Ağrı
Özet
Kanser tedavisinde sağkalım oranlarının artmasıyla birlikte, sürveyans dönemi hasta yönetiminde önemli bir aşama haline gelmiştir. Bu süreçte ağrı, sık karşılaşılan ve multidisipliner bir yaklaşım gerektiren bir sorun olarak öne çıkar. Kanserle ilişkili ağrı, yalnızca hastalığın ilerlemesi veya nüksünün bir göstergesi değil, aynı zamanda tedavi sonrası komplikasyonlar, psikososyal faktörler ve eşlik eden hastalıklara bağlı olarak da ortaya çıkabilir. Kanser kaynaklı kronik ağrı, primer tümör, metastazlar veya tedavi süreçleriyle ilişkili olabilir. Ağrının yaygınlığı, kanser türü ve evresi gibi faktörlere bağlı olarak değişiklik göstermekle birlikte, pankreas ve baş-boyun kanserlerinde daha yüksek orandadır. Tedavi sonrası dönemde ağrının en sık nedenleri arasında kemoterapiye bağlı periferik nöropati, radyasyona bağlı komplikasyonlar ve cerrahi sonrası ağrı bulunur. Etkili ağrı yönetimi, sadece hastaların fiziksel iyilik halini artırmakla kalmaz, aynı zamanda potansiyel nükslerin ve komplikasyonların erken teşhis edilmesine de olanak tanır. Bu bölüm, sürveyans döneminde ağrının değerlendirilmesi, olası nedenleri ve yönetim stratejilerini ele alarak, klinisyenlere pratik bir rehber sunmayı amaçlamaktadır. Ağrı yönetimindeki gelişmeler, hedeflenmiş ve kişiselleştirilmiş tedavi yaklaşımlarıyla kanser hastalarının yaşam kalitesini artırmada büyük bir potansiyel sunmaktadır.
As survival rates in cancer treatment have increased, the surveillance period has become an important phase in patient management. During this process, pain emerges as a common issue that requires a multidisciplinary approach. Cancer-related pain may not only be a sign of disease progression or recurrence, but can also arise due to post-treatment complications, psychosocial factors, and comorbid conditions. Chronic cancer pain can be associated with the primary tumor, metastases, or treatment processes. The prevalence of pain varies depending on factors such as cancer type and stage, with higher rates observed in pancreatic and head-neck cancers. In the post-treatment period, the most common causes of pain include chemotherapy-induced peripheral neuropathy, radiation-related complications, and post-surgical pain. Effective pain management not only enhances the physical well-being of patients but also facilitates the early detection of potential recurrences and complications. This chapter aims to provide clinicians with a practical guide by discussing the assessment of pain during the surveillance period, its possible causes, and management strategies. Advances in pain management offer great potential to improve the quality of life for cancer patients through more targeted and personalized treatment approaches.
Referanslar
Bennett, M.I., et al., The IASP classification of chronic pain for ICD-11: chronic cancer-related pain. Pain, 2019. 160(1): p. 38-44.
Raja, S.N., et al., The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain, 2020. 161(9): p. 1976-1982.
Van den Beuken-van Everdingen, M., et al., Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Annals of oncology, 2007. 18(9): p. 1437-1449.
Burton, A.W., et al., Chronic pain in the cancer survivor: a new frontier. Pain Medicine, 2007. 8(2): p. 189-198.
Sun, V., et al., Barriers to pain assessment and management in cancer survivorship. Journal of Cancer Survivorship, 2008. 2: p. 65-71.
Grudzen, C.R., et al., Emergency department–initiated palliative care in advanced cancer: a randomized clinical trial. JAMA oncology, 2016. 2(5): p. 591-598.
Laird, B.J., et al., Are cancer pain and depression interdependent? A systematic review. Psycho‐Oncology: Journal of the Psychological, Social and Behavioral Dimensions of Cancer, 2009. 18(5): p. 459-464.
Paolucci, T. and V.M. Saraceni, Management of chronic pain in osteoporosis: challenges and solutions. Journal of pain research, 2016: p. 177-186.
Fallon, M., Neuropathic pain in cancer. British journal of anaesthesia, 2013. 111(1): p. 105-111.
Caraceni, A. and S.M. Weinstein, Classification of cancer pain syndromes. Oncology (Williston Park, NY), 2001. 15(12): p. 1627-40, 1642; discussion 1642.
Schaible, H.-G. and F. Richter, Pathophysiology of pain. Langenbeck's archives of surgery, 2004. 389: p. 237-243.
Fong, A. and S.A. Schug, Pathophysiology of pain: a practical primer. Plastic and reconstructive surgery, 2014. 134(4S-2): p. 8S-14S.
Rowe, J.M., et al., Recommended guidelines for the management of autologous and allogeneic bone marrow transplantation: a report from the Eastern Cooperative Oncology Group (ECOG). Annals of Internal Medicine, 1994. 120(2): p. 143-158.
Péus, D., N. Newcomb, and S. Hofer, Appraisal of the Karnofsky Performance Status and proposal of a simple algorithmic system for its evaluation. BMC medical informatics and decision making, 2013. 13: p. 1-7.
Caraceni, A., et al., Pain measurement tools and methods in clinical research in palliative care: recommendations of an Expert Working Group of the European Association of Palliative Care. Journal of pain and symptom management, 2002. 23(3): p. 239-255.
Ngamkham, S., et al., The McGill Pain Questionnaire as a multidimensional measure in people with cancer: an integrative review. Pain Management Nursing, 2012. 13(1): p. 27-51.
Van Herk, R., et al., Observation scales for pain assessment in older adults with cognitive impairments or communication difficulties. Nursing Research, 2007. 56(1): p. 34-43.
