Orthoherpesviridae
Özet
Bu kitap bölümü, Orthoherpesviridae ailesine ait virusların ruminantlar ve domuzlardaki enfeksiyonlarını, moleküler yapılarından klinik bulgularına, epidemiyolojik özelliklerinden kontrol stratejilerine kadar çok yönlü olarak incelemektedir. BoAHV-1 enfeksiyonları solunum ve genital sistemde; BoAHV-5 ise nörolojik sistemde ciddi etkiler yaratmaktadır. BoGHV-4, subklinik seyirli olmasına rağmen mastitis ve metritis gibi hastalıklarda etkili olabilirken; BoAHV-2 enfeksiyonları genellikle meme dokusunda lokal lezyonlarla karakterizedir. Keçilerde görülen CpAHV-1 abort ve solunum yolu enfeksiyonlarına yol açmakta, CpGHV-2, OvHV-2 ve AlGHV-1 gibi etkenlerin neden olduğu MCF ise koyunlardan sığırlara geçerek yüksek mortaliteli vakalara neden olmaktadır. SuAHV-1 (Aujeszky hastalığı) domuzlarda nörolojik semptomlarla seyrederek ölüme yol açabilir ve zoonotik potansiyel taşımaktadır. Türkiye’de yapılan seroepidemiyolojik ve moleküler çalışmalar, bu virusların yaygınlığını ve sahadaki suşların genetik çeşitliliğini ortaya koymaktadır. Bu etkenlerin latent enfeksiyon oluşturma kapasiteleri, türler arası geçiş potansiyelleri ve tanıdaki zorlukları, enfeksiyonların kontrolünü karmaşık hale getirmektedir. Bu nedenle enfeksiyonların etkin kontrolünde serolojik ve moleküler tanı yöntemlerinin yanı sıra aşılama, karantina, biyogüvenlik ve izolasyon uygulamaları vazgeçilmezdir. Ayrıca, bu virusların hayvancılık sektöründe ciddi ekonomik kayıplara yol açtığı da vurgulanmaktadır.
Referanslar
Akkutay-Yoldar Z, Yoldar MT, Akkaş YB, et al. A web-based artificial intelligence system for label-free virus classification and detection of cytopathic effects. Scientific Reports. 2025;15(1):1-15. doi:10.1038/s41598-025-89639-0.
Albayrak H, Ozan E, Cavunt A. A serological survey of selected pathogens in wild boar (Sus scrofa) in northern Turkey. European Journal of Wildlife Research. 2013;59:893-897. doi:10.1007/s10344-013-0743-6.
Albayrak H, Tamer C, Ozan E, et al. Molecular identification and phylogeny of bovine herpesvirus-1 (BoHV-1) from cattle associated with respiratory disorders and death in Turkey. Medycyna Weterynaryjna-Veterinary Medicine-Science and Practice. 2020;76(6). doi:10.21521/mw.6393.
Albayrak H, Yazici Z, Okur-Gumusova S. Seroprevalence to bovine herpesvirus type 1 in sheep in Turkey. Veterinarski arhiv. 2007;77(3):257.
Alçay AÜ, Yilmaz H. A Cross-sectional study on the transmission dynamics of Bovine Herpesvirus-1 infection in the farms located in the Thrace Region of Turkey. Journal of the Hellenic Veterinary Medical Society. 2022;73(2):4193-4202. doi:10.12681/jhvms.26963.
Altamiranda EAG, Manrique JM, Pérez S, et al. Molecular characterization of the first bovine herpesvirus 4 (BoHV-4) strains isolated from in vitro bovine embryos production in Argentina. PLoS One. 2015;10(7):e0132212. doi:10.1371/journal.pone.0132212.
Amaral BP, Jardim JC, Cargnelutti JF, et al. Pathogenesis of Bovine alphaherpesvirus 2 in calves following different routes of inoculation. Pesquisa Veterinária Brasileira. 2020;40(5):360-367. doi:10.1590/1678-5150-pvb-6588.
Aslan ME, Azkur AK, Gazyagci S. Epidemiology and genetic characterization of BVDV, BHV-1, BHV-4, BHV-5 and Brucella spp. infections in cattle in Turkey. Journal of Veterinary Medical Science. 2015;77(11):1371-1377. doi:10.1292/jvms.14-0657.
