Böceklerle Biyoteknolojik Mücadelede RNAi Uygulamaları

Wingard, SA. Hosts and symptoms of ring spot, a virus disease of plants. Journal of Agricultural Research. 1928, 37: 127–153.

Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell. 1990, 2: 279–289.

Fire A, Xu SQ, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998; 391: 806–811.

Mao YB, Cai WJ, Wang JW, et al. Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. Nature Biotechnology. 2007, 25(11): 1307-1313.

Sadeq S, Al-Hashimi S, Cusack CM, et al. Endogenous double stranded RNA. Non-Coding RNA, 2021, 7(1):15.

Hutvagner G, Zamore PD. RNAi: nature abhors a double strand. Current Opinion in Genetics and Development. 2002, 12(2): 225–232.

Hannon GJ. RNA interference. Nature. 2002. 418(6894): 244–251.

Lu Y, Deng X, Zhu Q. The dsRNA delivery, targeting and application in pest control. Agronomy. 2023, 13(3):714.

Schmitt-Engel C, Schultheis D, Schwirz J, et al. The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology. Nature Communications. 2015, 6(1): 7822.

Choudry MW, Nawaz P, Jahan N, et al. RNA based gene silencing modalities to control insect and fungal plant pests: challenges and future prospects. Physiological and Molecular Plant Pathology, 2024; 130:102241.

Sang H, Kim JI. Advanced strategies to control plant pathogenic fungi by host-induced gene silencing (HIGS) and spray-induced gene silencing (SIGS). Plant Biotechnology Reports. 2020, 14(1): 1-8.

Zhang J, Khan SA, Hasse C, et al. Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids. Science. 2015, 347(6225): 991-994.

Koči J, Ramaseshadri P, Bolognesi R, et al. Ultrastructural changes caused by Snf7 RNAi in larval enterocytes of western corn rootworm (Diabrotica virgifera virgifera Le Conte). PLoS One. 2014, 9(1): e83985.

Adeyinka OS, Nasir IA, Tabassum B. Host-induced silencing of the CpCHI gene resulted in developmental abnormalities and mortality in maize stem borer (Chilo partellus).PLoS One.2023;18(2), e0280963.

Mamta - Reddy KRK, Rajam MV. Targeting chitinase gene of Helicoverpa armigera by host-induced RNA interference confers insect resistance in tobacco and tomato. Plant Molecular Biology. 2016, 90(3): 281-292.

Yang J, Sun XQ, Zhu-Salzman K, et al. Host-induced gene silencing of brown planthopper glutathione S-transferase gene enhances rice resistance to sap-sucking insect pests. Journal of Pest Science. 2021, 94(3): 769-781.

Thakur N, Upadhyay SK, Verma PC, et al. Enhanced whitefly resistance in transgenic tobacco plants expressing double stranded RNA of v-ATPase A gene. PloS One.2014, 9(3): e87235.

Zhang W, Lib S, Zhoub Z, et al. The development and prospects of insect-resistant crops expressing doublestrand RNAs. New Crops. 2025, 2: 100061.

Rössner C, Lotz D, Becker A. VIGS goes viral: how VIGS transforms our understanding of plant science. Annual Review of Plant Biology. 2022, 73(1): 703-728.

Zotti M, Dos Santos EA, Cagliari D, et al. RNA interference technology in crop protection against arthropod pests, pathogens and nematodes. Pest Management Science. 2018, 74(6): 1239-1250.

Cagliari D, Dias NP, Galdeano DM, et al. Management of pest insects and plant diseases by non-transformative RNAi. Frontiers in Plant Science, 2019; 10: 1319.

Xue XY, Mao YB, Tao XY, et al. New approaches to agricultural insect pest control based on RNA interference. Advances in Insect Physiology. 2012, 42: 73-117.

Shi B, He H, Zhao C, et al. Potential of Virus-Mediated RNAi of Insect Genes in Plants to Control Aphids. Journal of Agricultural and Food Chemistry. 2025, 73(13): 7716-7724.

Burch‐Smith TM, Anderson JC, Martin GB, et al. Applications and advantages of virus‐induced gene silencing for gene function studies in plants. The Plant Journal. 2004; 39(5): 734-746.

Vaistij FE, Jones L. Compromised virus-induced gene silencing in RDR6-deficient plants. Plant Physiology. 2009, 149(3): 1399-1407.

