Köpeklerde Meme Tümörlerinin Sınıflandırılması
Özet
Meme bezleri, epidermisten gelişen modifiye deri altı apokrin ter bezleridir. Yenidoğan yavruya beslenme ve pasif bağışıklık sağlama gibi etkin rollere sahiptir. Pubertal yada prepubertal dönemde ovariohisterektomi uygulanmayan köpeklerde sıklıkla meme tümörüne rastlanır. Meme tümörlerinin insidansı hormonal durum, cins, yaş, obezite, kültürel ve sosyoekonomik durum gibi faktörlerden etkilenmektedir. Teşhiste ise histopatolojik analizler temel tanı yöntemidir. Günümüzde ise histopatolojik teşhisin yanısıra hücre profillerini ortaya koyan immunohistokimya panellerinin kullanımı prognoz ve tedavi içinde faydalıdır. Bu inceleme köpeklerde meme tümörüyle ilgili son gelişmelerin histopatolojik sınıflandırılması, histolojik derecelendirilmesi, moleküler ve klinik evrelendirme yönleriyle açıklanması hedeflenmiştir.
The mammary glands are modified subcutaneous apocrine sweat glands that develop from the epidermis. They have active roles such as providing nutrition and passive immunity to the newborn infant. Mammary tumors are frequently encountered in dogs that have not undergone ovariohysterectomy during the pubertal or prepubertal period. The incidence of mammary tumors is affected by factors such as hormonal status, breed, age, obesity, cultural and socioeconomic status. Histopathological analysis is the basic diagnostic method in diagnosis. Today, in addition to histopathological diagnosis, the use of immunohistochemistry panels that reveal cell profiles is useful for prognosis and treatment. This review aims to describe the latest developments in canine mammary tumors in terms of histopathological classification, histological grading, molecular and clinical staging.
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