Serviks Kanseri

Özet

Serviks kanseri kadınlarda görülen en sık dördüncü kanserdir. Diğer jinekolojik kanserlere kıyasla daha genç yaşta tanı alırlar. Bakım koordinasyonunun nasıl yapılacağı standardize edilmemiştir. Tedavi sonrası gözetimin ana amacı nükslerin erken tespit edilerek küratif tedavi şansının korunmasıdır. Yüksek riskli olup onkolojik tedavi alan hastalar ilk iki yıl üç ayda bir, beşinci yıla kadar altı ayda bir ve beşinci yıldan sonra yıllık takipleri planlanmalıdır. Diğer bir grup olan düşük riskli hastalar (onkolojik tedavi almayan) ilk iki yıl altı ayda bir, iki yıldan sonra ise yıllık takip planları yapılmalıdır. Servikal kanser tanılı hastalardan sağ kurtulan kadınlar için multidisipliner yaklaşım çok önemlidir. Detaylı fizik muayene, jinekolojik muayene ve sistem sorgusu değerlendirmenin en önemli bileşenidir. Asemptomatik servikal kanser hastalarında sınırlı yarar tanımlansa da nüks şüphesinde ve metastatik hasta takibinde görüntüleme yöntemlerinin katkısı daha fazladır. Hem lokal hemde uzak nüks riski taşıyan takip hastalarında nüksler en sık ilk iki yılda tespit edilir. Tedavi ilişkili uzun dönem komplikasyonların takibi ve tedavi yönetimi de multidisipliner takibin önemli bir gereksinimidir. Mesane disfonksiyonu, bağırsak disfonksiyonu, cinsel işlev bozukluğu, lenfödem, yorgunluk, psikososyal sorunlar ve seconder malignite görülmesi önemi uzun dönem takiplerde klinisyenlerin multidisipliner bakış açısı ile hastayı yönetmelerinin önemini ortaya koymaktadır. Bu çalışmada serviks kanseri tanısı olan hastaların tanı ve tedavi sürecinde takip algoritmaları değerlendirilecektir.

Cervical cancer is the fourth most common cancer among women and is diagnosed at a younger age than other gynaecological cancers. However, care coordination is not standardised, with the main aim of post-treatment surveillance being to detect recurrences early to preserve the chance of curative treatment.High-risk patients receiving oncological treatment should be followed up every three months for the first two years, every six months until the fifth year and annually after the fifth year. A further group of low-risk patients (not receiving oncological treatment) should be followed up every six months for the first two years and annually after two years.A multidisciplinary approach is very important for women who survive cervical cancer, with a detailed physical examination, gynaecological examination and system questioning being the most important components of the evaluation. Although the benefits of such an approach have been described as limited in asymptomatic cervical cancer patients, imaging modalities have been shown to contribute significantly to the suspicion of recurrence and the monitoring of metastatic patients.In follow-up patients at risk of both local and distant recurrence, recurrences are most commonly detected within the first two years.The management of treatment-related long-term complications is also an important requirement of multidisciplinary follow-up. The significance of bladder dysfunction, bowel dysfunction, sexual dysfunction, lymphedema, fatigue, psychosocial problems and secondary malignancy underscores the necessity for clinicians to adopt a multidisciplinary approach in long-term follow-up management. The present study will evaluate follow-up algorithms in the diagnosis and treatment process of patients diagnosed with cervical cancer.

Referanslar

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660

Maher EJ, Denton A. Survivorship, late effects and cancer of the cervix. Clin Oncol (R Coll Radiol). 2008;20(6):479-487. doi:10.1016/j.clon.2008.04.009

Landoni F, Maneo A, Colombo A, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997;350(9077):535-540. doi:10.1016/S0140-6736(97)02250-2

Mathevet P, Lécuru F, Uzan C, et al. Sentinel lymph node biopsy and morbidity outcomes in early cervical cancer: Results of a multicentre randomised trial (SENTICOL-2). Eur J Cancer. 2021;148:307-315. doi:10.1016/j.ejca.2021.02.009

Salani R, Khanna N, Frimer M, Bristow RE, Chen LM. An update on post-treatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncology (SGO) recommendations. Gynecol Oncol. 2017;146(1):3-10. doi:10.1016/j.ygyno.2017.03.022

Herrera FG, Breuneval T, Prior JO, Bourhis J, Ozsahin M. [(18)F]FDG-PET/CT metabolic parameters as useful prognostic factors in cervical cancer patients treated with chemo-radiotherapy. Radiat Oncol. 2016;11:43. Published 2016 Mar 16. doi:10.1186/s13014-016-0614-x

Bodurka-Bevers D, Morris M, Eifel PJ, Levenback C, Bevers MW, Lucas KR, et al. Posttherapy surveillance of women with cervical cancer: an outcomes analysis. Gynecologic oncology. 2000;78(2):187–93. doi: 10.1006/gyno.2000.5860

