Vitamin B1 (Tiamin)
Özet
Tiamin, B vitaminleri grubuna ait, suda çözünen hayati bir vitamindir. Karbonhidrat metabolizmasında önemli bir rol oynar ve vücudun enerji üretimine yardımcı olur. Sinir sistemi, kas fonksiyonları ve beyin sağlığı için gereklidir. Tam tahıllar, baklagiller, et (özellikle kırmızı et ve sakatat), süt ürünleri ve bazı sebzeler (örneğin ıspanak ve karnabahar) tiamin kaynağıdır. Eksikliği beriberi hastalığına, yorgunluğa, sinir sistemi bozukluklarına ve hafıza problemlerine yol açabilir. Alkol bağımlılığı olan kişilerde eksikliği daha sık görülür ve Wernicke-Korsakoff sendromuna neden olabilir. Günlük ihtiyacı, yaş ve cinsiyete göre değişmektedir. Tiamin eksikliği klinik olarak teşhis edilebilir ve tüm klinisyenler bu hastalığın farkında olmalıdır. Tiamin eksikliği olduğundan şüphelenilen hastalarda tiamin takviyesi mümkün olan en erken zamanda başlatılmalıdır. Tedavi güvenli, ucuz, basit ve hayat kurtarıcıdır. Tanı, tedaviye olumlu cevap verilmesiyle doğrulanır.
One essential water-soluble vitamin in the B vitamin family is thiamine. It aids in the body's energy production and is crucial to the metabolism of carbohydrates. It is essential for the health of the brain, muscles, and nervous system. Thiamine can be found in whole grains, legumes, meat (particularly red meat and offal), dairy products, and some plants (including cauliflower and spinach). Memory issues, exhaustion, nervous system illnesses, and beriberi might result from deficiencies. Wernicke-Korsakoff syndrome can result from deficiency, which is more prevalent in those who suffer from alcoholism. Age and gender have an impact on daily needs. Clinical diagnosis of thiamine deficiency is possible, and all medical professionals should be knowledgeable about this condition. When a patient is suspected of having thiamine, thiamine supplementation should begin as soon as possible.
Referanslar
Kayaalp OS. Suda eriyen vitaminler. İçinde: Kayaalp OS(ed). Tıbbi Farmakoloji: Rasyonel Tedavi Yönünden (10. Baskı). Ankara: Hacettepe-Taş Kitapçılık, 2002: 1489-500.
Sachdev HPS, Shah D, Kliegman R, et al.Vitamin b Complex Deficiency and Excess.Nelson Textbook of Pediatrics (19th ed) Phidelphia: Saunders, 2011: 191-8.
Polegato BF, Pereira AG, Azevedo PS, et al. Role of Thiamin in Health and Disease. Nutr Clin Pract. 2019;34(4):558-564. doi: 10.1002/ncp.10234.
Chawla J, Kvarnberg D. Hydrosoluble vitamins. Handb Clin Neurol. 2014;5120:891-914.
Marcé-Grau A, Martí-Sánchez L, Baide-Mairena H, et al. Genetic defects of thiamine transport and metabolism: A review of clinical phenotypes, genetics, and functional studies. J Inherit Metab Dis. 2019;42(4):581-597. doi: 10.1002/jimd.12125.
Wooley JA. Characteristics of thiamin and its relevance to the manage ment of heart failure. Nutr Clin Pract. 2008;23(5):487-493.
Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail. 2007;13(4):244-247
Manzetti S, Zhang J, van der Spoel D. Thiamin function, metabolism, uptake, and transport. Biochemistry. 2014;53(5):821-835.
Frank LL. Thiamin in clinical practice. JPEN J Parenter Enteral Nutr. 2015;39(5):503-520.
Fernandes LMP, Bezerra FR, Monteiro MC, et al. Thiamine defi ciency, oxidative metabolic pathways and ethanol-induced neurotox icity: how poor nutrition contributes to the alcoholic syndrome, as Marchiafava-Bignami disease. Eur J Clin Nutr. 2017;71(5):580-586.
Kerns JC, Gutierrez JL. Thiamin. Adv Nutr. 2017 ;8(2):395-397. doi: 10.3945/an.116.013979.
Nakamura ZM, Tatreau JR, Rosenstein DL, et al. Clinical char acteristics and outcomes associated with high-dose intravenous thi amineadministration in patients with encephalopathy. Psychosomatics. 2018;59(4):379-387.
Galvin R, Br˚athen G, Ivashynka A, et al. EFNSguidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010;17(12):1408-1418.
Harper CG, Giles M, Finlay-Jones R. Clinical signs in the Wernicke Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry. 1986;49(4):341-345.
Sechi G, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007;6(5):442-455.
Infante MT, Fancellu R, Murialdo A, et al.Challenges in diagnosis and treatment of Wernicke Encephalopathy: Report of 2 cases. Nutr Clin Pract. 2016;31(2):186-190.
Arts NJ, Walvoort SJ, Kessels RP. Korsakoff’s syndrome: a critical review. Neuropsychiatr Dis Treat. 2017; 13:2875-2890.
WHO| Thiamine deficiency and its prevention and control in major emergencies. WHO. Available at: http://www.who.int/nutrition/publications/emergencies/WHO_NHD_99.13/en/. Accessed, 2018
Stroh C, Meyer F, Manger T. Beriberi, a severe complication after metabolic surgery– review of the literature. Obes Facts. 2014;7(4):246-252.
