Mikrobiyota İle Endokrin Sistem Arasındaki İlişki
Özet
Referanslar
Blumberg R, Powrie F. Microbiota, disease, and back to health: a metastable journey. Sci Transl Med. 2012; 6;4(137): 137rv7. doi: 10.1126/scitranslmed.3004184.
Forsythe P, Sudo N, Dinan T, et al. Mood and gut feelings. Brain Behav Immun. 2010; 24(1): 9-16. doi:10.1016/j.bbi.2009.05.058
3.Neish AS. Mucosal immunity and the microbiome. Ann Am Thorac Soc. 2014; 11(1): 28–32. doi:10.1513/AnnalsATS.201306-161MG
Grenham S, Clarke G, Cryan J, et al. Brain-gut-Microbe communication in health and disease. Front Physiol. 2011; 2: 94. doi:10.3389/fphys.2011.00094
He S, Li H, Yu Z, et al. The Gut Microbiome and Sex Hormone-Related Diseases. Front. Microbiol. 2021; 12: 711137.doi: 10.3389/fmicb.2021.711137
Evans JM, Morris LS, Marchesi JR. The gut microbiome: the roleof a virtual organ in the endocrinology of the host. J Endocrinol. 2013; 218: 37–47. doi:10.1530/JOE-13-0131
Lyte M. Microbial endocrinology and infectious disease in the 21st century. Trends Microbiol. 2004; 12: 14 –20. doi:10.1016/j.tim.2003.11.004
Freestone PP, Sandrini SM, Haigh RD, et al. Microbial endocrinology: how stress influences susceptibility to infection. Trends Microbiol. 2008; 16: 55– 64. doi:10.1016/j.tim.2007.11.005
Clarke G, Stilling RM, Kennedy PJ, et al. Minireview: Gut Microbiota: The Neglected Endocrine Organ. Molecular Endocrinology. 2014; 28: 1221–1238. doi:10.1210/me.2014-1108
Lyte M. The microbial organ in the gut as a driver of homeostasis and disease. Med Hypotheses. 2010; 74: 634 – 638. doi:10.1016/j.mehy.2009.10.025
Flak MB, Neves JF, Blumberg RS. Immunology. Welcome to the microgenderome. Science. 2013; 1;339(6123): 1044-5. doi: 10.1126/science.1236226.
Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016; 14(8): e1002533. doi:10.1371/journal.pbio.1002533
Edwards DP. Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol. 2005; 67(1): 335–376. doi:10.1146/annurev. physiol.67.040403.120151
Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010; 464(7285): 59–65. doi:10.1038/nature08821
Franasiak JM, Scott RT. Introduction: microbiome in human reproduction. Fertil Steril. 2015; 104(6): 1341–1343. doi:10.1016/j.fertnstert.2015.10.021
Clemente-Suárez VJ, Redondo-Flórez L, Rubio-Zarapuz A, et al. Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches. Biomedicines. 2024; 12(1): 221. doi: 10.3390/biomedicines12010221.
Gibbons SM, Gilbert JA. Microbial Diversity-Exploration of Natural Ecosystems and Microbiomes. Curr. Opin. Genet. Dev. 2015; 35: 66–72.
Clapp M, Aurora N, Herrera L, et al. Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis. Clin. Pract. 2017; 7: 987. doi:10.4081/cp.2017.987
Thursby, E.; Juge, N. Introduction to the Human Gut Microbiota. Biochem. J. 2017; 474: 1823–1836. doi:10.1042/BCJ20160510
Ecklu-Mensah G, Gilbert J, Devkota S. Dietary Selection Pressures and Their Impact on the Gut Microbiome. Cell. Mol. Gastroenterol. Hepatol. 2022; 13: 7–18. doi:10.1016/j.jcmgh.2021.07.009
Degruttola AK, Low D, Mizoguchi A, et al. Current Understanding of Dysbiosis in Disease in Human and Animal Models. Inflamm. Bowel Dis. 2016; 22: 1137–1150. doi:10.1097/MIB.0000000000000750
Conlon MA, Bird AR. The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients. 2015; 7: 17–44. doi:10.3390/nu7010017
Suzuki TA, Ley RE. The Role of the Microbiota in Human Genetic Adaptation. Science. 2020; 370: 1180. doi:10.1126/science.aaz6827
Cotillard A, Kennedy SP, Kong LC, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013; 500(7464): 585-588. doi:10.1038/nature12480
Wu Z, Tian E, Chen Y, et al. Gut microbiota and its roles in the pathogenesis and therapy of endocrine system diseases. Microbiol Res. 2023; 268 127291. doi: 10.1016/j.micres.2022.127291.
Gwak MG, Chang SY. Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors. Immune Netw. 2021; 16;21(3): e20. doi: 10.4110/in.2021.21.e20.
Uzbay T. Germ-free animal experiments in the gut microbiota studies. Curr Opin Pharmacol. 2019; 49: 6-10. doi:10.1016/j.coph.2019.03.016
Carabotti M, Scirocco A, Maselli MA, et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015; 28(2): 203-209. PMID: 25830558
Goenka A, Kollmann TR. Development of immunity in early life. J Infect. 2015; 71(1): 112-20. doi: 10.1016/j.jinf.2015.04.027.
Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integr. Med. 2018; 17: 28–32. PMID: 31043907
Gao X, Lin SH, Ren F, et al. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016; 7(1): 11960. doi:10.1038/ncomms11960
Chao J, Coleman RA, Keating DJ, et al. Gut Microbiome Regulation of Gut Hormone Secretion. Endocrinology. 2025; 166(4): bqaf004. doi: 10.1210/endocr/bqaf004.
Rincon MT, Lamed R, White BA. Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis. Nat Rev Microbiol. 2008; 6(2): 121-131. doi:10.1038/nrmicro1817
Demigne C, Morand C, Levrat MA, et al. Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes. Br J Nutr. 1995; 74(2): 209-219. doi:10.1079/bjn19950124
Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc. 2003; 62(1): 67-72. doi:10.1079/PNS2002207
Donohoe DR, Garge N, Zhang X, et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 2011; 13(5): 517-526.31. doi:10.1016/j.cmet.2011.02.018
Wang GY, Qin SL, Zheng YN, et al. Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes. Anim Nutr. 2023; 15: 88-98. doi:10.1016/j.aninu.2023.07.001
Chiang JYL. Bile acid metabolism and signaling in liver disease and therapy. Liver Res. 2017; 1(1): 3-9. doi:10.1016/j.livres.2017.05.001
Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009; 32(2): 237-245. doi:10.2337/dc09-S355
Venkatesh M, Mukherjee S, Wang H, et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 2014; 41(2): 296-310. doi:10.1016/j.immuni.2014.06.014
Ye L, Bae M, Cassilly CD, et al. Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe. 2021; 29(2): 179-196. doi:10.1016/j.chom.2020.11.011
Zelante T, Iannitti RG, Cunha C, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013; 39(2): 372-385. doi:10.1016/j.immuni.2013.08.003
Lee JH, Lee J. Indole as an intercellular signal in microbial communities. FEMS Microbiol Rev. 2010; 34(4): 426-444. doi:10.1111/j.1574-6976.2009.00204.x
Zhou Y, Chen Y, He H, et al. The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases. Neuropharmacology. 2023; 15;239:109690. doi: 10.1016/j.neuropharm.2023.109690.
Smith T. A modıfıcatıon of the method for determınıng the productıon of ındol by bacterıa. J Exp Med. 1897; 2(5): 543-7. doi: 10.1084/jem.2.5.543.
Pascale A, Marchesi N, Marelli C, et al. Microbiota and metabolic diseases. Endocrine. 2018; 61 (3): 357–371. https://doi.org/10.1007/s 12020-018-1605-5.
Garrett W. Immune recognition of microbial metabolites. Nat. Rev. Immunol. 2020; 20(2): 91–92. https://doi.org/10.1038/s41577-019-0252-2.
Chen Q, Ren R, Zhang Q, et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021; 1;267:113542. doi: 10.1016/j.jep.2020.113542.
Obata Y, Castaño Á, Boeing S, et al. Neuronal programming by microbiota regulates intestinal physiology. Nature. 2020;578(7794):284-289. doi:10.1038/s41586-020-1975-8
Su Y, Li J, Wu L, Kuang H. Polysaccharides from TCM herbs exhibit potent anti-obesity effect by mediating the community structure of gut microbiota. Pharmazie. 2021; 76(10):473-479. doi:10.1691/ph.2021.1463
Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia. 2006;49(12):2824-2827. doi:10.1007/s00125-006-0465-3
Gao Y, Davis B, Zhu W, et al. Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo. Am J Physiol Gastrointest Liver Physiol. 2021; 320(4): 521-530. doi:10.1152/ajpgi.00279.2020
Sorini C, Cosorich I, Lo Conte M, et al. Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes. Proc Natl Acad Sci USA. 2019; 116(30): 15140-15149. doi:10.1073/pnas. 1814558116
Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504(7480): 451-455. doi:10.1038/nature12726
Tong Y, Tang J. Candida albicans infection and intestinal immunity. Microbiol Res. 2017;198:27-35. doi:10.1016/j.micres.2017.02.002
Postler TS, Ghosh S. Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System. Cell Metab. 2017; 26(1): 110-130. doi:10.1016/j.cmet.2017.05.008
Lin HV, Frassetto A, Kowalik EJ Jr, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One. 2012; 7(4): e35240. doi:10.1371/journal.pone.0035240
Mariño E, Richards JL, McLeod KH, et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017; 18(11): 1271. doi: 10.1038/ni1117-1271c.].
