Tularemi
Özet
Tularemi, Francisella tularensis adlı bakterinin sebep olduğu zoonotik bir hastalıktır. Kemiriciler, tavşanlar ve diğer hayvanlar bu bakteriyi taşıyabilir ve insanlara bulaştırabilir. Genellikle vektörler (örneğin, keneler veya sinekler) veya temas yoluyla insanlara geçer. Semptomları ateş, titreme, baş ağrısı, kas ağrıları, lenf bezlerinde şişme ve cilt lezyonlarıdır. Maruziyet şekline göre farklı klinik formları mevcuttur. Endemik bölgelerde şüphe ve hastalığın akla gelmesi önemlidir. Erken antibiyoterapi etkilidir. Tarım, avcılık ve doğa ile temas gibi faaliyetler hastalık riskini artırabilir. Özellikle tarım işçileri, veterinerler, avcılar ve ormanlık alanlarda çalışanlar risk altındadır. Koruyucu önlemler, hayvan temasını sınırlamak, koruyucu giysi kullanmak ve enfekte hayvan leşlerine dokunmamak gibi basit önlemlerle bulaşma riski azaltılabilir. Tularemi, nadir görülen bir hastalık olmasına rağmen, uygun önlemlerle enfeksiyon riski azaltılabilir.
Referanslar
Gürcan S. Epidemiology of tularemia. Balkan Med J. 2014 Mar;31(1):3-10. doi: 10.5152/balkanmedj.2014.13117. Epub 2014 Mar 1. PMID: 25207161; PMCID: PMC4115998.
McLendon MK, Apicella MA, Allen LA. Francisella tularensis: taxonomy, genetics, and Immunopathogenesis of a potential agent of biowarfare. Annu Rev Microbiol. 2006; 60:167-85. doi: 10.1146/annurev.micro.60.080805.142126. PMID: 16704343; PMCID: PMC1945232.
Caspar Y, Maurin M. Francisella tularensis Susceptibility to Antibiotics: A Comprehensive Review of the Data Obtained In vitro and in Animal Models. Front Cell Infect Microbiol. 2017 Apr 11; 7:122. doi: 10.3389/fcimb.2017.00122. PMID: 28443249; PMCID: PMC5386985.
Kingry LC, Petersen JM. Comparative review of Francisella tularensis and Francisella novicida. Front Cell Infect Microbiol. 2014 Mar 13; 4:35. doi: 10.3389/fcimb.2014.00035. PMID: 24660164; PMCID: PMC3952080.
Aravena-Román M, Merritt A, Inglis TJ. First case of Francisella bacteraemia in Western Australia. New Microbes New Infect. 2015 Oct 22; 8:75-7. doi: 10.1016/j.nmni.2015.10.004. PMID: 26649180; PMCID: PMC4644258.
Ramos JM, Pérez-Tanoira R, Martín-Martín I et al. Arthropod-Borne Bacteria Cause Nonmalarial Fever in Rural Ethiopia: A Cross-Sectional Study in 394 Patients. Vector Borne Zoonotic Dis. 2019 Nov;19(11):815-820. doi: 10.1089/vbz.2018.2396. Epub 2019 Jun 10. PMID: 31184993; PMCID: PMC6939579.
Kılıç S. A generel overview of Francisella tularensis an the epidemiology of tularemia in Turkey. Flora Dergisi, 2010;15(2):37-58
Maurin M. Francisella tularensis, Tularemia and Serological Diagnosis. Front Cell Infect Microbiol. 2020 Oct 26; 10:512090. doi: 10.3389/fcimb.2020.512090. PMID: 33194778; PMCID: PMC7649319.
Celli J, Zahrt TC. Mechanisms of Francisella tularensis intracellular pathogenesis. Cold Spring Harb Perspect Med. 2013 Apr 1;3(4): a010314. doi: 10.1101/cshperspect.a010314. PMID: 23545572; PMCID: PMC3683997.
Penn RL. Francisella tularensis (Tularemia). Mandell GL, Bennett JE, Dolin R. (Eds).Principles and Practice of Infectious Diseases içinde. 7th Ed, Churchill Livingstone, Philadelphia 2010: p.2927-2937
Evans ME, Gregory DW, Schaffner W et al. Tularemia: a 30-year experience with 88 cases. Medicine (Baltimore). 1985;64:251-69.
