2023 Nov 2;15(5):732–7.
Mallya L, Shenoy R, Mala K, et al. Evaluation of the antimicrobial efficacy of 20% Punica granatum, 0.2% chlorhexidine gluconate, and 2.5% sodium hypochlorite used alone or in combinations against Enterococcus faecalis: An in-vitro study. Journal of Conservative Dentistry. 2019;22(4):367.
Bhattacharya A, Chatterjee A, Ghosal S, et al. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian J Exp Biol. 1999 Jul;37(7):676–80.
Dubey S. Comparative antimicrobial efficacy of herbal alternatives ( Emblica officinalis , Psidium guajava ), MTAD, and 2.5% sodium hypochlorite against Enterococcus faecalis : An in vitro study. J Oral Biol Craniofac Res. 2016 Jan;6(1):46–9.
Javale P, Sabnis S. Antimicrobial properties and phytochemical analysis of Emblica officinalis [Internet]. 2009. Available from: https://www.researchgate.net/publication/228514313
Taleuzzaman M, Mahapatra DK, Gupta DK. Emblicanin-A and Emblicanin-B: Pharmacological and Nano-Pharmacotherapeutic Perspective for Healthcare Applications. In: Applied Pharmaceutical Practice and Nutraceuticals. First edition.: Apple Academic Press; 2021. p. 13–27.
Schofield P, Mbugua DM, Pell AN. Analysis of condensed tannins: a review. Anim Feed Sci Technol. 2001 May;91(1–2):21–40.
Jones GA, McAllister TA, Muir AD, et al. Effects of Sainfoin ( Onobrychis viciifolia Scop.) Condensed Tannins on Growth and Proteolysis by Four Strains of Ruminal Bacteria. Appl Environ Microbiol. 1994 Apr;60(4):1374–8.
Chavate PR, Ponnappa KC, Nanjappa AS. Comparative evaluation of the effect of ultrasonic and rotary agitation of herbal irrigating solutions on smear layer: A SEM study. Journal of Conservative Dentistry and Endodontics. 2024 Feb;27(2):164–9.
Lakshmaiah D, Irudayaraj N, Ambeth N, et al. Comparative Evaluation of Microhardness, Smear Layer Removal Efficacy and Depth of Penetration Using Punica granatum, Emblica officinalis and Sodium Hypochlorite As Endodontic Irrigants: An In Vitro Study. Cureus. 2023 Sep 6;
Article O, Bhargava KY, Aggarwal S, et al. COMPARATIVE EVALUATION OF THE EFFICACY OF THREE ANTI-OXIDANTS VS NAOCL AND EDTA: USED FOR ROOT CANAL IRRIGATION IN SMEAR LAYER REMOVAL-SEM STUDY.
Jain PA, Tejaswi S, Shetty S, et al. Comparative Evaluation of Antibacterial Activity of Punica granatum, Acacia nilotica and Emblica officinalis against Enterococcus faecalis and Their Smear Layer Removal Ability When Used as Endodontic Irrigants: an In-Vitro Study. International Journal of Research & Review (www.ijrrjournal.com) Vol [Internet]. 2019;6(8). Available from: www.ijrrjournal.com
Srivastava SC, Vijayaraje R, Krishi S, et al. A profile of Garlic production in India: Facts, trends and opportunities [Internet]. 2012. Available from: https://www.researchgate.net/publication/345362446
Zhang Y, Liu X, Ruan J, et al. Phytochemicals of garlic: Promising candidates for cancer therapy. Biomedicine & Pharmacotherapy. 2020 Mar;123:109730.
Fenwick GR, Hanley AB, Whitaker JR. The genus allium— part 1. CRC Critical Reviews in Food Science and Nutrition. 1985 Jan 29;22(3):199–271.
Tsai CW, Chen HW, Sheen LY, et al. Garlic: Health benefits and actions. Biomedicine (Taipei). 2012 Mar;2(1):17–29.
Prabhakaran P, Mariswamy A. A scanning electron microscope evaluation of efficacy of sodium hypochlorite and Allium sativum in smear layer removal in root canals with the use of modified evacuation system: An ex vivo study. Journal of Conservative Dentistry. 2018;21(4):401.
Mehta N, Gupta A, Mahesh S, et al. Comparative evaluation of antibacterial efficacy of Allium sativum extract, aqueous ozone, diode laser, and 3% sodium hypochlorite in root canal disinfection: An in vivo study. Journal of Conservative Dentistry. 2020;23(6):577.
Chaieb K, Hajlaoui H, Zmantar T, et al. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata ( Syzigium aromaticum L. Myrtaceae): a short review. Phytotherapy Research. 2007 Jun 23;21(6):501–6.
Moon SE, Kim HY, Cha JD. Synergistic effect between clove oil and its major compounds and antibiotics against oral bacteria. Arch Oral Biol. 2011 Sep;56(9):907–16.
