Omega - 6
Özet
Omega-6 yağ asitleri, insan sağlığı için gerekli olan çoklu doymamış yağ asitleridir. Hücre zarlarında bulunur, iltihaplanmayı ve kan pıhtılaşmasını düzenler, ayrıca enerji sağlar. Linoleik asit (LA), temel omega-6 yağ asididir ve gama-linolenik asit (GLA) ile araşidonik aside (AA) dönüşerek inflamatuar ve antienflamatuvar süreçlerde rol oynar. Omega-6’nın başlıca kaynakları bitkisel yağlar, kuruyemişler, tohumlar ve anne sütüdür. Yaşa ve cinsiyete göre değişen günlük alım önerileri vardır. İdeal omega-6/omega-3 oranı 4:1’dir, ancak Batı diyetlerinde omega-6 fazlalığı yaygındır ve bu durum kalp hastalıkları, diyabet ve obezite gibi kronik hastalıklara katkıda bulunabilir. Omega-6 eksikliği, cilt sorunları, kırılgan saç ve tırnaklar, bağışıklık sistemi bozuklukları ve ruh hali değişiklikleriyle ilişkilidir. Aşırı alımı ise inflamasyonu artırarak hastalık riskini yükseltebilir. Romatoid artrit ve metabolik sendrom gibi hastalıklar, omega-6/omega-3 dengesizliğiyle ilişkilidir. GLA takviyeleri mevcuttur, ancak bazı hastalıkların tedavisindeki etkinliği belirsizdir. Omega-6 ve omega-3 yağ asitlerinin dengeli tüketimi, genel sağlığın korunması için kritik öneme sahiptir. Farklı popülasyonlar için ideal alım seviyelerinin belirlenmesi amacıyla daha fazla araştırmaya ihtiyaç vardır.
Omega-6 fatty acids are essential polyunsaturated fats that play vital roles in human health. They are found in cell membranes, regulate inflammation and blood clotting, and provide energy. Linoleic acid (LA) is the primary omega-6 fatty acid, which is converted into gamma-linolenic acid (GLA) and arachidonic acid (AA), contributing to inflammatory and anti-inflammatory processes. Dietary sources of omega-6 include vegetable oils, nuts, seeds, and breast milk. The recommended intake varies by age and gender, with an ideal omega-6 to omega-3 ratio of 4:1. Western diets often have an excess of omega-6, which may contribute to chronic diseases like cardiovascular disorders, diabetes, and obesity. Deficiency of omega-6 can lead to skin issues, brittle hair and nails, immune dysfunction, and mood disorders. Conversely, excessive intake may promote inflammation, increasing the risk of diseases. Chronic conditions such as rheumatoid arthritis and metabolic syndrome are linked to an imbalance in omega-6/omega-3 consumption. GLA supplementation is available, but its effectiveness in treating certain conditions remains uncertain. Proper dietary balance of omega-6 and omega-3 fatty acids is crucial for maintaining overall health. Further studies are needed to establish optimal intake guidelines for various populations.
Referanslar
Calder PC. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Molecular Nutrition Food Research. 2008;52(8):885-897. doi: 10.1002/mnfr.200700289
Wall R, Ross RP, Fitzgerald GF, et al. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutrition Reviews. 2010;68(5):280-289. doi:10.1111/j.1753-4887.2010.00287.x
Simopoulos A. P. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine. 2008;233(6):674-688. doi: 10.3181/0711-MR-311
Harris WS, Pottala JV, Varvel SA, et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. Prostaglandins Leukotriens Essentionel Fatty Acids. 2013;88(4):257-263. doi: 10.1016/j.plefa.2012.12.004
Innes JK, Calder PC. Omega-6 fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids. 2018 May;132:41-48. doi: 10.1016/j.plefa.2018.03.004. Epub 2018 Mar 22. PMID: 29610056.
Sarajlic P, Vigor C, Avignon A, Zhou B, Oger C, Galano JM, Durand T, Sultan A, Bäck M. Omega-3 to omega-6 fatty acid oxidation ratio as a novel inflammation resolution marker for metabolic complications in obesity. Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1206-1213. doi: 10.1016/j.numecd.2023.03.007. Epub 2023 Mar 21. PMID: 37032252.
Egalini F, Guardamagna O, Gaggero G, Varaldo E, Giannone B, Beccuti G, Benso A, Broglio F. The Effects of Omega 3 and Omega 6 Fatty Acids on Glucose Metabolism: An Updated Review. Nutrients. 2023 Jun 8;15(12):2672. doi: 10.3390/nu15122672. PMID: 37375575; PMCID: PMC10301273.