Ata A, Kale M, Yavru S, et al. The effect of subclinical bovine herpesvirus 1 infection on fertility of cows and heifers. Acta Veterinaria. 2006;56(2-3):267-273. doi:10.2298/AVB0603267A.
Ata A, Kocamuftuoglu M, Hasircioglu S, et al. Investigation of Relationship Between Bovine Herpesvirus-1 (BHV-1) Infection and Fertility in Repeat Breeding Dairy Cows in Family-Type Small Dairy Farmsı. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2012;18(4). doi:10.9775/kvfd.2011.5893.
Ataseven VS, Ambarcıoğlu P, Doğan F. Serum and milk levels of antibodies to bovine viral diarrhoea virus, bovine herpesvirus-1 and -4, and circulation of different bovine herpesvirus-4 genotypes in dairy cattle with clinical mastitis. Journal of Veterinary Research. 2023;67(1):33-40. doi:10.2478/jvetres-2023-0010.
Atasever A, Mendil AS, Timurkan MO. Detection of bovine viral diarrhea virus and bovine herpes virus type 1 in cattle with and without endometritis. Veterinary Research Forum. 2023;14(10):541.
Aujeszky A. Ueber eine neue Infektionskrankheit bei Haustieren. Centralblatt für Bakteriologie, Infektionskrankheiten und Parasitenkunde, Erste Abteilung. 1902;32:353-357.
Aytoğu G, Toker EB, Yavaş O, et al. First isolation and molecular characterization of pseudorabies virus detected in Turkey. Molecular Biology Reports. 2021;49:1679-1686. doi:10.1007/s11033-021-06974-x.
Aytoğu G, Yeşilbağ K, Toker EB, et al. First isolation and characterization of Bovine Herpesvirus 1.2 b (BoHV-1.2 b) strain from respiratory tract of cattle in Turkey. Journal of Research in Veterinary Medicine. 2022;41(2):80-87. doi:10.30782/jrvm.1082913.
Baldacchino F, Muenworn V, Desquesnes M, et al. Transmission of pathogens by Stomoxys flies (Diptera, Muscidae): a review. Parasite. 2013;20:26. doi:10.1051/parasite/2013026.
Baydın MÖ, Dağalp SB. Investigation of the seroprevalence of BoHV-1 and CpHV-1 infections using gB/gE ELISA combination and VNT in selected goat flocks. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2017;64(4):329-35. doi:10.1501/Vetfak_0000002817.
Bianchessi L, Rocchi MS, Maley M, et al. Molecular tools to identify and characterize malignant catarrhal fever viruses (MCFV) of ruminants and captive Artiodactyla. Viruses. 2022;14(12):2697. doi:10.3390/v14122697.
Bilge-Dağalp S, Demir AB, Güngör E, et al. The sero-prevalence of bovine herpesvirus type 4 (BHV 4) infection in dairy herds in Turkey and possible interaction with reproductive disorders. Revue de Médecine Vétérinaire. 2007;4:201-205.
Biswas S, Bandyopadhyay S, Dimri U, et al. Bovine herpesvirus-1 (BHV-1) – a re-emerging concern in livestock: a revisit to its biology, epidemiology, diagnosis, and prophylaxis. Veterinary Quarterly. 2013;33(2):68-81. doi:10.1080/01652176.2013.799301.
Brenner J, Sharir B, Yadin H, et al. Herpesvirus type 2 in biopsy of a cow with possible pseudo-lumpy-skin disease. Veterinary Record. 2009;165:539-540. doi:10.1136/vr.165.18.539.
Brower A, Homb KM, Bochsler P, et al. Encephalitis in aborted bovine fetuses associated with Bovine herpesvirus 1 infection. Journal of Veterinary Diagnostic Investigation. 2008;20(3):297-303. doi:10.1177/104063870802000306.
Camero M, Larocca V, Lovero A, et al. Caprine herpesvirus type 1 infection in goat: not just a problem for females. Small Ruminant Research. 2015;128:59-62. doi:10.1016/j.smallrumres.2015.04.015.
Campos FS, Franco AC, Oliveira MT, et al. Detection of bovine herpesvirus 2 and bovine herpesvirus 4 DNA in trigeminal ganglia of naturally infected cattle by polymerase chain reaction. Veterinary Microbiology. 2014;171(1-2):182-188. doi:10.1016/j.vetmic.2014.03.012.
