Kawasaki Disease and Multisystem Inflammatory Syndrome in Children

Gorelik M, Chung SA, Ardalan K et al. 2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Kawasaki Disease. Arthritis Rheumatology. 2022 Apr;74(4):586-596. doi: 10.1002/art.42041.

Kawasaki T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi. 1967. Mar;16(3):178-222. doi: 10.1002/acr.24838.

T Kawasaki, F Kosaki, S Okawa et al. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974 Sep;54(3):271-6.

Singh S, Vignesh P, Burgner D. The epidemiology of Kawasaki disease: a global update.

Archives of Disease in Childhood. 2015 Nov;100(11):1084-8. doi: 10.1136/archdischild-2014-307536.

Makino N, Nakamura Y, Yashiro M et al. Epidemiological observations of Kawasaki disease in Japan, 2013-2014. Pediatrics Inernational. 2018 Jun;60(6):581-587. doi: 10.1111/ped.13544.

Maddox RA, Holman RC, Uehara R et al. Recurrent Kawasaki disease: USA and Japan. Pediatrics Inernational. 2015 Dec;57(6):1116-20. doi: 10.1111/ped.12733.

McCrindle BW, Rowley AH, Newburger JW et al. American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; and Council on Epidemiology and Prevention. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017 Apr 25;135(17):e927-e999. doi: 10.1161/CIR.0000000000000484.

K Stankovic, P Miailhes, D Bessis et al. Kawasaki-like syndromes in HIV-infected adults. Journal of Infection. 2007 Dec;55(6):488-94. doi: 10.1016/j.jinf.2007.09.005.

Uehara R, Yashiro M, Nakamura Y et al. Kawasaki disease in parents and children. Acta Paediatrica. 2003 Jun;92(6):694-7. doi: 10.1080/08035320310002768.

Greco A, Virgilio A, Rizzo MI et al. Kawasaki disease: an evolving paradigm. Autoimmunity Reviews. 2015 Aug;14(8):703-709. doi: 10.1016/j.autrev.2015.04.002.

Anne H. Rowley, Susan C. Baker et al. Ultrastructural, Immunofluorescence, and RNA Evidence Support the Hypothesis of a “New” Virus Associated With Kawasaki Disease. The Journal of Infectious Diseases. Volume 203, Issue 7, 1 April 2011, Pages 1021–1030. doi: 10.1093/infdis/jiq136.

Rowley AH, Shulman ST, Mask CA et al. IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease. The Journal of Infectious Diseases. 2000 Oct;182(4):1183-91. doi: 10.1086/315832.

H Suzuki, E Noda, M Miyawaki et al. Serum levels of neutrophil activation cytokines in Kawasaki disease. Pediatrics Inernational. 2001 Apr;43(2):115-9. doi: 10.1046/j.1442-200x.2001.01362.x.

Matsubara T, Ichiyama T, Furukawa S. Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease. Clinical and Experimental Immunology. 2005 Sep;141(3):381-7. doi: 10.1111/j.1365-2249.2005.02821.x.

Kumrah R, Vignesh P, Rawat A et al. Immunogenetics of Kawasaki disease. Clinical Reviews in Allergy & Immunology 2020 Aug;59(1):122-139. doi: 10.1007/s12016-020-08783-9.

Burgner D, Davila S, Breunis WB et al. International Kawasaki Disease Genetics Consortium. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genetics. 2009 Jan;5(1):e1000319. doi: 10.1371/journal.pgen.1000319.

Takahashi K, Oharaseki T, Yokouchi Y. Histopathological aspects of cardiovascular lesions in Kawasaki disease. International Journal of Rheumatic Diseseas. 2018 Jan;21(1):31-35. doi: 10.1111/1756-185X.13207.

Qiu Y, Zhang Y, Li Y et al. Molecular mechanisms of endothelial dysfunction in Kawasaki-disease-associated vasculitis. Frontiers in Cardiovasularc Medicine. 2022 Aug 8;9:981010. doi:10.3389/fcvm.2022.981010.

