Geriatrik Mesane (Lokal-Metastatik) ve Üst Üriner Sistem Kanseri Hastalarına Yaklaşım

World Health Organization. World report on ageing and health. Geneva: World Health Organization; 2015.

Soria F, Moschini M, Korn S, et al. How to optimally manage elderly bladder cancer patients? Translational and Andrology and Urology. 2016;5(5):683–691. https://doi.org/10.21037/tau.2016.04.08

Erlich A, Zlotta AR. Treatment of bladder cancer in the elderly. Investigative and Clinical Urology. 2016;57(Suppl 1):S26–S35. https://doi.org/10.4111/icu.2016.57.S1.S26

Hatakeyama S, Narita S, Okita K, et al. Management of bladder cancer in older patients. Japanese Journal of Clinical Oncology. 2022;52(3):203–213. https://doi.org/10.1093/jjco/hyab187

Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2024;74(3):229–263. https://doi.org/10.3322/caac.21834

Galsky MD. How I treat bladder cancer in elderly patients. Journal of Geriatric Oncology. 2015;6(1):1–7. https://doi.org/10.1016/j.jgo.2014.11.006

Compérat E, Larré S, Roupret M, et al. Clinicopathological characteristics of urothelial bladder cancer in patients less than 40 years old. Virchows Archiv: An International Journal of Pathology. 2015;466(5):589–594. https://doi.org/10.1007/s00428-015-1739-2

Laaksonen MA, MacInnis RJ, Canfell K, et al. The future burden of kidney and bladder cancers preventable by behavior modification in Australia: A pooled cohort study. International Journal of Cancer. 2020;146(3):874–883. https://doi.org/10.1002/ijc.32420

Steinmaus C, Ferreccio C, Acevedo J, et al. Increased lung and bladder cancer incidence in adults after in utero and early-life arsenic exposure. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. 2014;23(8):1529–1538. https://doi.org/10.1158/1055-9965.EPI-14-0059

Moschini M, Zaffuto E, Karakiewicz P, et al. External beam radiotherapy increases the risk of bladder cancer when compared with radical prostatectomy in patients affected by prostate cancer: A population-based analysis. European Urology. 2019;75(2):319–328. https://doi.org/10.1016/j.eururo.2018.09.034

Minami T, Fujita K, Hashimoto M, et al. External beam radiotherapy combination is a risk factor for bladder cancer in patients with prostate cancer treated with brachytherapy. World Journal of Urology. 2023;41(5):1317–1321. https://doi.org/10.1007/s00345-023-04380-5

Ramirez D, Gupta A, Canter D, et al. Microscopic haematuria at time of diagnosis is associated with lower disease stage in patients with newly diagnosed bladder cancer. BJU International. 2016;117(5):783–786. https://doi.org/10.1111/bju.13345

Oddens JR, Sylvester RJ, Brausi MA, et al. Increasing age is not associated with toxicity leading to discontinuation of treatment in patients with urothelial non-muscle-invasive bladder cancer randomised to receive 3 years of maintenance bacille Calmette-Guérin: Results from European Organisation for Research and Treatment of Cancer Genito-Urinary Group study 30911. BJU International. 2016;118(3):423–428. https://doi.org/10.1111/bju.13474

Zhao H, Chan VW, Castellani D, et al. Intravesical chemohyperthermia vs. bacillus Calmette-Guérin instillation for intermediate- and high-risk non-muscle invasive bladder cancer: A systematic review and meta-analysis. Frontiers in Surgery. 2021;8:775527. https://doi.org/10.3389/fsurg.2021.775527

Arends TJ, Nativ O, Maffezzini M, et al. Results of a randomised controlled trial comparing intravesical chemohyperthermia with mitomycin C versus bacillus Calmette-Guérin for adjuvant treatment of patients with intermediate- and high-risk non-muscle-invasive bladder cancer. European Urology. 2016;69(6):1046–1052. https://doi.org/10.1016/j.eururo.2016.01.006

