Endokrin Bozucu Kimyasallar

Kiess W,Haeusler G, Endocrine-disrupting chemicals - Best Practice & Research Clinical Endocrinology & Metabolism https://doi.org/10.1016/j.beem.2021.101566

1994 Aug;102(8):676–679. doi: 10.1289/ehp.94102676

E.R. Kabir, M.S. Rahman, I. Rahman, A review on endocrine disruptors and their possible impacts on human health. Environ. Toxicol. Pharmacol. 40, 241–258 (2015). https://doi.org/10. 1016/j.etap.2015.06.009

P. Balaguer, V. Delfosse, M. Grimaldi, W. Bourguet, Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses. Comptes Rendus Biologies 340, 414–420 (2017). https://doi.org/ 10.1016/j.crvi.2017.08.002

J.J. Heindel, R. Newbold, T.T. Schug, Endocrine disruptors and obesity. Nat. Rev. Endocrinol. 11, 653–661 (2015). https://doi. org/10.1038/nrendo.2015.163

R.M. Sargis, Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals. Endocr. Disruptors 3, e1080788 (2015). https://doi.org/10.1080/23273747.2015.1080788

De Coster, S.; van Larebeke, N. Endocrine-disrupting chemicals: Associated disorders and mechanisms of action. J. Environ. Public Health 2012, 2012, 713696

Russart, K.L.G.; Nelson, R.J. Light at night as an environmental endocrine disruptor. Physiol. Behav. 2018, 190, 82–89. [CrossRef]

S.de Coster, N.van Larebeke,, Endocrine-disrupting chemicals: associated disorders and mechanisms of action. J. Environ. Public Health 2012, 1–52 (2012). https://doi.org/10.1155/2012/ 713696

T.T. Schug, A. Janesick, B. Blumberg, J.J. Heindel, Endocrine disrupting chemicals and disease susceptibility. J. Steroid Bio chem. Mol. Biol. 127, 204–215 (2011). https://doi.org/10.1016/j. jsbmb.2011.08.007

Diamanti-Kandarakis, E.; Bourguignon, J.P.; Giudice, L.C.; Hauser, R.; Prins, G.S.; Soto, A.M.; Zoeller, R.T.; Gore, A.C. Endocrine disrupting chemicals: An Endocrine Society scientific statement. Endocr. Rev. 2009, 30, 293–342.

Diamanti-Kandarakis, E.; Palioura, E.; Kandarakis, S.A.; Koutsilieris, M. The impact of endocrine disruptors on endocrine targets. Horm. Metab. Res. 2010, 42, 543–552.

Fekete, C.; Lechan, R.M. Central regulation of hypotha- lamic-pituitary-thyroid axis under physiological and pathophysiological conditions. Endocr. Rev. 2014, 35, 159–194. [CrossRef] [PubMed]

Triggiani, V.; Tafaro, E.; Giagulli, V.A.; Sabbà, C.; Resta, F.; Licchelli, B.; Guastamacchia, E. Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr. Metab. Immune Disord. Drug Targets 2009, 9, 277–294.

Dumitrescu, A.M.; Refetoff, S. Inherited defects of thyroid hormone metabolism. Ann. Endocrinol. 2011, 72, 95–98.

Council on Environmental Health; Rogan, W.J.; Paulson, J.A.; Baum, C.; Brock-Utne, A.C.; Brumberg, H.L.; Campbell, C.C.; Lanphear, B.P.; Lowry, J.A.; Osterhoudt, K.C.; et al. Iodine deficiency, pollutant chemicals, and the thyroid: New information on an old problem. Pediatrics 2014, 133, 1163–1166.

Montaño, M.; Cocco, E.; Guignard, C.; Marsh, G.; Hoffmann, L.; Bergman, A.; Gutleb, A.C.; Murk, A.J. New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. Toxicol. Sci. 2012, 130, 94–105.

