Geriatrik Böbrek Kanseri Hastalarına Yaklaşım

Numakura K, Nakai Y, Kojima T, et al. Overview of clinical management for older patients with renal cell carcinoma. Japanese Journal of Clinical Oncology. 2022;52(7):665-81. 10.1093/jjco/hyac047

Scelo G, Larose TL. Epidemiology and Risk Factors for Kidney Cancer. Journal of Clinical Oncology. 2018;36(36):Jco2018791905. 10.1200/jco.2018.79.1905

Bai H, Jiang W, Wang D, et al. Efficacy and safety of surgery in renal carcinoma patients 75 years and older: a retrospective analysis. BMC Urology. 2022;22(1):135. 10.1186/s12894-022-01088-3

Hollingsworth JM, Miller DC, Daignault S, et al. Five-year survival after surgical treatment for kidney cancer: a population-based competing risk analysis. Cancer. 2007;109(9):1763-8. 10.1002/cncr.22600

Kutikov A, Egleston BL, Wong YN, et al. Evaluating overall survival and competing risks of death in patients with localized renal cell carcinoma using a comprehensive nomogram. Journal of Clinical Oncology. 2010;28(2):311-7. 10.1200/jco.2009.22.4816

Kanesvaran R, Le Saux O, Motzer R, et al. Elderly patients with metastatic renal cell carcinoma: position paper from the International Society of Geriatric Oncology. The Lancet Oncology. 2018;19(6):e317-e26. 10.1016/s1470-2045(18)30125-6

Mühlberg W, Platt D. Age-dependent changes of the kidneys: pharmacological implications. Gerontology. 1999;45(5):243-53. 10.1159/000022097

Anantharaju A, Feller A, Chedid A. Aging Liver. A review. Gerontology. 2002;48(6):343-53. 10.1159/000065506

Cheitlin MD. Cardiovascular physiology-changes with aging. The American Journal of Geriatric Cardiology. 2003;12(1):9-13. 10.1111/j.1076-7460.2003.01751.x

Ellis G, Gardner M, Tsiachristas A, et al. Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database of Systematic reviews. 2017;9(9):Cd006211. 10.1002/14651858.CD006211.pub3

Bex A, Ghanem YA, Albiges L, et al. European Association of Urology Guidelines on Renal Cell Carcinoma: The 2025 Update. European Urology. 2025;87(6):683-96. 10.1016/j.eururo.2025.02.020

Rostoft S, O'Donovan A, Soubeyran P, et al. Geriatric Assessment and Management in Cancer. Journal of Clinical Oncology. 2021;39(19):2058-67. 10.1200/jco.21.00089

Droz JP, Balducci L, Bolla M, et al. Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology. BJU International. 2010;106(4):462-9. 10.1111/j.1464-410X.2010.09334.x

Mohile SG, Dale W, Somerfield MR, et al. Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology. Journal of Clinical Oncology. 2018;36(22):2326-47. 10.1200/jco.2018.78.8687

Hollingsworth JM, Miller DC, Daignault S, et al. Rising incidence of small renal masses: a need to reassess treatment effect. Journal of the National Cancer Institute. 2006;98(18):1331-4. 10.1093/jnci/djj362

MacLennan S, Imamura M, Lapitan MC, et al. Systematic review of perioperative and quality-of-life outcomes following surgical management of localised renal cancer. European Urology. 2012;62(6):1097-117. 10.1016/j.eururo.2012.07.028

Huang WC, Elkin EB, Levey AS, et al. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors--is there a difference in mortality and cardiovascular outcomes? The Journal of Urology. 2009;181(1):55-61; discussion -2. 10.1016/j.juro.2008.09.017

Kates M, Badalato GM, Pitman M, et al. Increased risk of overall and cardiovascular mortality after radical nephrectomy for renal cell carcinoma 2 cm or less. The Journal of Urology. 2011;186(4):1247-53. 10.1016/j.juro.2011.05.054

Thompson RH, Atwell T, Schmit G, et al. Comparison of partial nephrectomy and percutaneous ablation for cT1 renal masses. European Urology. 2015;67(2):252-9. 10.1016/j.eururo.2014.07.021

Sun M, Becker A, Tian Z, et al. Management of localized kidney cancer: calculating cancer-specific mortality and competing risks of death for surgery and nonsurgical management. European Urology. 2014;65(1):235-41. 10.1016/j.eururo.2013.03.034

