Multipl Sklerozun Patogenezi

Compston A, Coles A. Multiple sclerosis. Vol. 372, The Lancet. Elsevier B.V.; 2008. p. 1502–17.

Lucchinetti C, Brück W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H, et al. Heterogeneity of Multiple Sclerosis Lesions: Implications for the Pathogenesis of Demyelination. 2000.

Carswell R. Pathological anatomy: illustrations of the elementary forms of disease. Longman, Orme, Brown, Green and Longman. 1838;

Frohman EM, Racke MK, Raine CS. Medical Progress Multiple Sclerosis-The Plaque and Its Pathogenesis [Internet]. 2006. Available from: www.nejm.org

Qin Y, Duquette P, Zhang Y, Talbot P, Poole R, Antel J. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis. Journal of Clinical Investigation. 1998 Sep 1;102(5):1045–50.

Paul WE, Schwartz RS, Datta SK. Autoimmunity and Autoimmune Diseases. In Fundamental Immunology. New York: Raven Press. 1989. p. 819-866.

Rodriguez M, Warrington AE, Pease LR. Human natural autoantibodies in the treatment of neurologic disease. 2009.

Lemus HN, Warrington AE, Rodriguez M. Multiple Sclerosis: Mechanisms of Disease and Strategies for Myelin and Axonal Repair. Vol. 36, Neurologic Clinics. W.B. Saunders; 2018. p. 1–11.

Ghasemi N, Razavi S, Nikzad E. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy Citation: Ghasemi N, Razavi Sh, Nikzad E. Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy. Vol. 19, CELL JOURNAL(Yakhteh).

Baecher-Allan C, Kaskow BJ, Weiner HL. Multiple Sclerosis: Mechanisms and Immunotherapy. Vol. 97, Neuron. Cell Press; 2018. p. 742–68.

Gandhi R, Laroni A, Weiner HL. Role of the innate immune system in the pathogenesis of multiple sclerosis. Vol. 221, Journal of Neuroimmunology. 2010. p. 7–14.

Kasper LH, Shoemaker J. Multiple sclerosis immunology: The healthy immune system vs the MS immune system. Neurology. 2010;74(SUPPL.):S2.

Abbas AK, Lichtman AH. Basic immunology : functions and disorders of the immune system. 6th ed. 2020. 96–118 p.

Zhu J, Paul WE. CD4 T cells: Fates, functions, and faults. Blood. 2008 Sep 1;112(5):1557–69.

Wynn TA. IL-13 effector functions. Vol. 21, Annual Review of Immunology. 2003. p. 425–56.

Ouyang W, Kolls JK, Zheng Y. The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation. Vol. 28, Immunity. 2008. p. 454–67.

Traugott U, Reinherz EL, Raine ’ CS. Multiple Sclerosis Distribution of T Cells, T Cell Subsets arm Ia-positive Macrophages in Lesions of Different Ages. Journal ofNeuroimmanology. 1983.

Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr C, Weiner HL. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol. 1986;19(6):578–87.

Losy J. Is MS an inflammatory or primary degenerative disease? J Neural Transm. 2013 Oct;120(10):1459–62.

Melzer N, Meuth SG, Wiendl H. CD8+ T cells and neuronal damage: Direct and collateral mechanisms of cytotoxicity and impaired electrical excitability. Vol. 23, FASEB Journal. FASEB; 2009. p. 3659–73.

Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, et al. IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. Journal of Clinical Investigation. 2013 Jan 2;123(1):247–60.

Greenfield AL, Hauser SL. B-cell Therapy for Multiple Sclerosis: Entering an era. Vol. 83, Annals of Neurology. John Wiley and Sons Inc.; 2018. p. 13–26.

Schirmer L, Srivastava R, Hemmer B. To look for a needle in a haystack: The search for autoantibodies in multiple sclerosis. Vol. 20, Multiple Sclerosis Journal. 2014. p. 271–9.

Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, et al. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain. 2011 Feb;134(2):534–41.

Henderson APD, Barnett MH, Parratt JDE, Prineas JW. Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions. Ann Neurol. 2009 Dec;66(6):739–53.

Barnas JL, Looney RJ, Anolik JH. B cell targeted therapies in autoimmune disease. Vol. 61, Current Opinion in Immunology. Elsevier Ltd; 2019. p. 92–9.

Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, et al. Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis. The Journal of Immunology. 2007 May 15;178(10):6092–9.

Vargas-Lowy D, Chitnis T. Pathogenesis of pediatric multiple sclerosis. Vol. 27, Journal of Child Neurology. 2012. p. 1394–407.

