Koenzim Q10
Özet
Koenzim Q10, benzokinon halkası ve izoprenid yan zincirinden oluşan, enerji sentezi için mitokondride elektron transport zincirinde oldukça önemli bir göreve sahip olan vitamin benzeri bileşiktir. Ayrıca güçlü bir antioksidandır. Diyet ile alınabildiği gibi daha çok endojen yol ile sentezlenir. Bu özelliği ile diğer vitaminlerden farklıdır. Ancak endojen sentezi yaş ile beraber azalır. Kalp, böbrek, karaciğer, beyin gibi organlarda daha fazla miktarda bulunur. Eksikliğinden de en çok bu organlar etkilenir. Primer koenzim Q10 eksikliğinin tedavisinde ve mitokondriyal hastalıklarda destek amaçlı kullanılır. Çocuklarda rutin profilaksi önerilmezken, kardiyomiyopatisi ve kalp yetmezliği olan hastalarda kullanımının önerildiği çalışmalar vardır.
Coenzyme Q10 is a vitamin-like compound composed of a benzoquinone ring and an isoprenoid side chain. It plays a crucial role in the electron transport chain in mitochondria for energy synthesis. Additionally, it is a potent antioxidant. While it can be obtained through the diet, it is primarily synthesized endogenously. This distinguishes it from other vitamins. However, endogenous synthesis decreases with age. Higher concentrations are found in organs such as the heart, kidneys, liver, and brain. These organs are also most affected by its deficiency. Coenzyme Q10 is used in the treatment of primary coenzyme Q10 deficiency and as a supportive therapy in mitochondrial diseases. While routine prophylaxis is not recommended for children, studies suggest its use in patients with cardiomyopathy and heart failure.
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