Kolin-İnositol-PABA

Yazarlar

Özet

Kolin, inositol ve PABA, çocuk sağlığı üzerinde önemli rol oynayan besin takviyeleridir. Kolin beyin gelişimi, sinir sistemi fonksiyonları ve hafıza için kritik bir bileşendir. Özellikle fetüs ve küçük çocuklarda beyin gelişimine katkı sağlar. Eksiklik durumunda, hafıza sorunları ve nörolojik gelişim gerilikleri görülebilir. İnositol, hücre sinyalleşmesi ve yağ metabolizmasında görev alır. Sinir sistemi sağlığı ve hücre zarlarının korunması için önemlidir. PABA, folik asit metabolizmasında görev alan bir bileşiktir ve cilt sağlığını destekler. Hücresel büyüme için önemlidir. PABA takviyesi genellikle cilt sağlığını korumak amacıyla kullanılır.

Referanslar

Bernhard W, Poets CF, Franz AR. Choline and choline-related nutrients in regular and preterm infant growth European Journal of Nutrition 2019; 58:931–945. doi: 10.1007/s00394-018-1834-7.

Wiedeman AM, Barr SI, Green TJ, et al. Dietary choline intake: Current state of knowledge across the life cycle. Nutrients 2018;10:1513. doi: 10.3390/nu10101513.

Bernhard W, Lange R, Graepler-Mainka U, et al. Choline supplementation in cystic fibrosis-the metabolic and clinical impact. Nutrients 2019;11:356. doi: 10.3390/nu11030656.

Wallace TC, Blusztajn JK, Caudill MA, et al. Choline: The underconsumed and underappreciated essential nutrient. Nutrition Today 2018;53:240–253. doi: 10.1097/NT.0000000000000302.

Shim E, Park E. Choline intake and its dietary reference values in Korea and other countries: a review. Nutrition Research and Practice 2022;16:S126–133. doi: 10.4162/nrp.2022.16.S1.S126.

Zhang LC, Jin X, Huang Z, et al. Protective effects of choline against hypoxia-induced injuries of vessels and endothelial cells. Experimental and Therapeutic Medicine 2017;13:2316–2324. doi: 10.3892/etm.2017.4276.

Rees G, Brough L, Orsatti GM, et al. Do micronutrient and omega-3 fatty acid supplements affect human maternal immunity during pregnancy? A scoping review. Nutrients 2022; 14:367. doi: 10.3390/nu14020367.

Parthasarathy LK, Seelan RS, Tobias C, et al. Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent. Subcellular Biochemistry 2006; 39:293–314. doi:10.1007/0-387-27600-9_12.

Kiani AK, Paolacci S, Bertelli M. From Myo-inositol to D-chiro-inositol molecular pathways. European Review for Medical and Pharmacological Sciences. 2021; 25 (5): 2390–2402.

Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie. 2013;95 (10): 1811–1827. doi:10.1016/j.biochi.2013.05.011.

United States National Institutes of Health. (2014, January 24). Para-aminobenzoic acid. Medline Plus Medical Encyclopedia. Retrieved from http://www.nlm.nih.gov/medlineplus. Accessed 2023 September.

Kluczyk A, Popek T, Kiyota T, et al. Drug evolution: p-aminobenzoic acid as a building block. Current Medical Chemistry 2002;9(21):1871-92. doi: 10.2174/0929867023368872.

Zeisel SH, Corbin KD. Choline. In: Erdman JW, Macdonald IA, Zeisel SH (eds.) Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:p(405-418).

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.

Zeisel SH. Choline. In: Coates PM, Betz JM, Blackman MR, et al.( eds.) Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010: p(136-143).

Zeisel SH. Choline. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR,(eds.) Modern Nutrition in Health and Disease. 11th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2014: p(416-426)

Hollenbeck CB. An introduction to the nutrition and metabolism of choline. Central Nervous System Agents in Medicinal Chemistry 2012;12:100-113.

