Endodontide Nanoteknoloji
Özet
Nanoyapılar, atom seviyesinde üç boyutlu uzayın alanı olan nanoölçek aralığında (1-100 nm) en az bir boyuta sahip nesneler olarak tanımlanmaktadır. Nanobilim, nanometre ölçeğindeki yapıların incelenmesidir. Nanoteknoloji ise bu bilimin pratik uygulamalarda kullanılmasını ifade etmektedir. Nanopartiküller, kanser tedavisi, ilaç dağıtımı, doku mühendisliği ve antimikrobiyal ajanlar gibi çeşitli tıbbi uygulamalarda kullanılmaktadır.
Yüksek yüzey-hacim oranı ve biyouyumluluk gibi yararlı özellikleriyle nanopartiküller, tıpta hedefe yönelik ilaç dağıtımı, kanser tedavisi ve antimikrobiyal kullanımlar gibi alanlarda kritik rol oynar. Diş hekimliğinde ise tanı ve tedavileri geliştirirler. Radyolojide, BT/MRG gibi görüntüleme tekniklerinde kontrast maddesi olarak kullanılarak yüksek hassasiyet sağlarlar. Restoratif diş hekimliği, dental rezinlerin mekanik dayanıklılığını ve antibakteriyel özelliklerini artırmak için nanopartikülleri kullanır. Ortodontide, gümüş nanopartiküller apareylerde bakteriyel büyümeyi azaltırken, nanopartikül destekli adezivler bağlantı performansını iyileştirir. Protetik diş hekimliği, malzemelere entegre edilen nanopartiküllerle bakteriyel kolonizasyonu engeller. Endodonti, kitosan nanopartiküllerin kök kanallarındaki bakteri yükünü düşürmesi ve gümüş nanopartiküllerin antimikrobiyal patların etkinliğini artırmasıyla avantaj sağlar. Biyoaktif cam nanopartikülleri ise kanal dezenfeksiyonu ve dentin remineralizasyonunda etkilidir.
Nanoteknoloji, diş hekimliğinin birçok alanında önemli yenilikler getirmektedir. Nanopartiküller, dental materyallerin mekanik, antibakteriyel ve biyouyumluluk özelliklerini iyileştirerek tedavi süreçlerini daha etkili ve güvenli hale getirmektedir. Ancak, uzun vadeli etkileri ve toksisite riskleri gibi konular hala araştırılmaktadır.
Nanostructures, defined as objects with at least one dimension in the nanoscale range (1-100 nm), underpin advancements in nanoscience (study of atomic-scale materials) and nanotechnology (their practical applications). Nanoparticles, with their high surface-to-volume ratio and biocompatibility, are pivotal in medicine for targeted drug delivery, cancer therapy, and antimicrobial uses.
In dentistry, they revolutionize diagnostics and treatments: in radiology, nanoparticles act as contrast agents in CT/MRI for precise imaging; restorative dentistry employs them to enhance dental resins’ mechanical strength and antibacterial properties; orthodontics utilizes silver nanoparticles to reduce bacterial colonization on appliances while nanoparticle-enhanced adhesives improve bonding performance. Prosthodontics integrates nanoparticles into materials to inhibit bacterial growth, and endodontics leverages chitosan nanoparticles to lower bacterial load in root canals, silver nanoparticles to boost antimicrobial pastes’ efficacy, and bioactive glass nanoparticles for dentin remineralization and canal disinfection. By improving mechanical durability, antibacterial action, and biocompatibility, nanotechnology elevates dental treatments’ safety and effectiveness. However, long-term impacts and potential toxicity risks remain under active investigation, necessitating further research to ensure their safe clinical integration. Nanoparticles redefine dental care, but rigorous validation is essential to fully harness their transformative potential.
Referanslar
Contera S, Bernardino de la Serna J, Tetley TD. Biotechnology, nanotechnology and medicine. Emerg Top Life Sci 2020;4(6):551-554.
Hulla JE, Sahu SC, Hayes AW. Nanotechnology: History and future. Hum Exp Toxicol 2015;34(12):1318-1321.
Rudramurthy GR, Swamy MK. Potential applications of engineered nanoparticles in medicine and biology: an update. J Biol Inorg Chem 2018;23(8):1185-1204.
Moraes G, Zambom C, Siqueira WL. Nanoparticles in Dentistry: A Comprehensive Review. Pharmaceuticals (Basel) 2021;14(8).
