Ağız Gargaraları ve Alternatiflerinin Yapımında Kullanılabilen Maddeler
Özet
Ağız ve diş sağlığının korunmasında diş fırçası, diş macunu ve diş ipinin yanında ağız gargaraları da görev alır. Ağız gargaraları; farklı etken ve yardımcı maddeler içeren, mikrobiyal dental plak oluşumunu önleyen/azaltan, normal oral mikrobiyal florada ve tükürükte 10’larca farklı mikroorganizma bulunsa da bu normal şartları bozmayan ama enfeksiyon yapıcı mikroorganizmaları kontrol altında tutmaya çalışan, antienflamatuvar etkisi de bulunabilen tedavi edici/koruyucu ajanlardır. Hastaların kullanım esnasında doğru miktar ve uygulama şekline uymaları gerekse de yan etkilerinin az olması gibi avantajı da vardır. Araştırmacılarca altın standart olarak kabul edilen klorheksidin glukonat ile benzidamin hidroklorür, povidon iyodür, hipokloröz asit gibi aktif bileşenler içeren çeşitleri vardır.
In addition to toothbrushes, toothpaste, and dental floss; mouthwashes also play a role in protecting oral and dental health. Mouthwashes are therapeutic/protective agents that contain different active and auxiliary substances, prevent/reduce microbial dental plaque formation, do not disrupt normal oral microbial flora, but also try to keep pathogen microorganisms under control, and may also have anti-inflammatory effects. Although patients must use the mouthwashes with the correct dose and application method, they also have the advantage of having few side effects. There are several variations of mouthwashes that contain active ingredients such as chlorhexidine gluconate, which is considered the gold standard by researchers, and benzydamine hydrochloride, povidone iodide, and hypochlorous acid.
Referanslar
Rosan B, Lamont RJ. Dental plaque formation. Microbes and Infection. 2000;2(13):1599-1607. https://doi.org/10.1016/S1286-4579(00)01316-2
Sugano N. Biological plaque control: novel therapeutic approach to periodontal disease. Journal of Oral Science. 2012;54:1-5. https://doi.org/10.2334/josnusd.54.1
Allmyr M, Panagiotidis G, Sparve E, et al. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. Basic and Clinical. Pharmacology and Toxicology. 2009;105(5):339-344. https://doi.org/10.1111/j.1742-7843.2009.00455.x
Axelsson P. Concept and practice of plaque-control. Pediatric Dentistry. 1981;3:101-113.
Moran JM. Home-use oral hygiene products: mouthrinses. Periodontology 2000. 2008;48:42-53.
Teles RP, Fonseca Teles FR. Antimicrobial agents used in the control of periodontal biofilms: effective adjuncts to mechanical plaque control? Brazilian Oral Research. 2009;23 (Suppl 1):39-48.
International Organization for Standardization of Dentistry Biological evaluation of medical devices.’’Tests for in vitro cytotoxicity’’, Germany, ISO 10993-5’’. 2009.
Parwani S, Parwani R, Chitnis P, et al. Comparative evaluation of anti-plaque efficacy of herbal and 0.2% chlorhexidine gluconate mouthwash in a 4-day plaque re-growth study. Journal of Indian Society of Periodontology. 2013;17(1):72-77. DOI: 10.4103/0972-124X.107478
Cho H, Lynham A, Hsu E. Postoperative interventions to reduce inflammatory complications after third molar surgery: Review of the current evidence. Australian Dental Journal. 2017;62(4):412-419. https://doi.org/10.1111/adj.12526
Cigerim L, Kaplan V. Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol+Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial. Medicina Oral, Patología Oral y Cirugía Bucal. 2018;24(1):e114-e122. doi: 10.4317/medoral.22590
Van Houte J. Role of micro-organisms in caries etiology. Journal of Dental Research. 1994;73(3):672-681. https://doi.org/10.1177/00220345940730031
Erkekoğlu P, Baydar T. Güncel in vitro sitotoksisite testleri. Hacettepe University Journal of the Faculty of Pharmacy. 2021;41(1):45-63.
