Büyükbaş ve Küçükbaş Hayvanlarda Lipit Metabolizması

D. E. Bauman, J. W. Perfield, M. J. De Veth, and A. Lock, “New perspectives on lipid digestion and metabolism in ruminants,” in Proc. Cornell Nutr. Conf, Cornell University NY, USA, 2003, pp. 175–189.

J. K. Drackley, “Lipid metabolism.,” CABI, pp. 97–119, 2000, doi: 10.1079/9780851993782.0097.

C. García, R. L. A. Montiel, and T. F. Borderas, “Grasa y proteína de la leche de vaca: componentes, síntesis y modificación,” Arch. Zootec., vol. 63, pp. 85–105, 2014.

M. Lourenço, E. Ramos-Morales, and R. J. Wallace, “The role of microbes in rumen lipolysis and biohydrogenation and their manipulation,” Animal, vol. 4, no. 7, pp. 1008–1023, 2010.

V. B. Woods and A. M. Fearon, “Dietary sources of unsaturated fatty acids for animals and their transfer into meat, milk and eggs: A review,” Livest. Sci., vol. 126, no. 1–3, pp. 1–20, 2009.

C. J. O’Connor, R. D. Manuel, and K. W. Turner, “Calf and lamb lingual lipases as catalysts for the hydrolysis of tributyrin, triolein, and 4-nitrophenylacetate,” J. Dairy Sci., vol. 76, no. 12, pp. 3674–3682, 1993.

N. A. Ibrahim et al., “Effects of vegetable oil supplementation on rumen fermentation and microbial population in ruminant: A review,” Trop. Anim. Health Prod., vol. 53, pp. 1–11, 2021.

A. Buccioni, M. Decandia, S. Minieri, G. Molle, and A. Cabiddu, “Lipid metabolism in the rumen: New insights on lipolysis and biohydrogenation with an emphasis on the role of endogenous plant factors,” Anim. Feed Sci. Technol., vol. 174, no. 1–2, pp. 1–25, 2012.

A. L. Martínez Marín, M. Pérez Hernández, L. M. Pérez Alba, D. Carrión-Pardo, and A. G. Gómez-Castro, “Metabolismo de los lípidos en los rumiantes,” 2010.

K. A. Beauchemin, S. M. McGinn, C. Benchaar, and L. Holtshausen, “Crushed sunflower, flax, or canola seeds in lactating dairy cow diets: Effects on methane production, rumen fermentation, and milk production,” J. Dairy Sci., vol. 92, no. 5, pp. 2118–2127, 2009.

M. J. de Veth, J. M. Griinari, A.-M. Pfeiffer, and D. E. Bauman, “Effect of CLA on milk fat synthesis in dairy cows: comparison of inhibition by methyl esters and free fatty acids, and relationships among studies,” Lipids, vol. 39, no. 4, pp. 365–372, 2004.

P. Lacasse, J. J. Kennelly, L. Delbecchi, and C. E. Ahnadi, “Addition of protected and unprotected fish oil to diets for dairy cows. I. Effects on the yield, composition and taste of milk,” J. Dairy Res., vol. 69, no. 4, pp. 511–520, 2002.

D. L. Palmquist, “The role of dietary fats in efficiency of ruminants,” J. Nutr., vol. 124, pp. 1377S-1382S, 1994.

T. C. Jenkins, “Lipid metabolism in the rumen,” J. Dairy Sci., vol. 76, no. 12, pp. 3851–3863, 1993.

B. Vlaeminck, V. Fievez, A. R. J. Cabrita, A. J. M. Fonseca, and R. J. Dewhurst, “Factors affecting odd-and branched-chain fatty acids in milk: A review,” Anim. Feed Sci. Technol., vol. 131, no. 3–4, pp. 389–417, 2006.

R. G. Vernon, “Lipid metabolism in the adipose tissue of ruminant animals,” Lipid Metab. Rumin. Anim., pp. 279–362, 1981.

R. C. Noble, “Digestion, absorption and transport of lipids in ruminant animals,” Lipid Metab. Rumin. Anim., pp. 57–93, 1981.

G. M. Sheriha, G. R. Waller, T. Chan, and A. D. Tillman, “Composition of bile acids in ruminants,” Lipids, vol. 3, pp. 72–78, 1968.

A. F. Hofmann, “The continuing importance of bile acids in liver and intestinal disease,” Arch. Intern. Med., vol. 159, no. 22, pp. 2647–2658, 1999.

L. Guo, J. Yao, and Y. Cao, “Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more,” Anim. Nutr., vol. 7, no. 4, pp. 1145–1151, 2021.