Ibhazehiebo, K.; Koibuchi, N. Thyroid hormone receptor- mediated transcription is suppressed by low dose phthalate. Niger. J. Physiol. Sci. 2011, 26, 143–149.

J.D. Meeker, K.K. Ferguson, Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the national health and nutrition examination survey (NHANES) 2007–2008. Environ. Health Perspect. 119, 1396–1402 (2011). https://doi. org/10.1289/ehp.1103582

International Agency for Research on Cancer Classifications. Available at https://monographs.iarc.who.int/agents-classified by-the-iarc/. [Accessed April 7, 2022].

D. Cuomo, I. Porreca, G. Cobellis, R. Tarallo, G. Nassa, G. Falco, A. Nardone, F. Rizzo, M. Mallardo, C. Ambrosino, Car cinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands. Mol. Cell. Endocrinol. 457, 20–34 (2017). https://doi.org/10.1016/j.mce.2017.01.027

Hu,X.; Saunders, N.; Safley, S.; Smith, M.R.; Liang, Y.; Tran, V.; Sharma, J.; Jones, D.P.; Weber, C.J. Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors. Surgery 2021, 169, 102–108.

A.C. Pesatori, D. Consonni, M. Rubagotti, P. Grillo, P.A. Bertazzi, Cancer incidence in the population exposed to dioxin after the “Seveso accident”: twenty years of follow-up. Environ. Health 8, 39 (2009). https://doi.org/10.1186/1476 069X-8-39

V.H. Dang, T.H. Nguyen, G.S. Lee, K.C. Choi, E.B. Jeung, In vitro exposure to xenoestrogens induces growth hormone tran scription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells. Steroids 74, 707–714 (2009). https:// doi.org/10.1016/j.steroids.2009.03.002

J. Simard, J.-F. Hubert, T. Hosseinzadeh, F. Labrie, Stimulation of growth hormone release and synthesis by estrogens in rat anterior pituitary cells in culture. Endocrinology 119, 2004–2011 (1986). https://doi.org/10.1210/endo-119-5-2004

A. Shah, C.G. Coburn, A. Watson-Siriboe, R. Whitley, A. Shahidzadeh, E.R. Gillard, R. Nichol, M. Leon-Olea, M. Gaertner, P.R.S. Kodavanti, M.C. Currás-Collazo, Altered car diovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs). Toxicol. Appl. Pharmacol. 256, 103–113 (2011).

W. Brogan, Effects of carbon tetrachloride on adrenocortical structure and function in guinea pigs. Toxicol. Appl. Pharma col. 75, 118–127 (1984). https://doi.org/10.1016/0041-008X (84)90082-6

Sargis, R.M. Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals. Endocr. Disruptors 2015, 3, e1080788

Hinson, J.P.; Raven, P.W. Effects of endocrine-disrupting chemicals on adrenal function. Best Pract. Res. Clin. Endocrinol. Metab. 2006, 20, 111–120.

Foulds, C.E.; Trevino, L.S.; York, B.; Walker, C.L. Endocrine-disrupting chemicals and fatty liver disease. Nat. Rev. Endocrinol. 2017, 13, 445–457.

R. Meli, A. Monnolo, C. Annunziata, C. Pirozzi, M.C. Ferrante, Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction. Antioxidants 9, 405 (2020). https://doi.org/10.3390/antiox9050405

Quesada, I.; Fuentes, E.; Viso-Leon, M.C.; Soria, B.; Ripoll, C.; Nadal, A. Low doses of the endocrine disruptor bisphenol-A and the native hormone 17-beta estradiol rapidly activate transcription factor CREB1. FASEB J. 2002, 16, 1671–1673.

Alonso-Magdalena, P.; Morimoto, S.; Ripoll, C.; Fuentes, E.; Nadal, A. The estrogenic effect of bisphenol-A disrupts-cell function in vivo and induces insulin-resistance. Environ. Health Perspect. 2006, 114, 106–112.