Pizzoferrato A, Ciapetti G, Stea S, Cenni E, Arciola CR, Granchi D. Cell culture methods for testing biocompatibility. Clinical Materials. 1994;15(3):173-190. https://doi.org/10.1016/0267-6605(94)90081-7
McDonnell G, Russell AD. Antiseptics and disinfectants: Activity, action, and resistance. Clinical Microbiology Reviews. 1999;12(1):147-179. https://doi.org/10.1128/cmr.12.1.147
Denton G. Chlorhexidine. SS Block (Ed.). Disinfection, Sterilization and Preservation. Philadelphia Lippincott Williams&Wilkins. 2001. 321-337.
Rowe RC, Sheskey PJ, Owen SC. Pharmaceutical Press and American Pharmacists Association. 2006.
Zhang TT, Tang SS, Fu LJ. The effectiveness of different concentrations of chlorhexidine for prevention of ventilator-associated pneumonia: A meta-analysis. Journal of Clinical Nursing. 2014;23(11-12):1461-1475. https://doi.org/10.1111/jocn.12312
Varoni, E, Tarce M, Lodi G, et al. Chlorhexidine (CHX) in dentistry: state of the art. Minerva Stomatol. 2012;61(9):399-419.
Silla MP, Almerich Silla JM. Use of chlorhexidine varnishes in preventing and treating periodontal disease. A review of the literature. Medicina oral, patologia oral y cirugia bucal. 2008;257-260.
Van Wınkelhoff AJ, Rams TE, Slots J. Systemic antibiotic therapy in periodontics. Periodontology 2000. 1996;10:45-78. https://doi.org/10.1111/j.1600-0757.1996.tb00068.x
Leard A, Addy M. The propensity of different brands of tea and coffee to cause staining associated with chlorhexidine. Journal of Clinical Periodontology. 1997;24:115-118. https://doi.org/10.1111/j.1600-051X.1997.tb00476.x
Iacono VJ, Aldredge WA, Lucks H, et al. Modern supragingival plaque control. International Dental Journal. 1998;48(53):290-297. https://doi.org/10.1111/j.1875-595X.1998.tb00719.x
Paolantonio M, Festa F, di Placido G, et al. Site-specific subgingival colonization by Actinobacillus actinomycetemcomitans in orthodontic patients. American Journal of Orthodontics and Dentofacial Orthopedics. 1999;115:423-428. https://doi.org/10.1016/S0889-5406(99)70263-5
Marinone MG, Savoldi E. Chlorhexidine and taste. Influence of mouthwashes concentration and of rinsing time. Minerva Stomatologica. 2000;49(5):221-226. PMID: 11068420
Eriksen HM, Nordbø H, Kantanen H, Et al. Chemical plaque control and extrinsic tooth discoloration. A review of possible mechanisms. Journal of Clinical Periodontology. 1985;12(5):345-350. https://doi.org/10.1111/j.1600-051X.1985.tb00924.x
Addy M. Chlorhexidine compared with other locally delivered antimicrobials. A short review. Journal of Clinical Periodontology. 1986;13(10):957-964. https://doi.org/10.1111/j.1600-051X.1986.tb01434.x
Mariotti AJ, Rumph DA. Chlorhexidine-induced changes to human gingival fibroblast collegen and non-collogen protein production. Journal of Periodontology. 1999;70(12):1443-1448. https://doi.org/10.1902/jop.1999.70.12.1443
Quirynen M, Teughels W, De Soete M, et al. Topical antiseptics and antibiotics in the initial therapy of chronic adult periodontitis; microbiological aspects. Periodontology 2000. 2002;28:72-90.
Addy M. Oral hygiene products: potential for harm to oral and systemic health? Periodontology 2000. 2008;48(1):54-65. 10.1111/j.1600-0757.2008.00253.x
Jose JE, Padmanabhan S, Chitharanjan AB. Systemic consumption of probiotic curd and use of probiotic toothpaste to reduce Streptococcus mutans in plaque around orthodontic brackets. American Journal of Orthodontics and Dentofacial Orthopedics. 2013;144(1):67-72. https://doi.org/10.1016/j.ajodo.2013.02.023
Gennaro A, Povidone iodine. Remington‟s Pharmaceutical Sciences. Easton, PA: Mack Publishing Company: 1169, 1990.