Sencan I, Sahin I, Kaya D et al. An outbreak of oropharyngeal tularemia with cervical adenopathy predominantly in the left side. Yonsei Med J. 2009 Feb 28;50(1):50-4. doi: 10.3349/ymj.2009.50.1.50. Epub 2009 Feb 24. PMID: 19259348; PMCID: PMC2649863.
Williams MS, Baker MR, Guina T et al. Retrospective Analysis of Pneumonic Tularemia in Operation Whitecoat Human Subjects: Disease Progression and Tetracycline Efficacy. Front Med (Lausanne). 2019 Oct 22;6:229. doi: 10.3389/fmed.2019.00229. PMID: 31696118; PMCID: PMC6818494.
Lindquist D, Chu MD, Probert WS. Francisella and Brucella.Murray PR, Baron EJ, Jorgensen (Eds). Manual of Clinical Microbiology içinde. 9th ed. Washington, DC: American Society for Microbiology Press; 2007: p.815-834.
McGinley-Smith DE, Tsao SS. Dermatoses from ticks. J Am Acad Dermatol. 2003 Sep;49(3):363-92; quiz 393-6. doi: 10.1067/s0190-9622(03)01868-1. PMID: 12963900.
Şenel E, Satılmış Ö, Acar B. Dermatologic manifestations of tularemia: a study of 151 cases in the mid-Anatolian region of Turkey. Int J Dermatol. 2015 Jan;54(1):e33-7. doi: 10.1111/ijd.12431. Epub 2014 Sep 10. PMID: 25208535.
Dietrich EA, Peterson JM. Francisella. Jorgensen J, Pfaller M, Carroll K, et al (Eds).Manual of Clinical Microbiology içinde. 12th ed, American Society for Microbiology Press, Washington DC 2019. p.871.
Larson MA, Sayood K, Bartling AM, Meyer JR, Starr C, Baldwin J, Dempsey MP. Differentiation of Francisella tularensis Subspecies and Subtypes. J Clin Microbiol. 2020 Mar 25;58(4):e01495-19. doi: 10.1128/JCM.01495-19. PMID: 31941692; PMCID: PMC7098747.
World Health Organization. (2007). WHO Guidelines on tularaemia. (15.01.2024 tarihinde https://iris.who.int/handle/10665/43793 adresimden ulaşılmıştır).
Beard CB, Dennis DT.Tularemia.Cohen J, Opal SM, Powderly WG (Eds).Infectious Diseasesiçinde.3rd ed. London, 2010; p.1226–1230.
American Academy of Pediatrics. Tularemia. Barnett ED, Lynfield R, Sawyer MH (Eds). Red Book: 2021-2024 Report of the Committee on Infectious Diseasesiçinde.32nd ed, Kimberlin DW, Itasca, IL 2021. p.822-825.
Gaci R, Alauzet C, Selton-Suty C et al. Francisella tularensis endocarditis: two case reports and a literature review. Infect Dis (Lond). 2017 Feb;49(2):128-131. doi: 10.1080/23744235.2016.1222546. Epub 2016 Aug 26. PMID: 27564142.
Cross JT, Jacobs RF. Tularemia: treatment failures with outpatient use of ceftriaxone. Clin Infect Dis. 1993 Dec;17(6):976-80. doi: 10.1093/clinids/17.6.976. PMID: 8110955.
Eliasson H, Broman T, Forsman M et al. Tularemia: current epidemiology and disease management. Infect Dis Clin North Am. 2006 Jun;20(2):289-311, ix. doi: 10.1016/j.idc.2006.03.002. PMID: 16762740.
Conlan JW, Sjöstedt A, Gelhaus HC et al. Modern Development and Production of a New Live Attenuated Bacterial Vaccine, SCHU S4 ΔclpB, to Prevent Tularemia. Pathogens. 2021 Jun 23;10(7):795. doi: 10.3390/pathogens10070795. PMID: 34201577; PMCID: PMC8308573.