Hipofarenks Kanseri

Yazarlar

Özet

Baş boyun kanserleri içinde hipopfarenks kanseri nadir görülen ve agresif seyreden tümörlerden olduğundan tedavisi düzenli takibi gerekmektedir. Hastalarda özellikle ilk iki yıl içinde nüks en sık görüldüğünden dolayı radyolojik görüntüleme ve semptomların takibi son derece önem arz etmektedir. Erken evrede tanı; lokal ileri veya boyun metastazı mevcut olana kadar klinik semptomların pek olmaması nedeniyle oldukça zordur. Tedavi sonrası düzenli takip, nüks hastalığı tespit etmeyi, gelişebilecek ikinci maligniteleri teşhis etmeyi ve geç komplikasyonları yönetebilmeyi sağlar. Hastaların uzun sağkalım ve yaşam kalitesi açısından yapılan kontroller oldukça önem arz etmektedir. 
Tüm hastaların olası tümör nüksünü, sağlık davranışlarını, beslenmeyi, diş sağlığını, konuşma ve yutma işlevini değerlendirmek için düzenli takipleri yapılmalı, klinik semptomları sorgulanmalıdır.

Hypopharynx cancer is rare and aggressive tumor among head and neck cancers, and regular surveillance is requred. Since reccurrence is most common in patients, especially in the first two years, clinical, radiological and personalized symptom follow-up is extremely important. Early diagnosis; that is difficult the lack of clinical symptoms until locally advanced or neck metastases are  pressent. Regular follow-up after treatment allows the diagnosis of recurrent disease, the diagnosis of possible second malignancies and the management of late complications. The controls of the patients in terms of long-term survival and quality of life are really important. All patients should be regularly followed up for possible tumor recurrence, health status, nutrition, dental treatment, speech and swallowing functions, and should be interviewed clinical symptoms.

Referanslar

Carvalho AL, Nishimoto IN, Califano JA, Kowalski LP. Trends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER database. Int J Cancer. 2005;114(5):806

Gatta G, Botta L, Sánchez MJ, Anderson LA, Pierannunzio D, Licitra L, EUROCARE. Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study. Eur J Cancer. 2015;51(15):2130. Epub 2015 Sep 26.

Curado MP, Hashibe M. Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 2009;21(3):194.

Hashibe M, Brennan P, Benhamou S. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007;99(10):777.

Sapkota A, Gajalakshmi V, Jetly DH, Roychowdhury S, Dikshit RP, Brennan P, Hashibe M, Boffetta P. Indoor air pollution from solid fuels and risk of hypopharyngeal/laryngeal and lung cancers: a multicentric case-control study from India. Int J Epidemiol. 2008;37(2):321

Shangina O, Brennan P, Szeszenia-Dabrowska N, Mates D, FabiánováE, Fletcher T, t'Mannetje A, Boffetta P, Zaridze D. Occupational exposure and laryngeal and hypopharyngeal cancer risk in central and eastern Europe. Am J Epidemiol. 2006;164(4):367

Wahlberg PC, Andersson KE, Biörklund AT, Möller TR. Carcinoma of the hypopharynx: analysis of incidence and survival in Sweden over a 30-year period. Head Neck. 1998;20(8):714

Eckel HE, Bradley J. Treatment options for hypopharyngeal cancer. 2019;83:47-53.

Meulemans J, Delaere P, Poorten V Vander. Primary treatment of t1 – t2 hypopharyngeal cancer : changing paradigms. Adv Otorhinolaryngol. 2019;83:54-65.

Lefebvre JL, Chevalier D, Luboinski B, et al. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst 1996;88:890-899. doi:10.1093/jnci/88.13.890. PMID: 8656441.

Janoray G, Pointreau Y, Garaud P, Chapet S, Alfonsi M, Sire C, Jadaud E, Calais G.J Natl Cancer Inst. 2015 Dec 16;108(4): djv368. doi: 10.1093/jnci/djv368. Print 2016 Apr.PMID: 26681800 Clinical Trial.

Ljumanovic R, Langendijk JA, Hoekstra OS, et al. Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma. Eur Radiol 2008; 18:2231.

Posner MR, Hershock DM, Blajman CR, et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 2007;357:1705-1715)

Pan Y, Li H, Zhu M, Xu B, Chen M, Zhang C, Zheng H. Neoadjuvant chemoimmunotherapy for laryngeal preservation in locally advanced hypopharyngeal cancer. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113197. doi: 10.1016/j.intimp.2024.113197. Epub 2024 Sep 18. PMID: 39298814.

Wu SG, Wang RJ, Zhou Y, Luo XY. Neoadjuvant therapy with chemotherapy and immune checkpoint inhibitor for laryngeal function preservation in locally advanced hypopharyngeal cancer. Front Immunol. 2024 Mar 8;15:1364799. doi: 10.3389/fimmu.2024.1364799. PMID: 38524124; PMCID: PMC10958379.

Chen S, Zhong Q, Zhang S, Zhang Y, Hou L, Ma H, He S, Lian M, He Y, Wang R, Fang J. Neoadjuvant immunochemotherapy in locally advanced laryngeal cancer and hypopharyngeal cancer: higher objective response rate and organ-preservation rate. Invest New Drugs. 2024 Dec;42(6):694-702. doi: 10.1007/s10637-024-01456-w. Epub 2024 Nov 28. PMID: 39607584.