Lanker-Klossner B, Widmer HR, Frey F. Non-development of resistance by bacteria during hospital use of povidone-iodine. Dermatology. 1997;195:10-13. https://doi.org/10.1159/000246024
Kunisada T, Yamada K, Oda S, et al. Investigation of the efficacy of povidoneiodine against antiseptics-resistant species. Dermatology. 1997;195:14-18. https://doi.org/10.1159/000246025
Michel D, Zach GA. Antiseptic efficacy of disinfecting solutions in suspension test in vitro against antiseptic-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli in pressure sore wounds after spinal cord injury. Dermatology. 1997;195:36-41. https://doi.org/10.1159/000246028
Forabosco A, Galetti R, Spinato S, et al. A comparative study of a surgical method and scaling and root planing using the Odontoson. Journal of Clinical Periodontology. 1996;23(7):611-614. https://doi.org/10.1111/j.1600-051X.1996.tb00583.x
Rahn R, Schneider S, Diehl 0, et al. Preventing post-treatment bacteremia: Comparing topical povidone-iodine and chlorhexidine. The Journal of the American Dental Association. 1995;126(8):1145-1148. https://doi.org/10.14219/jada.archive.1995.0334
Greenstein G. Povidone-Iodine‟s effects and role in the management of periodontal diseases: a review. Journal of Periodontology. 1999;70(11):1397-1405. https://doi.org/10.1902/jop.1999.70.11.1397
Fleischer W, Reimer K. Povidone-Iodine in antisepsis – State of the art. Dermatology. 1997;195:3-9. https://doi.org/10.1159/000246022
Nobukuni K, Hayakawa N, Namba R. The influence of long-term treatment with povidone-iodine on thyroid function. Dermatology. 1997;195:69-72. https://doi.org/10.1159/000246034
Linder N, Davidovitch N, Reichman B, et al. Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants. The Journal of Pediatrics. 1997;131:434-439. https://doi.org/10.1016/S0022-3476(97)80071-6
Hoang T, Jorgensen MG, Keim RG, et al. Povidone-iodine as a periodontal pocket disinfectant. Journal of Periodontal Research. 2003;38(3): 311-317. https://doi.org/10.1034/j.1600-0765.2003.02016.x
Catanese B, Lagana A, Curini L, et al. Bioequivalence study of two liquid formulations of benzydamine. Biopharmaceutics & Drug Disposition. 1988;9(1):113-118. https://doi.org/10.1002/bod.2510090111
Baldock GA, Brodie RR, Chasseaud LF, et al. Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects. Biopharmaceutics & Drug Disposition. 1991; 12(7): 481-492. https://doi.org/10.1002/bdd.2510120702
Opaleye ES, Noto AR, Sanchez Zv, et al. Recreational use of benzydamine as a hallucinogen among street youth in Brazil. Brazilian Journal of Psychiatry. 2009;31(3):208-213. https://doi.org/10.1590/S1516-44462009000300005
Scheie AA. Modes of action of currently known chemical antiplaque agents other than chlorhexidine. Journal of Dental Research. 1989;68:1609-1616.
Sharma N, Charles CH, Lynch MC, et al. Adjunctive benefit of an essential oil–containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: a six-month study. The Journal of the American Dental Association. 2004;135(4):496-504. https://doi.org/10.14219/jada.archive.2004.0217
Perona JS, Cabello-Moruno R, Ruiz-Gutierrez V. The role of virgin olive oil components in the modulation of endothelial function. The Journal of Nutritional Biochemistry. 2006;17(7):429-445. https://doi.org/10.1016/j.jnutbio.2005.11.007
Puertollano MA, Puertollano E, Alvarez de Cienfuegos G, et al. Significance of olive oil in the host immune resistance to infection. British Journal of Nutrition. 2007;98:S54-S58. https://doi.org/10.1017/S0007114507832934
Cardoso CR, Favoreto Jr S, Oliveira LL, et al. Oleic acid modulation of the immune response in wound healing: a new approach for skin repair. Immunobiology. 2011;216(3):409-415. https://doi.org/10.1016/j.imbio.2010.06.007
Jeffery NM, Yaqoob P, Newsholme EA, et al. The effects of olive oil upon rat serum lipid levels and lymphocyte functions appear to be due to oleic acid. Annals of Nutrition and Metabolism. 1996;40(2):71-80. https://doi.org/10.1159/000177898
Patel PV, Kumar S, Vidya GD, et al. Cytological Assessment of Healing Palatal Donor Site Wounds and Grafted Gingival Wounds after Application of Ozonated Oil: An Eighteen-Month Randomized Controlled Clinical Trial. Acta Cytologica. 2012;56:277-284. https://doi.org/10.1159/000336889
Wölfle U, Seelinger G, Schempp CM. Topical Application of St. Johnʼs Wort (Hypericum perforatum). Planta Medica. 2014;80:109-120. DOI: 10.1055/s-0033-1351019
Sosa S, Pace R, Bornancin A, et al. Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L. Journal of Pharmacy and Pharmacology. 2007;59:703-709. https://doi.org/10.1211/jpp.59.5.0011
Kang BY, Chung SW, Kim TS. Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by hpyericin, an active component of Hypericum perforatum. Planta Medica. 2001;67:364-366. DOI: 10.1055/s-2001-14333
Albert D, Zündorf I, Dingermann T, et al. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochemical Pharmacology. 2002;64:1767-1775. https://doi.org/10.1016/S0006-2952(02)01387-4
Hammer KD, Hillwig ML, Solco AK, et al. Inhibition of prostaglandin E(2) production by anti-inflammatory Hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. Journal of Agricultural and Food Chemistry. 2007;55:7323-7331.