Fuentes-Chust C, Parolo C, Rosati G, Rivas L, Perez-Toralla K, Simon S, et al. The Microbiome Meets Nanotechnology: Opportunities and Challenges in Developing New Diagnostic Devices. Adv Mater 2021;33(18):e2006104.
Zhu B, Macleod LC, Kitten T, Xu P. Streptococcus sanguinis biofilm formation & interaction with oral pathogens. Future Microbiol 2018;13(8):915-932.
Ferrer MD, Mira A. Oral Biofilm Architecture at the Microbial Scale. Trends Microbiol 2016;24(4):246-248.
He J, Zhu X, Qi Z, Wang C, Mao X, Zhu C, et al. Killing dental pathogens using antibacterial graphene oxide. ACS Appl Mater Interfaces 2015;7(9):5605-5611.
Qayyum S, Khan AU. Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance. Medchemcomm. 2016;7(8):1479-98.
Slomberg DL, Lu Y, Broadnax AD, Hunter RA, Carpenter AW, Schoenfisch MH. Role of size and shape on biofilm eradication for nitric oxide-releasing silica nanoparticles. ACS Appl Mater Interfaces 2013;5(19):9322-9329.
Bai YT, Zhang XQ, Chen XJ, Zhou G. Nanomedicines in oral cancer: inspiration comes from extracellular vesicles and biomimetic nanoparticles. Nanomedicine (Lond) 2022;17(23):1761-1778.
Satapathy S, Patro CS. Solid Lipid Nanoparticles for Efficient Oral Delivery of Tyrosine Kinase Inhibitors: A Nano Targeted Cancer Drug Delivery. Adv Pharm Bull 2022;12(2):298-308.
Kesharwani P, Ma R, Sang L, Fatima M, Sheikh A, Abourehab MAS, et al. Gold nanoparticles and gold nanorods in the landscape of cancer therapy. Mol Cancer 2023;22(1):98.
Xie L, Zhang X, Chu C, Dong Y, Zhang T, Li X, et al. Preparation, toxicity reduction and radiation therapy application of gold nanorods. J Nanobiotechnology 2021;19(1):454.
Nikitin MP, Shipunova VO, Deyev SM, Nikitin PI. Biocomputing based on particle disassembly. Nat Nanotechnol 2014;9(9):716-722.
Yakovtseva MN, Betzer O, Lunin AV, Mochalova EN, Beiderman M, Motiei M, et al. Magnetic and Gold Nanoparticles Optimized for Cancer Treatment via Cell Hitchhiking. Içinde: 2020 International Conference Laser Optics (ICLO). 2020.1-1
Huang P, Wang D, Su Y, Huang W, Zhou Y, Cui D, et al. Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy. J Am Chem Soc 2014;136(33):11748-11756.
Miao L, Guo S, Zhang J, Kim WY, Huang L. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater 2014;24(42):6601-6611.
He C, Duan X, Guo N, Chan C, Poon C, Weichselbaum RR, et al. Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nat Commun 2016;7:12499.
Sanchez-Moreno P, Ortega-Vinuesa JL, Peula-Garcia JM, Marchal JA, Boulaiz H. Smart Drug-Delivery Systems for Cancer Nanotherapy. Curr Drug Targets 2018;19(4):339-359.
Estelrich J, Escribano E, Queralt J, Busquets MA. Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery. Int J Mol Sci 2015;16(4):8070-8101.
Nikolova MP, Chavali MS. Metal Oxide Nanoparticles as Biomedical Materials. Biomimetics (Basel) 2020;5(2).
Hussein J, El-Banna M, Razik TA, El-Naggar ME. Biocompatible zinc oxide nanocrystals stabilized via hydroxyethyl cellulose for mitigation of diabetic complications. Int J Biol Macromol 2018;107(Pt A):748-754.
Fiandra L, Colombo M, Mazzucchelli S, Truffi M, Santini B, Allevi R, et al. Nanoformulation of antiretroviral drugs enhances their penetration across the blood brain barrier in mice. Nanomedicine 2015;11(6):1387-1397.
Shevtsov MA, Nikolaev BP, Yakovleva LY, Parr MA, Marchenko YY, Eliseev I, et al. 70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma. J Control Release 2015;220(Pt A):329-340.
Javidi M, Zarei M, Naghavi N, Mortazavi M, Nejat AH. Zinc oxide nano-particles as sealer in endodontics and its sealing ability. Contemp Clin Dent 2014;5(1):20-24.