Cheung PK, Chin RY, Eslick GD. Detecting residual/recurrent head neck squamous cell carcinomas using PET or PET/CT: Systematic review and meta-analysis. Otolaryngol Head Neck Surg 2016;154:421-432.

Heineman TE, Kuan EC, St John MA. When should surveillance imaging be performed after treatment for head and neck cancer? Laryngoscope 2017;127:533-534.

Mehanna H, Wong WL, McConkey CC, et al. PET-CT surveillance versus neck dissection in advanced head and neck cancer. N Engl J Med 2016;374:1444-1454.

Ng SP, Pollard C, 3rd, Berends J, et al. Usefulness of surveillance imaging in patients with head and neck cancer who are treated with definitive radiotherapy. Cancer 2019;125:1823-1829.

Pantvaidya GH, Agarwal JP, Deshpande MS, et al. PET-CT in recurrent head neck cancers: a study to evaluate impact on patient management. J Surg Oncol 2009;100:401-403.

Ho AS, Tsao GJ, Chen FW, et al. Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer and recurrence. Cancer 2013;19:1349-1356.

Paleri V, Urbano TG, Mehanna H, et al. Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 2016;130:S161-S169.

Klara Stagl, Stefan Grasl, Boban M Erovic , Stefan Janik. Head Neck. How effective is our current follow-up for patients with hypopharyngeal carcinoma? 2024 Dec;46(12):3030-3037. doi: 10.1002/hed.27881. Epub 2024 Jul 16.

Miranda Visini , Roland Giger, Mohamed Shelan, Olgun Elicin, Lukas Anschuetz. Laryngoscope. 2021 May;131(5):E1543-E1549. doi: 10.1002/lary.29186. Epub 2020 Oct 24. Predicting Factors for Oncological and Functional Outcome in Hypopharyngeal Cancer.

Grasl S, Frommlet F, Faisal M, et al. A new nomogram to predict oncological outcome in laryngeal and hypopharyngeal carcinoma patients after laryngopharyngectomy. Eur Arch Otorhinolaryngol. 2023;280(3):1381‐1390. doi:10.1007/S00405‐022‐07668‐1.

VanKoevering KK, Sabetsarvestani K, Sullivan SE, et al. Pituitary dysfunction after radiation for anterior skull base malignancies: Incidence and screening. J Neurol Surg B Skull Base 2020;81:75-81.

Cohen EE, LaMonte SJ, Erb NL, et al. American Cancer Society Head and Neck Cancer Survivorship Care Guideline. CA Cancer J Clin 2016;66:203- 239.

Ehrsson YT, Langius-Eklöf A, Laurell G. Nutritional surveillance and weight loss in head and neck cancer patients. Support Care Cancer 2012;20:757-765.

Locher JL, Bonner JA, Carroll WR, et al. Prophylactic percutaneous endoscopic gastrostomy tube placement in treatment of head and neck cancer: a comprehensive review and call for evidence-based medicine. JPEN J Parenter Enteral Nutr 2011;35:365-374.

Langius JA, van Dijk AM, Doornaert P, et al. More than 10% weight loss in head and neck cancer patients during radiotherapy is independently associated with 4 deterioration in quality of life. Nutr Cancer 2013;65:76-83.

Lefebvre T, Tack L, Lycke M, et al. Effectiveness of adjunctive analgesics in head and neck cancer patients receiving curative (chemo-) radiotherapy: a systematic review. Pain Med 2021;22:152-164.

Bar Ad V, Weinstein G, Dutta PR, et al. Gabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck cancer 6 treated with concurrent chemoradiotherapy. Cancer 2010;116:4206-4213.

Leenstra JL, Miller RC, Qin R, et al. Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or 7 without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]). J Clin Oncol 2014;32:1571-1577.

Sio TT, Le-Rademacher JG, Leenstra JL, et al. Effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash vs placebo on radiotherapy-related oral mucositis pain: the Alliance A221304 randomized clinical trial. JAMA 2019;321:1481-1490.

Cohen EE, LaMonte SJ, Erb NL, et al: American Cancer Society Head and Neck Cancer Survivorship Care Guideline. CA Cancer. J Clin 66:203-239, 2016 by permission of John Wiley and Sons on behalf of the American Cancer Society.

Ringash J: Survivorship and quality of life in head and neck cancer. J Clin Oncol 33: 3322-3327, 2015.

Aberle DR, Adams AM, Berg CD, et al: Reduced lung-cancer mortality with low- dose computed tomographic screening. N Engl J Med 365:395-409, 2011.

Borderud SP LY, Li Y, Burkhalter JE, et al: Electronic cigarette use among patients with cancer: Characteristics of electronic cigarette users and their smoking cessation outcomes. Cancer 120:3527-3535, 2014.

Katz PO GL, Gerson LB, Vela MF: Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108:308-328, quiz 329, 2013.

Diaz R, Jaboin JJ, Morales-Paliza M, et al: Hypothyroidism as a consequence of intensity-modulated radiotherapy with concurrent taxane-based chemotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 77:468-476, 2010.

Berna ́t L, Hrusˇa ́k D: Hypothyroidism after radiotherapy of head and neck cancer. J Craniomaxillofac Surg 42:356-361, 2014.

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29-36

Gelecek

7 Ağustos 2025

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