Endokrin Hastalıklarda Ozon Tedavisinin Yeri

Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Research and Clinical Practice. 2019;157:107843. doi:10.1016/j.diabres.2019.107843

Bocci V, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose–response relationship. Journal of Translational Medicine. 2011;9:66. doi:10.1186/1479-5876-9-66

Zhou W, Zheng X, Zhu D, et al. Clinical efficacy of ozone therapy in treating diabetic foot ulcers: a systematic review and meta-analysis. Frontiers in Endocrinology. 2023;14:1304034. doi:10.3389/fendo.2023.1304034

Martínez-Sánchez G, Al-Dalain SM, Menéndez S, et al. Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of Pharmacology. 2005;523(1–3):151–161. doi:10.1016/j.ejphar.2005.10.001

Amini L, Ashtiyani SC, Paknahad Z, et al. The effect of systemic ozone therapy on visual evoked potential in patients with type 2 diabetes mellitus: A randomized clinical trial. Complementary Therapies in Clinical Practice. 2023;53:101787. doi:10.1016/j.ctcp.2023.101787

Zajdel A, Wilczok A, Wilczok T. Ozonotherapy as an adjunct to non-surgical periodontal treatment: a randomized controlled clinical trial. Clinical Oral Investigations. 2023;27(4):1995–2002. doi:10.1007/s00784-023-04839-3

Bocci V. Ozone: A New Medical Drug. Dordrecht: Springer; 2011. doi:10.1007/978-94-007-1402-8

López MG, Cruz B, Díaz-Luis J, et al. Therapeutic effectiveness of ozone therapy in patients with hyperthyroidism: clinical and biochemical evaluation. Journal of Ozone Therapy. 2021;5(1):1–10. doi:10.7203/jo3t.5.1.2021.18929

Sagai M, Bocci V. Mechanisms of action involved in ozone therapy: Is healing induced via a mild oxidative stress? Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1-29

Delgado-Roche L, Riera-Romo M, Mesta F, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients. European Journal of Pharmacology. 2017;811:148–154. doi:10.1016/j.ejphar.2017.06.041

León OS, Menéndez S, Merino N, et al. Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediators of Inflammation. 1998;7(4):289–294. doi:10.1080/09629359891000151

Elvis AM, Ekta JS. Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine. 2011;2(1):66–70. doi:10.4103/0976-9668.82319

Sagai M, Bocci V. Fundamental mechanisms in ozone therapy: Induction of adaptation to oxidative stress by repeated ozonated autohemotherapy resulting in enhanced antioxidant capacity. Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1-29

Martínez-Sánchez G, Delgado-Roche L, Díaz-Benitez C, et al. Ozone oxidative preconditioning improves redox status and decreases mitochondrial damage in cardiac ischemia/reperfusion in rats. European Journal of Pharmacology. 2011;650(1):206–212. doi:10.1016/j.ejphar.2010.09.020

Viebahn-Hänsler R, León Fernández OS, Fahmy Z. Ozone in Medicine: The Low-Dose Ozone Concept—Guidelines and Treatment Strategies. Ozone: Science & Engineering. 2012;34(6):408–424. doi:10.1080/01919512.2012.717847

Dumesic DA, Oberfield SE, Stener-Victorin E, et al. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocrine Reviews. 2015;36(5):487–525. doi:10.1210/er.2015-1018

Zhang Y, Zhao H, Wang Y, et al. The therapeutic effect of ozone on oxidative stress and inflammation in polycystic ovary syndrome rat model. Gynecological Endocrinology. 2022;38(2):161–166. doi:10.1080/09513590.2021.1977122

Tang Y, Li Y, Zhang W, et al. Ozone therapy improves endocrine and metabolic disorders in PCOS rats through anti-inflammatory and antioxidant effects. Reproductive Biology and Endocrinology. 2023;21(1):22. doi:10.1186/s12958-023-01050-4

Zhang L, Wei Y, Li W, et al. Ozone therapy alleviates insulin resistance in PCOS rats by enhancing glucose transporter 4 expression. Experimental and Therapeutic Medicine. 2023;25(2):95. doi:10.3892/etm.2022.11780

Eraslan S, Eraslan M, Sönmez MF, et al. Ozone therapy ameliorates polycystic ovary morphology in a rat model: A histopathological study. Biomedical Research. 2021;32(1):75–81.

Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism. 2016;101(2):364–389. doi:10.1210/jc.2015-1710

Jackson TW, Henriquez AR, Snow SJ, et al. Adrenal stress hormone regulation of hepatic homeostatic function after an acute ozone exposure in Wistar-Kyoto male rats. Toxicological Sciences. 2022;189(1):73–90. Özdemir D, Çelik Ö, Elibol E, et al. Ozone therapy modulates adrenal cortex injury and inflammation in rats. Turkish Journal of Medical Sciences. 2022;52(3):812–819. doi:10.3906/sag-2108-173

Henriquez AR, Snow SJ, Jackson TW, et al. Metabolomics and liver transcriptomics reveal a role for adrenal-derived stress hormones in modulating ozone-induced metabolic effects in Wistar-Kyoto rats. Toxicological Sciences. 2020;177(2):377–391.Viebahn-Hänsler R. The Use o

Elvis AM, Ekta JS. Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine. 2011;2(1):66–70. doi:10.4103/0976-9668.82319

Doshi SB, Agarwal A. The role of oxidative stress in menopause. Journal of Mid-Life Health. 2013;4(3):140–146. doi:10.4103/0976-7800.115292

Sagai M, Bocci V. Mechanisms of ozone therapy: ischemia and oxidative stress modulation. Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1-29

Clavo B, Santana-Rodríguez N, Llontop P, et al. Ozone therapy and its role in medical practice: A critical review. Applied Sciences. 2022;12(22):11494. doi:10.3390/app122211494

Kodavanti UP, Royland JE, Osorio C, et al. Ozone-induced increase in serum corticosterone and adrenal-dependent immune modulation is abolished by adrenalectomy. Toxicological Sciences. 2018;165(1):139–152. doi:10.1093/toxsci/kfy128

Clavo B, Santana-Rodríguez N, Llontop P, et al. Ozone therapy and its role in medical practice: A critical review. Applied Sciences. 2022;12(22):11494. doi:10.3390/app122211494

Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes Research and Clinical Practice. 2019;157:107843. doi:10.1016/j.diabres.2019.107843

Bocci V, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose–response relationship. Journal of Translational Medicine. 2011;9:66. doi:10.1186/1479-5876-9-66

Zhou W, Zheng X, Zhu D, et al. Clinical efficacy of ozone therapy in treating diabetic foot ulcers: a systematic review and meta-analysis. Frontiers in Endocrinology. 2023;14:1304034. doi:10.3389/fendo.2023.1304034

Martínez-Sánchez G, Al-Dalain SM, Menéndez S, et al. Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of Pharmacology. 2005;523(1–3):151–161. doi:10.1016/j.ejphar.2005.10.001

Amini L, Ashtiyani SC, Paknahad Z, et al. The effect of systemic ozone therapy on visual evoked potential in patients with type 2 diabetes mellitus: A randomized clinical trial. Complementary Therapies in Clinical Practice. 2023;53:101787. doi:10.1016/j.ctcp.2023.101787

Zajdel A, Wilczok A, Wilczok T. Ozonotherapy as an adjunct to non-surgical periodontal treatment: a randomized controlled clinical trial. Clinical Oral Investigations. 2023;27(4):1995–2002. doi:10.1007/s00784-023-04839-3

Bocci V. Ozone: A New Medical Drug. Dordrecht: Springer; 2011. doi:10.1007/978-94-007-1402-8

López MG, Cruz B, Díaz-Luis J, et al. Therapeutic effectiveness of ozone therapy in patients with hyperthyroidism: clinical and biochemical evaluation. Journal of Ozone Therapy. 2021;5(1):1–10. doi:10.7203/jo3t.5.1.2021.18929

Sagai M, Bocci V. Mechanisms of action involved in ozone therapy: Is healing induced via a mild oxidative stress? Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1-29

Delgado-Roche L, Riera-Romo M, Mesta F, et al. Medical ozone promotes Nrf2 phosphorylation reducing oxidative stress and pro-inflammatory cytokines in multiple sclerosis patients. European Journal of Pharmacology. 2017;811:148–154. doi:10.1016/j.ejphar.2017.06.041

