Cinsel İşlev Bozukluğu
Özet
Genel sağlık ve yaşam kalitesinin ayrılmaz bir parçası olan cinsel sağlık (CS), kanser ve kanser tedavisinden olumsuz etkilenebilir. CS biyolojik, psikolojik, sosyal ve kültürel faktörlerden ve ergenler ve genç yetişkinler (EGET'ler) için gelişimsel faktörlerden etkilenir. EGET popülasyonu (15-39 yaş) psikoseksüel gelişim, kişiler arası ilişkiler ve farklı bağımsızlık düzeyleri açısından çeşitlilik göstermekte ve bu popülasyon için benzersiz CS ihtiyaçları ortaya çıkmaktadır. Kanser hastası EGET'ler, doğum kontrolü ve enfeksiyonun önlenmesi, cinsel işlev, beden imajı ve romantik/cinsel ilişkilerle ilgili karşılanmamış CS ihtiyaçlarına karşı özellikle savunmasızdır. Kanser tedavisi sırasında ve sonrasında cinsel işlev bozukluğu, EGET kanserden kurtulanların %30-%100'ü tarafından bildirilmektedir. Klinik kılavuzlar CS 'nin tartışılmasını ve işlev bozukluğu taramasını önermektedir, ancak şu anda psikoseksüel müdahaleler ve taramayı klinik bakıma dahil etme stratejileri ile ilgili ayrıntılar eksiktir. Araştırma ve klinik öncelikler arasında CS ile ilgili sağlayıcı- EGET iletişiminin iyileştirilmesi, CS ölçümlerinin ve tarama araçlarının standardizasyonu, pediatrik ve yetişkin klinik ortamlarında EGET 'lirin CS ihtiyaçlarını destekleyecek altyapı ve cinsel ve cinsiyet azınlığı EGET 'lirin araştırmaya katılımı yer almaktadır. Kanserde CS alanı geliştikçe, müdahalelerin EGET 'lere özgü gelişimsel ihtiyaçlara göre uyarlanması ve CS’ nin çok boyutlu yönlerini ele alması gerekmektedir.
Sexual health (SH), an integral part of general health and quality of life, can be negatively affected by cancer and cancer treatment. SH is influenced by biological, psychological, social and cultural factors and developmental factors for adolescents and young adults (AYAs). The AYA population (15-39 years) is diverse in terms of psychosexual development, interpersonal relationships, and different levels of independence, resulting in unique SH needs for this population. AYAs with cancer are particularly vulnerable to unmet SH needs related to contraception and infection prevention, sexual function, body image, and romantic/sexual relationships. Sexual dysfunction during and after cancer treatment is reported by 30%-100% of AYA cancer survivors. Clinical guidelines recommend discussion of SH and screening for dysfunction, but currently lack details regarding psychosexual interventions and strategies for incorporating screening into clinical care. Research and clinical priorities include improving provider-AYA communication regarding SH, standardisation of SH measures and screening tools, infrastructure to support the SH needs of AYAs in paediatric and adult clinical settings, and involvement of sexual and gender minority AYAs in research. As the field of SH in cancer evolves, interventions need to be tailored to the developmental needs specific to AYAs and address multidimensional aspects of SH.
Referanslar
DeLamater J, Friedrich WN. Human sexual development. Vol. 39, Journal of Sex Research. 2002.
Bancroft J. Human Sexuality and its Problems: Third Edition. Human Sexuality and its Problems: Third Edition. 2008.
McKee A, Albury K, Dunne M, Grieshaber S, Hartley J, Lumby C, et al. Healthy sexual development: A multidisciplinary framework for research. International Journal of Sexual Health. 2010;22(1).
World Health Organization. Defining Sexual Health. World Health Organization. 2006;(January).
Flynn KE, Lin L, Bruner DW, Cyranowski JM, Hahn EA, Jeffery DD, et al. Sexual Satisfaction and the Importance of Sexual Health to Quality of Life Throughout the Life Course of U.S. Adults. Journal of Sexual Medicine. 2016;13(11).
Frederick NN, Bingen K, Bober SL, Cherven B, Xu X, Quinn GP, et al. Pediatric oncology clinician communication about sexual health with adolescents and young adults: A report from the children’s oncology group. Cancer Med. 2021;10(15).