Faigle R, Mohme M, Levy M. Dry beriberi mimicking Guillain Barre syndrome as the first presenting sign of thiamine deficiency. Eur JNeurol. 2012;19(2): e14-15.
Riahi A, Mansour M, Bedoui I, et al. Acute beriberi neuropathy mimicking Guillain-Barr´ e syndrome after a strict vegetarian diet. Iran JNeurol. 2017;16(2):100-102.
DiNicolantonio JJ, Niazi AK, Lavie CJ, et al. Thiamine supplementation for the treatment of heart failure: a review of the literature. Congest Heart Fail. 2013;19(4):214-222.
Di Nicolantonio JJ, Liu J, O’Keefe JH. Thiamine and cardiovascular disease: a literature review. Prog Cardiovasc Dis. 2018; 61(1):27-32.
Roman-Campos D, Cruz JS. Current aspects of thiamine deficiencyon heart function. Life Sci. 2014;98(1):1-5.
Costa NA, Azevedo PS, Polegato BFet al. Thiamine as a metabolic resuscitator in septic shock: one size does not fit all. J Thorac Dis. 2016;8(6): e471-472.
ImamuraT, Kinugawa K. Shoshin beriberi with low cardiac output and hemodynamic deterioration treated dramatically by thiamine administration. Int Heart J. 2015;56(5):568-570.
Chisolm-Straker M, Cherkas D. Altered and unstable: wet beriberi, a clinical review. J Emerg Med. 2013;45(3):341-344.
Ward KE, Happel KI. Aneating disorder leading to wet beriberi heart failure in a 30-year-old woman. Am J Emerg Med. 2013;31(2): 460.e5.
Bhat JI, Rather HA, Ahangar AA, et al. Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: a study from northern India. Indian Heart J. 2017;69(1):24–27.
Coelho LS, Hueb JC, Minicucci MF, et al. Thiamin deficiency as a cause of reversible cor pulmonale. Arq Bras Cardiol. 2008;91(1): e7-9.
Moulin P, Cinq-Frais C, Gangloff C, et al. Béribéri du nourrisson: à propos d'un cas [Thiamine deficiency in infants: a case report]. Arch Pediatr. 2014;21(4):392-5. French. doi: 10.1016/j.arcped.2014.01.009.
Koekkoek KW AC, van Zanten AR H.Nutritionin the ICU:newtrends versus old-fashioned standard enteral feeding? Curr Opin Anaesthesiol. 2018;31(2):136-143.
Mallat J, Lemyze M, Thevenin D. Do not forget to give thiamine to your septic shock patient! J Thorac Dis. 2016;8(6):1062-1066.
Kerns JC, Arundel C, Chawla LS. Thiamin deficiency in people with obesity. Adv Nutr. 2015;6(2):147-153.
Nath A, Tran T, Shope TR, et al. Prevalence of clinical thiamine deficiency in individuals with medically complicated obesity. Nutr Res. 2017; 37:29-36.
Crook MA, Sriram K. Thiamine deficiency: the importance of recog nition and prompt management. Nutrition. 2014;30(7-8):953-954.
Ijaz S, Thorley H, Porter K, et al. Interventions for preventing or treating malnutrition in homeless problem-drinkers: a systematic review. Int J Equity Health. 2018;17(1):8.
Fama R, Le Berre A-P, Hardcastle C, et al. Neurological, nutri tional and alcohol consumption factors underlie cognitive and mo tor deficits in chronic alcoholism. Addict Biol. 2017. https://doi.org/ 10.1111/adb.12584.
Manzanares W, Hardy G. Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care. 2011;14(6):610-617.
McGarvey C, Franconi C, Prentice D, et al. Metformin induced encephalopathy:the role of thiamine.Intern Med J.2018;48(2):194-197.
World Health Organization. Thiamine deficiency and its prevention and control in major emergencies. Geneva: World Health Organization 1999. pp: 1–65
Thomson AD, Cook CC, Touquet R, Henry JA; Royal College of Physicians, London. “The Royal College of Physicians report on alcohol: guidelines for managing Wernicke's encephalopathy in the accident and Emergency Department.” Alcohol and alcoholism (Oxford, Oxfordshire) (2002): vol. 37,6:513-21. doi:10.1093/alcalc/37.6.513
Galvin, R, G. Bråthen, A. Ivashynka, et al. EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur. J. Neurol. 2010;17: 1408–1418
World Health Organization Western Pacific Region. Pocket book of hospital care for children. Guidelines for the management of common childhood illnesses. Manila, The Philippines: World Health Organization Western Pacific Region 2017
Coats D, Frank EL, Reid JM, et al. Thiamine pharmacokinetics in Cambodian mothers and their breastfed infants. Am J Clin Nutr. 2013;98(3):839-844. doi:10.3945/ajcn.113.062737
Saudubray JM, van den Berghe G, Walter JH (eds). Inborn Metabolic Diseases: Diagnosis and Treatment (5th ed). Berlin Springer.2011.
Costa NA, Azevedo PS, Polegato BF, et al. Thiamine as a metabolic resuscitator in septic shock: one size does not fit all. J Thorac Dis. 2016;8(6):E471-2. doi: 10.21037/jtd.2016.04.29. PMID: 27294249; PMCID: PMC4885966.
Manzanares W, Hardy G. Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):610-7. doi: 10.1097/MCO.0b013e32834b8911. PMID: 21912244.
