Çinko
Özet
Çinko, birçok fizyolojik fonksiyon için kritik bir eser element olup büyüme, immün sistem ve üreme sağlığı üzerinde önemli etkileri bulunmaktadır. Çinko, 300'den fazla enzimin aktivitesine katkı sağlar ve hücre bütünlüğünü koruyarak genetik ekspresyon, antioksidan, antiinflamatuvar faaliyetlerde rol oynar. Dünya genelinde çinko eksikliği, gelişmekte olan ülkelerde yaygın olup, Türkiye gibi tahıl ağırlıklı beslenilen bölgelerde emilim bozuklukları ve düşük biyoyararlanım nedeniyle sık görülmektedir. Çinko eksikliği, akrodermatitis enteropatika, büyüme geriliği, immün sistem fonksiyonlarında bozulmalar ve hipogonadizm gibi ciddi klinik belirtilerle ilişkilidir.
Zinc is an essential trace element with significant effects on growth, the immune and the reproductive system. It contributes to the activity of more than 300 enzymes, maintaining cellular integrity and playing a role in genetic expression, antioxidant, and anti-inflammatory processes. Zinc deficiency is common in developing countries and is frequently observed in regions with grain-based diets, such as Turkey, due to malabsorption and low bioavailability. Zinc deficiency is associated with severe clinical manifestations, including acrodermatitis enteropathica, growth retardation, immune system dysfunctions, and hypogonadism.
Referanslar
Prasad AS, Miale A Jr, Farid Z, et al. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism. Journal of Laboratory and Clinical Medicine; 1963;61: 537–549.
Prasad AS. Discovery of human zinc deficiency: its impact on human health and disease. Advances in Nutrition; 2013;4(2):176–190. doi: 10.3945/an.112.003210.
Wolf J, Sandstead HH, Rink L. Zinc In: Nordberg GF, Costa M (eds) Handbook on the Toxicology of Metals. 5th ed. New York: Academic Press, 2022. p. 963-984.
Khalid N, Ahmed A, Bhatti MS, et al. A Question Mark on Zinc Deficiency in 185 Million People in Pakistan—Possible Way Out. Critical Reviews in Food Science and Nutrition; 2014;54(9): 1222–1240. doi: 10.1080/10408398.2011.630541.
Walker CF, Ezzati M, Black R. Global and regional child mortality and burden of disease attributable to zinc deficiency. European Journal of Clinical Nutrition; 2009;63(5): 591–597. doi: 10.1038/ejcn.2008.9.
Brown KH, Rivera JA, Bhutta Z, et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutrition Bulletin; 2004;25: 99–203.
Kumera G, Gedle D, Alebel A, et al. Undernutrition and its association with socio-demographic, anemia and intestinal parasitic infection among pregnant women attending antenatal care at the University of Gondar Hospital, Northwest Ethiopia. Matern Health Neonatol Perinatol; 2018(12);4: 18. doi: 10.1186/s40748-018-0087-z.
Cakmak I. Zinc Deficiency in Wheat in Turkey In: Alloway BJ (eds) Micronutrient Deficiencies in Global Crop Production. Dordrecht: Springer; 2008. p. 181-200. doi: 10.1007/978-1-4020-6860-7_7.
Stiles LI, Ferrao K, Mehta KJ. Role of zinc in health and disease. Clin Exp Med; 2024;24(1): 38. doi: 10.1007/s10238-024-01302-6.
Kılıçbay F, Gücer Ş, Baytan B, et al. Bursa ilinde 1-16 yaş çocuklarda çinko eksikliği prevalansı. Güncel Pediatri Dergisi 2006; 4.
Vurallı D. İlkokul çağındaki çocuklarda A vitamini ve çinko düzeyinin belirlenmesi ve etki eden faktörlerin değerlendirilmesi (Uzmanlık Tezi). Ankara: 2010.
Ekemen C, Örnek Z, Karacı M, et al. Okul Çağındaki Çocuklarda Demir, Çinko ve A Vitamini Eksikliği Prevalansının Değerlendirilmesi Turkish J Pediatr Dis; 2019;3: 154-159. doi: 10.12956/tjpd.2018.371.
Wang T, Masedunskas A, Willett WC, et al. Vegetarian and vegan diets: benefits and drawbacks. Eur Heart J; 2023;44(36): 3423-3439. doi: 10.1093/eurheartj/ehad436.
National Institutes of Health Office of Dietary Supplements. Zinc: fact sheet for health professionals. (23.10.2023 tarihinde http://ods.od.nih. gov/factsheets/Zinc-HealthProfessional/ adresinden ulaşılmıştır)
Chao HC. Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases. Nutrients; 2023;15(19): 4093. doi:10.3390/nu15194093.
Strand TA, Mathisen M. Zinc - a scoping review for Nordic Nutrition Recommendations. Food Nutr Res; 2023;67: 10368. doi: 10.29219/fnr.v67.10368.
Maares M, Haase H. A guide to human zinc absorption: general overview and recent advances of in vitro intestinal models. Nutrients; 2020;12: 762. doi: 10.3390/nu12030762.