Caudill MA, Miller JW, Gregory JF, Shane B. Folate, choline, vitamin B12, and vitamin B6. In: H. SM, Caudill MA,(eds.) Biochemical, Physiological, and Molecular Aspects of Human Nutrition. 3rd ed; 2012:p(565-608).

Holm PI, Ueland PM, Kvalheim G, et al. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clinical Chemistry 2003;49:286-294.

Tsui MM. York JD. Roles of inositol phosphates and inositol pyrophosphates in development, cell signaling and nuclear processes. Advances in Enzyme Regulation 2010;50:324–337. doi:10.1016/j.advenzreg.2009.12.002.

Thomas MP, Mills SJ, Potter BV. The Other Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry) Angew. Chem. Int. Ed. Engl. 2016;55:1614–1650. doi: 10.1002/anie.201502227.

Mukai T, Kishi T, Matsuda Y, et al. A meta-analysis of inositol for depression and anxiety disorders. Human Psychopharmacology 2014;29:55–63. doi: 10.1002/hup.2369.

Tabrizi R, Ostadmohammadi V, Asemi Z. The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Lipids in Health and Disease.2018; 17 (1): 123. doi:10.1186/s12944-018-0779-4

Chatree S, Thongmaen N, Tantivejkul K, et al. Role of Inositols and Inositol Phosphates in Energy Metabolism. Molecules. 2020;25(21):5079. doi: 10.3390/molecules25215079.

Facchinetti F, Appetecchia M, Aragona C, et al. Experts' opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond. Expert Opinion on Drug Metabolism & Toxicology 2020:16(3):255-274. doi: 10.1080/17425255.2020.1737675.

Colazingari S. Fiorenza MT. Carlomagno G. et al. Improvement of mouse embryo quality by myo-inositol supplementation of IVF media. Journal of Assisted Reproduction and Genetics. 2014;31:463–469. doi: 10.1007/s10815-014-0188-1.

Hallman M, Epstein B.L. Role of myo-inositol in the synthesis of phosphatidylglycerol and phosphatidylinositol in the lung Biochemical and Biophysical Research Communications. 1980;92:1151–1159.doi: 10.1016/0006-291X(80)90407-6.

Kalaycı M, Türkes C, Arslan M, et al. Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors. Arch. Der Pharm. 2021, 354, 2000282.

Chikkula KW, Sundararajan R. Analgesic, anti-inflammatory, and antimicrobial activities of novel isoxazole/pyrimidine/pyrazole substituted benzimidazole analogs. Med. Chem. Res. 2017, 26, 3026–3037.

DiNardo JC, Downs CA. Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone-3. J. Cosmet. Dermatol. 2018, 17, 15–19.

Zeisel SH, Mar MH, Howe JC, et al. Concentrations of choline-containing compounds and betaine in common foods. J Nutr. 2003;133(5):1302-7. doi: 10.1093/jn/133.5.1302.

Mygind VL, Evans SE, Peddie MC, et al. Estimation of usual intake and food sources of choline and betaine in New Zealand reproductive age women. Asia Pac J Clin Nutr. 2013;22(2):319-24. doi: 10.6133/apjcn.2013.22.2.19.

Probst Y, Guan V, Neale E. Development of a Choline Database to Estimate Australian Population Intakes. Nutrients 2019:23;11(4):913. doi: 10.3390/nu11040913.

Rex S. Clements, Jr.3 MD. Betty Darnell, MS. Myo-inositol content of common foods: development of a high-myo-inositol diet. The American Journal of Clinical Nutrition 1980:1954-1967.

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on Dietary Reference Values for choline. EFSA Journal 2016;14(8): 4484. doi: 10.2903/j.efsa.2016.4484.

Wiedeman AM, Whitfield KC, March KM, et al, Concentrations of water-soluble forms of choline in human milk from lactating women in Canada and Cambodia. Nutrients 2018;10:381. doi: 10.3390/nu100303814.

Friesen RW, Novak EM, Hasman D, et al. Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants. Journal of Nutrition 2007;137:2641–6. doi: 10.1093/jn/137.12.2641.