Di Stasi SM, Giannantoni A, Giurioli A, et al. Sequential BCG and electromotive mitomycin versus BCG alone for high-risk superficial bladder cancer: A randomised controlled trial. The Lancet Oncology. 2006;7(1):43–51. https://doi.org/10.1016/S1470-2045(05)70472-1

Steinberg RL, Thomas LJ, Brooks N, et al. Multi-institution evaluation of sequential gemcitabine and docetaxel as rescue therapy for nonmuscle invasive bladder cancer. The Journal of Urology. 2020;203(5):902–909. https://doi.org/10.1097/JU.0000000000000688

Steinberg RL, Packiam VT, Thomas LJ, et al. Intravesical sequential gemcitabine and docetaxel versus bacillus Calmette-Guérin plus interferon in patients with recurrent non-muscle invasive bladder cancer following a single induction course of BCG. Urologic Oncology. 2022;40(1):9.e1–9.e7. https://doi.org/10.1016/j.urolonc.2021.03.024

Huguet J, Crego M, Sabaté S, et al. Cystectomy in patients with high risk superficial bladder tumors who fail intravesical BCG therapy: Pre-cystectomy prostate involvement as a prognostic factor. European Urology. 2005;48(1):53–59. https://doi.org/10.1016/j.eururo.2005.03.021

Moschini M, Sharma V, Dell'Oglio P, et al. Comparing long-term outcomes of primary and progressive carcinoma invading bladder muscle after radical cystectomy. BJU International. 2016;117(4):604–610. https://doi.org/10.1111/bju.13146

Miyake M, Tatsumi Y, Matsumoto H, et al. Outcomes of subsequent non-muscle-invasive bladder cancer treated with intravesical bacillus Calmette-Guérin after radical nephroureterectomy for upper urinary tract urothelial carcinoma. BJU International. 2018;121(5):764–773. https://doi.org/10.1111/bju.14111

Raj GV, Herr H, Serio AM, et al. Treatment paradigm shift may improve survival of patients with high risk superficial bladder cancer. The Journal of Urology. 2007;177(4):1283–1286. https://doi.org/10.1016/j.juro.2006.11.090

Fosså SD, Ous S, Berner A, et al. Clinical significance of the “palpable mass” in patients with muscle-infiltrating bladder cancer undergoing cystectomy after pre-operative radiotherapy. British Journal of Urology. 1991;67(1):54–60. https://doi.org/10.1111/j.1464-410x.1991.tb15070.x

Soma O, Hatakeyama S, Okamoto T, et al. Multicenter prospective study validating the efficacy of a quantitative assessment tool for frailty in patients with urological cancers. Medical Oncology (Northwood, London, England). 2019;36(10):88. https://doi.org/10.1007/s12032-019-1313-x

Mayr R, May M, Martini T, et al. Predictive capacity of four comorbidity indices estimating perioperative mortality after radical cystectomy for urothelial carcinoma of the bladder. BJU International. 2012;110(6 Pt B):E222–E227. https://doi.org/10.1111/j.1464-410X.2012.10938.x

Stein JP, Lieskovsky G, Cote R, et al. Radical cystectomy in the treatment of invasive bladder cancer: Long-term results in 1,054 patients. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2001;19(3):666–675. https://doi.org/10.1200/JCO.2001.19.3.666

International Collaboration of Trialists, Medical Research Council Advanced Bladder Cancer Working Party (now the National Cancer Research Institute Bladder Cancer Clinical Studies Group), European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Group, Australian Bladder Cancer Study Group, National Cancer Institute of Canada Clinical Trials Group, Finnbladder, Norwegian Bladder Cancer Study Group, Club Urologico Espanol de Tratamiento Oncologico Group, Griffiths G, Hall R, Sylvester R, Raghavan D, Parmar MK, et al. International phase III trial assessing neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: Long-term results of the BA06 30894 trial. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2011;29(16):2171–2177. https://doi.org/10.1200/JCO.2010.32.3139