Brooks RA, Rader JS, Dehdashti F, Mutch DG, Powell MA, Thaker PH, et al. Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer. Gynecologic oncology. 2009;112(1):104–9. doi: 10.1016/j.ygyno.2008.08.028

Sartori E, Pasinetti B, Carrara L, Gambino A, Odicino F, Pecorelli S. Pattern of failure and value of follow-up procedures in endometrial and cervical cancer patients. Gynecol Oncol. 2007;107(1 Suppl 1):S241-S247. doi:10.1016/j.ygyno.2007.07.025

Hodgkinson, Katharine et al. Long-term survival from gynecologic cancer: Psychosocial outcomes, supportive care needs and positive outcomes. Gynecologic Oncology, Volume 104, Issue 2, 381 - 389

Zanagnolo V, Minig LA, Gadducci A, et al. Surveillance procedures for patients for cervical carcinoma: a review of the literature. Int J Gynecol Cancer. 2009;19(3):306-313. doi:10.1111/IGC.0b013e3181a130f3

Osann K, Hsieh S, Nelson EL, et al. Factors associated with poor quality of life among cervical cancer survivors: implications for clinical care and clinical trials. Gynecol Oncol. 2014;135(2):266-272. doi:10.1016/j.ygyno.2014.08.036

Yu MC, Austin RM, Lin J, et al. The Role of High-Risk Human Papilloma Virus Testing in the Surveillance of Cervical Cancer After Treatment. Arch Pathol Lab Med. 2015;139(11):1437-1440. doi:10.5858/arpa.2014-0534-OA

Song D, Kong WM, Zhang TQ, et al. The negative conversion of high-risk human papillomavirus and its performance in surveillance of cervical cancer after treatment: a retrospective study. Arch Gynecol Obstet. 2017;295(1):197-203. doi:10.1007/s00404-016-4197-4

Ye S, Yang J, Cao D, Lang J, Shen K. A systematic review of quality of life and sexual function of patients with cervical cancer after treatment. Int J Gynecol Cancer. 2014;24(7):1146-1157. doi:10

Zullo MA, Manci N, Angioli R, Muzii L, Panici PB. Vesical dysfunctions after radical hysterectomy for cervical cancer: a critical review. Crit Rev Oncol Hematol. 2003;48(3):287-293. doi:10.1016/s1040-8428(03)00125-2

Brooks RA, Wright JD, Powell MA, et al. Long-term assessment of bladder and bowel dysfunction after radical hysterectomy. Gynecol Oncol. 2009;114(1):75-79. doi:10.1016/j.ygyno.2009.03.036

Sakuragi N. Nerve-sparing radical hysterectomy: time for a new standard of care for cervical cancer?. J Gynecol Oncol. 2015;26(2):81-82. doi:10.3802/jgo.2015.26.2.81

Holman LL, Levenback CF, Frumovitz M. Sentinel lymph node evaluation in women with cervical cancer. J Minim Invasive Gynecol. 2014;21(4):540-545. doi:10.1016/j.jmig.2013.12.095

Salvo G, Ramirez PT, Levenback CF, et al. Sensitivity and negative predictive value for sentinel lymph node biopsy in women with early-stage cervical cancer. Gynecol Oncol. 2017;145(1):96-101. doi:10.1016/j.ygyno.2017.02.005

Denton AS, Clarke NW, Maher EJ. Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis. Cochrane Database Syst Rev. 2002;2002(3):CD001773. doi:10.1002/14651858.CD001773

Pieterse QD, Maas CP, ter Kuile MM, et al. An observational longitudinal study to evaluate miction, defecation, and sexual function after radical hysterectomy with pelvic lymphadenectomy for early-stage cervical cancer. Int J Gynecol Cancer. 2006;16(3):1119-1129. doi:10.1111/j.1525-1438.2006.00461.x

Bjelic-Radisic V, Jensen PT, Vlasic KK, et al. Quality of life characteristics inpatients with cervical cancer. Eur J Cancer. 2012;48(16):3009-3018. doi:10.1016/j.ejca.2012.05.011

Vistad I, Cvancarova M, Fosså SD, Kristensen GB. Postradiotherapy morbidity in long-term survivors after locally advanced cervical cancer: how well do physicians' assessments agree with those of their patients?. Int J Radiat Oncol Biol Phys. 2008;71(5):1335-1342. doi:10.1016/j.ijrobp.2007.12.030

Chopra S, Dora T, Chinnachamy AN, et al. Predictors of grade 3 or higher late bowel toxicity in patients undergoing pelvic radiation for cervical cancer: results from a prospective study. Int J Radiat Oncol Biol Phys. 2014;88(3):630-635. doi:10.1016/j.ijrobp.2013.11.214