R. D. L. Pacheco et al., “Lysolecithin-derived feed additive improves feedlot performance, carcass characteristics, and muscle fatty acid profile of Bos indicus-influenced cattle fed in a tropical environment,” Front. Vet. Sci., vol. 10, p. 1041479, 2023.

W. M. F. Leat and F. A. Harrison, “Digestion, absorption and transport of lipids in the sheep,” Dig. Metab. Rumin., pp. 481–495, 1975.

J. H. Moore and W. W. Christie, “Digestion, absorption and transport of fats in ruminant animals.,” 1984.

D. Bauchart, “Lipid absorption and transport in ruminants,” J. Dairy Sci., vol. 76, no. 12, pp. 3864–3881, 1993.

D. L. Palmquist, “Influence of source and amount of dietary fat on digestibility in lactating cows,” J. Dairy Sci., vol. 74, no. 4, pp. 1354–1360, 1991.

R. A. Nafikov and D. C. Beitz, “Carbohydrate and lipid metabolism in farm animals1,” J. Nutr., vol. 137, no. 3, pp. 702–705, 2007.

M. M. Hussain, R. K. Kancha, Z. Zhou, J. Luchoomun, H. Zu, and A. Bakillah, “Chylomicron assembly and catabolism: role of apolipoproteins and receptors,” Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., vol. 1300, no. 3, pp. 151–170, 1996.

J. E. Braun and D. L. Severson, “Regulation of the synthesis, processing and translocation of lipoprotein lipase,” Biochem. J., vol. 287, no. Pt 2, p. 337, 1992.

J. P. McNamara and J. K. Hillers, “Adaptations in lipid metabolism of bovine adipose tissue in lactogenesis and lactation.,” J. Lipid Res., vol. 27, no. 2, pp. 150–157, 1986.

C. J. Fielding and P. E. Fielding, “Molecular physiology of reverse cholesterol transport.,” J. Lipid Res., vol. 36, no. 2, pp. 211–228, 1995.

R. W. Hanson and F. J. Ballard, “The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants,” Biochem. J., vol. 105, no. 2, pp. 529–536, 1967.

S. B. Smith and J. D. Crouse, “Relative contributions of acetate, lactate and glucose to lipogenesis in bovine intramuscular and subcutaneous adipose tissue,” J. Nutr., vol. 114, no. 4, pp. 792–800, 1984.

C. A. Foko Kuate, O. Ebenhöh, B. M. Bakker, and A. Raguin, “Kinetic data for modeling the dynamics of the enzymes involved in animal fatty acid synthesis,” Biosci. Rep., vol. 43, no. 7, p. BSR20222496, 2023.

K.-H. Kim, “Regulation of mammalian acetyl-coenzyme A carboxylase,” Annu. Rev. Nutr., vol. 17, no. 1, pp. 77–99, 1997.

A. Kuhla, T. Blei, R. Jaster, and B. Vollmar, “Aging is associated with a shift of fatty metabolism toward lipogenesis,” Journals Gerontol. Ser. A Biomed. Sci. Med. Sci., vol. 66, no. 11, pp. 1192–1200, 2011.

I. Louveau, M.-H. Perruchot, M. Bonnet, and F. Gondret, “Invited review: Pre-and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology,” Animal, vol. 10, no. 11, pp. 1839–1847, 2016.

G. P. Laliotis, I. Bizelis, and E. Rogdakis, “Comparative approach of the de novo fatty acid synthesis (lipogenesis) between ruminant and non ruminant mammalian species: from biochemical level to the main regulatory lipogenic genes,” Curr. Genomics, vol. 11, no. 3, pp. 168–183, 2010.

P. Iommelli et al., “Stearoyl-CoA desaturase activity and gene expression in the adipose tissue of buffalo bulls was unaffected by diets with different fat content and fatty acid profile,” Agriculture, vol. 11, no. 12, p. 1209, 2021.

R. G. Jensen, “The composition of bovine milk lipids: January 1995 to December 2000,” J. Dairy Sci., vol. 85, no. 2, pp. 295–350, 2002.

M. C. Neville and M. F. Picciano, “Regulation of milk lipid secretion and composition,” Annu. Rev. Nutr., vol. 17, no. 1, pp. 159–184, 1997.

D. E. Bauman and J. M. Griinari, “Nutritional regulation of milk fat synthesis,” Annu. Rev. Nutr., vol. 23, no. 1, pp. 203–227, 2003.