Pitocco D, Di Leo M, Tartaglione L, et al. The role of gut microbiota in mediating obesity and diabetes mellitus. Eur Rev Med Pharmacol Sci. 2020; 24(3): 1548-1562. doi:10.26355/eurrev_202002_20213
Liu J, Li Y, Sun C, et al. Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids. Pharmacol Res. 2020;152:104631. doi:10.1016/j.phrs.2020.104631
Kurita N, Yamashiro K, Kuroki T, et al. Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia. J Cereb Blood Flow Metab. 2020;40(12):2505-2520. doi:10.1177/0271678X19899577
Gangi E, Kapatral V, El-Azami El-Idrissi M, et al. Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity. 2004; 37(6-7): 515-520. doi:10.1080/08916930410001728074
Zhang J, Zhang F, Zhao C, et al. Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function. Endocrine. 2019; 64(3): 564-574. doi:10.1007/s12020-018-1831-x
Zhou L, Li X, Ahmed A, et al. Gut microbe analysis between hyperthyroid and healthy individuals. Curr Microbiol. 2014; 69(5): 675-680. doi:10.1007/s00284-014-0640-6
Ríos-Covián D, Ruas-Madiedo P, Margolles A, et al. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. 2016; 7:185. doi:10.3389/fmicb.2016.00185
Su X, Zhao Y, Li Y, et al. Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis. Clin Sci (Lond). 2020; 134(12): 1521-1535. doi:10.1042/CS20200475
Çatak J, Yıldırım Servi E, Memiş N. Obezite ve Mikrobiyota Etkileşimlerine Genel Bakış. Avrupa Bilim ve Teknoloji Dergisi. 2021; (31): 275-291. doi.org/10.31590/ejosat.935513
Breton J, Tennoune N, Lucas N, et al. Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. Cell Metab. 2016; 23(2): 324-334. doi:10.1016/j.cmet.2015.10.017
Crunkhorn S. Metabolic disorders: Safe cannabinoid receptor modulators in sight?. Nat Rev Drug Discov. 2012; 11(10): 749. doi:10.1038/nrd3851
Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. NatMed. 2016; 22(10): 1079. doi:10.1038/nm.4185
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012; 336(6086): 1268–73. doi:10.1126/science.1223490
Hasani-Ranjbar S, Larijani B. Human Microbiome as an approach to personalized medicine.Altern Ther HealthMed. 2017; 23(6): 8–9. PMID: 28987073
Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A. 1998; 95(12): 6578–83. doi:10.1073/pnas.95.12.6578
Costello EK, Stagaman K, Dethlefsen L, et al. The application of ecological theory toward an understanding of the human microbiome. Science. 2012; 336(6086): 1255–62. doi:10.1126/science.1224203
Kuntz TM, Gilbert JA. Introducing the microbiome into precision medicine. Trends Pharmacol Sci. 2017; 38(1): 81–91. doi:10.1016/j.tips.2016.10.001
Mallick H, Ma S, Franzosa EA, et al. Experimental design and quantitative analysis of microbial community multiomics. Genome Biol. 2017; 18(1): 228. doi:10.1186/s13059-017-1359-z
Bäckhed F, Ley RE, Sonnenburg JL, et al. Host-bacterial mutualism in the human intestine. Science. 2005; 307(5717): 1915–20. doi:10.1126/science.1104816
Shirvani Rad S, Nikkhah A, Orvatinia M, et al. Gut microbiota: a perspective of precision medicine in endocrine disorders. J Diabetes Metab Disord. 2020; 19(2): 1827-1834. doi:10.1007/s40200-020-00593-2
Riscuta G, Xi D, Pierre-Victor D, et al. Diet, Microbiome, and Epigenetics in the Era of Precision Medicine. Methods Mol Biol. 2018; 1856: 141-156. doi:10.1007/978-1-4939-8751-1_8
Grice EA, Kong HH, Conlan S, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009; 324(5931): 1190–2. doi:10.1126/science.1171700
Jiang W, Lu G, Gao D, et al. The relationships between the gut microbiota and its metabolites with thyroid diseases. Front Endocrinol (Lausanne). 2022; 13: 943408. doi:10.3389/fendo.2022.943408
Guo Z, Zhang J, Wang Z, et al. Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Sci Rep. 2016; 6: 20602. doi:10.1038/srep20602
Tong S, Zhang P, Cheng Q, et al. The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment. Front Cell Infect Microbiol. 2022; 12: 1051682. doi:10.3389/fcimb.2022.1051682
Raftogianis R, Creveling C, Weinshilboum R, et al. Estrogen metabolism by conjugation. J Natl Cancer Inst Monogr. 2000; (27): 113-124. doi:10.1093/oxfordjournals.jncimonographs.a024234
Shen RL, Dang XY, Dong JL, et al. Effects of oat β-glucan and barley β-glucan on fecal characteristics, intestinal microflora, and intestinal bacterial metabolites in rats. J Agric Food Chem. 2012; 60(45): 11301-11308. doi:10.1021/jf302824h