León OS, Menéndez S, Merino N, et al. Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediators of Inflammation. 1998;7(4):289–294. doi:10.1080/09629359891000151

Elvis AM, Ekta JS. Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine. 2011;2(1):66–70. doi:10.4103/0976-9668.82319

Sagai M, Bocci V. Fundamental mechanisms in ozone therapy: Induction of adaptation to oxidative stress by repeated ozonated autohemotherapy resulting in enhanced antioxidant capacity. Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1-29

Martínez-Sánchez G, Delgado-Roche L, Díaz-Benitez C, et al. Ozone oxidative preconditioning improves redox status and decreases mitochondrial damage in cardiac ischemia/reperfusion in rats. European Journal of Pharmacology. 2011;650(1):206–212. doi:10.1016/j.ejphar.2010.09.020

Viebahn-Hänsler R, León Fernández OS, Fahmy Z. Ozone in Medicine: The Low-Dose Ozone Concept—Guidelines and Treatment Strategies. Ozone: Science & Engineering. 2012;34(6):408–424. doi:10.1080/01919512.2012.717847

Dumesic DA, Oberfield SE, Stener-Victorin E, et al. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocrine Reviews. 2015;36(5):487–525. doi:10.1210/er.2015-1018

Zhang Y, Zhao H, Wang Y, et al. The therapeutic effect of ozone on oxidative stress and inflammation in polycystic ovary syndrome rat model. Gynecological Endocrinology. 2022;38(2):161–166. doi:10.1080/09513590.2021.1977122

Tang Y, Li Y, Zhang W, et al. Ozone therapy improves endocrine and metabolic disorders in PCOS rats through anti-inflammatory and antioxidant effects. Reproductive Biology and Endocrinology. 2023;21(1):22. doi:10.1186/s12958-023-01050-4

Zhang L, Wei Y, Li W, et al. Ozone therapy alleviates insulin resistance in PCOS rats by enhancing glucose transporter 4 expression. Experimental and Therapeutic Medicine. 2023;25(2):95. doi:10.3892/etm.2022.11780

Eraslan S, Eraslan M, Sönmez MF, et al. Ozone therapy ameliorates polycystic ovary morphology in a rat model: A histopathological study. Biomedical Research. 2021;32(1):75–81.

Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism. 2016;101(2):364–389. doi:10.1210/jc.2015-1710

Jackson TW, Henriquez AR, Snow SJ, et al. Adrenal stress hormone regulation of hepatic homeostatic function after an acute ozone exposure in Wistar-Kyoto male rats. Toxicological Sciences. 2022;189(1):73–90. Özdemir D, Çelik Ö, Elibol E, et al. Ozone therapy modulates adrenal cortex injury and inflammation in rats. Turkish Journal of Medical Sciences. 2022;52(3):812–819. doi:10.3906/sag-2108-173

Henriquez AR, Snow SJ, Jackson TW, et al. Metabolomics and liver transcriptomics reveal a role for adrenal-derived stress hormones in modulating ozone-induced metabolic effects in Wistar-Kyoto rats. Toxicological Sciences. 2020;177(2):377–391.Viebahn-Hänsler R. The Use o

Elvis AM, Ekta JS. Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine. 2011;2(1):66–70. doi:10.4103/0976-9668.82319

Doshi SB, Agarwal A. The role of oxidative stress in menopause. Journal of Mid-Life Health. 2013;4(3):140–146. doi:10.4103/0976-7800.115292

Sagai M, Bocci V. Mechanisms of ozone therapy: ischemia and oxidative stress modulation. Medical Gas Research. 2011;1:29. doi:10.1186/2045-9912-1-29

Clavo B, Santana-Rodríguez N, Llontop P, et al. Ozone therapy and its role in medical practice: A critical review. Applied Sciences. 2022;12(22):11494. doi:10.3390/app122211494

Kodavanti UP, Royland JE, Osorio C, et al. Ozone-induced increase in serum corticosterone and adrenal-dependent immune modulation is abolished by adrenalectomy. Toxicological Sciences. 2018;165(1):139–152. doi:10.1093/toxsci/kfy128

Clavo B, Santana-Rodríguez N, Llontop P, et al. Ozone therapy and its role in medical practice: A critical review. Applied Sciences. 2022;12(22):11494. doi:10.3390/app122211494