Tubal ve Non-Tubal Ektopik Gebelikler
Özet
Ektopik gebelik blastokistin uterusun endometriyal kavitesi dışında yerleşmesi sonucu meydana gelmektedir. İnsidansının %1-2 olduğu ve giderek arttığı bilinmektedir. Hayatı tehdit eden bu durum farklı anatomik alanlarda görülebilmektedir. Ancak hastaların hızlı, doğru ve uygun tedavisinin yapılabilmesi için nerde lokalize olduğunun tespiti son derece önemlidir. Sıklıkla tubal yerleşimli olsa da ultrasonografik bulgularla birlikte iyi değerlendirilmelidir. Ektopik gebelik tedavisi beta-hCG seviyelerine, USG bulgularına ve hasta özelliklerine bağlı olarak bekle-gör, medikal veya cerrahi tedavilerini ya da bu yaklaşımların kombinasyonlarını içermektedir. Sonuçların iyileştirilebilmesi için klinisyenlerin hızlıca uygun tedaviye geçmeleri gerekmektedir. Semptom ve bulguların her hastaya özel olarak değerlendirilmesi gerektiği unutulmamalıdır.
Ectopic pregnancy occurs when the blastocyst implants outside the uterine endometrial cavity. It is known to have an incidence of 1-2% and is increasing over time. This life-threatening condition can occur in various anatomical areas. However, determining its exact location is crucial for the rapid, accurate, and appropriate treatment of the patients. Although it is most commonly located in the fallopian tube, it should be thoroughly evaluated along with ultrasound findings. Treatment of ectopic pregnancy depends on beta-hCG levels, ultrasound findings, and patient characteristics, and may include expectant, medical, surgical treatments, or combinations of these approaches. To improve outcomes, clinicians must quickly transition to the appropriate treatment. It should be remembered that symptoms and signs must be evaluated individually for each patient.
Referanslar
Po L, Thomas J, Mills K, et al. Guideline No. 414: Management of Pregnancy of Unknown Location and Tubal and Nontubal Ectopic Pregnancies. Journal of obstetrics and gynaecology Canada: JOGC. 2021;43(5):614-630.e1. doi: 10.1016/j.jogc.2021.01.002.
Brim ACS, Barretto VRD, Reis-Oliveira JG, et al. Risk factors for ectopic pregnancy occurrence: Systematic review and meta-analysis. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2024 Nov 27. doi: 10.1002/ijgo.15965. Epub ahead of print. PMID: 39602079.
Ankum WM, Mol BW, Van der Veen F, et al. Risk factors for ectopic pregnancy: a meta-analysis. Fertility and sterility. 1996;65(6):1093-1099.
Practice Committee of American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertility and sterility. 2013;100(3):638-644. doi: 10.1016/j.fertnstert.2013.06.013.
Long Y, Zhu H, Hu Y, et al. Interventions for non-tubal ectopic pregnancy. The Cochrane database of systematic reviews. 2020;7(7):CD011174. doi: 10.1002/14651858.CD011174.pub2.
Houser M, Kandalaft N, Khati NJ. Ectopic pregnancy: a resident's guide to imaging findings and diagnostic pitfalls. Emergency radiology. 2022;29(1):161-172. doi: 10.1007/s10140-021-01974-7.
Weigert M, Gruber D, Pernicka E, et al. Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in in vitro fertilization-embryo transfer patients. Journal of assisted reproduction and genetics. 2009;26(1):13-17. doi: 10.1007/s10815-008-9278-2.
Li C, Zhao WH, Meng CX, et al. Contraceptive Use and the Risk of Ectopic Pregnancy: A Multi-Center Case-Control Study. PLoS One. 2014;9(12):e115031. doi: 10.1371/journal.pone.0115031.
Perkins KM, Boulet SL, Kissin DM, Jamieson DJ; National ART Surveillance (NASS) Group. Risk of ectopic pregnancy associated with assisted reproductive technology in the United States, 2001-2011. Obstetrics and gynecology. 2015;125(1):70-78. doi: 10.1097/AOG.0000000000000584.
Li C, Meng CX, Zhao WH, et al. Risk factors for ectopic pregnancy in women with planned pregnancy: a case-control study. European journal of obstetrics, gynecology, and reproductive biology. 2014;181:176-182. doi: 10.1016/j.ejogrb.2014.07.049.
Sahin S, Ozay A, Ergin E, et al. The risk of ectopic pregnancy following GnRH agonist triggering compared with hCG triggering in GnRH antagonist IVF cycles. Archives of gynecology and obstetrics. 2015;291(1):185-191. doi: 10.1007/s00404-014-3399-x.
Huang B, Hu D, Qian K, et al. Is frozen embryo transfer cycle associated with a significantly lower incidence of ectopic pregnancy? An analysis of more than 30,000 cycles. Fertility and sterility. 2014;102(5):1345-1349. doi: 10.1016/j.fertnstert.2014.07.1245.
Zhang B, Cui L, Tang R, et al. Reduced Ectopic Pregnancy Rate on Day 5 Embryo Transfer Compared with Day 3: A Meta-Analysis. PLoS One. 2017;12(1):e0169837. doi: 10.1371/journal.pone.0169837.
Committee on Practice Bulletins—Gynecology. ACOG Practice Bulletin No. 191: Tubal Ectopic Pregnancy. Obstetrics and gynecology. 2018;131(2):e65-e77. doi: 10.1097/AOG.0000000000002464.
Nadim B, Infante F, Lu C, et al. Morphological ultrasound types known as 'blob' and 'bagel' signs should be reclassified from suggesting probable to indicating definite tubal ectopic pregnancy. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2018;51(4):543-549. doi: 10.1002/uog.17435.