Molloy AM, Mills JL, Cox C, et al. Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. American Journal of Clinical Nutrition 2005:82:836–42. doi: 10.1093/ajcn/82.4.836.

Beemster P, Groenen P, Steegers-Theunissen R. Involvement of inositol in reproduction. Nutrition Research Reviews 2002;60:80–87. doi: 10.1301/00296640260042748.

Zheng Y, Li Y, Rimm EB, et al. Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men. American Journal of Clinical Nutrition 2016;104:173-180.

Tang WH, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. New England Journal of Medicine 2013;368:1575-1584.

Bertoia ML, Pai JK, Cooke JP, et al. Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease. Atherosclerosis 2014;235:94-101.

Bidulescu A, Chambless LE, Siega-Riz AM, et al. Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasculer Disorders 2007;7:20.

Dalmeijer GW, Olthof MR, Verhoef P, et al. Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women. European Journal of Clinical Nutrition 2008;62:386-394.

Higgins JP, Flicker L. Lecithin for dementia and cognitive impairment. Cochrane Database Systematic Reviews 2003:CD001015.

Leermakers ET, Moreira EM, Kiefte-de Jong JC, et al. Effects of choline on health across the life course: a systematic review. Nutrition Reviews 2015;73:500-522.

Nurk E, Refsum H, Bjelland I, et al. Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. British Journal of Nutrition 2013;109:511-519.

Synoradzki K, Grieb P. Citicoline: a superior form of choline. Nutrients 2019;11:1569.

Gareri P, Castagna A, Cotroneo AM, et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clinical Interventions in Aging 2015;10:1421–9. doi: 10.2147/CIA.S87886.

Jasielski P, Piedel F, Piwek M, Rocka A, Petit V, Rejdak K. Application of citicoline in neurological disorders: A systematic review. Nutrients 2020;12:3113. doi: 10.3390/nu12103113.

Marti-Carvajal AJ, Valli C, Marti-Amarista CE, et al. Citicoline for treating people with acute ischemic stroke. Cochrane Database of Systematic Reviews 2020;8:CD013066. doi: 10.1002/14651858.CD013066.pub2.

Que DS, Jamora RDG. Citicoline as adjuvant therapy in parkinson's disease: A systematic review. Clinical Therapeutics 2021;43:e19–31. doi: 10.1016/j.clinthera.2020.11.009.

Ma X, Zhang H, Pan Q, et al. Hypoxia/Aglycemia-induced endothelial barrier dysfunction and tight junction protein downregulation can be ameliorated by citicoline. PloS One 2013;8:e82604. doi: 10.1371/journal.pone.0082604.

Buchman AL, Dubin MD, Moukarzel AA, et al. Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology 1995;22:1399-403.

Fischer LM, daCosta KA, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. American Journal of Clinical Nutrition 2007;85:1275-1285.

Resseguie ME, da Costa KA, Galanko JA, Patel M, Davis IJ, Zeisel SH. Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem 2011;286:1649-1658.

Yu D, Shu XO, Xiang YB, et al. Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women. Journal of Nutrition 2014;144:2034-2040.

Nisa, Zaib & Akhtar, Tashfeen. (2019). Para-Aminobenzoic Acid-A Substrate of Immense Significance. Mini-Reviews in Organic Chemistry. 16. 10.2174/1570193X16666190828201234.

Xavier S, MacDonald S, Roth J, et al. The vitamin-like dietary supplement para-aminobenzoic acid enhances the antitumor activity of ionizing radiation. International Journal of Radiation Oncology, Biology, Physics 2006;65( 2):517-527

Jiang Y. Liu, T, Shi X, et al. p-Aminobenzoic acid inhibits the growth of soybean pathogen Xanthomonas axonopodis pv. glycines by altering outer membrane integrity. Pest management science. 2023 doi:10.1002/ps.7608.

Haroon F, Farwa U, Arif M, et al. Novel Para-Aminobenzoic Acid Analogs and Their Potential Therapeutic Applications. Biomedicines, 11. 2023. https://doi.org/10.3390/biomedicines11102686.