Stewart GJ, Mcleod JG, Basten A, Bashir H V. HLA Family Studies and Multiple Sclerosis: A Comion Gene, Dominantly Expressed.

Haines JL, Terwedow HA, Burgess K, Pericak-Vance MA, Rimmler JB, Martin ER, et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity The Multiple Sclerosis Genetics Group. Vol. 7, Human Molecular Genetics. 1998.

Sawcer S, Goodfellowt PN. Inheritance of susceptibility to multiple sclerosis. Curr Opin Immunol [Internet]. 1998;10:697–703. Available from: http://biomednet.com/elecref/0952791501000697

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study. New England Journal of Medicine. 2007 Aug 30;357(9):851–62.

Chitnis T, Glanz B, Jaffin S, Healy B. Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States. Multiple Sclerosis. 2009;15(5):627–31.

Gorman MP, Healy BC, Polgar-Turcsanyi M, Chitnis T. Increased Relapse Rate in Pediatric-Onset Compared With Adult-Onset Multiple Sclerosis [Internet]. Vol. 66, Arch Neurol. 2009. Available from: http://archneur.jamanetwork.com/

Kennedy J, O’Connor P, Sadovnick AD, Perara M, Yee I, Banwell B. Age at onset of multiple sclerosis may be influenced by place of residence during childhood rather than ancestry. Neuroepidemiology. 2006 Apr;26(3):162–7.

Banwell B, Mcgowan M, O’mahony J. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. www.thelancet.com/neurology [Internet]. 2011;10. Available from: www.thelancet.com/neurology

Disanto G, Magalhaes S, Handel AE, Morrison KM, Sadovnick AD, Ebers GC, et al. HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination On behalf of the Canadian Pediatric Demyelinating Disease Network [Internet]. 2011. Available from: www.neurology.org.

Ohlenbusch A, Pohl D. Myelin Oligodendrocyte Gene Polymorphisms and Childhood Multiple Sclerosis. 2002;

Anlar B, Alikas Ëifoglu M, Köse G, Güven A, Gürer Y, Yakut A, et al. Tumor Necrosis Factor-Alpha Gene Polymorphisms in Children with Multiple Sclerosis Statistical analysis. Vol. 32, Neuropediatrics. 2001.

Chitnis T, Krupp L, Yeh A, Rubin J, Kuntz N, Strober JB, et al. Pediatric Multiple Sclerosis. Vol. 29, Neurologic Clinics. 2011. p. 481–505.

Lünemann JD, Huppke P, Roberts S, Brück BW, Gärtner J, Münz C. Clinical/Scientific Notes BROADENED AND ELEVATED HUMORAL IMMUNE RESPONSE TO EBNA1 IN PEDIATRIC MULTIPLE SCLEROSIS [Internet]. 2008. Available from: www.neurology.org

Pohl D, Krone B, Rostasy K, Kahler E, Brunner E, Lehnert M, et al. High seroprevalence of Epstein-Barr virus in children with multiple sclerosis [Internet]. 2006. Available from: www.neurology.org

Simpson S, Blizzard L, Otahal P, Van Der Mei I, Taylor B. Latitude is significantly associated with the prevalence of multiple sclerosis: A meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82(10):1132–41.

Ahlgren C, Odén A, Lycke J. A nationwide survey of the prevalence of multiple sclerosis in immigrant populations of Sweden. Multiple Sclerosis Journal. 2012;18(8):1099–107.

Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-Hydroxyvitamin D Levels and Risk of Multiple Sclerosis [Internet]. Available from: http://jama.jamanetwork.com/

Lucas RM, Byrne SN, Correale J, Ilschner S, Hart PH. Ultraviolet radiation, vitamin D and multiple sclerosis. Vol. 5, Neurodegenerative disease management. 2015. p. 413–24.

Aranow C. Vitamin D and the Immune System. 2011.

Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol. 2010 May;67(5):618–24.

Wingerchuk DM. Smoking: Effects on multiple sclerosis susceptibility and disease progression. Vol. 5, Therapeutic Advances in Neurological Disorders. 2012. p. 13–22.

Mikaeloff Y, Caridade G, Tardieu M, Suissa S. Parental smoking at home and the risk of childhood-onset multiple sclerosis in children. Brain. 2007;130(10):2589–95.

Olsson T, Barcellos LF, Alfredsson L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Vol. 13, Nature Reviews Neurology. Nature Publishing Group; 2016. p. 26–36.