Wertz PW. Biochemistry of Human Stratum Corneum Lipids.Elias PM, Feingold KR (eds.), Skin Barrier. 1st ed. New York: CRC Press; 2006. p. 33–42. doi: 10.1201/b14173
Darios F, Davletov B. Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature. 2006;440(7085): 813-817. doi:10.1038/nature04598
Froyen E, Burns-Whitmore B. The Effects of Linoleic Acid Consumption on Lipid Risk Markers for Cardiovascular Disease in Healthy Individuals: A Review of Human Intervention Trials. Nutrients. 2020;12(8):2329. doi:10.3390/nu12082329
Brown MS, Radhakrishnan A, Goldstein JL. Retrospective on Cholesterol Homeostasis: The Central Role of Scap. Annual Review Biochemistry. 2018;87:783-807. doi: 10.1146/annurev-biochem-062917-011852
Horrobin DF. Nutritional and medical importance of gamma-linolenic acid. Progress in Lipid Research. 1992;31(2):163-194. doi:10.1016/0163-7827(92)90008-7
Patterson E, Wall R, Fitzgerald GF, et al. Health implications of high dietary omega-6 polyunsaturated Fatty acids. Journal of Nutrition and Metabolism. 2012;2012:539426. doi:10.1155/2012/539426
Gil A, Fontana L. Eicosanoids: Prostaglandins, leukotrienes, thromboxanes and related compounds. In: Caballero B (ed) Encyclopedia of Human Nutrition. 4th ed. Baltimore: Academic Press Incorporated; 2023. p.93-103. doi: 10.1016/B978-0-12-821848-8.00177-3
Skaper SD, Di Marzo V. Endocannabinoids in nervous system health and disease: the big picture in a nutshell. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2012;367(1607):3193-3200. doi:10.1098/rstb.2012.0313
Chi J, Cheng J, Wang S, et al. Promising Anti-Inflammatory Tools: Biomedical Efficacy of Lipoxins and Their Synthetic Pathways. International Journal of Molecular Sciences. 2023;24(17):13282. doi:10.3390/ijms241713282.
Mariamenatu AH, Abdu EM. Overconsumption of Omega-6 Polyunsaturated Fatty Acids (PUFAs) versus Deficiency of Omega-3 PUFAs in Modern-Day Diets: The Disturbing Factor for Their "Balanced Antagonistic Metabolic Functions" in the Human Body. Journal of Lipids. 2021; 2021:8848161. doi: 10.1155/2021/8848161
Doi T, Hori M, Harada-Shiba M, et al. Patients with LDLR and PCSK9 gene variants experienced higher incidence of cardiovascular outcomes in heterozygous familial hypercholesterolemia. Journal of the American Heart Association. 2021;10(4):e018263. doi: 10.1161/JAHA.120.018263
Silva PDS, Da Costa WA, Salazar DLAR, et al. Commercial and therapeutic potential of plant-based fatty acids. In: Waisundara V (ed) Biochemistry and Health Benefits of Fatty Acids. 1st ed. London: IntechOpen, 2018. doi: 10.5772/intechopen.81122
Kiełbasa A, Monedeiro F, Bernatowicz-Łojko U, at all. The Content of Selected Omega-3 Free Fatty Acids in Breast Milk Samples. International Dairy Journal. 2024;148, 105803 doi: 10.1016/j.idairyj.2023.105803.
Bzikowska-Jura A, Czerwonogrodzka-Senczyna A, Jasińska-Melon E, et al. The Concentration of Omega-3 Fatty Acids in Human Milk Is Related to Their Habitual but Not Current Intake. Nutrients. 2019;11(7):1585. doi:10.3390/nu11071585.
Horrobin DF. Nutritional and medical importance of gamma-linolenic acid. Progres in Lipid Researc. 1992; 31(2): 163-194. doi: 10.1016/0163-7827(92)90008-7
Isesele P, Enstad S, Huong P, at al. Breast Milk from Non-Obese Women with a High Omega-6 to Omega-3 Fatty Acid Ratio, but Not from Women with Obesity, Increases Lipogenic Gene Expression in 3T3-L1 Preadipocytes, Suggesting Adipocyte Dysfunction. Biomedicines. 2022;10(5):1129. doi: 10.3390/biomedicines10051129
Mazurier E, Rigourd V, Perez P, et al. Effects of Maternal Supplementation With Omega-3 Precursors on Human Milk Composition. Journal of Human Lactation. 2017;33(2):319-328. doi:10.1177/0890334417691946
Hahn-Holbrook J, Fish A, Glynn LM. Human Milk Omega-3 Fatty Acid Composition is Associated with Infant Temperament. Nutrients. 2019;11(12):2964. doi:10.3390/nu11122964
Osouli-Tabrizi, Shirin et al. “The effectiveness of omega-3 fatty acids on health outcomes in women with breast cancer: A systematic review.” Food science & nutrition vol. 11,8 4355-4371. 22 May. 2023, doi:10.1002/fsn3.3409
Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: National Academy Press; 2005.