Alonso-Magdalena, P.; Laribi, O.; Ropero, A.B.; Fuentes, E.; Ripoll, C.; Soria, B.; Nadal, A. Low doses of bisphenol-A and diethystilbestrol impair Ca2+ signals in pancreatic-cells through a non classical membrane estrogen receptor within intact islets of Langerhans. Environ. Health Perspect. 2005, 113, 969–977.

Lenzen, S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008, 51, 216–226.

Cargnelutti, F.; Di Nisio, A.; Pallotti, F.; Sabovic, I.; Spaziani, M.; Tarsitano, M.G.; Paoli, D.; Foresta, C. Effects of endocrine disruptors on fetal testis development, male puberty, and transition age. Endocrine 2021, 72, 358–374.

Gea, M.; Toso, A.; Bentivegna, G.N.; Buganza, R.; Abrigo, E.; De Sanctis, L.; Schilirò, T. Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals: A Pilot Study. Int. J. Environ. Res. Public Health 2023, 20, 14

Polak, G.; Banaszewska, B.; Filip, M.; Radwan, M.; Wdowiak, A. Environmental Factors and Endometriosis. Int. J. Environ. Res. Public Health 2021, 18, 11025.

Kawa,I.A.; Akbar, M.; Fatima, Q.; Mir, S.A.; Jeelani, H.; Manzoor, S.; Rashid, F. Endocrine disrupting chemical Bisphenol A and its potential effects on female health. Diabetes Metab. Syndr. 2021, 15, 803–811.

Rehman,S.; Usman, Z.; Rehman, S.; AlDraihem, M.; Rehman, N.; Rehman, I.; Ahmad, G. Endocrine disrupting chemicals and impact on male reproductive health. Transl. Androl. Urol. 2018, 7, 490–503.]

Fenichel, P.; Chevalier, N.; Lahlou, N.; Coquillard, P.; Wagner-Mahler, K.; Pugeat, M.; Panaia-Ferrari, P.; Brucker-Davis, F. Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryp torchidism. Front. Endocrinol. 2018, 9, 786.

Sharma, A.; Mollier, J.; Brocklesby, R.W.; Caves, C.; Jayasena, C.N.; Minhas, S. Endocrine-disrupting chemicals and male reproductive health. Reprod. Med. Biol. 2020, 19, 243–253.

Richter, C.A.; Birnbaum, L.S.; Farabollini, F.; Newbold, R.R.; Rubin, B.S.; Talsness, C.E.; Vandenbergh, J.G.; Walser-Kuntz, D.R.; vomSaal, F.S. In vivo effects of bisphenol A in laboratory rodent studies. Reprod. Toxicol. 2007, 24, 199–224.

De Angelis, C.; Mazzella, M.; Pivonello, R. Interferenti endocrini e funzione gonadica: Focus su steroidogenesi testicolare e infertilità maschile. L’Endocrinologo 2022, 23, 52–60. [CrossRef]

Fittipaldi, S.; Bimonte, V.M.; Soricelli, A.; Aversa, A.; Lenzi, A.; Greco, E.A.; Migliaccio, S. Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: A potential mechanism of endocrine disruptor atherogenic effect. J. Endocrinol. Investig. 2019, 42, 727–739.

De Angelis, C.; Galdiero, M.; Pivonello, C.; Salzano, C.; Gianfrilli, D.; Piscitelli, P.; Lenzi, A.; Colao, A.; Pivonello, R. The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility. Reprod. Toxicol. 2017, 73, 105–127.