Lehmann V, Keim MC, Ferrante AC, Olshefski RS, Gerhardt CA. Psychosexual development and satisfaction with timing of developmental milestones among adult survivors of childhood cancer. Psychooncology. 2018;27(8).
Candy B, Jones L, Vickerstaff V, Tookman A, King M. Interventions for sexual dysfunction following treatments for cancer in women. Vol. 2016, Cochrane Database of Systematic Reviews. 2016.
Liavaag AH, Dørum A, Bjøro T, Oksefjell H, Fosså SD, Tropé C, et al. A controlled study of sexual activity and functioning in epithelial ovarian cancer survivors. A therapeutic approach. Gynecol Oncol. 2008;108(2).
Guntupalli SR, Sheeder J, Ioffe Y, Tergas A, Wright JD, Davidson SA, et al. Sexual and Marital Dysfunction in Women With Gynecologic Cancer. In: International Journal of Gynecological Cancer. 2017.
Lim-Watson MZ, Hays RD, Kingsberg S, Kallich JD, Murimi-Worstell IB. A Systematic Literature Review of Health-related Quality of Life Measures for Women with Hypoactive Sexual Desire Disorder and Female Sexual Interest/Arousal Disorder. Vol. 10, Sexual Medicine Reviews. 2022.
Murphy D, Klosky JL, Termuhlen A, Sawczyn KK, Quinn GP. The need for reproductive and sexual health discussions with adolescent and young adult cancer patients. Vol. 88, Contraception. 2013.
Ojha RP, Tota JE, Offutt-Powell TN, Klosky JL, Minniear TD, Jackson BE, et al. Human Papillomavirus-Associated Subsequent Malignancies among Long-Term Survivors of Pediatric and Young Adult Cancers. PLoS One. 2013;8(8).
Cherven B, Sampson A, Bober SL, Bingen K, Frederick N, Freyer DR, et al. Sexual health among adolescent and young adult cancer survivors: A scoping review from the Children’s Oncology Group Adolescent and Young Adult Oncology Discipline Committee. CA Cancer J Clin. 2021;71(3).
Stanton AM, Handy AB, Meston CM. Sexual function in adolescents and young adults diagnosed with cancer: A systematic review. Vol. 12, Journal of Cancer Survivorship. 2018.
Schover LR. Sexual quality of life in men and women after cancer. Vol. 22, Climacteric. 2019.
Maiorino MI, Chiodini P, Bellastella G, Giugliano D, Esposito K. Sexual dysfunction in women with cancer: a systematic review with meta-analysis of studies using the Female Sexual Function Index. Endocrine. 2016;54(2).
Rosenberg SM, Tamimi RM, Gelber S, Ruddy KJ, Bober SL, Kereakoglow S, et al. Treatment-related amenorrhea and sexual functioning in young breast cancer survivors. Cancer. 2014;120(15).
Hovén E, Fagerkvist K, Jahnukainen K, Ljungman L, Lähteenmäki PM, Axelsson O, et al. Sexual dysfunction in young adult survivors of childhood cancer – A population-based study. Eur J Cancer. 2021;154.
Lehmann V, Hagedoorn M, Gerhardt CA, Fults M, Olshefski RS, Sanderman R, et al. Body issues, sexual satisfaction, and relationship status satisfaction in long-term childhood cancer survivors and healthy controls. Psychooncology. 2016;25(2).
Wettergren L, Kent EE, Mitchell SA, Zebrack B, Lynch CF, Rubenstein MB, et al. Cancer negatively impacts on sexual function in adolescents and young adults: The AYA HOPE study. Psychooncology. 2017;26(10).
Olsson M, Steineck G, Enskär K, Wilderäng U, Jarfelt M. Sexual function in adolescent and young adult cancer survivors—a population-based study. Journal of Cancer Survivorship. 2018;12(4).
Vani MF, Lucibello KM, Trinh L, Santa Mina D, Sabiston CM. Body image among adolescents and young adults diagnosed with cancer: A scoping review. Vol. 30, Psycho-Oncology. 2021.