Sun M, Bianchi M, Trinh QD, et al. Comparison of partial vs radical nephrectomy with regard to other-cause mortality in T1 renal cell carcinoma among patients aged ≥75 years with multiple comorbidities. BJU International. 2013;111(1):67-73. 10.1111/j.1464-410X.2012.11254.x

Shuch B, Hanley J, Lai J, et al. Overall survival advantage with partial nephrectomy: a bias of observational data? Cancer. 2013;119(16):2981-9. 10.1002/cncr.28141

Ingels A, Duc S, Bensalah K, et al. Postoperative outcomes of elderly patients undergoing partial nephrectomy. Scientific Reports 2021;11(1):17201. 10.1038/s41598-021-96676-y

Zhang M, Zhao Z, Duan X, et al. Partial versus radical nephrectomy for T1b-2N0M0 renal tumors: A propensity score matching study based on the SEER database. PLOS ONE. 2018;13(2):e0193530. 10.1371/journal.pone.0193530

Calpin GG, Ryan FR, McHugh FT, et al. Comparing the outcomes of open, laparoscopic and robot-assisted partial nephrectomy: a network meta-analysis. BJU International. 2023;132(4):353-64. 10.1111/bju.16093

Gupta R, Eraky A, Elkun Y, et al. Comparative outcomes of multi-port versus single-port robotic-assisted partial nephrectomy with same-day discharge: impact of surgical approach. Journal of Robotic Surgery. 2025;19(1):374. 10.1007/s11701-025-02522-y

Karakiewicz PI, Briganti A, Chun FK, et al. Multi-institutional validation of a new renal cancer-specific survival nomogram. Journal of Clinical Oncology. 2007;25(11):1316-22. 10.1200/jco.2006.06.1218

Kunkle DA, Crispen PL, Li T, et al. Tumor size predicts synchronous metastatic renal cell carcinoma: implications for surveillance of small renal masses. The Journal of Urology. 2007;177(5):1692-6; discussion 7. 10.1016/j.juro.2007.01.029

Smaldone MC, Kutikov A, Egleston BL, et al. Small renal masses progressing to metastases under active surveillance: a systematic review and pooled analysis. Cancer. 2012;118(4):997-1006. 10.1002/cncr.26369

Kim JH, Li S, Khandwala Y, et al. Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014. JAMA Surgery. 2019;154(3):225-31. 10.1001/jamasurg.2018.4602

Tomaszewski JJ, Uzzo RG, Kutikov A, et al. Assessing the burden of complications after surgery for clinically localized kidney cancer by age and comorbidity status. Urology. 2014;83(4):843-9. 10.1016/j.urology.2013.12.048

Sohlberg EM, Metzner TJ, Leppert JT. The Harms of Overdiagnosis and Overtreatment in Patients with Small Renal Masses: A Mini-review. European Urology Focus. 2019;5(6):943-5. 10.1016/j.euf.2019.03.006

Campbell S, Uzzo RG, Allaf ME, et al. Renal Mass and Localized Renal Cancer: AUA Guideline. The Journal of Urology. 2017;198(3):520-9. 10.1016/j.juro.2017.04.100

Shi L, He Y, Liu C, et al. Local ablation vs partial nephrectomy in T1N0M0 renal cell carcinoma: An inverse probability of treatment weighting analysis. Cancer Medicine. 2020;9(21):7988-8003. 10.1002/cam4.3433

Bertolo R, Garisto J, Armanyous S, et al. Perioperative, oncological and functional outcomes after robotic partial nephrectomy vs. cryoablation in the elderly: A propensity score matched analysis. Urologic Oncology: Seminars and Original Investigations. 2019;37(4):294.e9-.e15. 10.1016/j.urolonc.2018.12.016

Nandanan N, Veccia A, Antonelli A, et al. Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses: a multicenter study. Central European Journal of Urology. 2020;73(1):33-8. 10.5173/ceju.2020.0019

Widdershoven CV, Aarts BM, Zondervan PJ, et al. Renal biopsies performed before versus during ablation of T1 renal tumors: implications for prevention of overtreatment and follow-up. Abdominal Radiology. 2021;46(1):373-9. 10.1007/s00261-020-02613-4

Pickersgill NA, Vetter JM, Kim EH, et al. Ten-Year Experience with Percutaneous Cryoablation of Renal Tumors: Tumor Size Predicts Disease Progression. Journal of Endourology. 2020;34(12):1211-7. 10.1089/end.2019.0882