Can-Sahna K, Abayli H, Ilgin M, et al. Investigation of some neuroinfectious viral agents in Turkish cattle: first detection and molecular characterization of bovine herpesvirus type 5 (BoHV-5). Pakistan Veterinary Journal. 2024;44(3).
Can MF, Ataseven VS, Yalçın C. Estimation of production and reproductive performance losses in dairy cattle due to bovine herpesvirus 1 (BoHV-1) infection. Veterinarski Arhiv. 2016;86(4):499–513.
Černe D, Hostnik P, Toplak I, et al. Detection of Pseudorabies in dogs in Slovenia between 2006 and 2020: from clinical and diagnostic features to molecular epidemiology. Transboundary and Emerging Diseases. 2023. doi:10.1155/2023/4497806.
Cheng Z, Kong Z, Liu P, et al. Natural infection of a variant pseudorabies virus leads to bovine death in China. Transboundary and Emerging Diseases. 2019;67(2):518-522. doi:10.1111/tbed.13427.
D'Arce RCF, Almeida RS, Silva TC, et al. Restriction endonuclease and monoclonal antibody analysis of Brazilian isolates of bovine herpesviruses types 1 and 5. Veterinary Microbiology. 2002;88(4):315-324. doi:10.1016/S0378-1135(02)00126-8.
Dağalp SB, Alkan F, Çalışkan E, et al. The investigation of the herpesviruses (BoHV-1 and BoHV-4) on the occurrence of the reproductive disorders in dairy cattle herds, Turkey. Revue de Médecine Vétérinaire. 2012;163(4):206-211.
Dağalp SB, Güngör EO, Başak A, et al. The investigation of the presence of bovine herpesvirus type 4 (BoHV-4) in cows with metritis in a dairy herd. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2010;50(1):87-91. doi:10.1501/Vetfak_0000002316.
Dağalp S, Farzani T, Doğan F, et al. Development of a BoHV-4 viral vector expressing TgD of BoHV-1 and evaluation of its immunogenicity in mouse model. Brazilian Journal of Microbiology. 2021;52(3):1119-1133. doi:10.1007/s42770-021-00525-z.
Egyed L, Ballagi-Pordány A, Bartha A, et al. Studies of in vivo distribution of bovine herpesvirus type 4 in the natural host. Journal of Clinical Microbiology. 1996;34:1091-1095. doi:10.1128/jcm.34.5.1091-1095.1996.
Ehlers B, Goltz M, Ejercito MP, et al. Bovine herpesvirus type 2 is closely related to the primate alphaherpesviruses. Virus Genes. 1999;19:197-203. doi:10.1023/A:1008184630066.
Erhan M, Onar B, Csontas L, et al. Serological survey on some virus and Bedsonia diseases of cattle. Pendik Veteriner Kontrol Araştırma Dergisi. 1971;4:55-58.
Farzani TA, Földes K, Hanifehnezhad A, et al. Bovine herpesvirus type 4 (BoHV-4) vector delivering nucleocapsid protein of Crimean-Congo hemorrhagic fever virus induces comparable protective immunity against lethal challenge in IFNα/β/γR−/− mice models. Viruses. 2019;11(3):237. doi:10.3390/v11030237.
Ferrara G, Longobardi C, D'Ambrosi F, et al. Aujeszky's disease in South-Italian wild boars (Sus scrofa): a serological survey. Animals. 2021;11(11):3298. doi:10.3390/ani11113298.
Ferrara G, Pagnini U, Parisi A, et al. A pseudorabies outbreak in hunting dogs in Campania region (Italy): a case presentation and epidemiological survey. BMC Veterinary Research. 2024;20. doi:10.1186/s12917-024-04189-3.
Freuling CM, Hlinak A, Schulze C, et al. Suid alphaherpesvirus 1 of wild boar origin as a recent source of Aujeszky's disease in carnivores in Germany. Virology Journal. 2023;20. doi:10.1186/s12985-023-02074-3.
Gatherer D, Depledge DP, Hartley CA, et al. ICTV virus taxonomy profile: Herpesviridae 2021. Journal of General Virology. 2021;102(10):001673. doi:10.1099/jgv.0.001673.