D. Cuomo, I. Porreca, G. Cobellis, R. Tarallo, G. Nassa, G. Falco, A. Nardone, F. Rizzo, M. Mallardo, C. Ambrosino, Car cinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands. Mol. Cell. Endocrinol. 457, 20–34 (2017). https://doi.org/10.1016/j.mce.2017.01.027

Sun W., Lei Y., Jiang Z., Wang K., Liu H., Xu T. (2024). BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway. J. Adv. Res. PubMed PMID: 38311007. Epub 2024/02/05. eng. 10.1016/j.jare.2024.01.029

Ngalame N.N.O., Makia N.L., Waalkes M.P., Tokar E.J. Mitigation of Arsenic-Induced Acquired Cancer Phenotype in Prostate Cancer Stem Cells by miR-143 Restoration. Toxicol. Appl. Pharmacol. 2016;312:11–18. doi: 10.1016/j.taap.2015.12.013.

Severson P.L., Tokar E.J., Vrba L., Waalkes M.P., Futscher B.W. Agglomerates of Aberrant DNA Methylation Are Associated with Toxicant-Induced Malignant Transformation. Epigenetics. 2012;7:1238–1248. doi: 10.4161/epi.22163.

Kitamura M., Kasai A. Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway. Cancer Lett. 2007;252:184–194. doi: 10.1016/j.canlet.2006.11.015.

Tai V, Leung W, Grey A, Reid IR, Bolland MJ. Calcium intake and bone mineral density: systematic review and meta-analysis. BMJ. 2015;351:h4183. doi: 10.1136/bmj.h4183.

Vannucci L, Fossi C, Quattrini S, Guasti L, Pampaloni B, Gronchi G, et al. Calcium intake in bone health: a focus on calcium-rich mineral waters. Nutrients. 2018;10:1930. doi: 10.3390/nu10121930.

Veldurthy V, Wei R, Oz L, Dhawan P, Jeon YH, Christakos S. Vitamin D, calcium homeostasis and aging. Bone Res. 2016;4:16041. doi: 10.1038/boneres.2016.41

Suzuki N, Hattori A. Bisphenol A suppresses osteoclastic and osteoblastic activities in the cultured scales of goldfish. Life Sci. 2003;73:2237–47. doi: 10.1016/s0024-3205(03)00603-9.

Shi X, Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol Sci. 2010;115:391–400. doi: 10.1093/toxsci/kfq066.pkb

Alvarez-Lloret P, Lind PM, Nyberg I, Orberg J, Rodriguez-Navarro AB. Effects of 3,3’,4,4’,5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague-Dawley rats. Toxicol Lett. 2009;187:63–8. doi: 10.1016/j.toxlet.2009.01.030

Li L, Yang X. The essential element manganese, oxidative stress, and metabolic diseases: links and interactions. Oxidative Med Cell Longev. (2018) 2018:7580707. doi: 10.1155/2018/7580707,

Kiess W,Haeusler G, Endocrine-disrupting chemicals - Best Practice & Research Clinical Endocrinology & Metabolism https://doi.org/10.1016/j.beem.2021.101566

1994 Aug;102(8):676–679. doi: 10.1289/ehp.94102676

E.R. Kabir, M.S. Rahman, I. Rahman, A review on endocrine disruptors and their possible impacts on human health. Environ. Toxicol. Pharmacol. 40, 241–258 (2015). https://doi.org/10. 1016/j.etap.2015.06.009

P. Balaguer, V. Delfosse, M. Grimaldi, W. Bourguet, Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses. Comptes Rendus Biologies 340, 414–420 (2017). https://doi.org/ 10.1016/j.crvi.2017.08.002

J.J. Heindel, R. Newbold, T.T. Schug, Endocrine disruptors and obesity. Nat. Rev. Endocrinol. 11, 653–661 (2015). https://doi. org/10.1038/nrendo.2015.163

R.M. Sargis, Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals. Endocr. Disruptors 3, e1080788 (2015). https://doi.org/10.1080/23273747.2015.1080788

De Coster, S.; van Larebeke, N. Endocrine-disrupting chemicals: Associated disorders and mechanisms of action. J. Environ. Public Health 2012, 2012, 713696