Koeberle A, Rossi A, Bauer J, et al. Hyperforin, an Anti-Inflammatory Constituent from St. Johnʼs Wort, Inhibits Microsomal Prostaglandin E(2) Synthase-1 and Suppresses Prostaglandin E(2) Formation in vivo. Frontiers in Pharmacology. 2011;2:7. https://doi.org/10.3389/fphar.2011.00007
Côté J, Caillet S, Doyon G, et al. Bioactive Compounds in Cranberries and their Biological Properties. Critical Reviews in Food Science and Nutrition. 2010;50(7):666-679. https://doi.org/10.1080/10408390903044107
Heinonen M. Antioxidant activity and antimicrobial effect of berry phenolics –a Finnish perspective. Molecular Nutrition Food Research. 2007;51(6):684–791. https://doi.org/10.1002/mnfr.200700006
Vinson JA, Bose P, Proch J, et al. Cranberries and cranberry products: Powerful in vitro, ex vivo, and in vivo sources of antioxidants. Journal of Agricultural and Food Chemistry. 2008;56(14):5884-5891.
La VD, Howell AB, Grenier D. Cranberry Proanthocyanidins Inhibit MMP Production and Activity. Journal of Dental Research. 2009;88(7):627-632. http://dx.doi.org/101177/0022034509339487
Singhal R, Patil P, Siddibhavi M, et al. Antimicrobial and Antibiofilm Effect of Cranberry Extract on Streptococcus mutans and Lactobacillus acidophilus: An In Vitro Study. International Journal of Clinical Pediatric Dentistry. 2020;13(1):11-15. doi: 10.5005/jp-journals-10005-1707
Moghbel A, Farjzadeh A, Aghel N, et al. The effect of green tea on prevention of mouth bacterial infection, halitosis, and plaque formation on teeth. Iranian Journal of Toxicology. [Internet]. 2011;5(14):502-515.
Cheng TO. All teas are not created equal: The Chinese green tea and cardiovascular health. International Journal of Cardiology. 2006;108(3):301-308. https://doi.org/10.1016/j.ijcard.2005.05.038
Arab H, Maroofian A, Golestani S, et al. Review of the therapeutic effects of Camellia sinensis (green tea) on oral and periodontal health. Journal of medicinal plants research. 2011;5(23):5465-5469.
Okamoto M, Sugimoto A, Leung KP, et al. Inhibitory effect of greentea catechins on cysteine proteinases in Porphyromonas gingivalis. Oral Microbiology and Immunology. 2023;19(2):118-120. https://doi.org/10.1046/j.0902-0055.2003.00112.x
Kaur H, Jain S, Kaur A. Comparative evaluation of the antiplaque effectiveness of green tea catechin mouthwash with chlorhexidine gluconate. Journal of Indian Society of Periodontology. 2014;18(2):178-182.
Abdulbaqi HR, Himratul-Aznita WH, Baharuddin NA. Anti-plaque effect of a synergistic combination of green tea and Salvadora persica L. against primary colonizers of dental plaque. Archives of Oral Biology. 2016;70:117-124. https://doi.org/10.1016/j.archoralbio.2016.06.011
Valkenburg C, Van der Weijden FA, Slot DE. Plaque control and reduction of gingivitis: The evidence for dentifrices. Periodontology 2000. 2019;79:221-232. https://doi.org/10.1111/prd.12257
Karim B, Bhaskar DJ, Agali C, et al. Effect of Aloe vera mouthwash on periodontal health: triple blind randomized control trial. Oral Health and Dental Management. 2014;13(1):14-19.