Flores R, Shi J, Fuhrman B, et al. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. J Transl Med. 2012; 10: 253. doi:10.1186/1479-5876-10-253
Secky L, Svoboda M, Klameth L, et al. The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors. J Drug Deliv. 2013; 2013: 957605. doi:10.1155/2013/957605
Chase D, Goulder A, Zenhausern F, et al. The vaginal and gastrointestinal microbiomes in gynecologic cancers: a review of applications in etiology, symptoms and treatment. Gynecol Oncol. 2015; 138(1): 190-200. doi:10.1016/j.ygyno.2015.04.036
Laviolette LA, Garson K, Macdonald EA, et al. 17beta-estradiol accelerates tumor onset and decreases survival in a transgenic mouse model of ovarian cancer. Endocrinology. 2010; 151(3): 929-938. doi:10.1210/en.2009-0602
Van Eldere J, Robben J, De Pauw G, et al. Isolation and identification of intestinal steroid-desulfating bacteria from rats and humans. Appl Environ Microbiol. 1988; 54(8): 2112-2117. doi:10.1128/aem.54.8.2112-2117.1988
Kodama S, Hosseinpour F, Goldstein JA, et al. Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. Nucleic Acids Res. 2011; 39(19): 8392-8403. doi:10.1093/nar/gkr458
Purohit A, Woo LW, Potter BV. Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Mol Cell Endocrinol. 2011; 340(2): 154-160. doi:10.1016/j.mce.2011.06.012
D'Amelio P, Sassi F. Gut Microbiota, Immune System, and Bone. Calcif Tissue Int. 2018;102(4):415-425. doi:10.1007/s00223-017-0331-y
De Martinis M, Ginaldi L, Allegra A, et al. The Osteoporosis/Microbiota Linkage: The Role of miRNA. Int J Mol Sci. 2020; 21(23): 8887. doi:10.3390/ijms21238887
Li L, Rao S, Cheng Y, et al. Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity. Microbiologyopen. 2019; 8(8): e00810. doi:10.1002/mbo3.810
Ohlsson C, Sjögren K. Osteomicrobiology: A New Cross-Disciplinary Research Field. Calcif Tissue Int. 2018; 102(4): 426-432. doi:10.1007/s00223-017-0336-
Takiishi T, Fenero CIM, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017; 5(4): e1373208. doi:10.1080/21688370.2017.1373208
Waterhouse M, Hope B, Krause L, et al. Vitamin D and the gut microbiome: a systematic review of in vivo studies. Eur J Nutr. 2019; 58(7): 2895-2910. doi:10.1007/s00394-018-1842-7
Li JY, Chassaing B, Tyagi AM, et al. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest. 2016; 126(6): 2049-2063. doi:10.1172/JCI86062
Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature. 2016; 535(7610): 65-74. doi:10.1038/nature18847
De Martinis M, Sirufo MM, Viscido A, et al. Food Allergy Insights: A Changing Landscape. Arch Immunol Ther Exp (Warsz). 2020; 68(2): 8. doi:10.1007/s00005-020-00574-6
De Martinis M, Sirufo MM, Viscido A, et al. Food Allergies and Ageing. Int J Mol Sci. 2019; 20(22): 5580. doi:10.3390/ijms2022558
Ellur G, Sukhdeo SV, Khan MT, et al. Maternal high protein-diet programs impairment of offspring's bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts. Cell Mol Life Sci. 2021; 78(4): 1729-1744. doi:10.1007/s00018-020-03608-6
De Martinis M, Sirufo MM, Suppa M, et al. New Perspectives in Food Allergy. Int J Mol Sci. 2020; 21(4): 1474. doi:10.3390/ijms21041474
Neuman H, Debelius JW, Knight R, et al. Microbial endocrinology: the interplay between the microbiota and the endocrine system. FEMS Microbiol Rev. 2015; 39(4): 509-521. doi:10.1093/femsre/fuu010
Mayorga-Ramos A, Barba-Ostria C, Simancas-Racines D, et al. Protective role of butyrate in obesity and diabetes: New insights. Front Nutr. 2022; 9: 1067647. doi:10.3389/fnut.2022.1067647
Petrillo T, Semprini E, Tomatis V, et al. Putative Complementary Compounds to Counteract Insulin-Resistance in PCOS Patients. Biomedicines. 2022; 10(8): 1924. doi:10.3390/biomedicines10081924
Sun Y, Gao S, Ye C, et al. Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications. Front Cell Infect Microbiol. 2023; 13: 1142041. doi:10.3389/fcimb.2023.1142041
Amisi CA. Markers of insulin resistance in Polycystic ovary syndrome women: An update. World J Diabetes. 2022; 13(3): 129-149. doi:10.4239/wjd.v13.i3.129
Martínez-Montoro JI, Damas-Fuentes M, Fernández-García JC, et al. Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review. Front Endocrinol (Lausanne). 2022; 13: 869951. doi:10.3389/fendo.2022.869951
Referanslar
Blumberg R, Powrie F. Microbiota, disease, and back to health: a metastable journey. Sci Transl Med. 2012; 6;4(137): 137rv7. doi: 10.1126/scitranslmed.3004184.