Moore JB, Canzona MR, Puccinelli-Ortega N, Little-Greene D, Duckworth KE, Fingeret MC, et al. A qualitative assessment of body image in adolescents and young adults (AYAs) with cancer. Psychooncology. 2021;30(4).
Nahata L, Morgan TL, Lipak KG, Olshefski RS, Gerhardt CA, Lehmann V. Romantic Relationships and Physical Intimacy among Survivors of Childhood Cancer. J Adolesc Young Adult Oncol. 2020;9(3).
Hughes MK. Sexuality and the cancer survivor: A silent coexistence. Cancer Nurs. 2000;23(6).
Ussher JM, Allison K, Perz J, Power R. LGBTQI cancer patients’ quality of life and distress: A comparison by gender, sexuality, age, cancer type and geographical remoteness. Front Oncol. 2022;12.
Meana M, Binik YM, Khalife S, Cohen DR. Biopsychosocial profile of women with dyspareunia. Obstetrics and Gynecology. 1997;90(4).
Goldstein AT, Pukall CF, Goldstein I. Female sexual pain disorders: Evaluation and management. Female Sexual Pain Disorders: Evaluation and Management. 2020.
Andersen BL, DeRubeis RJ, Berman BS, Gruman J, Champion VL, Massie MJ, et al. Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: An American Society of Clinical Oncology guideline adaptation. Vol. 32, Journal of Clinical Oncology. 2014.
Weaver KE, Forsythe LP, Reeve BB, Alfano CM, Rodriguez JL, Sabatino SA, et al. Mental and physical health-related quality of life among U.S. cancer survivors: Population estimates from the 2010 National Health Interview Survey. Cancer Epidemiology Biomarkers and Prevention. 2012;21(11).
Coccia PF, Pappo AS, Beaupin L, Borges VF, Borinstein SC, Chugh R, et al. Adolescent and young adult oncology, version 2.2018: Clinical practice guidelines in oncology. Vol. 16, JNCCN Journal of the National Comprehensive Cancer Network. 2018.
Children’s Oncology Group. Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent and Young Adult Cancers. Children’s Oncology Group. 2018;(October).
Carter J, Lacchetti C, Andersen BL, Barton DL, Bolte S, Damast S, et al. Interventions to address sexual problems in people with cancer: American society of clinical oncology clinical practice guideline adaptation of cancer care Ontario guideline. Journal of Clinical Oncology. 2018;36(5).
Meacham LR, Burns K, Orwig KE, Levine J. Standardizing Risk Assessment for Treatment-Related Gonadal Insufficiency and Infertility in Childhood Adolescent and Young Adult Cancer: The Pediatric Initiative Network Risk Stratification System. Vol. 9, Journal of Adolescent and Young Adult Oncology. 2020.
Mulder RL, Font-Gonzalez A, Green DM, Loeffen EAH, Hudson MM, Loonen J, et al. Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group. Vol. 22, The Lancet Oncology. 2021.
Nahata L, Liles SM, Gerhardt CA, Housten AJ, Jalili D, O’Brien SH, et al. Clinicians’ perspectives on barriers and facilitators to sperm banking in adolescent males with cancer: a mixed-methods study. J Assist Reprod Genet. 2023;40(12).
Laurence V, Gbolade BA, Morgan SJ, Glaser A. Contraception for teenagers and young adults with cancer. Eur J Cancer. 2004;40(18).
Committee Opinion No. 539: Adolescents and long-acting reversible contraception: Implants and intrauterine devices. Vol. 120, Obstetrics and Gynecology. 2012.
Patel A, Schwarz EB. Cancer and contraception. Contraception. 2012;86(3).
Carter J, Stabile C, Seidel B, Baser RE, Goldfarb S, Goldfrank DJ. Vaginal and sexual health treatment strategies within a female sexual medicine program for cancer patients and survivors. Journal of Cancer Survivorship. 2017;11(2).
Labrie F, Archer DF, Koltun W, Vachon A, Young D, Frenette L, et al. Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause. Menopause. 2018;25(11).
Bruyniks N, Nappi RE, Castelo-Branco C, De Villiers TJ, Simon J. Effect of ospemifene on moderate or severe symptoms of vulvar and vaginal atrophy. Climacteric. 2016;19(1).