Kumar GR, Devanand G, John BD, et al. Preliminary Antiplaque Efficacy of Aloe Vera Mouthwash on 4 Day Plaque Re -Growth Model: Randomized Control Trial. Ethiopian Journal of Health Sciences. 2014; 24(2):139-144. https://doi.org/10.4314/ejhs.v24i2.6
Jafer M, Patil S, Hosmani J, et al. Chemical Plaque Control Strategies in the Prevention of Biofilm-associated Oral Diseases. The Journal of Contemporary Dental Practice. 2016;17(4):337-343. https://doi.org/10.5005/jp-journals-10024-1851
Burdock GA. Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology. 1998;36(4):347-363. https://doi.org/10.1016/S0278-6915(97)00145-2
Akca AE, Akca G, Topçu FT, et al. The Comparative Evaluation of the Antimicrobial Effect of Propolis with Chlorhexidine against Oral Pathogens: An in Vitro Study. BioMed Research International. 2016;1, Article ID 3627463.://doi.org/10.1155/2016/3627463
Hayacibara MF, Koo H, Rosalen PL, et al. In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development. Journal of Ethnopharmacology. 2005;101(1-3):110-115. https://doi.org/10.1016/j.jep.2005.04.001
Hinds WC. Aerosol technology: Properties, behavior, and measurement of airborne particles, 2nd ed. New York, Wiley, 1999.
Morita C, Nishida T, Ito K. Biological toxicity of acid electrolyzed functional water: Effect of oral administration on mouse digestive tract and changes in body weight. Archives of Oral Biology. 2011;56(4): 359-366. https://doi.org/10.1016/j.archoralbio.2010.10.016
Kubota A, Goda T, Tsuru T, et al. Efficacy and safety of strong acid electrolyzed water for peritoneal lavage to prevent surgical site infection in patients with perforated appendicitis. Surgery Today. 2015; 45(7): 876-879. https://doi.org/10.1007/s00595-014-1050-x
Chen CJ, Chen CC, Ding SJ. Effectiveness of Hypochlorous Acid to Reduce the Biofilms on Titanium Alloy Surfaces in Vitro. International Journal of Molecular Sciences. 2016;17(7):1161. https://doi.org/10.3390/ijms17071161
Hiebert JM, Robson MC. The Immediate and Delayed Post-Debridement Effects on Tissue Bacterial Wound Counts of Hypochlorous Acid Versus Saline Irrigation in Chronic Wounds. Eplasty. 2016;16:261-268.
Block MS, Rowan BG. Hypochlorous Acid: A Review. Journal of Oral and Maxillofacial Surgery. 2020;78(9):1461-1466. https://doi.org/10.1016/j.joms.2020.06.029
Stroman D, Mintun K, Epstein A, et al. Reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin. Clinical Ophthalmology. 2017;11:707-714.
Overholt B, Reynolds K, Wheeler D. 1151. A Safer, More Effective Method for Cleaning and Disinfecting GI Endoscopic Procedure Rooms. Open Forum Infectious Diseases. 2018;5(suppl 1):S346. doi: 10.1093/ofid/ofy210.984
Romero-Olid MDN, Bucataru E, Ramos-Garcia P, et al. Efficacy of chlorhexidine after oral surgery procedures on wound healing: systematic review and meta-analysis. Antibiotics. 2023;12(10):1552. https://doi.org/10.3390/antibiotics12101552
Canullo L, Laino L, Longo F, et al. Does Chlorhexidine Prevent Complications in Extractive, Periodontal, and Implant Surgery? A Systematic Review and Meta-analysis with Trial Sequential Analysis. International Journal of Oral & Maxillofacial Implants. 2020;35(6):p1149. doi: 10.11607/jomi.8216
Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, et al. Randomized, double-blind study of effectiveness of intra-alveolar application of chlorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. Journal of Oral and Maxillofacial Surgery. 2010;68(6):1322-1326. https://doi.org/10.1016/j.joms.2009.08.022
Sato S, Oguri S, Yamaguchi K, et al. Pumping injection of sodium hyaluronate for patients with non-reducing disc displacement of the temporomandibular joint: two year follow-up. Journal of Cranio-Maxillofacial Surgery. 2001;29(2):89-93. https://doi.org/10.1054/jcms.2000.0189
Sukumar S, Drizhal I. Hyaluronic acid and periodontitis. Acta Medica. 2007;50(4):225-228.