Forsythe P, Sudo N, Dinan T, et al. Mood and gut feelings. Brain Behav Immun. 2010; 24(1): 9-16. doi:10.1016/j.bbi.2009.05.058
3.Neish AS. Mucosal immunity and the microbiome. Ann Am Thorac Soc. 2014; 11(1): 28–32. doi:10.1513/AnnalsATS.201306-161MG
Grenham S, Clarke G, Cryan J, et al. Brain-gut-Microbe communication in health and disease. Front Physiol. 2011; 2: 94. doi:10.3389/fphys.2011.00094
He S, Li H, Yu Z, et al. The Gut Microbiome and Sex Hormone-Related Diseases. Front. Microbiol. 2021; 12: 711137.doi: 10.3389/fmicb.2021.711137
Evans JM, Morris LS, Marchesi JR. The gut microbiome: the roleof a virtual organ in the endocrinology of the host. J Endocrinol. 2013; 218: 37–47. doi:10.1530/JOE-13-0131
Lyte M. Microbial endocrinology and infectious disease in the 21st century. Trends Microbiol. 2004; 12: 14 –20. doi:10.1016/j.tim.2003.11.004
Freestone PP, Sandrini SM, Haigh RD, et al. Microbial endocrinology: how stress influences susceptibility to infection. Trends Microbiol. 2008; 16: 55– 64. doi:10.1016/j.tim.2007.11.005
Clarke G, Stilling RM, Kennedy PJ, et al. Minireview: Gut Microbiota: The Neglected Endocrine Organ. Molecular Endocrinology. 2014; 28: 1221–1238. doi:10.1210/me.2014-1108
Lyte M. The microbial organ in the gut as a driver of homeostasis and disease. Med Hypotheses. 2010; 74: 634 – 638. doi:10.1016/j.mehy.2009.10.025
Flak MB, Neves JF, Blumberg RS. Immunology. Welcome to the microgenderome. Science. 2013; 1;339(6123): 1044-5. doi: 10.1126/science.1236226.
Sender R, Fuchs S, Milo R. Revised estimates for the number of human and bacteria cells in the body. PLoS Biol. 2016; 14(8): e1002533. doi:10.1371/journal.pbio.1002533
Edwards DP. Regulation of signal transduction pathways by estrogen and progesterone. Annu Rev Physiol. 2005; 67(1): 335–376. doi:10.1146/annurev. physiol.67.040403.120151
Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010; 464(7285): 59–65. doi:10.1038/nature08821
Franasiak JM, Scott RT. Introduction: microbiome in human reproduction. Fertil Steril. 2015; 104(6): 1341–1343. doi:10.1016/j.fertnstert.2015.10.021
Clemente-Suárez VJ, Redondo-Flórez L, Rubio-Zarapuz A, et al. Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches. Biomedicines. 2024; 12(1): 221. doi: 10.3390/biomedicines12010221.
Gibbons SM, Gilbert JA. Microbial Diversity-Exploration of Natural Ecosystems and Microbiomes. Curr. Opin. Genet. Dev. 2015; 35: 66–72.
Clapp M, Aurora N, Herrera L, et al. Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis. Clin. Pract. 2017; 7: 987. doi:10.4081/cp.2017.987
Thursby, E.; Juge, N. Introduction to the Human Gut Microbiota. Biochem. J. 2017; 474: 1823–1836. doi:10.1042/BCJ20160510
Ecklu-Mensah G, Gilbert J, Devkota S. Dietary Selection Pressures and Their Impact on the Gut Microbiome. Cell. Mol. Gastroenterol. Hepatol. 2022; 13: 7–18. doi:10.1016/j.jcmgh.2021.07.009
Degruttola AK, Low D, Mizoguchi A, et al. Current Understanding of Dysbiosis in Disease in Human and Animal Models. Inflamm. Bowel Dis. 2016; 22: 1137–1150. doi:10.1097/MIB.0000000000000750
Conlon MA, Bird AR. The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients. 2015; 7: 17–44. doi:10.3390/nu7010017
Suzuki TA, Ley RE. The Role of the Microbiota in Human Genetic Adaptation. Science. 2020; 370: 1180. doi:10.1126/science.aaz6827
Cotillard A, Kennedy SP, Kong LC, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013; 500(7464): 585-588. doi:10.1038/nature12480
Wu Z, Tian E, Chen Y, et al. Gut microbiota and its roles in the pathogenesis and therapy of endocrine system diseases. Microbiol Res. 2023; 268 127291. doi: 10.1016/j.micres.2022.127291.
Gwak MG, Chang SY. Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors. Immune Netw. 2021; 16;21(3): e20. doi: 10.4110/in.2021.21.e20.
Uzbay T. Germ-free animal experiments in the gut microbiota studies. Curr Opin Pharmacol. 2019; 49: 6-10. doi:10.1016/j.coph.2019.03.016
Carabotti M, Scirocco A, Maselli MA, et al. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015; 28(2): 203-209. PMID: 25830558
Goenka A, Kollmann TR. Development of immunity in early life. J Infect. 2015; 71(1): 112-20. doi: 10.1016/j.jinf.2015.04.027.
Appleton J. The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health. Integr. Med. 2018; 17: 28–32. PMID: 31043907
Gao X, Lin SH, Ren F, et al. Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016; 7(1): 11960. doi:10.1038/ncomms11960
Chao J, Coleman RA, Keating DJ, et al. Gut Microbiome Regulation of Gut Hormone Secretion. Endocrinology. 2025; 166(4): bqaf004. doi: 10.1210/endocr/bqaf004.