Hebbadj S, Cazzato RL, Garnon J, et al. Safety Considerations and Local Tumor Control Following Percutaneous Image-Guided Cryoablation of T1b Renal Tumors. CardioVascular and Interventional Radiology. 2018;41(3):449-58. 10.1007/s00270-017-1820-0

Zargar H, Atwell TD, Cadeddu JA, et al. Cryoablation for Small Renal Masses: Selection Criteria, Complications, and Functional and Oncologic Results. European Urology. 2016;69(1):116-28. 10.1016/j.eururo.2015.03.027

Johnson BA, Sorokin I, Cadeddu JA. Ten-Year Outcomes of Renal Tumor Radio Frequency Ablation. The Journal of Urology. 2019;201(2):251-8. 10.1016/j.juro.2018.08.045

Psutka SP, Feldman AS, McDougal WS, et al. Long-term oncologic outcomes after radiofrequency ablation for T1 renal cell carcinoma. European Urology. 2013;63(3):486-92. 10.1016/j.eururo.2012.08.062

Kunkle DA, Uzzo RG. Cryoablation or radiofrequency ablation of the small renal mass : a meta-analysis. Cancer. 2008;113(10):2671-80. 10.1002/cncr.23896

Siva S, Pham D, Kron T, et al. Stereotactic ablative body radiotherapy for inoperable primary kidney cancer: a prospective clinical trial. BJU International. 2017;120(5):623-30. 10.1111/bju.13811

Correa RJM, Louie AV, Zaorsky NG, et al. The Emerging Role of Stereotactic Ablative Radiotherapy for Primary Renal Cell Carcinoma: A Systematic Review and Meta-Analysis. European Urology Focus. 2019;5(6):958-69. 10.1016/j.euf.2019.06.002

Siva S, Pham D, Gill S, et al. A systematic review of stereotactic radiotherapy ablation for primary renal cell carcinoma. BJU International. 2012;110(11 Pt B):E737-43. 10.1111/j.1464-410X.2012.11550.x

Soo WK, King MT, Pope A, et al. Integrated Geriatric Assessment and Treatment Effectiveness (INTEGERATE) in older people with cancer starting systemic anticancer treatment in Australia: a multicentre, open-label, randomised controlled trial. The Lancet Healthy Longevity. 2022;3(9):e617-e27. 10.1016/s2666-7568(22)00169-6

Janssen MWW, Linxweiler J, Terwey S, et al. Survival outcomes in patients with large (≥7cm) clear cell renal cell carcinomas treated with nephron-sparing surgery versus radical nephrectomy: Results of a multicenter cohort with long-term follow-up. PLOS ONE. 2018;13(5):e0196427. 10.1371/journal.pone.0196427

Hsu RCJ, Barclay M, Loughran MA, et al. Time trends in service provision and survival outcomes for patients with renal cancer treated by nephrectomy in England 2000-2010. BJU International. 2018;122(4):599-609. 10.1111/bju.14217

Blom JH, van Poppel H, Maréchal JM, et al. Radical nephrectomy with and without lymph-node dissection: final results of European Organization for Research and Treatment of Cancer (EORTC) randomized phase 3 trial 30881. European Urology. 2009;55(1):28-34. 10.1016/j.eururo.2008.09.052

Luo X, Li JX, Liu YT, et al. Influence of lymph node dissection in patients undergoing radical nephrectomy for non-metastatic renal cell carcinoma: a systematic review and meta-analysis. European Review for Medical and Pharmacological Sciences. 2019;23(14):6079-90. 10.26355/eurrev_201907_18422

Bhindi B, Wallis CJD, Boorjian SA, et al. The role of lymph node dissection in the management of renal cell carcinoma: a systematic review and meta-analysis. BJU International. 2018;121(5):684-98. 10.1111/bju.14127

Gershman B, Thompson RH, Boorjian SA, et al. Radical Nephrectomy with or without Lymph Node Dissection for High Risk Nonmetastatic Renal Cell Carcinoma: A Multi-Institutional Analysis. The Journal of Urology. 2018;199(5):1143-8. 10.1016/j.juro.2017.11.114

Haferkamp A, Bastian PJ, Jakobi H, et al. Renal cell carcinoma with tumor thrombus extension into the vena cava: prospective long-term followup. The Journal of Urology. 2007;177(5):1703-8. 10.1016/j.juro.2007.01.039

