Kaposi Sarkomu

Özet

Kaposi Sarkomu (KS) endotel hücrelerinin multifokal malignitesi olup Kaposi Sarkomu ilişkili Herpesvirüs’le sıkı bir ilişkisi mevcuttur. AIDS ilişkili, endemik, klasik ve iyatrojenik ya da transplantasyon ilişkili dört tipi vardır. HIV(+) hastalarda HIV enfeksiyonunun yönetimi KS tedavisinde önemlidir. Lokal tedaviler, kemoterapi, immünoterapi gibi sistemik tedaviler, radyoterapi tedavide kullanılmaktadır. Hastaların takibinde anamnez, detaylı fizik muayene, laboratuvar testleri önemli olup, sistemik hastalık, progresif/refrakter hastalık varlığında takiplerde ek olarak radyolojik görüntüleme yöntemleri (X-RAY, BT, MRI, PET-BT) de kullanılmaktadır. HIV(+) vakalarda HIV tedavisinin yönetimi ve takibi KS tedavisinde önemlidir.

Kaposi Sarcoma (KS) is a multifocal malignancy of endothelial cells and is strongly associated with Kaposi's Sarcoma-associated Herpesvirus (KSHV). There are four types of KS: AIDS-related, endemic, classic, and iatrogenic or transplant-associated. In HIV-positive patients, the management of HIV infection plays a critical role in the treatment of KS. Treatment modalities include local therapies, chemotherapy, immunotherapy, and radiotherapy. During patient follow-up, taking a detailed medical history, conducting thorough physical examinations, and performing laboratory tests are crucial. Additionally, in the presence of systemic or progressive/refractory disease, radiological imaging methods such as X-ray, CT, MRI, and PET-CT are also utilized. The management and monitoring of HIV treatment are essential components in the management of KS in HIV-positive patients.

Referanslar

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Esser, Stefan, et al. "S1 Guidelines for the Kaposi Sarcoma." JDDG: Journal der Deutschen Dermatologischen Gesellschaft 20.6 (2022): 892-904.

Sayfalar

463-468

Gelecek

7 Ağustos 2025

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