Gandhi AK, Sharma DN, Rath GK, et al. Early clinical outcomes and toxicity of intensity modulated versus conventional pelvic radiation therapy for locally advanced cervix carcinoma: a prospective randomized study. Int J Radiat Oncol Biol Phys. 2013;87(3):542-548. doi:10.1016/j.ijrobp.2013.06.2059

Jensen PT, Groenvold M, Klee MC, Thranov I, Petersen MA, Machin D. Longitudinal study of sexual function and vaginal changes after radiotherapy for cervical cancer [published correction appears in Int J Radiat Oncol Biol Phys. 2004 Mar 15;58(4):1321]. Int J Radiat Oncol Biol Phys. 2003;56(4):937-949. doi:10.1016/s0360-3016(03)00362-6

Maas CP, ter Kuile MM, Laan E, et al. Objective assessment of sexual arousal in women with a history of hysterectomy. BJOG. 2004;111(5):456-462. doi:10.1111/j.1471-0528.2004.00104

Rauh LA, Pannone AF, Cantrell LA. Hormone replacement therapy after treatment for cervical cancer: Are we adhering to standard of care?. Gynecol Oncol. 2017;147(3):597-600. doi:10.1016/j.ygyno.2017.09.009

Ferrandina G, Mantegna G, Petrillo M, et al. Quality of life and emotional distress in early stage and locally advanced cervical cancer patients: a prospective, longitudinal study. Gynecol Oncol. 2012;124(3):389-394. doi:10.1016/j.ygyno.2011.09.041

Mathevet P, Lécuru F, Uzan C, et al. Sentinel lymph node biopsy and morbidity outcomes in early cervical cancer: Results of a multicentre randomised trial (SENTICOL-2). Eur J Cancer. 2021;148:307-315. doi:10.1016/j.ejca.2021.02.009

Gianoni M, Mathevet P, Uzan C, et al. Does the Sentinel Lymph Node Sampling Alone Improve Quality of Life in Early Cervical Cancer Management?. Front Surg. 2020;7:31. Published 2020 Jun 12. doi:10.3389/fsurg.2020.00031

Pasek M, Suchocka L, Urbański K. Quality of life in cervical cancer patients treated with radiation therapy. J Clin Nurs. 2013;22(5-6):690-697. doi:10.1111/j.1365-2702.2012.04350.x

Bartoces MG, Severson RK, Rusin BA, Schwartz KL, Ruterbusch JJ, Neale AV. Quality of life and self-esteem of long-term survivors of invasive and noninvasive cervical cancer. J Womens Health (Larchmt). 2009;18(5):655-661. doi:10.1089/jwh.2008.0959

Carpenter KM, Andersen BL, Fowler JM, Maxwell GL. Sexual self schema as a moderator of sexual and psychological outcomes for gynecologic cancer survivors. Arch Sex Behav. 2009;38(5):828-841. doi:10.1007/s10508-008-9349-6

Distefano M, Riccardi S, Capelli G, et al. Quality of life and psychological distress in locally advanced cervical cancer patients administered pre-operative chemoradiotherapy. Gynecol Oncol. 2008;111(1):144-150. doi:10.1016/j.ygyno.2008.06.034

Cull A, Cowie VJ, Farquharson DI, Livingstone JR, Smart GE, Elton RA. Early stage cervical cancer: psychosocial and sexual outcomes of treatment. Br J Cancer. 1993;68(6):1216-1220. doi:10.1038/bjc.1993.507

Papatla K, Halpern MT, Hernandez E, et al. Second primary anal and oropharyngeal cancers in cervical cancer survivors. Am J Obstet Gynecol. 2019;221(5):478.e1-478.e6. doi:10.1016/j.ajog.2019.05.025

Lingen MW, Abt E, Agrawal N, et al. Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity: A report of the American Dental Association. J Am Dent Assoc. 2017;148(10):712-727.e10. doi:10.1016/j.adaj.2017.07.032

Stier EA, Chiao EY. Anal Cancer and Anal Cancer precursors in Women with a History of HPV-Related Dysplasia and Cancer. Semin Colon Rectal Surg. 2017;28(2):97-101. doi:10.1053/j.scrs.2017.04.008

Clarke MA, Wentzensen N. Strategies for screening and early detection of anal cancers: A narrative and systematic review and meta-analysis of cytology, HPV testing, and other biomarkers. Cancer Cytopathol. 2018;126(7):447-460. doi:10.1002/cncy.22018

Jhamad S, Aanjane R, Jaiswal S, Jain S, Bhagat P. Second Primary Cancer after Radiotherapy for Cervical Cancer. J Midlife Health. 2018;9(4):207-209. doi:10.4103/jmh.JMH_74_18

https://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf,1.2025

Sayfalar

371-378

Gelecek

7 Ağustos 2025

Lisans

Lisans