Deliveliotis C, Papatsoris A, Chrisofos M, et al. Urinary diversion in high-risk elderly patients: Modified cutaneous ureterostomy or ileal conduit? Urology. 2005;66(2):299–304. https://doi.org/10.1016/j.urology.2005.03.031

Osterman CK, Babu DS, Geynisman DM, et al. Efficacy of split schedule versus conventional schedule neoadjuvant cisplatin-based chemotherapy for muscle-invasive bladder cancer. The Oncologist. 2019;24(5):688–690. https://doi.org/10.1634/theoncologist.2018-0561

Nielsen ME, Mallin K, Weaver MA, et al. Association of hospital volume with conditional 90-day mortality after cystectomy: An analysis of the National Cancer Data Base. BJU International. 2014;114(1):46–55. https://doi.org/10.1111/bju.12566

Noon AP, Albertsen PC, Thomas F, et al. Competing mortality in patients diagnosed with bladder cancer: Evidence of undertreatment in the elderly and female patients. British Journal of Cancer. 2013;108(7):1534–1540. https://doi.org/10.1038/bjc.2013.106

Alfred Witjes J, Lebret T, Comperat EM, et al. Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. European Urology. 2017;71(3):462–475. https://doi.org/10.1016/j.eururo.2016.06.020

Fedeli U, Fedewa SA, Ward EM, et al. Treatment of muscle invasive bladder cancer: Evidence from the National Cancer Database, 2003 to 2007. Journal of Urology. 2011;185(1):72–78. https://doi.org/10.1016/j.juro.2010.09.015

Khan MS, Gan C, Ahmed K, Ismail AF, et al. A single-centre early phase randomised controlled three-arm trial of open, robotic, and laparoscopic radical cystectomy (CORAL). European Urology. 2016;69(4):613–621. https://doi.org/10.1016/j.eururo.2015.07.038

Djaladat H, Bruins HM, Miranda G, et al. The association of preoperative serum albumin level and ASA score on early complications and survival after radical cystectomy. BJU International. 2014;113(6):887–893. https://doi.org/10.1111/bju.12240

Richters A, Ripping TM, Kiemeney LA, et al. Hospital volume is associated with postoperative mortality after radical cystectomy for bladder cancer. BJU International. 2021;128(4):511–518. https://doi.org/10.1111/bju.15334

Fahmy O, Khairul-Asri MG, Schubert T, et al. Long-term oncological outcomes after trimodality therapy and radical cystectomy with/without neoadjuvant chemotherapy: A meta-analysis. Urol Oncol. 2018;36(2):43–53. https://doi.org/10.1016/j.urolonc.2017.10.002

Zlotta AR, Ballas LK, Niemierko A, et al. Radical cystectomy versus trimodality therapy for muscle-invasive bladder cancer: A propensity score matched and weighted analysis. Lancet Oncology. 2023;24(6):669–681. https://doi.org/10.1016/S1470-2045(23)00170-5

Galsky MD, Stensland KD, Moshier E, et al. Effectiveness of adjuvant chemotherapy for locally advanced bladder cancer. Journal of Clinical Oncology. 2016;34(8):825–832. https://doi.org/10.1200/JCO.2015.64.1076

Chiang RS, Glover MJ, Khaki AR, Srinivas S, et al. Immunotherapy for urothelial carcinoma: Focus on clinical utility of nivolumab. Onco Targets and therapy. 2022;15:1259–1269. https://doi.org/10.2147/OTT.S369043

Powles T, Valderrama BP, Gupta S, EV-302 Trial Investigators, et al. Enfortumab vedotin and pembrolizumab in untreated advanced urothelial cancer. The New England Journal of Medicine. 2024;390(10):875–888. https://doi.org/10.1056/NEJMoa2312117

van der Heijden MS, Sonpavde G, Powles T, CheckMate 901 Trial Investigators, et al. Nivolumab plus gemcitabine-cisplatin in advanced urothelial carcinoma. The New England Journal of Medicine. 2023;389(19):1778–1789. https://doi.org/10.1056/NEJMoa2309863