Russart, K.L.G.; Nelson, R.J. Light at night as an environmental endocrine disruptor. Physiol. Behav. 2018, 190, 82–89. [CrossRef]

S.de Coster, N.van Larebeke,, Endocrine-disrupting chemicals: associated disorders and mechanisms of action. J. Environ. Public Health 2012, 1–52 (2012). https://doi.org/10.1155/2012/ 713696

T.T. Schug, A. Janesick, B. Blumberg, J.J. Heindel, Endocrine disrupting chemicals and disease susceptibility. J. Steroid Bio chem. Mol. Biol. 127, 204–215 (2011). https://doi.org/10.1016/j. jsbmb.2011.08.007

Diamanti-Kandarakis, E.; Bourguignon, J.P.; Giudice, L.C.; Hauser, R.; Prins, G.S.; Soto, A.M.; Zoeller, R.T.; Gore, A.C. Endocrine disrupting chemicals: An Endocrine Society scientific statement. Endocr. Rev. 2009, 30, 293–342.

Diamanti-Kandarakis, E.; Palioura, E.; Kandarakis, S.A.; Koutsilieris, M. The impact of endocrine disruptors on endocrine targets. Horm. Metab. Res. 2010, 42, 543–552.

Fekete, C.; Lechan, R.M. Central regulation of hypotha- lamic-pituitary-thyroid axis under physiological and pathophysiological conditions. Endocr. Rev. 2014, 35, 159–194. [CrossRef] [PubMed]

Triggiani, V.; Tafaro, E.; Giagulli, V.A.; Sabbà, C.; Resta, F.; Licchelli, B.; Guastamacchia, E. Role of iodine, selenium and other micronutrients in thyroid function and disorders. Endocr. Metab. Immune Disord. Drug Targets 2009, 9, 277–294.

Dumitrescu, A.M.; Refetoff, S. Inherited defects of thyroid hormone metabolism. Ann. Endocrinol. 2011, 72, 95–98.

Council on Environmental Health; Rogan, W.J.; Paulson, J.A.; Baum, C.; Brock-Utne, A.C.; Brumberg, H.L.; Campbell, C.C.; Lanphear, B.P.; Lowry, J.A.; Osterhoudt, K.C.; et al. Iodine deficiency, pollutant chemicals, and the thyroid: New information on an old problem. Pediatrics 2014, 133, 1163–1166.

Montaño, M.; Cocco, E.; Guignard, C.; Marsh, G.; Hoffmann, L.; Bergman, A.; Gutleb, A.C.; Murk, A.J. New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. Toxicol. Sci. 2012, 130, 94–105.

Ibhazehiebo, K.; Koibuchi, N. Thyroid hormone receptor- mediated transcription is suppressed by low dose phthalate. Niger. J. Physiol. Sci. 2011, 26, 143–149.

J.D. Meeker, K.K. Ferguson, Relationship between urinary phthalate and bisphenol A concentrations and serum thyroid measures in U.S. adults and adolescents from the national health and nutrition examination survey (NHANES) 2007–2008. Environ. Health Perspect. 119, 1396–1402 (2011). https://doi. org/10.1289/ehp.1103582

International Agency for Research on Cancer Classifications. Available at https://monographs.iarc.who.int/agents-classified by-the-iarc/. [Accessed April 7, 2022].

D. Cuomo, I. Porreca, G. Cobellis, R. Tarallo, G. Nassa, G. Falco, A. Nardone, F. Rizzo, M. Mallardo, C. Ambrosino, Car cinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands. Mol. Cell. Endocrinol. 457, 20–34 (2017). https://doi.org/10.1016/j.mce.2017.01.027

Hu,X.; Saunders, N.; Safley, S.; Smith, M.R.; Liang, Y.; Tran, V.; Sharma, J.; Jones, D.P.; Weber, C.J. Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors. Surgery 2021, 169, 102–108.