Zhang J, Li H, Zhong X, et al. RNA-interference-mediated aphid control in crop plants: a review. Agriculture. 2022, 12(12): 2108.

Kolliopoulou A, Taning CN, Smagghe G, et al. Viral delivery of dsRNA for control of insect agricultural pests and vectors of human disease: prospects and challenges. Frontiers in Physiology. 2017, 8: 399.

Liu J, Smagghe G, Swevers L. Transcriptional response of BmToll9-1 and RNAi machinery genes to exogenous dsRNA in the midgut of Bombyx mori. Journal of Insect Physiology. 2013, 59(6): 646-654.

Ivashuta S, Zhang Y, Wiggins BE, et al. Environmental RNAi in herbivorous insects. Rna. 2015, 21(5): 840-850.

Hunter WB, Bextine BR., Shatters Jr. RG, et al. Emerging psyllid genomes- increasing RNA-interference targets for insect management. DSP1. 93rd Annual Meeting Florida Entomological Society. 2010a, 25–28 July. http://flaentsoc.org/2010annmeetabstracts.pdf.

Hunter WB, Glick E, Bextine BR, et al. RNA-interference to reducing insect pests: plant infusions. DSP2. 93rd Annual meeting Florida Entomological Society 2010b, 25–28 July. http://flaentsoc.org/2010annmeetabstracts.pdf.

Zhu F, Xu J, Palli R, Ferguson J, et al. Ingested RNA interference for managing the populations of the Colorado potato beetle, Leptinotarsa decemlineata. Pest Management Science, 2011, 67(2): 175-182.

Luan JB, Ghanim M, Liu SS, et al.. Silencing the ecdysone synthesis and signaling pathway genes disrupts nymphal development in the whitefly. Insect Biochemistry and Molecular Biology 2013, 43(8): 740-746.

Li H, Guan R, Guo H, et al. New insights into an RNAi approach for plant defence against piercing-sucking and stem-borer insect pests. Plant Cell Environment. 2015, 38: 2277–2285.

San Miguel K, Scott JG. The next generation of insecticides: dsRNA is stable as a foliar‐applied insecticide. Pest Management Science. 2016, 72(4): 801-809.

Camargo RA, Barbosa GO, Possignolo IP, et al. RNA interference as a gene silencing tool to control Tuta absoluta in tomato (Solanum lycopersicum). PeerJ. 2016; 4: e2673. doi: 10.7717/peerj.2673.

Majidiani S, PourAbad R, Laudani F, et al.). RNAi in Tuta absoluta management: Effects of injection and root delivery of dsRNAs. Journal of Pest Science, 2019, 92: 1409–1419.

Khan F, Kim M, Kim Y. Greenhouse test of spraying dsRNA to control the western flower thrips, Frankliniella occidentalis, infesting hot peppers. BMC Biotechnology. 2023, 23(1): 10.

Hough J, Howard JD, Brown S, et al. Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides. Frontiers in Bioengineering and Biotechnology.2022, 10: 980592.

Siddique AB, Rahman MZ, Gain N, et al. Harnessing double-stranded RNA (dsRNA): a sustainable approach to pest management. Physiology and Molecular Biology of Plants. 2025, 1-21.

Rodrigues T, Sridharan K, Manley B, et al. Development of dsRNA as a sustainable bioinsecticide: from laboratory to field. In: Brittany MR, Beth AL (eds) Crop Protection Products for Sustainable Agriculture. American Chemical Society, 2021. p. 65–82.

Khajuria C, Ivashuta S, Wiggins E, et al. Development and characterization of the first dsRNA-resistant insect population from western corn rootworm, Diabrotica virgifera virgifera LeConte. PLoS ONE. 2018, 13:e0197059.

Mishra S, Dee J, Moar W, et al. Selection for high levels of resistance to double-stranded RNA (dsRNA) in Colorado potato beetle (Leptinotarsa decemlineata Say) using non-transgenic foliar delivery. Scientific Reports. 2021, 11: 6523.

Ulrich J, Dao VA, Majumdar U, et al. Large scale RNAi screen in Tribolium reveals novel target genes for pest control and the proteasome as prime target. BMC Genomics. 2015, 16: 1–9.

Jarosch A, Moritz RF. RNA interference in honeybees: off-target effects caused by dsRNA.Apidologie. 2012, 43(2): 128-138.