Gong M, Myster F, van Campe W, et al. Wildebeest-derived malignant catarrhal fever: a bovine peripheral T cell lymphoma caused by cross-species transmission of Alcelaphine gammaherpesvirus 1. Viruses. 2023;15. doi:10.3390/v15020526.
Gonzalez J, Passantino G, Esnal A, et al. Abortion in goats by Caprine alphaherpesvirus 1 in Spain. Reproduction in Domestic Animals. 2017;52(6):1093-1096. doi:10.1111/rda.13034.
Graham DA. Bovine herpesvirus-1 (BoHV-1) in cattle – a review with emphasis on reproductive impacts and the emergence of infection in Ireland and the United Kingdom. Irish Veterinary Journal. 2013;66:1-12. doi:10.1186/2046-0481-66-15.
Gregory L, Gaeta NC, Bettini A, et al. Use of a commercial ELISA kit specific for glycoprotein E peptides to indirectly detect Caprine Herpesvirus 1 (CpHV-1) in the state of São Paulo, Brazil. Arquivos do Instituto Biológico. 2020;87:e0012020. doi:10.1590/1808-1657000012020.
Gür S, Doğan N. The possible role of bovine herpesvirus type‐4 infection in cow infertility. Animal Science Journal. 2010;81(3):304-308. doi:10.1111/j.1740-0929.2010.00743.x.
Gür S, Erol N, Yapıcı O, et al. The role of goats as reservoir hosts for bovine herpes virus 1 under field conditions. Tropical Animal Health and Production. 2019;51:753-758. doi:10.1007/s11250-018-1746-9.
Hao F, Mao L, Li W, et al. Epidemiological investigation and genomic characterization of Caprine herpesvirus 1 from goats in China. Infection, Genetics and Evolution. 2020;79:104168. doi:10.1016/j.meegid.2019.104168.
Holzhauer M. Fatal outbreaks of malignant catarrhal fever in two dairy herds in the Netherlands. Journal of Dairy & Veterinary Sciences. 2018;5(5). doi:10.19080/JDVS.2018.05.555672.
TURKAI. AIRVIC: AI Recognition of Viral CPE. AIRVIC is an artificial intelligence model designed to detect virus-induced cytopathic effects (CPE). Available from: https://airvic.turkai.com/ (Accessed 15th March 2025)
ICTV (International Committee on Taxonomy of Virus). ICTV Report Chapters. Herpesviridae. Family: Herpesviridae. Subfamily Alphaherpesvirinae. Genus: Varicellovirus. 2023. Available from: https://ictv.global/report/chapter/herpesviridae/herpesviridae/varicellovirus (Accessed 15th March 2025)
İnce ÖB, Şevik M. Risk assessment and seroprevalence of bovine herpesvirus type 1 infection in dairy herds in the inner Aegean Region of Turkey. Comparative Immunology, Microbiology and Infectious Diseases. 2022;80:101741. doi:10.1016/j.cimid.2021.101741.
Jones C. Bovine herpesvirus 1 counteracts immune responses and immune-surveillance to enhance pathogenesis and virus transmission. Frontiers in Immunology. 2019;10:1008. doi:10.3389/fimmu.2019.01008.
Kale M, Ata A, Kocamüftüoğlu M, et al. Bovine herpesvirus type 4 (BHV-4) infection in relation to fertility in repeat breeder dairy cows. Acta Veterinaria. 2011;61(1):13-19. doi:10.2298/AVB1101013K.
Klamminger S, Prunner I, Giuliodori MJ, Drillich M. Uterine infection with bovine herpesvirus type 4 in dairy cows. Reproduction in Domestic Animals. 2016;52(1):115-121. doi:10.1111/rda.12865.
Kruger ER, Penha TR, Stoffelo DR, et al. Bovine Herpesvirus 4 in Parana State, Brazil: case report, viral isolation, and molecular identification. Brazilian Journal of Microbiology. 2015;46:279-283. doi:10.1590/S1517-838246120130949.
Lanave G, Larocca V, Losurdo M, et al. Isolation and characterization of bovine alphaherpesvirus 2 strain from an outbreak of bovine herpetic mammillitis in a dairy farm. BMC Veterinary Research. 2020;16:1-9. doi:10.1186/s12917-020-02325-3.
Levings R, Roth J. Immunity to bovine herpesvirus 1: I. Viral lifecycle and innate immunity. Animal Health Research Reviews. 2013;14(1):88-102. doi:10.1017/S1466252313000042.