A.C. Pesatori, D. Consonni, M. Rubagotti, P. Grillo, P.A. Bertazzi, Cancer incidence in the population exposed to dioxin after the “Seveso accident”: twenty years of follow-up. Environ. Health 8, 39 (2009). https://doi.org/10.1186/1476 069X-8-39

V.H. Dang, T.H. Nguyen, G.S. Lee, K.C. Choi, E.B. Jeung, In vitro exposure to xenoestrogens induces growth hormone tran scription and release via estrogen receptor-dependent pathways in rat pituitary GH3 cells. Steroids 74, 707–714 (2009). https:// doi.org/10.1016/j.steroids.2009.03.002

J. Simard, J.-F. Hubert, T. Hosseinzadeh, F. Labrie, Stimulation of growth hormone release and synthesis by estrogens in rat anterior pituitary cells in culture. Endocrinology 119, 2004–2011 (1986). https://doi.org/10.1210/endo-119-5-2004

A. Shah, C.G. Coburn, A. Watson-Siriboe, R. Whitley, A. Shahidzadeh, E.R. Gillard, R. Nichol, M. Leon-Olea, M. Gaertner, P.R.S. Kodavanti, M.C. Currás-Collazo, Altered car diovascular reactivity and osmoregulation during hyperosmotic stress in adult rats developmentally exposed to polybrominated diphenyl ethers (PBDEs). Toxicol. Appl. Pharmacol. 256, 103–113 (2011).

W. Brogan, Effects of carbon tetrachloride on adrenocortical structure and function in guinea pigs. Toxicol. Appl. Pharma col. 75, 118–127 (1984). https://doi.org/10.1016/0041-008X (84)90082-6

Sargis, R.M. Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals. Endocr. Disruptors 2015, 3, e1080788

Hinson, J.P.; Raven, P.W. Effects of endocrine-disrupting chemicals on adrenal function. Best Pract. Res. Clin. Endocrinol. Metab. 2006, 20, 111–120.

Foulds, C.E.; Trevino, L.S.; York, B.; Walker, C.L. Endocrine-disrupting chemicals and fatty liver disease. Nat. Rev. Endocrinol. 2017, 13, 445–457.

R. Meli, A. Monnolo, C. Annunziata, C. Pirozzi, M.C. Ferrante, Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction. Antioxidants 9, 405 (2020). https://doi.org/10.3390/antiox9050405

Quesada, I.; Fuentes, E.; Viso-Leon, M.C.; Soria, B.; Ripoll, C.; Nadal, A. Low doses of the endocrine disruptor bisphenol-A and the native hormone 17-beta estradiol rapidly activate transcription factor CREB1. FASEB J. 2002, 16, 1671–1673.

Alonso-Magdalena, P.; Morimoto, S.; Ripoll, C.; Fuentes, E.; Nadal, A. The estrogenic effect of bisphenol-A disrupts-cell function in vivo and induces insulin-resistance. Environ. Health Perspect. 2006, 114, 106–112.

Alonso-Magdalena, P.; Laribi, O.; Ropero, A.B.; Fuentes, E.; Ripoll, C.; Soria, B.; Nadal, A. Low doses of bisphenol-A and diethystilbestrol impair Ca2+ signals in pancreatic-cells through a non classical membrane estrogen receptor within intact islets of Langerhans. Environ. Health Perspect. 2005, 113, 969–977.

Lenzen, S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008, 51, 216–226.

Cargnelutti, F.; Di Nisio, A.; Pallotti, F.; Sabovic, I.; Spaziani, M.; Tarsitano, M.G.; Paoli, D.; Foresta, C. Effects of endocrine disruptors on fetal testis development, male puberty, and transition age. Endocrine 2021, 72, 358–374.