Galsky MD, Hahn NM, Rosenberg J, et al. Treatment of metastatic urothelial cancer “unfit” for cisplatin-based chemotherapy Journal of Clinical Oncology. 2011;29(17):2432–2438. https://doi.org/10.1200/JCO.2011.34.8433

De Santis M, Bellmunt J, Mead G, et al. Randomized phase II/III trial of gemcitabine/carboplatin vs. methotrexate/carboplatin/vinblastine in advanced urothelial cancer unfit for cisplatin: EORTC 30986. Journal of Clinical Oncology. 2009;27(33):5634–5639. https://doi.org/10.1200/JCO.2008.21.4924

Powles T, Park SH, Voog E, et al. Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma. The New England Journal of Medicine. 2020;383(13):1218–1230. https://doi.org/10.1056/NEJMoa2002788

Balar AV, Castellano D, O'Donnell PH, et al. First-line pembrolizumab in cisplatin-ineligible urothelial cancer (KEYNOTE-052). Lancet Oncology. 2017;18(11):1483–1492. https://doi.org/10.1016/S1470-2045(17)30616-2

Balar AV, Galsky MD, Rosenberg JE, IMvigor210 Study Group, et al. Atezolizumab as first-line treatment in cisplatin-ineligible urothelial carcinoma: Phase 2 trial. Lancet. 2017;389(10064):67–76. https://doi.org/10.1016/S0140-6736(16)32455-2

Siegel RL, Miller KD, Wagle NS, Jemal A, et al. Cancer statistics, 2023. CA: a cancer journal for clinicians. 2023;73(1):17–48. https://doi.org/10.3322/caac.21763

Soria F, Shariat SF, Lerner SP, et al. Epidemiology, diagnosis, and prognostic assessment of upper-tract urothelial carcinoma. World journal of urology. 2017;35(3):379–387. https://doi.org/10.1007/s00345-016-1928-x

Mori K, Janisch F, Parizi MK, et al. Prognostic value of variant histology in upper tract urothelial carcinoma: Meta-analysis. Journal of Urology. 2020;203(6):1075–1084. https://doi.org/10.1097/JU.0000000000000523

Baard J, Cormio L, Cavadas V, et al. Contemporary presentation, diagnostics and management of upper tract urothelial cancer: CROES registry. Current opinion in urology 2021;31(4):354–362. https://doi.org/10.1097/MOU.0000000000000899

Janisch F, Shariat SF, Baltzer P, et al. Diagnostic performance of MDCTU in upper tract urothelial carcinoma: Meta-analysis. World journal of urology. 2020;38(5):1165–1175. https://doi.org/10.1007/s00345-019-02875-8

Coleman JA, Clark PE, Bixler BR, et al. AUA/SUO guideline: Diagnosis and management of non-metastatic upper tract urothelial carcinoma. Journal of Urology. 2023;209(6):1071–1081. https://doi.org/10.1097/JU.0000000000003480

Kim HS, Jeong CW, Kwak C, et al. Demographic factors and prognosis in upper tract urothelial carcinoma: Meta-analysis. Oncotarget. 2017;8(5):7464–7476. https://doi.org/10.18632/oncotarget.10708

Seisen T, Peyronnet B, Dominguez-Escrig JL, et al. Kidney-sparing surgery vs. radical nephroureterectomy: Systematic review. European Urology. 2016;70(6):1052–1068. https://doi.org/10.1016/j.eururo.2016.07.014

Gallioli A, Basile G, Territo A, et al. Second-look ureteroscopy in conservative management of upper tract urothelial carcinoma. World journal of urology. 2023;41(10):2743–2749. https://doi.org/10.1007/s00345-023-04577-8

Jeldres C, Lughezzani G, Sun M, et al. Segmental ureterectomy in transitional cell carcinoma of the ureter. Journal of Urology. 2010;183(4):1324–1329. https://doi.org/10.1016/j.juro.2009.12.018

Margulis V, Shariat SF, Matin SF, et al. Outcomes of radical nephroureterectomy: A series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer. 2009;115(6):1224–1233. https://doi.org/10.1002/cncr.24135

