Vitamin B5 (Pantotenik Asit)
Özet
Özetle; B5Vitamini çeşitli diyet kaynaklarından kolayca elde edilebilir Pantotenik asit eksikliği belirli bir hastalıkla ilişkilendirilmemiş olsa da, vitamin eksikliği klinik olarak genel bir halsizliğe neden olur fakat izole pantotenik asit eksikliği nadir karşılaşılan bir durumdur. Pantotenik asit, koenzim A (KoA) ve açil-taşıyıcı proteinin (ACP) birleşiminden oluşmaktadır. CoA, A, D vitaminleri, kolesterol, steroidler, hem A, yağ asitleri, karbonhidratlar, amino asitler ve proteinler dahil olmak üzere birçok molekülün sentezinde ve parçalanmasında önemli bir role sahiptir
Pantotenik asidin başlıca besin kaynakları yumurta sarısı, karaciğer, böbrek, brokoli ve süttür. Pantotenik asidin önemli konsantrasyonları tavuk, sığır eti, patates ve tam tahıllarda da bulunur. Pantotenik asidin başlıca besin kaynağı koenzim A (CoA) formundadır. Pantotenik asit ayrıca kolondaki bakteriler tarafından üretilir .Pantotenik asit için bilinen bir toksisite yoktur . Aşırı alım böbrekler tarafından atılır. Yaşa göre ve ihtiyaca göre diyetle alınması önerilen günlük alım miktarları çocuklar için 1,6 ila 4 mg/gün arasında degişmekle birlikte ve yetişkinler için ortalama 5 mg/gündür.
In summary, The vitamin B5 is readily available from diverse dietary sources, a fact which is underscored by the difficulty encountered in attempting to induce pantothenate deficiency. Although pantothenic acid deficiency has not been linked with any particular disease, deficiency of the vitamin results in generalized malaise clinically. The vitamin pantothenic acid is an integral part of the acylation carriers, CoA and acyl carrier protein (ACP). CoA has a crucial role in the synthesis and degradation of many molecules, including vitamins A, D, cholesterol, steroids, heme A, fatty acids, carbohydrates, amino acids, and proteins.The major dietary sources of pantothenic acid are egg yolk, liver, kidney, broccoli, and milk. Substantial concentrations of pantothenic acid are also found in chicken, beef, potatoes, and whole grains.There is no known toxicity for pantothenic acid. Excess intake is excreted by the kidneys.
Referanslar
Berger MM, Shenkin A, Schweinlin A, et al. ESPEN micronutrient guideline. Clin Nutr. 2022;41(6):1357-424. doi: 10.1016/j.clnu.
Williams R.J., Bradway E.M. The further fractination of yeast nutrilites and their relationship to vitamin B and Wildiers’ "bios". J. Am. Chem. Soc. 1931;53:783–789. doi: 10.1021/ja01353a051
Powers H. J., Riboflavin (vitamin B-2) and health, Am J Clin Nutr, 2003;77:1352-60.
Trumbo PR. Pantothenic acid. In: Ross AC, Caballero B, Cousins RJ, et al., eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2014:351-7.
Miller JW, Rucker RB. Pantothenic acid. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:375-90.
Saldanha LG, Dwyer JT, Bailen RA. Modernization of the national institutes of health dietary supplement label database. Journal of Food Composition and Analysis 2021;102:104058.
Horvath Z, Vecsei L. Current medical aspects of pantethine. Ideggyogy Sz 2009;62:220-9.
Pantothenic Acid. Erişim tarihi: 11.12.2023 https://ods.od.nih.gov/factsheets/PantothenicAcid.Consumer
Müller M.A., Medlock J., Prágai Z., Warnke I., Litta G., Kleefeldt A., Kaiser K., De Potzolli B. Ullmann’s Encyclopedia of Industrial Chemistry. John Wiley & Sons, Inc.; Hoboken, NJ, USA: 2019. Vitamins, Vitamin B5; pp. 1–16.
Rucker, Robert B., and Kathryn Bauerly. "Pantothenic acid." Handbook of vitamins 5 (2013).
Wall BT, Stephens FB, Marimuthu K, et al. Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans J Appl Physiol, 2012;112:272-8.
Evans M, Rumberger JA, Azumano I, et al. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation Vasc Health Risk Manag, 2014;10:89-100.
Patassini Stefano, et al. Cerebral vitamin B5 (D-pantothenic acid) deficiency as a potential cause of metabolic perturbation and neurodegeneration in Huntington’s disease. Metabolites 2019;9.6:113.
Kennedy, David O. "B vitamins and the brain: mechanisms, dose and efficacy—a review." Nutrients 2016;8.2:68.
Dezfouli MA, Jaberi E, Alavi A, Rezvani M, Shahidi G, Elahi E, Rohani M. Pantothenate kinase 2 mutation with eye-of-the-tiger sign on magnetic resonance imaging in three siblings. Iran J Neurol. 2012;11(4):155-8
Kurian MA, Hayflick SJ. Pantothenate kinase-associated neurodegeneration (PKAN) and PLA2G6-associated neurodegeneration (PLAN): review of two major neurodegeneration with brain iron accumulation (NBIA) phenotypes. Int Rev Neurobiol. 2013;110:49-71
Proksch E., de Bony R., Trapp S., Topical use of dexpanthenol: a 70th anniversary article , J Dermatolog Treat. 2017;28(8):766-73.
Tantilipikorn P, Tunsuriyawong P, Jareoncharsri P, et al. A randomized, prospective, double-blind study of the efficacy of dexpanthenol nasal spray on the postoperative treatment of patients with chronic rhinosinusitis after endoscopic sinus surgery. J Med Assoc Thai. 2012;95(1):58-63.
Celebi S, Tepe C, Yelken K, Celik O. Efficacy of dexpanthenol for pediatric post-tonsillectomy pain and wound healing. Ann Otol Rhinol Laryngol. 2013;122(7):464-7.
Evans M, Rumberger JA, Azumano I, et al. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vasc Health Risk Manag. 2014;10:89-100.
Ross AC, et al. Modern nutrition in health and disease. Jones & Bartlett Learning, 2020.
Marcel H, Tomas S, Nejmonova I, et al. Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3 and B5. Nutrients 2022;14(3):484. doi: 10.3390/nu14030484.
Miller JW, Rucker RB. Pantothenic acid. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:375-90.