Gea, M.; Toso, A.; Bentivegna, G.N.; Buganza, R.; Abrigo, E.; De Sanctis, L.; Schilirò, T. Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals: A Pilot Study. Int. J. Environ. Res. Public Health 2023, 20, 14

Polak, G.; Banaszewska, B.; Filip, M.; Radwan, M.; Wdowiak, A. Environmental Factors and Endometriosis. Int. J. Environ. Res. Public Health 2021, 18, 11025.

Kawa,I.A.; Akbar, M.; Fatima, Q.; Mir, S.A.; Jeelani, H.; Manzoor, S.; Rashid, F. Endocrine disrupting chemical Bisphenol A and its potential effects on female health. Diabetes Metab. Syndr. 2021, 15, 803–811.

Rehman,S.; Usman, Z.; Rehman, S.; AlDraihem, M.; Rehman, N.; Rehman, I.; Ahmad, G. Endocrine disrupting chemicals and impact on male reproductive health. Transl. Androl. Urol. 2018, 7, 490–503.]

Fenichel, P.; Chevalier, N.; Lahlou, N.; Coquillard, P.; Wagner-Mahler, K.; Pugeat, M.; Panaia-Ferrari, P.; Brucker-Davis, F. Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryp torchidism. Front. Endocrinol. 2018, 9, 786.

Sharma, A.; Mollier, J.; Brocklesby, R.W.; Caves, C.; Jayasena, C.N.; Minhas, S. Endocrine-disrupting chemicals and male reproductive health. Reprod. Med. Biol. 2020, 19, 243–253.

Richter, C.A.; Birnbaum, L.S.; Farabollini, F.; Newbold, R.R.; Rubin, B.S.; Talsness, C.E.; Vandenbergh, J.G.; Walser-Kuntz, D.R.; vomSaal, F.S. In vivo effects of bisphenol A in laboratory rodent studies. Reprod. Toxicol. 2007, 24, 199–224.

De Angelis, C.; Mazzella, M.; Pivonello, R. Interferenti endocrini e funzione gonadica: Focus su steroidogenesi testicolare e infertilità maschile. L’Endocrinologo 2022, 23, 52–60. [CrossRef]

Fittipaldi, S.; Bimonte, V.M.; Soricelli, A.; Aversa, A.; Lenzi, A.; Greco, E.A.; Migliaccio, S. Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: A potential mechanism of endocrine disruptor atherogenic effect. J. Endocrinol. Investig. 2019, 42, 727–739.

De Angelis, C.; Galdiero, M.; Pivonello, C.; Salzano, C.; Gianfrilli, D.; Piscitelli, P.; Lenzi, A.; Colao, A.; Pivonello, R. The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility. Reprod. Toxicol. 2017, 73, 105–127.

D. Cuomo, I. Porreca, G. Cobellis, R. Tarallo, G. Nassa, G. Falco, A. Nardone, F. Rizzo, M. Mallardo, C. Ambrosino, Car cinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands. Mol. Cell. Endocrinol. 457, 20–34 (2017). https://doi.org/10.1016/j.mce.2017.01.027

Sun W., Lei Y., Jiang Z., Wang K., Liu H., Xu T. (2024). BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway. J. Adv. Res. PubMed PMID: 38311007. Epub 2024/02/05. eng. 10.1016/j.jare.2024.01.029

Ngalame N.N.O., Makia N.L., Waalkes M.P., Tokar E.J. Mitigation of Arsenic-Induced Acquired Cancer Phenotype in Prostate Cancer Stem Cells by miR-143 Restoration. Toxicol. Appl. Pharmacol. 2016;312:11–18. doi: 10.1016/j.taap.2015.12.013.

Severson P.L., Tokar E.J., Vrba L., Waalkes M.P., Futscher B.W. Agglomerates of Aberrant DNA Methylation Are Associated with Toxicant-Induced Malignant Transformation. Epigenetics. 2012;7:1238–1248. doi: 10.4161/epi.22163.

Kitamura M., Kasai A. Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway. Cancer Lett. 2007;252:184–194. doi: 10.1016/j.canlet.2006.11.015.

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