D. E. Bauman, “Biosynthesis of milk fat.,” Lactation, pp. 31–75, 1974.

S. McCarthy and G. H. Smith, “Synthesis of milk fat from β-hydroxybutyrate and acetate by ruminant mammary tissue in vitro,” Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., vol. 260, no. 2, pp. 185–196, 1972.

Y. Yu et al., “Regulation of Milk Fat Synthesis: Key Genes and Microbial Functions,” Microorganisms, vol. 12, no. 11, p. 2302, 2024.

Y. Chilliard, A. Ferlay, Y. Faulconnier, M. Bonnet, J. Rouel, and F. Bocquier, “Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants,” Proc. Nutr. Soc., vol. 59, no. 1, pp. 127–134, 2000.

M. Lafontan and D. Langin, “Lipolysis and lipid mobilization in human adipose tissue,” Prog. Lipid Res., vol. 48, no. 5, pp. 275–297, 2009.

G. A. Contreras, C. Strieder-Barboza, and W. Raphael, “Adipose tissue lipolysis and remodeling during the transition period of dairy cows,” J. Anim. Sci. Biotechnol., vol. 8, pp. 1–12, 2017.

H. Tsuruta, K. Yamahara, M. Yasuda-Yamahara, and S. Kume, “Emerging pathophysiological roles of ketone bodies,” Physiology, vol. 39, no. 3, pp. 167–177, 2024.

Q. Qu, F. Zeng, X. Liu, Q. J. Wang, and F. Deng, “Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer,” Cell Death Dis., vol. 7, no. 5, pp. e2226–e2226, 2016.

F. Giannessi, “Carnitine palmitoyltransferase inhibitors in the management of type 2 diabetes: an old promise to be maintained,” Drugs Futur., vol. 28, pp. 371–381, 2003.

P. Schönfeld and L. Wojtczak, “Short-and medium-chain fatty acids in energy metabolism: the cellular perspective,” J. Lipid Res., vol. 57, no. 6, pp. 943–954, 2016.

G. C. Yaney and B. E. Corkey, “Fatty acid metabolism and insulin secretion in pancreatic beta cells,” Diabetologia, vol. 46, pp. 1297–1312, 2003.

F. Bocquier, N. Atti, A. Purroy, and Y. Chilliard, “The role of body reserves in the metabolic adaptation of different breeds of sheep to food shortage.,” 2000.

D. E. Bauman, J. W. Perfield, M. J. De Veth, and A. Lock, “New perspectives on lipid digestion and metabolism in ruminants,” in Proc. Cornell Nutr. Conf, Cornell University NY, USA, 2003, pp. 175–189.

J. K. Drackley, “Lipid metabolism.,” CABI, pp. 97–119, 2000, doi: 10.1079/9780851993782.0097.

C. García, R. L. A. Montiel, and T. F. Borderas, “Grasa y proteína de la leche de vaca: componentes, síntesis y modificación,” Arch. Zootec., vol. 63, pp. 85–105, 2014.

M. Lourenço, E. Ramos-Morales, and R. J. Wallace, “The role of microbes in rumen lipolysis and biohydrogenation and their manipulation,” Animal, vol. 4, no. 7, pp. 1008–1023, 2010.

V. B. Woods and A. M. Fearon, “Dietary sources of unsaturated fatty acids for animals and their transfer into meat, milk and eggs: A review,” Livest. Sci., vol. 126, no. 1–3, pp. 1–20, 2009.

C. J. O’Connor, R. D. Manuel, and K. W. Turner, “Calf and lamb lingual lipases as catalysts for the hydrolysis of tributyrin, triolein, and 4-nitrophenylacetate,” J. Dairy Sci., vol. 76, no. 12, pp. 3674–3682, 1993.

N. A. Ibrahim et al., “Effects of vegetable oil supplementation on rumen fermentation and microbial population in ruminant: A review,” Trop. Anim. Health Prod., vol. 53, pp. 1–11, 2021.

A. Buccioni, M. Decandia, S. Minieri, G. Molle, and A. Cabiddu, “Lipid metabolism in the rumen: New insights on lipolysis and biohydrogenation with an emphasis on the role of endogenous plant factors,” Anim. Feed Sci. Technol., vol. 174, no. 1–2, pp. 1–25, 2012.

A. L. Martínez Marín, M. Pérez Hernández, L. M. Pérez Alba, D. Carrión-Pardo, and A. G. Gómez-Castro, “Metabolismo de los lípidos en los rumiantes,” 2010.

K. A. Beauchemin, S. M. McGinn, C. Benchaar, and L. Holtshausen, “Crushed sunflower, flax, or canola seeds in lactating dairy cow diets: Effects on methane production, rumen fermentation, and milk production,” J. Dairy Sci., vol. 92, no. 5, pp. 2118–2127, 2009.