Wingard, SA. Hosts and symptoms of ring spot, a virus disease of plants. Journal of Agricultural Research. 1928, 37: 127–153.

Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell. 1990, 2: 279–289.

Fire A, Xu SQ, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998; 391: 806–811.

Mao YB, Cai WJ, Wang JW, et al. Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol. Nature Biotechnology. 2007, 25(11): 1307-1313.

Sadeq S, Al-Hashimi S, Cusack CM, et al. Endogenous double stranded RNA. Non-Coding RNA, 2021, 7(1):15.

Hutvagner G, Zamore PD. RNAi: nature abhors a double strand. Current Opinion in Genetics and Development. 2002, 12(2): 225–232.

Hannon GJ. RNA interference. Nature. 2002. 418(6894): 244–251.

Lu Y, Deng X, Zhu Q. The dsRNA delivery, targeting and application in pest control. Agronomy. 2023, 13(3):714.

Schmitt-Engel C, Schultheis D, Schwirz J, et al. The iBeetle large-scale RNAi screen reveals gene functions for insect development and physiology. Nature Communications. 2015, 6(1): 7822.

Choudry MW, Nawaz P, Jahan N, et al. RNA based gene silencing modalities to control insect and fungal plant pests: challenges and future prospects. Physiological and Molecular Plant Pathology, 2024; 130:102241.

Sang H, Kim JI. Advanced strategies to control plant pathogenic fungi by host-induced gene silencing (HIGS) and spray-induced gene silencing (SIGS). Plant Biotechnology Reports. 2020, 14(1): 1-8.

Zhang J, Khan SA, Hasse C, et al. Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids. Science. 2015, 347(6225): 991-994.

Koči J, Ramaseshadri P, Bolognesi R, et al. Ultrastructural changes caused by Snf7 RNAi in larval enterocytes of western corn rootworm (Diabrotica virgifera virgifera Le Conte). PLoS One. 2014, 9(1): e83985.

Adeyinka OS, Nasir IA, Tabassum B. Host-induced silencing of the CpCHI gene resulted in developmental abnormalities and mortality in maize stem borer (Chilo partellus).PLoS One.2023;18(2), e0280963.

Mamta - Reddy KRK, Rajam MV. Targeting chitinase gene of Helicoverpa armigera by host-induced RNA interference confers insect resistance in tobacco and tomato. Plant Molecular Biology. 2016, 90(3): 281-292.

Yang J, Sun XQ, Zhu-Salzman K, et al. Host-induced gene silencing of brown planthopper glutathione S-transferase gene enhances rice resistance to sap-sucking insect pests. Journal of Pest Science. 2021, 94(3): 769-781.

Thakur N, Upadhyay SK, Verma PC, et al. Enhanced whitefly resistance in transgenic tobacco plants expressing double stranded RNA of v-ATPase A gene. PloS One.2014, 9(3): e87235.

Zhang W, Lib S, Zhoub Z, et al. The development and prospects of insect-resistant crops expressing doublestrand RNAs. New Crops. 2025, 2: 100061.

Rössner C, Lotz D, Becker A. VIGS goes viral: how VIGS transforms our understanding of plant science. Annual Review of Plant Biology. 2022, 73(1): 703-728.

Zotti M, Dos Santos EA, Cagliari D, et al. RNA interference technology in crop protection against arthropod pests, pathogens and nematodes. Pest Management Science. 2018, 74(6): 1239-1250.

Cagliari D, Dias NP, Galdeano DM, et al. Management of pest insects and plant diseases by non-transformative RNAi. Frontiers in Plant Science, 2019; 10: 1319.

Xue XY, Mao YB, Tao XY, et al. New approaches to agricultural insect pest control based on RNA interference. Advances in Insect Physiology. 2012, 42: 73-117.

Shi B, He H, Zhao C, et al. Potential of Virus-Mediated RNAi of Insect Genes in Plants to Control Aphids. Journal of Agricultural and Food Chemistry. 2025, 73(13): 7716-7724.

Burch‐Smith TM, Anderson JC, Martin GB, et al. Applications and advantages of virus‐induced gene silencing for gene function studies in plants. The Plant Journal. 2004; 39(5): 734-746.

Vaistij FE, Jones L. Compromised virus-induced gene silencing in RDR6-deficient plants. Plant Physiology. 2009, 149(3): 1399-1407.