Li H, Cunha CW, Taus NS, et al. Malignant catarrhal fever: inching toward understanding. Annual Review of Animal Biosciences. 2014;2(1):209-233. doi:10.1146/annurev-animal-022513-114156.
Li H, Gailbreath KL, Bender LC, et al. Evidence of three new members of malignant catarrhal fever virus group in muskox (Ovibos moschatus), Nubian ibex (Capra nubiana), and gemsbok (Oryx gazella). Journal of Wildlife Diseases. 2003;39(4):875-880. doi:10.7589/0090-3558-39.4.875.
Li H, Wunschmann A, Keller J, et al. Caprine herpesvirus-2-associated malignant catarrhal fever in white-tailed deer (Odocoileus virginianus). Journal of Veterinary Diagnostic Investigation. 2003;15(1):46-49. doi:10.1177/104063870301500110.
Lin, J., Chen, R. H., Yang, M. J., Zhu, Y. M., & Xue, F. (2021). Isolation and molecular characterization of bovine herpesvirus 4 from cattle in mainland China. Archives of Virology. 166(2), 619-626.
Machado GF, Bernardi F, Hosomi FYM, et al. Bovine herpesvirus-5 infection in a rabbit experimental model: immunohistochemical study of the cellular response in the CNS. Microbial Pathogenesis. 2013;57:10-16. doi:10.1016/j.micpath.2013.01.003.
Mahajan V, Banga HS, Deka D, et al. Comparison of diagnostic tests for diagnosis of infectious bovine rhinotracheitis in natural cases of bovine abortion. Journal of Comparative Pathology. 2013;149(4):391-401. doi:10.1016/j.jcpa.2013.05.002.
Maidana SS, Ladelfa MF, Perez SE, et al. Characterization of BoHV-5 field strains circulation and report of transient specific subtype of bovine herpesvirus 5 in Argentina. BMC Veterinary Research. 2011;7:8. doi:10.1186/1746-6148-7-8.
Marin M, Burucúa M, Rensetti D, et al. Distinctive features of bovine alphaherpesvirus types 1 and 5 and the virus-host interactions that might influence clinical outcomes. Archives of Virology. 2020;165:285-301. doi:10.1007/s00705-019-04494-5.
Megid J, Vicente AF, Appolinário CM, et al. Outbreak control and clinical, pathological, and epidemiological aspects and molecular characterization of a bovine herpesvirus type 5 on a feedlot farm in São Paulo State. BioMed Research International. 2015;2015:1-5. doi:10.1155/2015/981230.
Mettenleiter TC. Aujeszky's disease and the development of the marker/DIVA vaccination concept. Pathogens. 2020;9(7):563. doi:10.3390/pathogens9070563.
Nural ERO, Gür S, Koç BT, et al. A serological investigation of Bovine enterovirus-1, Bovine herpesvirus-1, Bovine viral diarrhea virus, and Parainfluenza-3 infections in camels in Western Turkey. Veterinaria Italiana. 2020;56(4):257-262.
O'Neill R, Fitzpatrick JL, Glass E, et al. Optimisation of the response to respiratory virus vaccines in cattle. Veterinary Record. 2007;161(8):269-270. doi:10.1136/vr.161.8.269.
Oberto F, Carella E, Caruso C, et al. A qualitative PCR assay for the discrimination of Bubaline Herpesvirus 1, Bovine Herpesvirus 1 and Bovine Herpesvirus 5. Microorganisms. 2023;11. doi:10.3390/microorganisms11030577.
Oğuzoğlu TÇ, Salar S, Adıgüzel E, et al. Detection and characterisation of sheep-associated malignant catarrhal fever infection from ruminants by using tegument and gB gene sequences of OvHV-2. The Onderstepoort Journal of Veterinary Research. 2020;87. doi:10.4102/ojvr.v87i1.1886.
Ossiboff RJ, Raphael BL, Ammazzalorso AD, et al. Three novel herpesviruses of endangered Clemmys and Glyptemys turtles. PLoS One. 2015;10(4):e0122901. doi:10.1371/journal.pone.0122901.
Ostler JB, Jones C. The Bovine Herpesvirus 1 latency-reactivation cycle, a chronic problem in the cattle industry. Viruses. 2023;15. doi:10.3390/v15020552.