Rincon MT, Lamed R, White BA. Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis. Nat Rev Microbiol. 2008; 6(2): 121-131. doi:10.1038/nrmicro1817
Demigne C, Morand C, Levrat MA, et al. Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes. Br J Nutr. 1995; 74(2): 209-219. doi:10.1079/bjn19950124
Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc. 2003; 62(1): 67-72. doi:10.1079/PNS2002207
Donohoe DR, Garge N, Zhang X, et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 2011; 13(5): 517-526.31. doi:10.1016/j.cmet.2011.02.018
Wang GY, Qin SL, Zheng YN, et al. Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes. Anim Nutr. 2023; 15: 88-98. doi:10.1016/j.aninu.2023.07.001
Chiang JYL. Bile acid metabolism and signaling in liver disease and therapy. Liver Res. 2017; 1(1): 3-9. doi:10.1016/j.livres.2017.05.001
Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009; 32(2): 237-245. doi:10.2337/dc09-S355
Venkatesh M, Mukherjee S, Wang H, et al. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 2014; 41(2): 296-310. doi:10.1016/j.immuni.2014.06.014
Ye L, Bae M, Cassilly CD, et al. Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe. 2021; 29(2): 179-196. doi:10.1016/j.chom.2020.11.011
Zelante T, Iannitti RG, Cunha C, et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22. Immunity. 2013; 39(2): 372-385. doi:10.1016/j.immuni.2013.08.003
Lee JH, Lee J. Indole as an intercellular signal in microbial communities. FEMS Microbiol Rev. 2010; 34(4): 426-444. doi:10.1111/j.1574-6976.2009.00204.x
Zhou Y, Chen Y, He H, et al. The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases. Neuropharmacology. 2023; 15;239:109690. doi: 10.1016/j.neuropharm.2023.109690.
Smith T. A modıfıcatıon of the method for determınıng the productıon of ındol by bacterıa. J Exp Med. 1897; 2(5): 543-7. doi: 10.1084/jem.2.5.543.
Pascale A, Marchesi N, Marelli C, et al. Microbiota and metabolic diseases. Endocrine. 2018; 61 (3): 357–371. https://doi.org/10.1007/s 12020-018-1605-5.
Garrett W. Immune recognition of microbial metabolites. Nat. Rev. Immunol. 2020; 20(2): 91–92. https://doi.org/10.1038/s41577-019-0252-2.
Chen Q, Ren R, Zhang Q, et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021; 1;267:113542. doi: 10.1016/j.jep.2020.113542.
Obata Y, Castaño Á, Boeing S, et al. Neuronal programming by microbiota regulates intestinal physiology. Nature. 2020;578(7794):284-289. doi:10.1038/s41586-020-1975-8
Su Y, Li J, Wu L, Kuang H. Polysaccharides from TCM herbs exhibit potent anti-obesity effect by mediating the community structure of gut microbiota. Pharmazie. 2021; 76(10):473-479. doi:10.1691/ph.2021.1463
Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia. 2006;49(12):2824-2827. doi:10.1007/s00125-006-0465-3
Gao Y, Davis B, Zhu W, et al. Short-chain fatty acid butyrate, a breast milk metabolite, enhances immature intestinal barrier function genes in response to inflammation in vitro and in vivo. Am J Physiol Gastrointest Liver Physiol. 2021; 320(4): 521-530. doi:10.1152/ajpgi.00279.2020
Sorini C, Cosorich I, Lo Conte M, et al. Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes. Proc Natl Acad Sci USA. 2019; 116(30): 15140-15149. doi:10.1073/pnas. 1814558116
Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013; 504(7480): 451-455. doi:10.1038/nature12726
Tong Y, Tang J. Candida albicans infection and intestinal immunity. Microbiol Res. 2017;198:27-35. doi:10.1016/j.micres.2017.02.002
Postler TS, Ghosh S. Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System. Cell Metab. 2017; 26(1): 110-130. doi:10.1016/j.cmet.2017.05.008
Lin HV, Frassetto A, Kowalik EJ Jr, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One. 2012; 7(4): e35240. doi:10.1371/journal.pone.0035240
Mariño E, Richards JL, McLeod KH, et al. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017; 18(11): 1271. doi: 10.1038/ni1117-1271c.].
