Vitamin C
Özet
C vitamini (askorbik asit) doğada yaygın olarak bulunan, suda çözünen ve birçok önemli işlevi olan bir vitamindir. C vitamini kolajen ve karnitin sentezinde, demir emiliminde, noradrenalin sentezinde, serbest radikal zincir reaksiyonlarının inaktivasyonunda, enfeksiyonların önlenmesinde, süresinin kısaltılmasında ve şiddetinin hafifletilmesinde rol oynarken birçok enzim için de kofaktör görevi görür. Diyetle alınan C vitamini eksikliği iskorbüt adı verilen bir hastalığa neden olur. İnsanlar ve diğer primatlar tarafından sentezlenemez ve diyetle alınması gerekir. Plazma ve doku C vitamini konsantrasyonları tüketilen miktara, biyoyararlanıma, renal atılım ve kullanıma bağlıdır.
Vitamin C (ascorbic acid) is a widely available in nature, water-soluble vitamin with many important functions. Vitamin C is involved in collagen and carnitine synthesis, iron absorption, noradrenaline synthesis, inactivation of free radical chain reactions, preventing, shortening the duration and alleviating the severity of infections while acts as a cofactor for many enzymes. A deficiency of dietary vitamin C causes a disease called scurvy. It cannot be synthesized by humans and other primates and must be obtained from the diet. Plasma and tissue vitamin C concentrations depend on the amount consumed, bioavailability, renal excretion and utilization.
Referanslar
Chatterjee IB. Ascorbic acid metabolism. World Rev Nutr Diet. 1978;30:69-87.
Lind J. A Treatise on the Scurvy: A. Millar; 1757.
King CG. The biological synthesis of ascorbic acid. World Rev Nutr Diet. 1973;18:47-59.
Loewus FA. Aspects of ascorbic acid biosynthesis in plants. Ann N Y Acad Sci. 1961;92(1):57-78.
Frank A, Wagner G, Yang JC. Biosynthesis and metabolism of ascorbic acid in plants. Annals of the New York Academy of Sciences. 1975;258(1 Second Confer):7-23.
Mapson L. Biogenesis of L-ascorbic acid in plants and animals. The Vitamins. 1967;1:369-83.
Chatterjee IB, Kar NC, Ghosh NC, Guha BC. Biosynthesis of L-ascorbic acid: missing steps in animals incapable of synthesizing the vitamin. Nature. 1961;192(4798):163-4.
Burns JJ. Missing step in man, monkey and guinea pig required for the biosynthesis of L-ascorbic acid. Nature. 1957;180(4585):553.
Lykkesfeldt J, Michels AJ, Frei B. Vitamin C. Adv Nutr. 2014;5(1):16-8.
Lykkesfeldt J, Tveden-Nyborg P. The Pharmacokinetics of Vitamin C. Nutrients. 2019;11(10).
Tveden-Nyborg P, Lykkesfeldt J. Does vitamin C deficiency increase lifestyle-associated vascular disease progression? Evidence based on experimental and clinical studies. Antioxid Redox Signal. 2013;19(17):2084-104.
Nowak D. Vitamin C in Human Health and Disease. Nutrients. 2021;13(5).
Carr AC, Rowe S. Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective. Nutrients. 2020;12(7):1963. doi: 10.3390/nu12071963.
Johnston CS, Steinberg FM, Rucker RB. Ascorbic acid. Handbook of vitamins. 2007;4:489-520.
Lykkesfeldt J, Poulsen HE. Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials. Br J Nutr. 2010;103(9):1251-9.
Robitaille L, Hoffer LJ. A simple method for plasma total vitamin C analysis suitable for routine clinical laboratory use. Nutr J. 2016;15:40.
Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A. 1996;93(8):3704-9.
Levine M, Wang Y, Padayatty SJ, Morrow J. A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A. 2001;98(17):9842-6.
Hoffer LJ. Re: "Vitamin C deficiency in a population of young Canadian adults". Am J Epidemiol. 2010;171(3):387; author reply -8.
Granger M, Eck P. Dietary Vitamin C in Human Health. Adv Food Nutr Res. 2018;83:281-310.
Birlouez-Aragon I, Fieux B, Potier De Courcy G, Hercberg S. Vitamine C. Apports nutritionnels conseillés Paris: Tec et Doc Lavoisier. 2001:215-20.
Society GN. New reference values for vitamin C intake. Annals of Nutrition and Metabolism. 2015;67(1):13-20.
Otten J, Hellwig J, Meyers L. Institute of medicine dietary reference intakes: the essential guide to nutrient requirements. Washington, DC: National Academies Press; 2006.
Trapani S, Rubino C, Indolfi G, Lionetti P. A Narrative Review on Pediatric Scurvy: The Last Twenty Years. Nutrients. 2022;14(3).
Pan T, Hennrikus EF, Hennrikus WL. Modern Day Scurvy in Pediatric Orthopaedics: A Forgotten Illness. J Pediatr Orthop. 2021;41(3):e279-e84.
Thiemann S, Cimorelli V, Bajwa NM. Case Report: Uncommon cause of limp in the 21(st) century. Front Endocrinol (Lausanne). 2022;13:968015.
Cloney K, Ramsey S, Burns E. Vitamin C deficiency in a 12-year-old male presenting with knee pain: a case report. CJEM. 2022;24(5):544-6.
Masci D, Rubino C, Basile M, Indolfi G, Trapani S. When the limp has a dietary cause: A retrospective study on scurvy in a tertiary Italian pediatric hospital. Front Pediatr. 2022;10:981908.
Dosedel M, Jirkovsky E, Macakova K, Krcmova LK, Javorska L, Pourova J, et al. Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients. 2021;13(2):615.
Heymann WR. Scurvy in children. J Am Acad Dermatol. 2007;57(2):358-9.
Hirschmann JV, Raugi GJ. Adult scurvy. J Am Acad Dermatol. 1999;41(6):895-906; quiz 7-10.
Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11):1211.
Nutrition AAoPCo. Water-soluble vitamins. Pediatric Nutrition, 8th ed, Kleinman RE, Greer FR (Eds), American Academy of Pediatrics. 2019:655.
Weinstein M, Babyn P, Zlotkin S. An orange a day keeps the doctor away: scurvy in the year 2000. Pediatrics. 2001;108(3):E55.
Kliegman R, Stanton B, St Geme J, Schor N, Behrman R. Nelson Tratado de pediatria. 20. ed. São Paulo (SP): Elsevier; 2017.
Lykkesfeldt J, Carr AC. Vitamin C - a scoping review for Nordic Nutrition Recommendations 2023. Food Nutr Res. 2023;67. doi: 10.29219/fnr.v67.10300.