Guo M, Fan S, Chen Q et al. Platelet-derived microRNA-223 attenuates TNF-α induced monocytes adhesion to arterial endothelium by targeting ICAM-1 in Kawasaki disease. Frontiers in Immunology. 2022 Aug 2;13:922868. doi: 10.3389/fimmu.2022.922868.

Orenstein JM, Shulman ST, Fox LM et al. Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study. PLoS One. 2012;7(6):e38998. doi: 10.1371/journal.pone.0038998.

Kobayashi T, Ayusawa M, Suzuki H et al. Revision of diagnostic guidelines for Kawasaki disease (6th revised edition). Pediatrics International. 2020 Oct;62(10):1135-1138. doi: 10.1111/ped.14326.

Graeff N, Groot N, Ozen S et al. European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease - the SHARE initiative. Rheumatology (Oxford). 2019 Apr 1;58(4):672-682. doi: 10.1093/rheumatology/key344.

Tremoulet AH, Jain S, Chandrasekar D et al. Evolution of laboratory values in patients with Kawasaki disease. The Pediatric Infectious Disease Journal. 2011 Dec;30(12):1022-6. doi: 10.1097/INF.0b013e31822d4f56.

Kwon H, Lee JH, Jung JY et al. N-terminal pro-brain natriuretic peptide can be an adjunctive diagnostic marker of hyper-acute phase of Kawasaki disease. European Journal of Pediatrics. 2016 Dec;175(12):1997-2003. doi: 10.1007/s00431-016-2798-3.

Kavey RE, Allada V, Daniels SR et al. Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation. 2006 Dec 12;114(24):2710-38. doi: 10.1161/CIRCULATIONAHA.106.179568.

Hua W, Ma F, Wang Y et al. A new scoring system to predict Kawasaki disease with coronary artery lesions. Clinical Rheumatology. 2019 Apr;38(4):1099-1107. doi: 10.1007/s10067-018-4393-7.

Lo MS, Newburger JW. Role of intravenous immunoglobulin in the treatment of Kawasaki disease. Internatinale Journal of Rheumatic Diseases. 2018 Jan;21(1):64-69. doi: 10.1111/1756-185X.13220.

Dajani AS, Taubert KA, Takahashi M et al. Guidelines for long-term management of patients with Kawasaki disease. Report from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 1994 Feb;89(2):916-22. doi: 10.1161/01.cir.89.2.916.

Jia X, Du X, Bie S et al. What dose of aspirin should be used in the initial treatment of Kawasaki disease? A meta-analysis. Rheumatology (Oxford). 2020 Aug 1;59(8):1826-1833. doi: 10.1093/rheumatology/keaa050.

Dionne A, Son MBF, Randolph AG. An Update on Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2. The Pediatric Infectious Disease Journal. 2022 Jan 1;41(1):e6-e9. doi: 10.1097/INF.0000000000003393.

Belay ED, Abrams J, Oster ME, et al. Trends in geographic and temporal distribution of US children with multisystem inflammatory syndrome during the COVID-19 pandemic. JAMA Pediatrics. 2021;175(8):837–845. doi: 10.1001/jamapediatrics.2021.0630.

Jonat B, Gorelik M, Boneparth A et al. Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children's Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up. Pediatric Critical Care Medicine. 2021 Mar 1;22(3):e178-e191. doi: 10.1097/PCC.0000000000002598.

Nakra NA, Blumberg DA, Herrera-Guerra A et al. Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management. Children (Basel). 2020 Jul 1;7(7):69. doi: 10.3390/children7070069.

Diorio C, Shraim R, Vella LA et al.Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. Nature Communications. 2021 Dec 10;12(1):7222. doi: 10.1038/s41467-021-27544-6.

Vella LA, Rowley AH. Current Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome in Children. Current Pediatrics Reports. 2021;9(4):83-92. doi: 10.1007/s40124-021-00257-6.