Fang F, Hu YS. Efficacy of topical application of hyaluronic acid in reducing complications after mandibular third molar surgery: a systematic review and meta-analysis. European Review for Medical & Pharmacological Sciences. 2023;27(8):3243-3254.
Koray M, Ofluoglu D, Onal EA, et al. Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. International journal of oral and maxillofacial surgery. 2014;43(11):1399-1403. https://doi.org/10.1016/j.ijom.2014.05.003
Kazancioglu HO, Kurklu E, Ezirganli S. Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery. 2014:43(5); 644-648. https://doi.org/10.1016/j.ijom.2013.11.006
Sivalingam VP, Panneerselvam E, Raja K, et al. Does topical ozone therapy improve patient comfort after surgical removal of impacted mandibular third molar? A randomized controlled trial. Journal of oral and maxillofacial surgery. 2017;75(1):51.e1-e9. https://doi.org/10.1016/j.joms.2016.09.014
Glória JCR, Douglas-de-Oliveira DW, e Silva LDA, et al. Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial. BMC Oral Health. 2020;20:1-9. https://doi.org/10.1186/s12903-020-01183-7
Nisha S, Shivamallu AB, Gujjari SK, et al. Efficacy of preprocedural boric acid mouthrinse in reducing viable bacteria in dental aerosols produced during ultrasonic scaling. Contemporary Clinical Dentistry. 2021;12(3):282-288. DOI: 10.4103/ccd.ccd_374_20
Eshghpour M, Mortazavi H, Mohammadzadeh Rezaei N, et al. Effectiveness of green tea mouthwash in postoperative pain control following surgical removal of impacted third molars: double blind randomized clinical trial. DARU Journal of Pharmaceutical Sciences. 2013;21:1-6. https://doi.org/10.1186/2008-2231-21-59
Kaplan V, Hasanoglu Erbasar GN, Cigerim L, et al. Effect of St. John’s wort oil and olive oil on the postoperative complications after third molar surgery: Randomized, double-blind clinical trial. Clinical Oral Investigations. 2021;25:2429-2438. https://doi.org/10.1007/s00784-020-03639-0
Polat HB, Özdemir H, Ay S. Effect of different mouth rinses on third molar surgery–related oral malodor. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2008;105(3), e1-e8. https://doi.org/10.1016/j.tripleo.2007.09.015
Coello-Gómez A, Navarro-Suárez S, Diosdado-Cano JM, et al. Postoperative effects on lower third molars of using mouthwashes with super-oxidized solution versus 0.2% chlorhexidine gel: A randomized double-blind trial. Medicina Oral, Patología Oral y Cirugía Bucal. 2018;23(6), e716-e722. doi: 10.4317/medoral.22622
Erbasar GNH, Kaplan V, Cigerim L, et al. Effect of combined boric acid and chlorhexidine mouthwashes on postoperative complications and periodontal healing after impacted third molar surgery: a-double blind randomized study. Clinical Oral Investigations. 2023;27(7):3817-3826. https://doi.org/10.1007/s00784-023-04999-z
Arekhi N, Mortazavi N, Bahramnejad E, et al. Assessment of a combined mouthwash on pain relief in pericoronitis: a randomized clinical study. BMC Oral Health. 2024;24(1):855. https://doi.org/10.1186/s12903-024-04660-5
Macfarlane TV, Kawecki MM, Cunningham C, et al. (2011). Mouthwash use in general population: results from adult dental health survey in grampian, Scotland. Journal of oral & maxillofacial research. 2011;(1(4):e2. doi: 10.5037/jomr.2010.1402
Boulares A, Jdidi H, Bragazzi NL. Impact of Mouthwash-Induced Oral Microbiome Disruption on Alzheimer's Disease Risk: A Perspective Review. International Dental Journal. 2025;75(1):45-50. https://doi.org/10.1016/j.identj.2024.07.005