M. J. de Veth, J. M. Griinari, A.-M. Pfeiffer, and D. E. Bauman, “Effect of CLA on milk fat synthesis in dairy cows: comparison of inhibition by methyl esters and free fatty acids, and relationships among studies,” Lipids, vol. 39, no. 4, pp. 365–372, 2004.

P. Lacasse, J. J. Kennelly, L. Delbecchi, and C. E. Ahnadi, “Addition of protected and unprotected fish oil to diets for dairy cows. I. Effects on the yield, composition and taste of milk,” J. Dairy Res., vol. 69, no. 4, pp. 511–520, 2002.

D. L. Palmquist, “The role of dietary fats in efficiency of ruminants,” J. Nutr., vol. 124, pp. 1377S-1382S, 1994.

T. C. Jenkins, “Lipid metabolism in the rumen,” J. Dairy Sci., vol. 76, no. 12, pp. 3851–3863, 1993.

B. Vlaeminck, V. Fievez, A. R. J. Cabrita, A. J. M. Fonseca, and R. J. Dewhurst, “Factors affecting odd-and branched-chain fatty acids in milk: A review,” Anim. Feed Sci. Technol., vol. 131, no. 3–4, pp. 389–417, 2006.

R. G. Vernon, “Lipid metabolism in the adipose tissue of ruminant animals,” Lipid Metab. Rumin. Anim., pp. 279–362, 1981.

R. C. Noble, “Digestion, absorption and transport of lipids in ruminant animals,” Lipid Metab. Rumin. Anim., pp. 57–93, 1981.

G. M. Sheriha, G. R. Waller, T. Chan, and A. D. Tillman, “Composition of bile acids in ruminants,” Lipids, vol. 3, pp. 72–78, 1968.

A. F. Hofmann, “The continuing importance of bile acids in liver and intestinal disease,” Arch. Intern. Med., vol. 159, no. 22, pp. 2647–2658, 1999.

L. Guo, J. Yao, and Y. Cao, “Regulation of pancreatic exocrine in ruminants and the related mechanism: The signal transduction and more,” Anim. Nutr., vol. 7, no. 4, pp. 1145–1151, 2021.

R. D. L. Pacheco et al., “Lysolecithin-derived feed additive improves feedlot performance, carcass characteristics, and muscle fatty acid profile of Bos indicus-influenced cattle fed in a tropical environment,” Front. Vet. Sci., vol. 10, p. 1041479, 2023.

W. M. F. Leat and F. A. Harrison, “Digestion, absorption and transport of lipids in the sheep,” Dig. Metab. Rumin., pp. 481–495, 1975.

J. H. Moore and W. W. Christie, “Digestion, absorption and transport of fats in ruminant animals.,” 1984.

D. Bauchart, “Lipid absorption and transport in ruminants,” J. Dairy Sci., vol. 76, no. 12, pp. 3864–3881, 1993.

D. L. Palmquist, “Influence of source and amount of dietary fat on digestibility in lactating cows,” J. Dairy Sci., vol. 74, no. 4, pp. 1354–1360, 1991.

R. A. Nafikov and D. C. Beitz, “Carbohydrate and lipid metabolism in farm animals1,” J. Nutr., vol. 137, no. 3, pp. 702–705, 2007.

M. M. Hussain, R. K. Kancha, Z. Zhou, J. Luchoomun, H. Zu, and A. Bakillah, “Chylomicron assembly and catabolism: role of apolipoproteins and receptors,” Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., vol. 1300, no. 3, pp. 151–170, 1996.

J. E. Braun and D. L. Severson, “Regulation of the synthesis, processing and translocation of lipoprotein lipase,” Biochem. J., vol. 287, no. Pt 2, p. 337, 1992.

J. P. McNamara and J. K. Hillers, “Adaptations in lipid metabolism of bovine adipose tissue in lactogenesis and lactation.,” J. Lipid Res., vol. 27, no. 2, pp. 150–157, 1986.

C. J. Fielding and P. E. Fielding, “Molecular physiology of reverse cholesterol transport.,” J. Lipid Res., vol. 36, no. 2, pp. 211–228, 1995.

R. W. Hanson and F. J. Ballard, “The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants,” Biochem. J., vol. 105, no. 2, pp. 529–536, 1967.

S. B. Smith and J. D. Crouse, “Relative contributions of acetate, lactate and glucose to lipogenesis in bovine intramuscular and subcutaneous adipose tissue,” J. Nutr., vol. 114, no. 4, pp. 792–800, 1984.