Cierech M, Osica I, Kolenda A, Wojnarowicz J, Szmigiel D, Lojkowski W, et al. Mechanical and Physicochemical Properties of Newly Formed ZnO-PMMA Nanocomposites for Denture Bases. Nanomaterials (Basel) 2018;8(5).
Huang L, Jing S, Zhuo O, Meng X, Wang X. Surface Hydrophilicity and Antifungal Properties of TiO(2) Films Coated on a Co-Cr Substrate. Biomed Res Int 2017;2017:2054723.
Wolfbeis OS. An overview of nanoparticles commonly used in fluorescent bioimaging. Chem Soc Rev 2015;44(14):4743-4768.
Zhou W, Gao X, Liu D, Chen X. Gold Nanoparticles for In Vitro Diagnostics. Chem Rev 2015;115(19):10575-10636.
Jia S, Zhang R, Li Z, Li J. Clinical and biological significance of circulating tumor cells, circulating tumor DNA, and exosomes as biomarkers in colorectal cancer. Oncotarget 2017;8(33):55632-55645.
Xu Y, Luo C, Wang J, Chen L, Chen J, Chen T, et al. Application of nanotechnology in the diagnosis and treatment of bladder cancer. J Nanobiotechnology 2021;19(1):393.
Azevedo R, Soares J, Gaiteiro C, Peixoto A, Lima L, Ferreira D, et al. Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer. Talanta 2018;184:347-355.
Yasui T, Yanagida T, Ito S, Konakade Y, Takeshita D, Naganawa T, et al. Unveiling massive numbers of cancer-related urinary-microRNA candidates via nanowires. Sci Adv 2017;3(12):e1701133.
Gardner L, Kostarelos K, Mallick P, Dive C, Hadjidemetriou M. Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome. Nat Rev Clin Oncol 2022;19(8):551-561.
Kumar B, Singh S, Skvortsova I, Kumar V. Promising Targets in Anti-cancer Drug Development: Recent Updates. Curr Med Chem 2017;24(42):4729-4752.
Alimardani V, Rahiminezhad Z, DehghanKhold M, Farahavar G, Jafari M, Abedi M, et al. Nanotechnology-based cell-mediated delivery systems for cancer therapy and diagnosis. Drug Deliv Transl Res 2023;13(1):189-221.
Zhang Y, Yang H, An X, Wang Z, Yang X, Yu M, et al. Controlled Synthesis of Ag(2) Te@Ag(2) S Core-Shell Quantum Dots with Enhanced and Tunable Fluorescence in the Second Near-Infrared Window. Small 2020;16(14):e2001003.
Loo C, Lin A, Hirsch L, Lee MH, Barton J, Halas N, et al. Nanoshell-enabled photonics-based imaging and therapy of cancer. Technol Cancer Res Treat 2004;3(1):33-40.
Shrivas K, Nirmalkar N, Thakur SS, Deb MK, Shinde SS, Shankar R. Sucrose capped gold nanoparticles as a plasmonic chemical sensor based on non-covalent interactions: Application for selective detection of vitamins B(1) and B(6) in brown and white rice food samples. Food Chem 2018;250:14-21.
Deng S, Gu J, Jiang Z, Cao Y, Mao F, Xue Y, et al. Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer. J Nanobiotechnology 2022;20(1):415.
Majumder J, Minko T. Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19. AAPS J 2021;23(1):14.
Fischer NO, Rasley A, Corzett M, Hwang MH, Hoeprich PD, Blanchette CD. Colocalized delivery of adjuvant and antigen using nanolipoprotein particles enhances the immune response to recombinant antigens. J Am Chem Soc 2013;135(6):2044-2047.
Zhou J, Kroll AV, Holay M, Fang RH, Zhang L. Biomimetic Nanotechnology toward Personalized Vaccines. Adv Mater 2020;32(13):e1901255.
Monsky WL, Vien DS, Link DP. Nanotechnology development and utilization: a primer for diagnostic and interventional radiologists. Radiographics 2011;31(5):1449-1462.
San Valentin EMD, Barcena AJR, Klusman C, Martin B, Melancon MP. Nano-embedded medical devices and delivery systems in interventional radiology. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2023;15(1):e1841.
Chen T, Mori Y, Inui-Yamamoto C, Komai Y, Tago Y, Yoshida S, et al. Polymer-brush-afforded SPIO Nanoparticles Show a Unique Biodistribution and MR Imaging Contrast in Mouse Organs. Magn Reson Med Sci 2017;16(4):275-283.