Moreews M, Le Gouge K, Khaldi-Plassart S. Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children. Science Immunology. 2021 May 25;6(59):eabh1516 doi: 10.1126/sciimmunol.abh1516.

Whittaker E, Bamford A, Kenny J et al. PIMS-TS Study Group and EUCLIDS and PERFORM Consortia. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020 Jul 21;324(3):259-269. doi: 10.1001/jama.2020.10369.

Feldstein LR, Rose EB, Horwitz SM et al. Overcoming COVID-19 Investigators; CDC COVID-19 Response Team. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. New England Journal of Medicine. 2020 Jul 23;383(4):334-346. doi: 10.1056/NEJMoa2021680.

Miller J, Cantor A, Zachariah P et al. Gastrointestinal Symptoms as a Major Presentation Component of a Novel Multisystem Inflammatory Syndrome in Children That Is Related to Coronavirus Disease 2019: A Single Center Experience of 44 Cases.

Gastroenterology. 2020 Oct;159(4):1571-1574.e2. doi: 10.1053/j.gastro.2020.05.079.

Blevrakis E, Vergadi E, Stefanaki M et al. Mesenteric Lymphadenitis Presenting as Acute Abdomen in a Child with Multisystem Inflammatory Syndrome. Infectious Disease Reports. 2022 Jun 6;14(3):428-432. doi: 10.3390/idr14030046.

Winant AJ, Blumfield E, Liszewski MC et al. Thoracic Imaging Findings of Multisystem Inflammatory Syndrome in Children Associated with COVID-19: What Radiologists Need to Know Now. Radiology Cardiothorac Imaging. 2020 Jul 30;2(4):e200346. doi: 10.1148/ryct.2020200346.

Belhadjer Z, Méot M, Bajolle F et al. Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic. Circulation. 2020 Aug 4;142(5):429-436. doi: 10.1161/CIRCULATIONAHA.120.048360.

Son MBF, Murray N, Friedman K et al. Overcoming COVID-19 Investigators.Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. New England Journal of Medicine. 2021 Jul 1;385(1):23-34. doi: 10.1056/NEJMoa2102605.

Whitworth H, Sartain SE, Kumar R et al. Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C. Blood. 2021 Jul 15;138(2):190-198. doi: 10.1182/blood.2020010218.

Valverde I, Singh Y, Toledo JS, Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe. Circulation. 2021 Jan 5;143(1):21-32. doi:10.1161/CIRCULATIONAHA.120.050065. Epub 2020 Nov 9.

Bautista-Rodriguez C, Sanchez-de-Toledo J, Clark BC et al. Multisystem Inflammatory Syndrome in Children: An International Survey. Pediatrics. 2021 Feb;147(2):e2020024554. doi: 10.1542/peds.2020-024554. Epub 2020 Nov 24

Henderson LA, Canna SW, Friedman KG et al. American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 3. Arthritis Rheumatology. 2022 Apr;74(4):e1-e20. doi: 10.1002/art.42062. Epub 2022 Feb 3.

Ouldali N, Toubiana J, Antona D et al. French Covid-19 Paediatric Inflammation Consortium. Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children. JAMA. 2021 Mar 2;325(9):855-864. doi: 10.1001/jama.2021.0694.

Feldstein LR, Tenforde MW, Friedman KG, Newhams M et al. Overcoming COVID-19 Investigators. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021 Mar 16;325(11):1074-1087. doi: 10.1001/jama.2021.2091

Basalely A, Gurusinghe S, Schneider J et al. Acute kidney injury in pediatric patients hospitalized with acute COVID-19 and multisystem inflammatory syndrome in children associated with COVID-19. Kidney International. 2021 Jul;100(1):138-145. doi: 10.1016/j.kint.2021.02.026.

LaRovere KL, Riggs BJ, Poussaint TY et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurology. 2021 May 1;78(5):536-547. doi: 10.1001/jamaneurol.2021.0504.