C. A. Foko Kuate, O. Ebenhöh, B. M. Bakker, and A. Raguin, “Kinetic data for modeling the dynamics of the enzymes involved in animal fatty acid synthesis,” Biosci. Rep., vol. 43, no. 7, p. BSR20222496, 2023.

K.-H. Kim, “Regulation of mammalian acetyl-coenzyme A carboxylase,” Annu. Rev. Nutr., vol. 17, no. 1, pp. 77–99, 1997.

A. Kuhla, T. Blei, R. Jaster, and B. Vollmar, “Aging is associated with a shift of fatty metabolism toward lipogenesis,” Journals Gerontol. Ser. A Biomed. Sci. Med. Sci., vol. 66, no. 11, pp. 1192–1200, 2011.

I. Louveau, M.-H. Perruchot, M. Bonnet, and F. Gondret, “Invited review: Pre-and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology,” Animal, vol. 10, no. 11, pp. 1839–1847, 2016.

G. P. Laliotis, I. Bizelis, and E. Rogdakis, “Comparative approach of the de novo fatty acid synthesis (lipogenesis) between ruminant and non ruminant mammalian species: from biochemical level to the main regulatory lipogenic genes,” Curr. Genomics, vol. 11, no. 3, pp. 168–183, 2010.

P. Iommelli et al., “Stearoyl-CoA desaturase activity and gene expression in the adipose tissue of buffalo bulls was unaffected by diets with different fat content and fatty acid profile,” Agriculture, vol. 11, no. 12, p. 1209, 2021.

R. G. Jensen, “The composition of bovine milk lipids: January 1995 to December 2000,” J. Dairy Sci., vol. 85, no. 2, pp. 295–350, 2002.

M. C. Neville and M. F. Picciano, “Regulation of milk lipid secretion and composition,” Annu. Rev. Nutr., vol. 17, no. 1, pp. 159–184, 1997.

D. E. Bauman and J. M. Griinari, “Nutritional regulation of milk fat synthesis,” Annu. Rev. Nutr., vol. 23, no. 1, pp. 203–227, 2003.

D. E. Bauman, “Biosynthesis of milk fat.,” Lactation, pp. 31–75, 1974.

S. McCarthy and G. H. Smith, “Synthesis of milk fat from β-hydroxybutyrate and acetate by ruminant mammary tissue in vitro,” Biochim. Biophys. Acta (BBA)-Lipids Lipid Metab., vol. 260, no. 2, pp. 185–196, 1972.

Y. Yu et al., “Regulation of Milk Fat Synthesis: Key Genes and Microbial Functions,” Microorganisms, vol. 12, no. 11, p. 2302, 2024.

Y. Chilliard, A. Ferlay, Y. Faulconnier, M. Bonnet, J. Rouel, and F. Bocquier, “Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants,” Proc. Nutr. Soc., vol. 59, no. 1, pp. 127–134, 2000.

M. Lafontan and D. Langin, “Lipolysis and lipid mobilization in human adipose tissue,” Prog. Lipid Res., vol. 48, no. 5, pp. 275–297, 2009.

G. A. Contreras, C. Strieder-Barboza, and W. Raphael, “Adipose tissue lipolysis and remodeling during the transition period of dairy cows,” J. Anim. Sci. Biotechnol., vol. 8, pp. 1–12, 2017.

H. Tsuruta, K. Yamahara, M. Yasuda-Yamahara, and S. Kume, “Emerging pathophysiological roles of ketone bodies,” Physiology, vol. 39, no. 3, pp. 167–177, 2024.

Q. Qu, F. Zeng, X. Liu, Q. J. Wang, and F. Deng, “Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer,” Cell Death Dis., vol. 7, no. 5, pp. e2226–e2226, 2016.

F. Giannessi, “Carnitine palmitoyltransferase inhibitors in the management of type 2 diabetes: an old promise to be maintained,” Drugs Futur., vol. 28, pp. 371–381, 2003.

P. Schönfeld and L. Wojtczak, “Short-and medium-chain fatty acids in energy metabolism: the cellular perspective,” J. Lipid Res., vol. 57, no. 6, pp. 943–954, 2016.

G. C. Yaney and B. E. Corkey, “Fatty acid metabolism and insulin secretion in pancreatic beta cells,” Diabetologia, vol. 46, pp. 1297–1312, 2003.

F. Bocquier, N. Atti, A. Purroy, and Y. Chilliard, “The role of body reserves in the metabolic adaptation of different breeds of sheep to food shortage.,” 2000.