Zhang J, Li H, Zhong X, et al. RNA-interference-mediated aphid control in crop plants: a review. Agriculture. 2022, 12(12): 2108.

Kolliopoulou A, Taning CN, Smagghe G, et al. Viral delivery of dsRNA for control of insect agricultural pests and vectors of human disease: prospects and challenges. Frontiers in Physiology. 2017, 8: 399.

Liu J, Smagghe G, Swevers L. Transcriptional response of BmToll9-1 and RNAi machinery genes to exogenous dsRNA in the midgut of Bombyx mori. Journal of Insect Physiology. 2013, 59(6): 646-654.

Ivashuta S, Zhang Y, Wiggins BE, et al. Environmental RNAi in herbivorous insects. Rna. 2015, 21(5): 840-850.

Hunter WB, Bextine BR., Shatters Jr. RG, et al. Emerging psyllid genomes- increasing RNA-interference targets for insect management. DSP1. 93rd Annual Meeting Florida Entomological Society. 2010a, 25–28 July. http://flaentsoc.org/2010annmeetabstracts.pdf.

Hunter WB, Glick E, Bextine BR, et al. RNA-interference to reducing insect pests: plant infusions. DSP2. 93rd Annual meeting Florida Entomological Society 2010b, 25–28 July. http://flaentsoc.org/2010annmeetabstracts.pdf.

Zhu F, Xu J, Palli R, Ferguson J, et al. Ingested RNA interference for managing the populations of the Colorado potato beetle, Leptinotarsa decemlineata. Pest Management Science, 2011, 67(2): 175-182.

Luan JB, Ghanim M, Liu SS, et al.. Silencing the ecdysone synthesis and signaling pathway genes disrupts nymphal development in the whitefly. Insect Biochemistry and Molecular Biology 2013, 43(8): 740-746.

Li H, Guan R, Guo H, et al. New insights into an RNAi approach for plant defence against piercing-sucking and stem-borer insect pests. Plant Cell Environment. 2015, 38: 2277–2285.

San Miguel K, Scott JG. The next generation of insecticides: dsRNA is stable as a foliar‐applied insecticide. Pest Management Science. 2016, 72(4): 801-809.

Camargo RA, Barbosa GO, Possignolo IP, et al. RNA interference as a gene silencing tool to control Tuta absoluta in tomato (Solanum lycopersicum). PeerJ. 2016; 4: e2673. doi: 10.7717/peerj.2673.

Majidiani S, PourAbad R, Laudani F, et al.). RNAi in Tuta absoluta management: Effects of injection and root delivery of dsRNAs. Journal of Pest Science, 2019, 92: 1409–1419.

Khan F, Kim M, Kim Y. Greenhouse test of spraying dsRNA to control the western flower thrips, Frankliniella occidentalis, infesting hot peppers. BMC Biotechnology. 2023, 23(1): 10.

Hough J, Howard JD, Brown S, et al. Strategies for the production of dsRNA biocontrols as alternatives to chemical pesticides. Frontiers in Bioengineering and Biotechnology.2022, 10: 980592.

Siddique AB, Rahman MZ, Gain N, et al. Harnessing double-stranded RNA (dsRNA): a sustainable approach to pest management. Physiology and Molecular Biology of Plants. 2025, 1-21.

Rodrigues T, Sridharan K, Manley B, et al. Development of dsRNA as a sustainable bioinsecticide: from laboratory to field. In: Brittany MR, Beth AL (eds) Crop Protection Products for Sustainable Agriculture. American Chemical Society, 2021. p. 65–82.

Khajuria C, Ivashuta S, Wiggins E, et al. Development and characterization of the first dsRNA-resistant insect population from western corn rootworm, Diabrotica virgifera virgifera LeConte. PLoS ONE. 2018, 13:e0197059.

Mishra S, Dee J, Moar W, et al. Selection for high levels of resistance to double-stranded RNA (dsRNA) in Colorado potato beetle (Leptinotarsa decemlineata Say) using non-transgenic foliar delivery. Scientific Reports. 2021, 11: 6523.

Ulrich J, Dao VA, Majumdar U, et al. Large scale RNAi screen in Tribolium reveals novel target genes for pest control and the proteasome as prime target. BMC Genomics. 2015, 16: 1–9.

Jarosch A, Moritz RF. RNA interference in honeybees: off-target effects caused by dsRNA.Apidologie. 2012, 43(2): 128-138.