Lee, Jean et al. “Changes in the consumption of isoflavones, omega-6, and omega-3 fatty acids in women with metastatic breast cancer adopting a whole-food, plant-based diet: post-hoc analysis of nutrient intake data from an 8-week randomized controlled trial.” Frontiers in nutrition vol. 11 1338392. 21 Mar. 2024, doi:10.3389/fnut.2024.1338392
Von Schacky C. Omega-3 index and cardiovascular health. Nutrients. 2014;6:799–814. doi: 10.3390/nu6020799
Salar B, Uz A. Omega Fatty Acids: Biological Effects and Herbal Sources. Hacettepe University Journal of the Faculty of Pharmacy. 2021;41(3): 194-209. doi: 10.52794/hujpharm.920079
Chaves H, Singh RB, Khan S, et al. High omega-6/omega-3 fatty acid ratio diets and risk of noncommunicable diseases: is the tissue, the main tissue? In: Watson RS, Singh RB, Takahashi T (eds.) The Role of Functional Food Security in Global Health. Elsevier; 2019. pp. 217–259.
Simopoulos A. P. Omega-6/omega-3 essential fatty acid ratio and chronic diseases. Food Reviews International. 2004;20(1):77–90. doi: 10.1081/FRI-120028831
Tulk H. M., Robinson L. E. Modifying the n-6/n-3 polyunsaturated fatty acid ratio of a high–saturated fat challenge does not acutely attenuate postprandial changes in inflammatory markers in men with metabolic syndrome. Metabolism. 2009;58(12):1709–1716. doi: 10.1016/j.metabol.2009.05.031
DiNicolantonio JJ, O'Keefe JH. Importance of maintaining a low omega-6/omega-3 ratio for reducing inflammation. Open Heart. 2018;5(2):e000946. doi: 10.1136/openhrt-2018-000946
Turan H, Erkoyuncu İ, Kocatepe D. Omega-6, Omega-3 Yağ Asitleri ve Balık. Aquaculture Studies. 2013;2013(2):0-0. doi: 10.17693/yunusae.v2013i21905.235422
Fujii M, Nakashima H, Tomozawa J, et al. Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. Experimental Dermatology. 2013;22(4):272-277. doi: 10.1111/exd.12120
Arshad Z, Rezapour-Firouzi S, Ebrahimifar M, et al. Association of delta-6-desaturase expression with aggressiveness of cancer, diabetes mellitus, and multiple sclerosis. A Narrative Review. Asian Pacific Journal of Cancer Preventation. 2019;20(4):1005-1018. doi:10.31557/APJCP.2019.20.4.1005.
Nervi AM, Peluffo RO, Brenner RR, et al. Effect of ethanol administration on fatty acid desaturation. Lipids. 1980;15(4):263–268. doi: 10.1007/BF02535837
Rajasekaran A. General Perspective- The Future of Drug Discovery. In: Chackalamannil S, Rotella D, Ward S. (eds.). Comprehensive Medicinal Chemistry III. 3th ed. Elsevier; 2017. p. 365-380.
Richard JL, Martin C, Maille M, et al. Effects of dietary-intake of gamma-linolenic acid on blood-lipids and phospholipid fatty acids in healthy human subjects. Journal of Clinical Biochemistry and Nutrition. 1990; 8(1): 75-84. doi: 10.3164/JCBN.8.75
RX Mediafarma. Ver. 2023. İzmir: Gemaş Mühendislik; 2023.
Perrotta G (2023) Omega-3/omega-6 fatty acids: The effects on the psychophysical well-being of adolescents and adults. Int J Clin Endocrinol Metab 9(1): 008-018. DOI: 10.17352/ijcem.000057
Bayles B, Usatine R. Evening primrose oil. American Family Physician. 2009;80(12):1405-1408.
Everett DJ, Perry CJ, Bayliss P. Carcinogenicity studies of efamol evening primrose oil in rats and mice. Medical Science Research 1988; 16(16): 865-866.