Chen Z, Yang F, Ge L, et al. Outcomes of renal cell carcinoma with associated venous tumor thrombus: experience from a large cohort and short time span in a single center. BMC Cancer. 2021;21(1):766. 10.1186/s12885-021-08508-x

Abel EJ, Carrasco A, Karam J, et al. Positive vascular wall margins have minimal impact on cancer outcomes in patients with non-metastatic renal cell carcinoma (RCC) with tumour thrombus. BJU International. 2014;114(5):667-73. 10.1111/bju.12515

Tabbara MM, González J, Martucci M, et al. Current Approaches in Surgical and Immunotherapy-Based Management of Renal Cell Carcinoma with Tumor Thrombus. Biomedicines. 2023;11(1). 10.3390/biomedicines11010204

Hakimi K, Campbell SC, Nguyen MV, et al. PADRES: a phase 2 clinical trial of neoadjuvant axitinib for complex partial nephrectomy. BJU International. 2024;133(4):425-31. 10.1111/bju.16217

Aiello A, Farzaneh F, Candore G, et al. Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention. Frontiers in Immunology. 2019;10:2247. 10.3389/fimmu.2019.02247

Presley CJ, Gomes F, Burd CE, et al. Immunotherapy in Older Adults With Cancer. Journal of Clinical Oncology. 2021;39(19):2115-27. 10.1200/jco.21.00138

Kasherman L, Siu DHW, Lee KWC, et al. Efficacy of immune checkpoint inhibitors in older adults with advanced stage cancers: A meta-analysis. Journal of Geriatric Oncology. 2020;11(3):508-14. 10.1016/j.jgo.2019.05.013

Landre T, Des Guetz G, Chouahnia K, et al. Immune Checkpoint Inhibitors for Patients Aged ≥ 75 Years with Advanced Cancer in First- and Second-Line Settings: A Meta-Analysis. Drugs & Aging. 2020;37(10):747-54. 10.1007/s40266-020-00788-5

Petrelli F, Inno A, Ghidini A, et al. Efficacy of immune checkpoint inhibitors in elderly patients aged ≥ 75 years. Cancer Immunology, Immunotherapy. 2021;70(6):1777-80. 10.1007/s00262-020-02779-2

Schulz GB, Rodler S, Szabados B, et al. Safety, efficacy and prognostic impact of immune checkpoint inhibitors in older patients with genitourinary cancers. Journal of Geriatric Oncology. 2020;11(7):1061-6. 10.1016/j.jgo.2020.06.012

Li P, Jahnke J, Pettit AR, et al. Comparative Survival Associated With Use of Targeted vs Nontargeted Therapy in Medicare Patients With Metastatic Renal Cell Carcinoma. JAMA Network Open. 2019;2(6):e195806. 10.1001/jamanetworkopen.2019.5806

Kaymakcalan MD, Xie W, Albiges L, et al. Risk factors and model for predicting toxicity-related treatment discontinuation in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy: Results from the International Metastatic Renal Cell Carcinoma Database Consortium. Cancer. 2016;122(3):411-9. 10.1002/cncr.29773

Khambati HK, Choueiri TK, Kollmannsberger CK, et al. Efficacy of targeted therapy for metastatic renal cell carcinoma in the elderly patient population. Clinical Genitourinary Cancer. 2014;12(5):354-8. 10.1016/j.clgc.2014.02.009

Bellmunt J, Négrier S, Escudier B, et al. The medical treatment of metastatic renal cell cancer in the elderly: position paper of a SIOG Taskforce. Critical Reviews in Oncology/Hematology. 2009;69(1):64-72. 10.1016/j.critrevonc.2008.08.002

Hermansen CK, Donskov F. Outcomes based on age in patients with metastatic renal cell carcinoma treated with first line targeted therapy or checkpoint immunotherapy: Older patients more prone to toxicity. Journal of Geriatric Oncology. 2021;12(5):827-33. 10.1016/j.jgo.2020.12.008

Teishima J, Murata D, Inoue S, et al. Improved prognosis for elderly patients with metastatic renal cell carcinoma in the era of targeted therapy. Molecular and Clinical Oncology. 2020;12(6):557-64. 10.3892/mco.2020.2020

Rini BI, Dorff TB, Elson P, et al. Active surveillance in metastatic renal-cell carcinoma: a prospective, phase 2 trial. The Lancet Oncology. 2016;17(9):1317-24. 10.1016/s1470-2045(16)30196-6