Danelon M, Pessan JP, Neto FN, de Camargo ER, Delbem AC. Effect of toothpaste with nano-sized trimetaphosphate on dental caries: In situ study. J Dent 2015;43(7):806-813.
Melo MAS, Garcia IM, Mokeem L, Weir MD, Xu HHK, Montoya C, et al. Developing Bioactive Dental Resins for Restorative Dentistry. J Dent Res 2023;102(11):1180-1190.
Garcia IM, Balhaddad AA, Ibrahim MS, Weir MD, Xu HHK, Collares FM, et al. Antibacterial response of oral microcosm biofilm to nano-zinc oxide in adhesive resin. Dent Mater 2021;37(3):e182-e193.
López de Dicastillo C, Guerrero Correa M, B. Martínez F, Streitt C, José Galotto M. Antimicrobial Effect of Titanium Dioxide Nanoparticles. Içinde: Antimicrobial Resistance - A One Health Perspective IntechOpen. 2021.
Balhaddad AA, Garcia IM, Mokeem L, Alsahafi R, Collares FM, Sampaio de Melo MA. Metal Oxide Nanoparticles and Nanotubes: Ultrasmall Nanostructures to Engineer Antibacterial and Improved Dental Adhesives and Composites. Bioengineering (Basel) 2021;8(10).
Besinis A, De Peralta T, Tredwin CJ, Handy RD. Review of nanomaterials in dentistry: interactions with the oral microenvironment, clinical applications, hazards, and benefits. ACS Nano 2015;9(3):2255-2289.
Garcia IM, Leitune VCB, Visioli F, Samuel SMW, Collares FM. Influence of zinc oxide quantum dots in the antibacterial activity and cytotoxicity of an experimental adhesive resin. J Dent 2018;73:57-60.
Ghahremani L, Shirkavand S, Akbari F, Sabzikari N. Tensile strength and impact strength of color modified acrylic resin reinforced with titanium dioxide nanoparticles. J Clin Exp Dent 2017;9(5):e661-e665.
Meena A, MHS, PA, & KSR. Effect of adding nanoalumina and marble dust powder on the physical, mechanical, and thermo‐mechanical characterization of dental composite. Polym Compos. 2018;39(S1):321-31.
Mandhalkar R, Paul P, Reche A. Application of Nanomaterials in Restorative Dentistry. Cureus 2023;15(1):e33779.
Toledano M, Vallecillo-Rivas M, Aguilera FS, Osorio MT, Osorio E, Osorio R. Polymeric zinc-doped nanoparticles for high performance in restorative dentistry. J Dent 2021;107:103616.
Mertens C, Wiens D, Steveling HG, Sander A, Freier K. Maxillary sinus-floor elevation with nanoporous biphasic bone graft material for early implant placement. Clin Implant Dent Relat Res 2014;16(3):365-373.
Abou Neel EA, Bozec L, Perez RA, Kim HW, Knowles JC. Nanotechnology in dentistry: prevention, diagnosis, and therapy. Int J Nanomedicine 2015;10:6371-6394.
Roopavath UK, Soni R, Mahanta U, Deshpande AS, Rath SN. 3D printable SiO(2) nanoparticle ink for patient specific bone regeneration. RSC Adv 2019;9(41):23832-23842.
Glowacka-Sobotta A, Ziental D, Czarczynska-Goslinska B, Michalak M, Wysocki M, Guzel E, et al. Nanotechnology for Dentistry: Prospects and Applications. Nanomaterials (Basel) 2023;13(14).
Verma SK, & CR. Nanorobotics in dentistry–A review. Indian J Dent. 2014;62-70.
Yamamoto K, Ohashi S, Aono M, Kokubo T, Yamada I, Yamauchi J. Antibacterial activity of silver ions implanted in SiO2 filler on oral streptococci. Dent Mater 1996;12(4):227-229.
Zakrzewski W, Dobrzynski M, Dobrzynski W, Zawadzka-Knefel A, Janecki M, Kurek K, et al. Nanomaterials Application in Orthodontics. Nanomaterials (Basel) 2021;11(2).
Gracco A, Dandrea M, Deflorian F, Zanella C, De Stefani A, Bruno G, et al. Application of a Molybdenum and Tungsten Disulfide Coating to Improve Tribological Properties of Orthodontic Archwires. Nanomaterials (Basel) 2019;9(5).