Ji R, He Z, Fang S, et al. Robot-assisted vs. laparoscopic nephroureterectomy for upper urinary tract urothelial carcinoma: a systematic review and meta-analysis based on comparative studies. Frontiers in Oncology. 2022;12:964256. https://doi.org/10.3389/fonc.2022.964256

Rouprêt M, Smyth G, Irani J, et al. Oncological risk of laparoscopic surgery in urothelial carcinomas. World Journal of Urology. 2009;27(1):81–88. https://doi.org/10.1007/s00345-008-0349-x

Leow JJ, Chong YL, Chang SL, et al. Neoadjuvant and adjuvant chemotherapy for upper tract urothelial carcinoma: Meta-analysis. European Urology. 2021;79(5):635–654. https://doi.org/10.1016/j.eururo.2020.07.003

Birtle AJ, Jones R, Chester J, et al. Improved disease-free survival with adjuvant chemotherapy after nephroureterectomy: POUT trial final results. Journal of Clinical Oncology. 2024;42(13):1466–1471. https://doi.org/10.1200/JCO.23.01659

Bajorin DF, Witjes JA, Gschwend JE, et al. Adjuvant nivolumab versus placebo in muscle-invasive urothelial carcinoma. The New England Journal of Medicine. 2021;384(22):2102–2114. https://doi.org/10.1056/NEJMoa2034442

Moschini M, Xylinas E, Zamboni S, RISC Investigators, et al. Efficacy of surgery at primary tumor site for metastatic urothelial cancer: Multicenter database analysis. European Urology Oncology. 2020;3(1):94–101. https://doi.org/10.1016/j.euo.2019.06.014

Tan WS, Sarpong R, Khetrapal P, et al. Can renal and bladder ultrasound replace computerized tomography urogram in patients investigated for microscopic hematuria? The Journal of Urology. 2018;200(5):973–980. https://doi.org/10.1016/j.juro.2018.04.065

Planelles Gómez J, Olmos Sánchez L, Cardosa Benet JJ, et al. Holmium YAG photocoagulation: Safe and economical alternative to transurethral resection in small nonmuscle-invasive bladder tumors. Journal of Endourology. 2017;31(7):674–678. https://doi.org/10.1089/end.2017.0154

Xu Y, Guan W, Chen W, et al. Comparing the treatment outcomes of potassium-titanyl-phosphate laser vaporization and transurethral electroresection for primary nonmuscle-invasive bladder cancer: A prospective, randomized study. Lasers in Surgery and Medicine. 2015;47(4):306–311. https://doi.org/10.1002/lsm.22342

Tan WS, Contieri R, Buffi NM, et al. International Bladder Cancer Group intermediate-risk nonmuscle-invasive bladder cancer scoring system predicts outcomes of patients on active surveillance. The Journal of Urology. 2023;210(5):763–770. https://doi.org/10.1097/JU.0000000000003639

Shariat SF, Milowsky M, Droller MJ. Bladder cancer in the elderly. Urologic Oncology. 2009;27(6):653–667. https://doi.org/10.1016/j.urolonc.2009.07.020

Sylvester RJ, van der Meijden AP, Lamm DL. Intravesical bacillus Calmette-Guérin reduces the risk of progression in patients with superficial bladder cancer: A meta-analysis of the published results of randomized clinical trials. The Journal of Urology. 2002;168(5):1964–1970. https://doi.org/10.1016/S0022-5347(05)64273-5

Malmström PU, Sylvester RJ, Crawford DE, et al. An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guérin for non-muscle-invasive bladder cancer. European Urology. 2009;56(2):247–256. https://doi.org/10.1016/j.eururo.2009.04.038

Dammert P, Boujaoude Z, Rafferty W, et al. Fever of unknown origin and pancytopenia caused by culture-proven delayed onset disseminated bacillus Calmette-Guérin infection after intravesical instillation. BMJ Case Reports. 2013;2013:bcr2013008949. https://doi.org/10.1136/bcr-2013-008949