Travmatik Hemorajik Kontuzyon
Özet
Travmatik hemorajik kontüzyon, travmatik beyin hasarını takiben en sık gözlenen intrakraniyal lezyonlardan biridir ve sıklıkla frontal ve temporal lobları etkiler. Lezyonlar intrakraniyal basınç artışı ve herniasyon gibi ciddi sekonder komplikasyonlara neden olabilir. Kontüzyon hacminin değerlendirilmesinde yaygın olarak kullanılan ABC/2 yöntemi, lezyon takibi ve tedavi planlamasında pratik bir araçtır. Hacim artışı ≥%33 veya ≥12.5 mL olduğunda progresyondan söz edilir. Düşük Glasgow Koma Skoru (≤8), ileri yaş, antikoagülan/antiplatelet kullanımı, yüksek nötrofil/lenfosit oranı (NLR) ve monosit/lenfosit oranı (MLR) progresyonun belirteçleri arasında yer almaktadır. Tanıda bilgisayarlı tomografi hızlı ve etkili bir yöntemken, manyetik rezonans görüntüleme özellikle ödem ve mikroskobik lezyonları ortaya koymada üstündür. Tedavi yaklaşımı konservatif ve cerrahi yöntemler arasında bireyselleştirilmelidir. Komplikasyonlar arasında posttravmatik epilepsi, hidrosefali, enfeksiyonlar ve koagülopati ön plandadır. Bu nedenle erken tanı, multidisipliner yaklaşım ve zamanında müdahale, klinik sonuçları iyileştirmede kritik rol oynar.
Traumatic hemorrhagic contusion is one of the most commonly observed intracranial lesions following traumatic brain injury and typically affects the frontal and temporal lobes. These lesions may result in serious secondary complications such as elevated intracranial pressure and herniation. The ABC/2 method is frequently used to estimate contusion volume and aids in both monitoring and treatment planning. A volumetric increase of ≥33% or ≥12.5 mL is considered significant for progression. Predictive factors for progression include low Glasgow Coma Scale (≤8), advanced age, use of anticoagulant/antiplatelet agents, and elevated neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR). While computed tomography provides a rapid and effective diagnostic tool, magnetic resonance imaging offers superior detection of edema and microscopic lesions. Treatment strategies should be individualized and may involve either conservative or surgical approaches. Common complications include post-traumatic epilepsy, hydrocephalus, infections, and coagulopathy. Therefore, early diagnosis, multidisciplinary management, and timely intervention play a crucial role in improving clinical outcomes.
Referanslar
Najem D, Rennie K, Ribecco-Lutkiewicz M, Ly D, Haukenfrers J, Liu Q, et al. Traumatic brain injury: classification, models, and markers. Biochemistry and cell biology. 2018;96(4):391-406.
Vella MA, Crandall ML, Patel MB. Acute management of traumatic brain injury. Surgical Clinics. 2017;97(5):1015-30.
Dewan MC, Rattani A, Gupta S, Baticulon RE, Hung Y-C, Punchak M, et al. Estimating the global incidence of traumatic brain injury. Journal of neurosurgery. 2018;130(4):1080-97.
Pellot JE, De Jesus O. Cerebral contusion. 2020.
Maas AI, Menon DK, Adelson PD, Andelic N, Bell MJ, Belli A, et al. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. The Lancet Neurology. 2017;16(12):987-1048.
Adatia K, Newcombe VF, Menon DK. Contusion progression following traumatic brain injury: a review of clinical and radiological predictors, and influence on outcome. Neurocritical care. 2021;34(1):312-24.
Jirlow U, Hossain I, Korhonen O, Depreitere B, Rostami E. Cerebral contusions-Pathomechanism, predictive factors for progression and historical and current management. Brain and Spine. 2024:103329.
Greve MW, Zink BJ. Pathophysiology of traumatic brain injury. Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine: A Journal of Translational and Personalized Medicine. 2009;76(2):97-104.
Werner C, Engelhard K. Pathophysiology of traumatic brain injury. British journal of anaesthesia. 2007;99(1):4-9.
Loane DJ, Kumar A. Microglia in the TBI brain: the good, the bad, and the dysregulated. Experimental neurology. 2016;275:316-27.
Zhang H, Duan X, Zhang Y, Zhuang G, Cao D, Meng W, et al. Association between Monocyte-to-lymphocyte ratio and hematoma progression after cerebral contusion. Neurocritical Care. 2024;40(3):953-63.
Leary OP, Merck LH, Yeatts SD, Pan I, Liu DD, Harder TJ, et al. Computer-assisted measurement of traumatic brain hemorrhage volume is more predictive of functional outcome and mortality than standard abc/2 method: an analysis of computed tomography imaging data from the progesterone for traumatic brain injury experimental clinical treatment phase-iii trial. Journal of Neurotrauma. 2021;38(5):604-15.
Baldon IV, Amorim AC, Santana LM, Solla DJ, Kolias A, Hutchinson P, et al. The extravasation of contrast as a predictor of cerebral hemorrhagic contusion expansion, poor neurological outcome and mortality after traumatic brain injury: A systematic review and meta-analysis. Plos one. 2020;15(7):e0235561.
Coles J. Imaging after brain injury. British journal of anaesthesia. 2007;99(1):49-60.
Yuh EL, Mukherjee P, Lingsma HF, Yue JK, Ferguson AR, Gordon WA, et al. Magnetic resonance imaging improves 3‐month outcome prediction in mild traumatic brain injury. Annals of neurology. 2013;73(2):224-35.
Marehbian J, Muehlschlegel S, Edlow BL, Hinson HE, Hwang DY. Medical management of the severe traumatic brain injury patient. Neurocritical care. 2017;27:430-46.
Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, et al. Surgical management of traumatic parenchymal lesions. Neurosurgery. 2006;58(3):S2-25.
Golub VM, Reddy DS. Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions. Pharmacological reviews. 2022;74(2):387-438.
Chen K-H, Lee C-P, Yang Y-H, Yang Y-H, Chen C-M, Lu M-L, et al. Incidence of hydrocephalus in traumatic brain injury: a nationwide population-based cohort study. Medicine. 2019;98(42):e17568.
Kourbeti I, Vakis A, Papadakis J, Karabetsos D, Bertsias G, Filippou M, et al. Infections in traumatic brain injury patients. Clinical microbiology and infection. 2012;18(4):359-64.
Juratli TA, Zang B, Litz RJ, Sitoci K-H, Aschenbrenner U, Gottschlich B, et al. Early hemorrhagic progression of traumatic brain contusions: frequency, correlation with coagulation disorders, and patient outcome: a prospective study. Journal of neurotrauma. 2014;31(17):1521-7.