Jackson-Koku, G., Beck depression inventory. Occupational medicine, 2016. 66(2): p. 174-175.
Bech, P., et al., The Hamilton Depression Scale (HAM-D) and the Montgomery–Åsberg Depression Scale (MADRS). A psychometric re-analysis of the European Genome-Based Therapeutic Drugs for Depression Study using Rasch analysis. Psychiatry research, 2014. 217(3): p. 226-232.
Stern, A.F., The hospital anxiety and depression scale. Occupational medicine, 2014. 64(5): p. 393-394.
Wiffen, P.J., et al., Oral paracetamol (acetaminophen) for cancer pain. Cochrane Database of Systematic Reviews, 2017(7).
Derry, S., et al., Oral nonsteroidal anti‐inflammatory drugs (NSAIDs) for cancer pain in adults. Cochrane Database of Systematic Reviews, 2017(7).
Straube, C., et al., Codeine, alone and with paracetamol (acetaminophen), for cancer pain. Cochrane Database of Systematic Reviews, 2014(9).
Wiffen, P.J., S. Derry, and R.A. Moore, Tramadol with or without paracetamol (acetaminophen) for cancer pain. Cochrane Database of Systematic Reviews, 2017(5).
Caraceni, A., et al., Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. The lancet oncology, 2012. 13(2): p. e58-e68.
Klepstad, P., S. Kaasa, and P.C. Borchgrevink, Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review. Palliative medicine, 2011. 25(5): p. 424-430.
Paice, J.A., et al., Use of opioids for adults with pain from cancer or cancer treatment: ASCO guideline. Journal of Clinical Oncology, 2023. 41(4): p. 914-930.
Swarm, R.A. and M. Dans, NCCN frameworks for resource stratification of NCCN guidelines: adult cancer pain and palliative care. Journal of the National Comprehensive Cancer Network, 2018. 16(5S): p. 628-631.
Fallon, M., et al., Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Annals of Oncology, 2018. 29: p. iv166-iv191.
Bennett, M.I., A.-M. Bagnall, and S.J. Closs, How effective are patient-based educational interventions in the management of cancer pain? Systematic review and meta-analysis. PAIN®, 2009. 143(3): p. 192-199.
Bennett, M.I., Effectiveness of antiepileptic or antidepressant drugs when added to opioids for cancer pain: systematic review. Palliative medicine, 2011. 25(5): p. 553-559.
Guan, J., S. Tanaka, and K. Kawakami, Anticonvulsants or antidepressants in combination pharmacotherapy for treatment of neuropathic pain in cancer patients: a systematic review and meta-analysis. The Clinical journal of pain, 2016. 32(8): p. 719-725.
Cantarero-Villanueva, I., et al., Effectiveness of water physical therapy on pain, pressure pain sensitivity, and myofascial trigger points in breast cancer survivors: a randomized, controlled clinical trial. Pain Medicine, 2012. 13(11): p. 1509-1519.
Wood, H., et al., Updates in palliative care–overview and recent advancements in the pharmacological management of cancer pain. Clinical medicine, 2018. 18(1): p. 17-22.
Eilami, O., et al., The effect of religious psychotherapy emphasizing the importance of prayers on mental health and pain in cancer patients. Journal of religion and health, 2019. 58: p. 444-451.
Brown, L.F., et al., The association of depression and anxiety with health‐related quality of life in cancer patients with depression and/or pain. Psycho‐Oncology, 2010. 19(7): p. 734-741.
Sheinfeld Gorin, S., et al., Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. Journal of Clinical Oncology, 2012. 30(5): p. 539-547.
Heathcote, L.C. and C. Eccleston, Pain and cancer survival: a cognitive-affective model of symptom appraisal and the uncertain threat of disease recurrence. Pain, 2017. 158(7): p. 1187-1191.
Warth, M., et al., Psychosocial interventions for pain management in advanced cancer patients: a systematic review and meta-analysis. Current oncology reports, 2020. 22: p. 1-9.
Network, N.C.C., NCCN clinical practice guidelines in oncology. http://www. nccn. org/professionals/physician_gls/PDF/occult. pdf, 2008.
Yuan, A., et al., Psychological aspect of cancer: From stressor to cancer progression. experimental and therapeutic medicine, 2010. 1(1): p. 13-18.
Bourgeois, S. and U. Yaylacicegi, Electronic health records: Improving patient safety and quality of care in texas acute care hospitals. International Journal of Healthcare Information Systems and Informatics (IJHISI), 2010. 5(3): p. 1-13.
Costa, W.A., et al., Pain and quality of life in breast cancer patients. Clinics, 2017. 72: p. 758-763.
Syrjala, K.L., et al., Psychological and behavioral approaches to cancer pain management. Journal of Clinical Oncology, 2014. 32(16): p. 1703-1711.
Schreiber, K.L., et al., Predicting, preventing and managing persistent pain after breast cancer surgery: the importance of psychosocial factors. Pain management, 2014. 4(6): p. 445-459.
Li, Z., et al., Burden of cancer pain in developing countries: a narrative literature review. ClinicoEconomics and outcomes research, 2018: p. 675-691.
Henschke, N., S.J. Kamper, and C.G. Maher. The epidemiology and economic consequences of pain. in Mayo Clinic Proceedings. 2015. Elsevier.
Stinson, J.N., et al., Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents. Pain, 2006. 125(1-2): p. 143-157.
Schuster, M., et al., Opioid rotation in cancer pain treatment: a systematic review. Deutsches Ärzteblatt International, 2018. 115(9): p. 135.