Cheng HC, Chen MS, Peng BY, Lin WT, Shen YK, Wang YH. Surface Treatment on Physical Properties and Biocompatibility of Orthodontic Power Chains. Biomed Res Int 2017;2017:6343724.
Farhadian N, Usefi Mashoof R, Khanizadeh S, Ghaderi E, Farhadian M, Miresmaeili A. Streptococcus mutans counts in patients wearing removable retainers with silver nanoparticles vs those wearing conventional retainers: A randomized clinical trial. Am J Orthod Dentofacial Orthop 2016;149(2):155-160.
Elabd GM, Eldars W, Shamaa MS, Tawfik MA. Evaluation of the antibacterial effect of titanium dioxide nanoparticles combined with acrylic laminates for functional orthodontic appliances: a randomized controlled clinical trial. BMC Oral Health 2024;24(1):20.
Chladek G, Mertas A, Krawczyk C, Stencel R, Jabłońska-Stencel E. The influence of silver nanoparticles introduced into RTV-silicone matrix on the activity against Streptococcus mutans. Archives of Materials Science and Engineering. 2016;78(2):59-65.
Nam KY. Characterization and antimicrobial efficacy of Portland cement impregnated with silver nanoparticles. J Adv Prosthodont 2017;9(3):217-223.
Alp G, Johnston WM, Yilmaz B. Optical properties and surface roughness of prepolymerized poly(methyl methacrylate) denture base materials. J Prosthet Dent 2019;121(2):347-352.
Acosta-Torres LS, Mendieta I, Nunez-Anita RE, Cajero-Juarez M, Castano VM. Cytocompatible antifungal acrylic resin containing silver nanoparticles for dentures. Int J Nanomedicine 2012;7:4777-4786.
Coutinho IF, Aras MA, D’souza KM. Nanomaterials and their application in prosthodontics: a review. Journal of Research in Dentistry. 2018;6(6):124.
Priyadarsini S, Mukherjee S, Mishra M. Nanoparticles used in dentistry: A review. J Oral Biol Craniofac Res 2018;8(1):58-67.
Mok ZH, Proctor G, Thanou M. Emerging nanomaterials for dental treatments. Emerg Top Life Sci 2020;4(6):613-625.
Wang L, Liu Q, Jing D, Zhou S, Shao L. Biomechanical properties of nano-TiO(2) addition to a medical silicone elastomer: the effect of artificial ageing. J Dent 2014;42(4):475-483.
Nair N, James B, Devadathan A, Johny MK, Mathew J, Jacob J. Comparative Evaluation of Antibiofilm Efficacy of Chitosan Nanoparticle- and Zinc Oxide Nanoparticle-Incorporated Calcium Hydroxide-Based Sealer: An In vitro Study. Contemp Clin Dent 2018;9(3):434-439.
Virlan MJ, Miricescu D, Radulescu R, Sabliov CM, Totan A, Calenic B, et al. Organic Nanomaterials and Their Applications in the Treatment of Oral Diseases. Molecules 2016;21(2).
Barreras US, Mendez FT, Martinez RE, Valencia CS, Rodriguez PR, Rodriguez JP. Chitosan nanoparticles enhance the antibacterial activity of chlorhexidine in collagen membranes used for periapical guided tissue regeneration. Mater Sci Eng C Mater Biol Appl 2016;58:1182-1187.
Hsu SH, Huang GS. Substrate-dependent Wnt signaling in MSC differentiation within biomaterial-derived 3D spheroids. Biomaterials 2013;34(20):4725-4738.
Hsueh-Chuan Hsu. Preparation of chitosan/hydroxyapatite composite coating obtained from crab shells on hierarchical micro/nano-textured Ti surface. Surf Coat Technol. 2022, 437: 128364
Dragland IS, Wellendorf H, Kopperud H, Stenhagen I, Valen H. Investigation on the antimicrobial activity of chitosan-modified zinc oxide-eugenol cement. Biomater Investig Dent 2019;6(1):99-106.
DaSilva L, Finer Y, Friedman S, Basrani B, Kishen A. Biofilm formation within the interface of bovine root dentin treated with conjugated chitosan and sealer containing chitosan nanoparticles. J Endod 2013;39(2):249-253.
Elsaka S, Elnaghy A. Effect of addition of chitosan to self-etching primer: antibacterial activity and push-out bond strength to radicular dentin. J Biomed Res 2012;26(4):288-294.