Pedersen K, Turnage C, Gaston W, et al. Pseudorabies detected in hunting dogs in Alabama and Arkansas after close contact with feral swine (Sus scrofa). BMC Veterinary Research. 2018;14(1). doi:10.1186/s12917-018-1718-3.
Petrini S, König P, Righi C, et al. Serological cross-reactivity between bovine alphaherpesvirus 2 and bovine alphaherpesvirus 1 in a gB-ELISA: a case report in Italy. Frontiers in Veterinary Science. 2020;7:587885. doi:10.3389/fvets.2020.587885.
Queiroz-Castro VLD, da Costa EP, Alves SVP, et al. Detection of bovine herpesvirus 1 in genital organs of naturally infected cows. Theriogenology. 2019;130:125-129. doi:10.1016/j.theriogenology.2019.03.003.
Rissi DR, Rech RR, Flores EF, et al. Meningoencephalitis by bovine herpesvirus-5. Pesquisa Veterinária Brasileira. 2007;27:251-252. doi:10.1590/S0100-736X2007000700001.
Russo L, Capra E, Franceschi V, et al. Characterization of BoHV-4 ORF45. Frontiers in Microbiology. 2022;14. doi:10.1101/2022.12.07.519449.
Selim A, Shoulah S, Alsubki RA, et al. Sero-survey of bovine herpes virus-1 in dromedary camels and associated risk factors. BMC Veterinary Research. 2022;18(1):362. doi:10.1186/s12917-022-03448-5.
Serena MS, Metz GE, Lozada MI, et al. First isolation and molecular characterization of Suid herpesvirus type 1 from a domestic dog in Argentina. Open Veterinary Journal. 2018;8(2):131-139. doi:10.4314/ovj.v8i2.3.
Gür S. Prevalence of bovine viral diarrhoea, bovine herpesvirus type 1 and 4 infections in repeat breeding cows in Western Turkey. Brazilian Journal of Veterinary Research and Animal Science. 2011;48(3):228-233.
Suavet F, Champion JL, Bartolini L, et al. First description of infection of Caprine herpesvirus 1 (CpHV-1) in goats in mainland France. Pathogens. 2016;5(1):17. doi:10.3390/pathogens5010017.
Thiry J, Widén F, Grégoire F, et al. Isolation and characterisation of a ruminant alphaherpesvirus closely related to bovine herpesvirus 1 in a free-ranging red deer. BMC Veterinary Research. 2007;3(1):26. doi:10.1186/1746-6148-3-26.
Toker EB, Yeşilbağ K, Ateş Ö, et al. High mortality rate of shipping fever cases in cattle caused by bovine herpesvirus type 1 (BoHV-1). Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2022. doi:10.33988/auvfd.834671.
Tuncer-Göktuna P, Alpay G, Öner EB, Yeşilbağ K. The role of herpesviruses (BoHV-1 and BoHV-4) and pestiviruses (BVDV and BDV) in ruminant abortion cases in western Turkey. Tropical Animal Health and Production. 2016;48:1021-1027. doi:10.1007/s11250-016-1050-5.
Turan T, Isidan H, Atasoy MO, et al. Genetic diversity of ovine herpesvirus 2 strains obtained from malignant catarrhal fever cases in eastern Turkey. Virus Research. 2020;276:197801. doi:10.1016/j.virusres.2019.197801.
Uzlu E, Erkılıç EE, Adalı Y, et al. Evaluation of blood and cerebrospinal fluid biochemistry, cytology and haematological parameters in head-and-eye form of malignant catarrhal fever in cattle. Erciyes Üniversitesi Veteriner Fakültesi Dergisi. 2023;20(2):86-93. doi:10.32707/ercivet.1332128.
Vercammen F, De Deken R, Mortelmans J. Aujeszky's disease or pseudorabies. In: Kaandorp S (ed.) Transmissible Diseases Handbook. 2nd ed. European Association of Zoo and Wildlife Veterinarians (EAZWV); 2004.
Watanabe TTN, Moeller Jr RB, Crossley BM, et al. Outbreaks of bovine herpesvirus 2 infections in calves causing ear and facial skin lesions. Journal of Veterinary Diagnostic Investigation. 2017;29(5):686-690. doi:10.1177/1040638717704480.