Pitocco D, Di Leo M, Tartaglione L, et al. The role of gut microbiota in mediating obesity and diabetes mellitus. Eur Rev Med Pharmacol Sci. 2020; 24(3): 1548-1562. doi:10.26355/eurrev_202002_20213
Liu J, Li Y, Sun C, et al. Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids. Pharmacol Res. 2020;152:104631. doi:10.1016/j.phrs.2020.104631
Kurita N, Yamashiro K, Kuroki T, et al. Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia. J Cereb Blood Flow Metab. 2020;40(12):2505-2520. doi:10.1177/0271678X19899577
Gangi E, Kapatral V, El-Azami El-Idrissi M, et al. Characterization of a recombinant Yersinia enterocolitica lipoprotein; implications for its role in autoimmune response against thyrotropin receptor. Autoimmunity. 2004; 37(6-7): 515-520. doi:10.1080/08916930410001728074
Zhang J, Zhang F, Zhao C, et al. Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function. Endocrine. 2019; 64(3): 564-574. doi:10.1007/s12020-018-1831-x
Zhou L, Li X, Ahmed A, et al. Gut microbe analysis between hyperthyroid and healthy individuals. Curr Microbiol. 2014; 69(5): 675-680. doi:10.1007/s00284-014-0640-6
Ríos-Covián D, Ruas-Madiedo P, Margolles A, et al. Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health. Front Microbiol. 2016; 7:185. doi:10.3389/fmicb.2016.00185
Su X, Zhao Y, Li Y, et al. Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis. Clin Sci (Lond). 2020; 134(12): 1521-1535. doi:10.1042/CS20200475
Çatak J, Yıldırım Servi E, Memiş N. Obezite ve Mikrobiyota Etkileşimlerine Genel Bakış. Avrupa Bilim ve Teknoloji Dergisi. 2021; (31): 275-291. doi.org/10.31590/ejosat.935513
Breton J, Tennoune N, Lucas N, et al. Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth. Cell Metab. 2016; 23(2): 324-334. doi:10.1016/j.cmet.2015.10.017
Crunkhorn S. Metabolic disorders: Safe cannabinoid receptor modulators in sight?. Nat Rev Drug Discov. 2012; 11(10): 749. doi:10.1038/nrd3851
Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. NatMed. 2016; 22(10): 1079. doi:10.1038/nm.4185
Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012; 336(6086): 1268–73. doi:10.1126/science.1223490
Hasani-Ranjbar S, Larijani B. Human Microbiome as an approach to personalized medicine.Altern Ther HealthMed. 2017; 23(6): 8–9. PMID: 28987073
Whitman WB, Coleman DC, Wiebe WJ. Prokaryotes: the unseen majority. Proc Natl Acad Sci U S A. 1998; 95(12): 6578–83. doi:10.1073/pnas.95.12.6578
Costello EK, Stagaman K, Dethlefsen L, et al. The application of ecological theory toward an understanding of the human microbiome. Science. 2012; 336(6086): 1255–62. doi:10.1126/science.1224203
Kuntz TM, Gilbert JA. Introducing the microbiome into precision medicine. Trends Pharmacol Sci. 2017; 38(1): 81–91. doi:10.1016/j.tips.2016.10.001
Mallick H, Ma S, Franzosa EA, et al. Experimental design and quantitative analysis of microbial community multiomics. Genome Biol. 2017; 18(1): 228. doi:10.1186/s13059-017-1359-z
Bäckhed F, Ley RE, Sonnenburg JL, et al. Host-bacterial mutualism in the human intestine. Science. 2005; 307(5717): 1915–20. doi:10.1126/science.1104816
Shirvani Rad S, Nikkhah A, Orvatinia M, et al. Gut microbiota: a perspective of precision medicine in endocrine disorders. J Diabetes Metab Disord. 2020; 19(2): 1827-1834. doi:10.1007/s40200-020-00593-2
Riscuta G, Xi D, Pierre-Victor D, et al. Diet, Microbiome, and Epigenetics in the Era of Precision Medicine. Methods Mol Biol. 2018; 1856: 141-156. doi:10.1007/978-1-4939-8751-1_8
Grice EA, Kong HH, Conlan S, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009; 324(5931): 1190–2. doi:10.1126/science.1171700
Jiang W, Lu G, Gao D, et al. The relationships between the gut microbiota and its metabolites with thyroid diseases. Front Endocrinol (Lausanne). 2022; 13: 943408. doi:10.3389/fendo.2022.943408
Guo Z, Zhang J, Wang Z, et al. Intestinal Microbiota Distinguish Gout Patients from Healthy Humans. Sci Rep. 2016; 6: 20602. doi:10.1038/srep20602
Tong S, Zhang P, Cheng Q, et al. The role of gut microbiota in gout: Is gut microbiota a potential target for gout treatment. Front Cell Infect Microbiol. 2022; 12: 1051682. doi:10.3389/fcimb.2022.1051682
Raftogianis R, Creveling C, Weinshilboum R, et al. Estrogen metabolism by conjugation. J Natl Cancer Inst Monogr. 2000; (27): 113-124. doi:10.1093/oxfordjournals.jncimonographs.a024234
Shen RL, Dang XY, Dong JL, et al. Effects of oat β-glucan and barley β-glucan on fecal characteristics, intestinal microflora, and intestinal bacterial metabolites in rats. J Agric Food Chem. 2012; 60(45): 11301-11308. doi:10.1021/jf302824h