Lee NY, Ko WC, Hsueh PR. Nanoparticles in the Treatment of Infections Caused by Multidrug-Resistant Organisms. Front Pharmacol 2019;10:1153.
Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH. The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry. Int J Nanomedicine 2020;15:2555-2562.
Kaushal A, Khurana I, Yadav P, Allawadhi P, Banothu AK, Neeradi D, et al. Advances in therapeutic applications of silver nanoparticles. Chem Biol Interact 2023;382:110590.
Abbaszadegan A, Nabavizadeh M, Gholami A, Aleyasin ZS, Dorostkar S, Saliminasab M, et al. Positively charged imidazolium-based ionic liquid-protected silver nanoparticles: a promising disinfectant in root canal treatment. Int Endod J 2015;48(8):790-800.
Singh R, Wagh P, Wadhwani S, Gaidhani S, Kumbhar A, Bellare J, et al. Synthesis, optimization, and characterization of silver nanoparticles from Acinetobacter calcoaceticus and their enhanced antibacterial activity when combined with antibiotics. Int J Nanomedicine 2013;8:4277-4290.
Yousefshahi H, Aminsobhani M, Shokri M, Shahbazi R. Anti-bacterial properties of calcium hydroxide in combination with silver, copper, zinc oxide or magnesium oxide. Eur J Transl Myol 2018;28(3):7545.
Baras BH, Melo MAS, Sun J, Oates TW, Weir MD, Xie X, et al. Novel endodontic sealer with dual strategies of dimethylaminohexadecyl methacrylate and nanoparticles of silver to inhibit root canal biofilms. Dent Mater 2019;35(8):1117-1129.
Charannya S, Duraivel D, Padminee K, Poorni S, Nishanthine C, Srinivasan MR. Comparative Evaluation of Antimicrobial Efficacy of Silver Nanoparticles and 2% Chlorhexidine Gluconate When Used Alone and in Combination Assessed Using Agar Diffusion Method: An In vitro Study. Contemp Clin Dent 2018;9(Suppl 2):S204-S209.
Mejias Carpio IE, Santos CM, Wei X, Rodrigues DF. Toxicity of a polymer-graphene oxide composite against bacterial planktonic cells, biofilms, and mammalian cells. Nanoscale 2012;4(15):4746-4756.
Raura N, Garg A, Arora A, Roma M. Nanoparticle technology and its implications in endodontics: a review. Biomater Res 2020;24(1):21.
Hu W, Peng C, Lv M, Li X, Zhang Y, Chen N, et al. Protein corona-mediated mitigation of cytotoxicity of graphene oxide. ACS Nano 2011;5(5):3693-3700.
Jafari N, Habashi MS, Hashemi A, Shirazi R, Tanideh N, Tamadon A. Application of bioactive glasses in various dental fields. Biomater Res 2022;26(1):31.
Waltimo T, Mohn D, Paque F, Brunner TJ, Stark WJ, Imfeld T, et al. Fine-tuning of bioactive glass for root canal disinfection. J Dent Res 2009;88(3):235-238.
Vichery C, Nedelec JM. Bioactive Glass Nanoparticles: From Synthesis to Materials Design for Biomedical Applications. Materials (Basel) 2016;9(4).
Mohn D, Zehnder M, Imfeld T, Stark WJ. Radio-opaque nanosized bioactive glass for potential root canal application: evaluation of radiopacity, bioactivity and alkaline capacity. Int Endod J 2010;43(3):210-217.
Correia BL, Gomes A, Noites R, Ferreira JMF, Duarte AS. New and Efficient Bioactive Glass Compositions for Controlling Endodontic Pathogens. Nanomaterials (Basel) 2022;12(9).
Capuano N, Amato A, Dell'Annunziata F, Giordano F, Folliero V, Di Spirito F, et al. Nanoparticles and Their Antibacterial Application in Endodontics. Antibiotics (Basel) 2023;12(12).
Guerreiro-Tanomaru JM, Trindade-Junior A, Costa BC, da Silva GF, Drullis Cifali L, Basso Bernardi MI, et al. Effect of zirconium oxide and zinc oxide nanoparticles on physicochemical properties and antibiofilm activity of a calcium silicate-based material. ScientificWorldJournal 2014;2014:975213.
Kishen A, Shi Z, Shrestha A, Neoh KG. An investigation on the antibacterial and antibiofilm efficacy of cationic nanoparticulates for root canal disinfection. J Endod 2008;34(12):1515-1520.