Williams LBA, Fry LM, Herndon DR, et al. A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle. PLoS One. 2019;14(4):e0215605. doi:10.1371/journal.pone.0215605.
Xu L, Tao Q, Xu T, et al. Pathogenicity characteristics of different subgenotype pseudorabies virus in newborn piglets. Frontiers in Veterinary Science. 2024;11. doi:10.3389/fvets.2024.1438354.
Yazici Z, Albayrak H, Ozan E, et al. Serological status of bovine herpesvirus type 1 in cattle in small-scale private farms in the Central Black Sea Region, Turkey. Pakistan Veterinary Journal. 2015;35(1):101–102.
Yazici Z, Ozan E, Tamer C, et al. Serological study on the presence of some alpha-herpesviruses in goats of northern Anatolia, Turkey. Veterinary Research Forum. 2021;12(3):273.
Yeşilbağ K. Seroprevalence of malignant catarrhal fever-related gammaherpesviruses in domestic ruminants in Turkey. Tropical Animal Health and Production. 2007;39:363-368. doi:10.1007/s11250-007-9024-2.
Yeşilbağ K, Güngör B. Seroprevalence of bovine respiratory viruses in North-Western Turkey. Tropical Animal Health and Production. 2008;40:55-60. doi:10.1007/s11250-007-9053-x.
Yeşilbağ K, Bilge-Dağalp S, Okur-Gümüşova S, et al. Studies on herpesvirus infections of goats in Turkey: prevalence of antibodies to bovine herpesvirus 1. Revue de Médecine Vétérinaire. 2003;154:772-774.
Yıldırım S, Özkan C, Yener Z, et al. Van’da bir inekte yalancı kuduz (Aujeszky) hastalığının immunohistokimyasal teşhisi. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016;23(1). doi:10.9775/kvfd.2016.16071.
Yıldız H, Babaoğlu AR. Molecular investigation of bovine viral diarrhea virus, bovine herpes virus-1 and bovine herpes virus-4 infections in abortion cases of cattle in Van district, Turkey. Van Veterinary Journal. 2022;33(3):106-111. doi:10.36483/vanvetj.1165216.
Yildirim Y, Bilge-Dağalp S, Yilmaz V, et al. Molecular characterisation of ovine herpesvirus type 2 (OvHV-2) in Turkey. Acta Veterinaria Hungarica. 2012;60(4):521-527. doi:10.1556/avet.2012.046.
Yilmaz A, Umar S, Turan N, et al. Current scenario of viral diseases and vaccination strategies of cattle in Turkey. The Journal of Infection in Developing Countries. 2022;16(08):1230-1242. doi:10.3855/jidc.14767.
Yilmaz V, Coşkun N. Investigation of Bovine Herpes Virus type 1 infection in sheep in the Kars Province of Turkey. Harran Üniversitesi Veteriner Fakültesi Dergisi. 2016;5(1):40-43.
Zajac MPDM, Ladelfa MF, Kotsias F, et al. Biology of bovine herpesvirus 5. The Veterinary Journal. 2010;184(2):138-145. doi:10.1016/j.tvjl.2009.03.035.
Zheng HH, Fu PF, Chen HY, et al. Pseudorabies virus: from pathogenesis to prevention strategies. Viruses. 2022;14(8):1638. doi:10.3390/v14081638.
https://viralzone.expasy.org/176, Erişim Tarihi: 01.02.2025
https://viralzone.expasy.org/5836, Erişim Tarihi: 17.02.2025
http://www.cabidigitallibrary.org/doi/10.1079/cabicompendium.91729, Erişim Tarihi: 12.02.2025
https://ictv.global/report/chapter/orthoherpesviridae/orthoherpesviridae/gammaherpesvirinae, Erişim Tarihi: 04.03.2025
https://nadis.org.uk/disease-a-z/cattle/ibr-infectious-bovine-rhinotracheitis, Erişim Tarihi: 25.02.2025
https://www.veterinary-practice.com/article/a-practitioners-guide-to-infectious-bovine-rhinotracheitis, Erişim Tarihi: 06.03.2025
https://www.ukvetlivestock.com/content/clinical/control-of-infectious-bovine-rhinotracheitis Erişim Tarihi:19.03.2025
https://ictv.global/report/chapter/orthoherpesviridae/orthoherpesviridae/gammaherpesvirinae Erişim Tarihi:01.04.2025