Hugar S, Patel PM, Nagmoti J, et al. An in vitro Comparative Evaluation of Efficacy of Disinfecting Ability of Garlic Oil, Neem Oil, Clove Oil, and Tulsi Oil with autoclaving on Endodontic K Files tested against Enterococcus faecalis. Int J Clin Pediatr Dent. 2017 Sep;10(3):283–8.
Gupta A, Duhan J, Tewari S, et al. Comparative evaluation of antimicrobial efficacy of S yzygium aromaticum, O cimum sanctum and C innamomum zeylanicum plant extracts against E nterococcus faecalis : a preliminary study. Int Endod J. 2013 Aug 18;46(8):775–83.
Khan R, Islam B, Akram M, et al. Antimicrobial Activity of Five Herbal Extracts Against Multi Drug Resistant (MDR) Strains of Bacteria and Fungus of Clinical Origin. Molecules. 2009 Feb 4;14(2):586–97.
Pai MithunBH, Prashant G, Murlikrishna K, et al. Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: An in vitro study. Indian Journal of Dental Research. 2010;21(3):334.
Sahoo S, Kar D, Mohapatra S, et al. Antibacterial activity of Hybanthus enneaspermus against selected urinary tract pathogens. Indian J Pharm Sci. 2006;68(5):653.
Vamsi K, Kumar Bholla P. Antibacterial Activity of Hybanthus Enneaspermus against Enterococcus Faecalis - A Root Canal Organism. International Journal of Dental Sciences and Research. 2014 Nov 20;2(6C):14–6.
McKay DL, Blumberg JB. A Review of the bioactivity and potential health benefits of chamomile tea ( Matricaria recutita L.). Phytotherapy Research. 2006 Jul 20;20(7):519–30.
Venkataram V, Gokhale ST, Kenchappa M, et al. Effectiveness of chamomile (Matricaria recutita L.), MTAD and sodium hypochlorite irrigants on smear layer. European Archives of Paediatric Dentistry. 2013 Aug;14(4):247–52.
Alves A de MH, Gonçalves JCR, Cruz JS, et al. Evaluation of the sesquiterpene (−)-α-bisabolol as a novel peripheral nervous blocker. Neurosci Lett. 2010 Mar;472(1):11–5.
Sadr Lahijani MS, Raoof Kateb HR, Heady R, et al. The effect of German chamomile (Marticaria recutita L.) extract and tea tree (Melaleuca alternifolia L.) oil used as irrigants on removal of smear layer: a scanning electron microscopy study. Int Endod J. 2006 Mar 28;39(3):190–5.
McKay DL, Blumberg JB. A Review of the bioactivity and potential health benefits of chamomile tea ( Matricaria recutita L.). Phytotherapy Research. 2006 Jul 20;20(7):519–30.
Wang MY, West BJ, Jensen CJ, et al. Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin. 2002 Dec;23(12):1127–41.
Murray PE, Farber RM, Namerow KN, et al. Evaluation of Morinda citrifolia as an Endodontic Irrigant. J Endod. 2008 Jan;34(1):66–70.
Murray PE, Farber RM, Namerow KN, et al. Evaluation of Morinda citrifolia as an Endodontic Irrigant. J Endod. 2008 Jan;34(1):66–70.
Chandwani M, Mittal R, Chandak S, et al. Effectiveness of Morinda citrifolia juice as an intracanal irrigant in deciduous molars: An in vivo study. Dent Res J (Isfahan). 2017;14(4):246.
Podar R, Kulkarni GP, Dadu SS, et al. In vivo antimicrobial efficacy of 6% Morinda citrifolia, Azadirachta indica, and 3% sodium hypochlorite as root canal irrigants. Eur J Dent. 2015 Oct 23;09(04):529–34.
Segal R, Pisanty S, Wormser R, et al. Anticariogenic Activity of Licorice and Glycyrrhizine I: Inhibition of In Vitro Plaque Formation by Streptococcus mutans. J Pharm Sci. 1985 Jan;74(1):79–81.
Sedighinia F, Safipour Afshar A, Soleimanpour S, et al. Antibacterial activity of Glycyrrhiza glabra against oral pathogens: an in vitro study. Avicenna J Phytomed. 2012;2(3):118–24.
Malvania EA, Sharma AS, Sheth SA, et al. In Vitro Analysis of Licorice (Glycyrrhiza glabra) Root Extract Activity on Streptococcus mutans in Comparison to Chlorhexidine and Fluoride Mouthwash. J Contemp Dent Pract. 2019 Dec 1;20(12):1389–94.
GÜLDAS HE, KECECI AD, CETIN ES, et al. Evaluation of antimicrobial efficacy of cetrimide and <i>Glycyrrhiza glabra L.</i> extract against <i>Enterococcus faecalis</i> biofilm grown on dentin discs in comparison with NaOCl. Dent Mater J. 2016;35(5):721–7.
Sharma H, Yunus G, Agrawal R, et al. Antifungal efficacy of three medicinal plants Glycyrrhiza glabra, Ficus religiosa, and Plantago major against oral Candida albicans: A comparative analysis. Indian Journal of Dental Research. 2016;27(4):433.