Kondaiah P, Yaduvanshi PS, Sharp PA, et al. Iron and zinc homeostasis and interactions: Does enteric zinc excretion cross-talk with intestinal iron absorption? Nutrients; 2019;11: 1885. doi: 10.3390/nu11081885.
Barffour MA, Bernstein RM, Hinnouho GM, et al. Insulin-like Growth Factor 1 (IGF1), IGF Binding Protein-3 (IGFBP3) and Growth Response to Daily Zinc Supplementation: A Randomized Trial in Rural Laotian Children. Nutrients; 2023;15(11): 2590. doi: 10.3390/nu15112590
Caputo M, Pigni S, Agosti E, et al. Regulation of GH and GH Signaling by Nutrients. Cells; 2021;10(6): 1376. doi: 10.3390/cells10061376.
Molenda M, Kolmas J. The role of zinc in bone tissue health and regeneration—a review. Biol Trace Elem Res; 2023;201: 5640–5651. doi: 10.1007/s12011-023-03631-1.
Franco C, Canzoniero LMT. Zinc homeostasis and redox alterations in obesity. Front Endocrinol (Lausanne); 2024;14:1273177. doi: 10.3389/fendo.2023.1273177.
Severo JS, Morais JBS, de Freitas TEC, et al. The role of zinc in thyroid hormones metabolism. Int J Vitam Nutr Res; 2019;89: 80–88. doi: 10.1024/0300-9831/a000262.
Allouche-Fitoussi D, Breitbart H. The role of zinc in male fertility. Int J Mol Sci; 2020;21: 7796. doi: 10.3390/ijms21207796.
Chen B, Yu P, Chan WN, et al. Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets. Signal Transduct Target Ther; 2024;9(1): 6. doi: 10.1038/s41392-023-01679-y.
Institute of Medicine (US) Panel on Micronutrients. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington (DC): National Academies Press (US); 2001. (24/03/2024 tarihinde https://www.ncbi.nlm.nih.gov/books/NBK222310/ adresinden ulaşılmıştır) doi: 10.17226/10026.
Maxfield L, Shukla S, Crane JS. Zinc Deficiency In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. (24/03/2024 tarihinde https://www.ncbi.nlm.nih.gov/books/NBK493231/ adresinden ulaşılmıştır).
Barnes PM, Moynahan EJ. Zinc deficiency in acrodermatitis enteropathica. Proceedings of the Royal Society of Medicine; 1973;66: 327–329.
Marcdante KJ, Kliegman RM, Schuh AM. Zinc. In: Nelson Essentials of Pediatrics. 9th ed. International Edition. Philadelphia: Elsevier; 2023. p.126-127.
Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev; 2016;12: CD005436. doi: 10.1002/14651858.CD005436.pub5.
Miranda CTOF, Vermeulen-Serpa KM, Pedro ACC, et al. Zinc in sickle cell disease: A narrative review. J Trace Elem Med Biol; 2022;72: 126980. doi: 10.1016/j.jtemb.2022.126980.
Watson L, Cartwright D, Jardine LA, et al. Transient neonatal zinc deficiency in exclusively breastfed preterm infants. J Paediatr Child Health; 2018;54(3): 319-322. doi:10.1111/jpc.13780.
Romero-Velarde E, Villalpando-Carrión S, Pérez-Lizaur AB, et al. Consenso para las prácticas de alimentación complementaria en lactantes sanos [Guidelines for complementary feeding in healthy infants]. Bol Med Hosp Infant Mex; 2016;73(5): 338-356. doi:10.1016/j.bmhimx.2016.06.007.
Kondaiah P, Yaduvanshi PS, Sharp PA, et al. Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption? Nutrients; 2019;11(8): 1885. doi: 10.3390/nu11081885.
Chemek M, Kadi A, Merenkova S, et al. Improving Dietary Zinc Bioavailability Using New Food Fortification Approaches: A Promising Tool to Boost Immunity in the Light of COVID-19. Biology (Basel); 2023;12(4): 514. doi: 10.3390/biology12040514.
American Academy of Pediatrics Committee on Nutrition. Liver disease. In: Pediatric Nutrition, 8th ed, Kleinman RE, Greer FR (Eds), American Academy of Pediatrics, 2019. p.1199.
Hawrysz Z, Woźniacka A. Zinc: an undervalued microelement in research and treatment. Postepy Dermatol Alergol; 2023;40(2): 208-214. doi:10.5114/ada.2023.127639.
Sangeetha VJ, Dutta S, Moses JA, et al. Zinc nutrition and human health: Overview and implications. eFood; 2022;3: e17. doi: 10.1002/efd2.17.
ASPEN Recommendations on Appropriate Parenteral Nutrition Dosing for Neonatal and Pediatric Patients (23/10/2023 tarihinde https://www.nutritioncare.org/PNResources/ adresinden ulaşılmıştır)
Rouhani P, Rezaei Kelishadi M, Saneei P. Effect of zinc supplementation on mortality in under 5-year children: a systematic review and meta-analysis of randomized clinical trials. Eur J Nutr; 2022;61(1): 37-54. doi:10.1007/s00394-021-02604-1.
