Bipolar Afektif Bozukluk Etyopatogenezinde Genetik, Nöroendokrin ve Nörokimyasal Faktörlerin İncelenmesi

Bobo W V. The Diagnosis and Management of Bipolar I and II Disorders: Clinical Practice Update. Mayo Clin Proc 2017;92: 1532–1551.

Caspi A, Moffitt TE. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 2006;7: 583–590.

Hara T, Owada Y, Takata A. Genetics of bipolar disorder: insights into its complex architecture and biology from common and rare variants. J Hum Genet 2023;68: 183–191.

Mullins N, Forstner AJ, O’Connell KS, Coombes B, Coleman JRI, Qiao Z et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet 2021;53: 817–829.

Bonacina G, Carollo A, Esposito G. The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders Genes. 2023;14. doi:10.3390/GENES14020352.

Roy B, Verma AK, Funahashi Y, Dwivedi Y. Deciphering the epigenetic role of long non‐coding RNAs in mood disorders: Focus on human brain studies. Clin Transl Med. 2025;15: e70135.

Fries GR, Li Q, McAlpin B, Rein T, Walss-Bass C, Soares JC et al. The role of DNA methylation in the pathophysiology and treatment of bipolar disorder. Neurosci Biobehav Rev 2016;68: 474–488.

Duffy A, Goodday SM, Keown-Stoneman C, Scotti M, Maitra M, Nagy C et al. Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents. Int J Bipolar Disord 2019; 7. doi:10.1186/S40345-019-0152-1.

Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 2018;362. doi:10.1126/SCIENCE.AAT8127.

Young LT, Warsh JJ, Kish SJ, Shannak K, Hornykeiwicz O. Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder. Biol Psychiatry 1994;35: 121–127.

Shiah IS, Yatham LN. Serotonin in mania and in the mechanism of action of mood stabilizers: a review of clinical studies. Bipolar Disord 2000;2: 77–92.

Ackenheil M. Neurotransmitters and signal transduction processes in bipolar affective disorders: a synopsis. J Affect Disord 2001;62: 101–111.

Baumann B, Danos P, Krell D, Diekmann S, Wurthmann C, Bielau H et al. Unipolar-bipolar dichotomy of mood disorders is supported by noradrenergic brainstem system morphology. J Affect Disord 1999;54: 217–224.

Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH et al. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Mol Psychiatry 2017;22: 666–679.

Wilkinson ST, Sanacora G. A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems. Drug Discov Today 2019; 24: 606–615.

Benes FM. The neurobiology of bipolar disorder: from circuits to cells to molecular regulation. Curr Top Behav Neurosci 2011; 5: 127–138.

Sanacora G, Gueorguieva R, Epperson CN, Wu Y Te, Appel M, Rothman DL et al. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 2004;61: 705–713.

Brady RO, Mccarthy JM, Prescot AP, Jensen JE, Cooper AJ, Cohen BM et al. Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder. Bipolar Disord 2013;15: 434–439.

Luscher B, Shen Q, Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Mol Psychiatry 2011;16: 383–406.

Yalin N. Revisiting Neuroimaging Endophenotypes in the Era of Machine Learning: The Key Role of Clinical Measures in Identifying Risk for Bipolar Disorder. Biol Psychiatry 2025;97: 215–216.

Andreazza AC, Noronha Frey B, Erdtmann B, Salvador M, Rombaldi F, Santin A et al. DNA damage in bipolar disorder. Psychiatry Res 2007;153: 27–32.

Sagar R, Pattanayak RD. Potential biomarkers for bipolar disorder: Where do we stand? Indian J Med Res 2017;145: 7–16.

Smedler E, Louhivuori L, Romanov RA, Masini D, Ellstrom ID, Wang C et al. Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety. Proc Natl Acad Sci. 2022;119. doi:10.1073/PNAS.2108768119.

Harrison PJ, Geddes JR, Tunbridge EM. The Emerging Neurobiology of Bipolar Disorder. Trends Neurosci 2018;41: 18–30.

Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, Lyoo IK et al. Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 2004;61: 450–458.

El-Mallakh RS, Wyatt RJ. The Na,K-ATPase hypothesis for bipolar illness. Biol Psychiatry 1995;37: 235–244.

Resende R, Fernandes T, Pereira AC, De Pascale J, Marques AP, Oliveira P et al. Mitochondria, endoplasmic reticulum and innate immune dysfunction in mood disorders: Do Mitochondria-Associated Membranes (MAMs) play a role? Biochim Biophys Acta Mol Basis Dis. 2020;1866. doi:10.1016/J.BBADIS2020.165752.

Gershon A, Johnson SL, Miller I. Chronic stressors and trauma: prospective influences on the course of bipolar disorder. Psychol Med 2013;43: 2583–2592.

Weiss RB, Stange JP, Boland EM, Black SK, LaBelle DR, Abramson LY et al. Kindling of life stress in bipolar disorder: comparison of sensitization and autonomy models. J Abnorm Psychol 2015;124: 4–16.

Lupien SJ, Maheu F, Tu M, Fiocco A, Schramek TE. The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition. Brain Cogn 2007;65: 209–237.

van den Berg MT, Wester VL, Vreeker A, Koenders MA, Boks MP, van Rossum EFC et al. Higher cortisol levels may proceed a manic episode and are related to disease severity in patients with bipolar disorder. Psychoneuroendocrinology 2020;119. doi:10.1016/JPSYNEUEN2020104658.

Drexhage HA, Bergink V, Poletti S, Benedetti F, Osborne LM. Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression, and postpartum autoimmune thyroid disease. Expert Rev Clin Immunol 2025. doi:10.1080/1744666X.20242420053.

Wang TY, Chang YH, Lee SY, Chang HH, Tsai TY, Tseng HH et al. Transdiagnostic features of inflammatory markers and executive function across psychiatric disorders. J Psychiatr Res 2025;181: 160–168.