Harwood AJ, Agam G, Barnes SA et al. Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. Molecular Psychiatry, 2005;10(2): 117-126. doi:10.1038/sj.mp.4001616.

Shaltiel G, Shamir A, Belmaker RH, et al. Valproate decreases inositol biosynthesis. Biological Psychiatry, 2007:61(1):72-76.

Henry RJ, Sobota L. Lipsky SK, et al. Sulfonamides and trimethoprim. Antimicrobial Agents and Chemotherapy 1988;32(2):184-191. doi:10.1128/AAC.32.2.184.

Cronstein BN, Naime D, Ostad E, et al. Methotrexate mechanism of action in rheumatoid arthritis. Arthritis & Rheumatology, 1994;37(6):735-746. doi:10.1002/art.1780370602.

Türkiye Cumhuriyeti Tarım ve Orman Bakanlığı. (n.d.). Takviye gıda sorgu.https://ggbs.tarim.gov.tr/cis/servlet/StartCISPage?PAGEURL=/FSIS/ggbs.takviyeGidaSorgu.html&POPUPTITLE=AnaMenu.Kolin.Erişim tarihi:12/09/2024.

Miranda MTF de Sá, Camila RS de Almeida, Andreia AMP, et al. Efficacy of Myo-Inositol and D-Chiro-Inositol in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis. Journal of Clinical Endocrinology & Metabolism, 2017; 102(6): 2085-2097.

Türkiye Cumhuriyeti Tarım ve Orman Bakanlığı. (n.d.). Takviye gıda sorgu.https://ggbs.tarim.gov.tr/cis/servlet/StartCISPage?PAGEURL=/FSIS/ggbs.takviyeGidaSorgu.html&POPUPTITLE=AnaMenu.PABA.Erişim tarihi:12/09/2024.

Mackie BS, Mackie LE, Smith JA, et al. The PABA story. Australasian Journal of Dermatology 1999;40(1):51-53. doi:10.1046/j.1440-0960.1999.00319.x.

Caudill MA. Pre- and postnatal health: evidence of increased choline needs. Journal of the American Dietetic Association 2010;110:1198-1206.

Wu BT, Innis SM, Mulder KA, et al Low plasma vitamin B-12 is associated with a lower pregnancy-associated rise in plasma free choline in Canadian pregnant women and lower postnatal growth rates in their male infants. American Journal of Clinical Nutrition 2013;98:1209-1217.

Abratte CM, Wang W, Li R, et al. Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women. Journal of Nutritional Biochemistry 2008;19:158-165.

Brody LC, Conley M, Cox C, et al. A polymorphism, R653Q, in the trifunctional enzyme methylen etetra hydrofolate dehydrogenase /methenyl tetrahydrofolate cyclohydrolase/ formyl tetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. American Journal of Human Genetics. 2002;71(5):1207-15. doi: 10.1086/344213.47.

74.Wu BT, Dyer RA, King DJ, et al. Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. PLoS One 2012;7:e43448.

Shaw GM, Finnell RH, Blom HJ, et al. Choline and risk of neural tube defects in a folate-fortified population. Epidemiology 2009;20:714-9.

Mills JL, Fan R, Brody LC, et al. Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects. American Journal of Clinical Nutrition 2014;100:1069-1074.

Corbin KD, Zeisel SH. The nutrigenetics and nutrigenomics of the dietary requirement for choline. Progress in Molecular Biology and Translational Science 2012;108:159-77.

Biswas S, Giri S. Importance of choline as essential nutrient and its role in prevention of various toxicities. Prague Medical Report 2015;116:5-15.

da Costa KA, Corbin KD, Niculescu MD, et al. Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups. FASEB Journal 2014;28:2970-2978.

Carlomagno G, Unfer V. Inositol safety: clinical evidences. European Review for Medical and Pharmacological Sciences 2011:(8):931-936.

Balch JF, Balch PA. Prescription for nutritional healing: A practical A-Z reference to drug-free remedies using vitamins, minerals, herbs & food supplements. Garden City Park, New York: Avery Publishing; 1990.

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