Flores R, Shi J, Fuhrman B, et al. Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study. J Transl Med. 2012; 10: 253. doi:10.1186/1479-5876-10-253
Secky L, Svoboda M, Klameth L, et al. The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors. J Drug Deliv. 2013; 2013: 957605. doi:10.1155/2013/957605
Chase D, Goulder A, Zenhausern F, et al. The vaginal and gastrointestinal microbiomes in gynecologic cancers: a review of applications in etiology, symptoms and treatment. Gynecol Oncol. 2015; 138(1): 190-200. doi:10.1016/j.ygyno.2015.04.036
Laviolette LA, Garson K, Macdonald EA, et al. 17beta-estradiol accelerates tumor onset and decreases survival in a transgenic mouse model of ovarian cancer. Endocrinology. 2010; 151(3): 929-938. doi:10.1210/en.2009-0602
Van Eldere J, Robben J, De Pauw G, et al. Isolation and identification of intestinal steroid-desulfating bacteria from rats and humans. Appl Environ Microbiol. 1988; 54(8): 2112-2117. doi:10.1128/aem.54.8.2112-2117.1988
Kodama S, Hosseinpour F, Goldstein JA, et al. Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure. Nucleic Acids Res. 2011; 39(19): 8392-8403. doi:10.1093/nar/gkr458
Purohit A, Woo LW, Potter BV. Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Mol Cell Endocrinol. 2011; 340(2): 154-160. doi:10.1016/j.mce.2011.06.012
D'Amelio P, Sassi F. Gut Microbiota, Immune System, and Bone. Calcif Tissue Int. 2018;102(4):415-425. doi:10.1007/s00223-017-0331-y
De Martinis M, Ginaldi L, Allegra A, et al. The Osteoporosis/Microbiota Linkage: The Role of miRNA. Int J Mol Sci. 2020; 21(23): 8887. doi:10.3390/ijms21238887
Li L, Rao S, Cheng Y, et al. Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity. Microbiologyopen. 2019; 8(8): e00810. doi:10.1002/mbo3.810
Ohlsson C, Sjögren K. Osteomicrobiology: A New Cross-Disciplinary Research Field. Calcif Tissue Int. 2018; 102(4): 426-432. doi:10.1007/s00223-017-0336-
Takiishi T, Fenero CIM, Câmara NOS. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue Barriers. 2017; 5(4): e1373208. doi:10.1080/21688370.2017.1373208
Waterhouse M, Hope B, Krause L, et al. Vitamin D and the gut microbiome: a systematic review of in vivo studies. Eur J Nutr. 2019; 58(7): 2895-2910. doi:10.1007/s00394-018-1842-7
Li JY, Chassaing B, Tyagi AM, et al. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest. 2016; 126(6): 2049-2063. doi:10.1172/JCI86062
Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature. 2016; 535(7610): 65-74. doi:10.1038/nature18847
De Martinis M, Sirufo MM, Viscido A, et al. Food Allergy Insights: A Changing Landscape. Arch Immunol Ther Exp (Warsz). 2020; 68(2): 8. doi:10.1007/s00005-020-00574-6
De Martinis M, Sirufo MM, Viscido A, et al. Food Allergies and Ageing. Int J Mol Sci. 2019; 20(22): 5580. doi:10.3390/ijms2022558
Ellur G, Sukhdeo SV, Khan MT, et al. Maternal high protein-diet programs impairment of offspring's bone mass through miR-24-1-5p mediated targeting of SMAD5 in osteoblasts. Cell Mol Life Sci. 2021; 78(4): 1729-1744. doi:10.1007/s00018-020-03608-6
De Martinis M, Sirufo MM, Suppa M, et al. New Perspectives in Food Allergy. Int J Mol Sci. 2020; 21(4): 1474. doi:10.3390/ijms21041474
Neuman H, Debelius JW, Knight R, et al. Microbial endocrinology: the interplay between the microbiota and the endocrine system. FEMS Microbiol Rev. 2015; 39(4): 509-521. doi:10.1093/femsre/fuu010
Mayorga-Ramos A, Barba-Ostria C, Simancas-Racines D, et al. Protective role of butyrate in obesity and diabetes: New insights. Front Nutr. 2022; 9: 1067647. doi:10.3389/fnut.2022.1067647
Petrillo T, Semprini E, Tomatis V, et al. Putative Complementary Compounds to Counteract Insulin-Resistance in PCOS Patients. Biomedicines. 2022; 10(8): 1924. doi:10.3390/biomedicines10081924
Sun Y, Gao S, Ye C, et al. Gut microbiota dysbiosis in polycystic ovary syndrome: Mechanisms of progression and clinical applications. Front Cell Infect Microbiol. 2023; 13: 1142041. doi:10.3389/fcimb.2023.1142041
Amisi CA. Markers of insulin resistance in Polycystic ovary syndrome women: An update. World J Diabetes. 2022; 13(3): 129-149. doi:10.4239/wjd.v13.i3.129
Martínez-Montoro JI, Damas-Fuentes M, Fernández-García JC, et al. Role of the Gut Microbiome in Beta Cell and Adipose Tissue Crosstalk: A Review. Front Endocrinol (Lausanne). 2022; 13: 869951. doi:10.3389/fendo.2022.869951