Villegas E, González-Mesa E, Benítez MJ, et al. Tubal ectopic pregnancy two years after laparoscopic supracervical hysterectomy. BMC Women’s Health. 2014;14:69. doi: 10.1186/1472-6874-14-69.
Van den Hof MC, Smithies M, Nevo O, et al. No. 375-Clinical Practice Guideline on the Use of First Trimester Ultrasound. Journal of obstetrics and gynaecology Canada: JOGC. 2019;41(3):388-395. doi: 10.1016/j.jogc.2018.09.020.
Bertizlioğlu, M. Ektopik Gebelik., Önay Derin D (ed.), Sağlık Bilimleri Alanında Uluslararası Araştırmalar XVIII içinde. Konya: Eğitim Yayınevi; 2024. p. 57-59.
Barash JH, Buchanan EM, Hillson C. Diagnosis and management of ectopic pregnancy. American Academy of Family Physicians. 2014;90(1):34-40.
Elshamy E, Zakaria Y, Alajami F, et al. Expectant management versus systemic methotrexate in the management of persistent pregnancy of unknown location, a seven-year retrospective analysis. Archives of gynecology and obstetrics. 2024;309(3):1035-1041. doi: 10.1007/s00404-023-07332-x.
Levgur M, Tsai T, Kang K, et al. Endometrial stripe thickness in tubal and intrauterine pregnancies. Fertility and sterility. 2000;74(5):889-891. doi: 10.1016/s0015-0282(00)01542-9.
Doubilet PM. Ultrasound evaluation of the first trimester. Radiologic clinics of North America. 2014;52(6):1191-1199. doi: 10.1016/j.rcl.2014.07.004.
Reid S, Condous G. Is there a need to definitively diagnose the location of a pregnancy of unknown location? the case for “no.” Fertility and sterility. 2012;98(5):1085–1090. doi: 10.1016/j.fertnstert.2012.09.032
Rubal L, Chung K. Do you need to definitively diagnose the location of a pregnancy of unknown location? The case for "yes". Fertility and sterility. 2012;98(5):1078-1084. doi: 10.1016/j.fertnstert.2012.09.033.
Mullany K, Minneci M, Monjazeb R, et al. Overview of ectopic pregnancy diagnosis, management, and innovation. Womens Health (Lond). 2023;19:17455057231160349. doi: 10.1177/17455057231160349.
Brady P, Imudia AN, Awonuga AO, et al. Pregnancies of unknown location after in vitro fertilization: minimally invasive management with Karman cannula aspiration. Fertility and sterility. 2014;101(2):420-426. doi: 10.1016/j.fertnstert.2013.10.056.
Practice Committee of American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertility and sterility. 2013;100(3):638-644. doi: 10.1016/j.fertnstert.2013.06.013.
Alleyassin A, Khademi A, Aghahosseini M, et al. Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertility and sterility. 2006;85(6):1661-1666. doi: 10.1016/j.fertnstert.2005.11.055.
Elson J, Tailor A, Banerjee S, et al. Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2004;23(6):552-556. doi: 10.1002/uog.1061.
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 94: Medical management of ectopic pregnancy. Obstetrics and gynecology. 2008;111(6):1479-1485. doi: 10.1097/AOG.0b013e31817d201e.
Menon S, Colins J, Barnhart KT. Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. Fertility and sterility. 2007;87(3):481-484. doi: 10.1016/j.fertnstert.2006.10.007.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology. ACOG Practice Bulletin No. 193: Tubal Ectopic Pregnancy. Obstetrics and gynecology. 2018;131(3):e91-e103. doi: 10.1097/AOG.0000000000002560. Erratum in: Obstetrics and gynecology. 2019;133(5):1059. doi: 10.1097/AOG.0000000000003269.
ACOG Practice Bulletin No. 193 Summary: Tubal Ectopic Pregnancy. Obstetrics and gynecology. 2018;131(3):613-615. doi: 10.1097/AOG.0000000000002559.
Barnhart KT, Gosman G, Ashby R, et al. The medical management of ectopic pregnancy: a meta-analysis comparing "single dose" and "multidose" regimens. Obstetrics and gynecology. 2003;101(4):778-784. doi: 10.1016/s0029-7844(02)03158-7.
Guvendag Guven ES, Dilbaz S, Dilbaz B, et al. Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study. Acta obstetricia et gynecologica Scandinavica. 2010;89(7):889-895. doi: 10.3109/00016349.2010.486825.
Hajenius PJ, Mol F, Mol BW, et al. Interventions for tubal ectopic pregnancy. The Cochrane database of systematic reviews. 2007;2007(1):CD000324. doi: 10.1002/14651858.CD000324.pub2.
Capmas P, Bouyer J, Fernandez H. Treatment of ectopic pregnancies in 2014: new answers to some old questions. Fertility and sterility. 2014;101(3):615-620. doi: 10.1016/j.fertnstert.2014.01.029.
Wallwiener D, Becker S. Atlas of Gynecologic Surgery. (4th edition). Stuttgart: Thieme; 2013.
Mol F, van Mello NM, Strandell A, et al. European Surgery in Ectopic Pregnancy (ESEP) study group. Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial. Lancet. 2014;383(9927):1483-1489. doi: 10.1016/S0140-6736(14)60123-9.
Fernandez H, Capmas P, Lucot JP, et al. GROG. Fertility after ectopic pregnancy: the DEMETER randomized trial. Human reproduction. 2013;28(5):1247-1253. doi: 10.1093/humrep/det037.