Nöroinflamasyon ve Kan Beyin Bariyeri
Özet
Kan-beyin bariyeri (KBB), merkezi sinir sistemini (MSS) inflamatuar mediatörler ve bağışıklık hücreleri içeren periferik dolaşımdan ayıran önemli bir fizyolojik bariyerdir. Periferik inflamasyonun KBB’yi çeşitli yollarla bozabileceği ve bunun sonucunda farklı MSS hastalıklarına yol açabileceği gösterilmiştir. Bu bariyerin disfonksiyonunun, Alzheimer hastalığı (AH), Parkinson hastalığı (PH), amiyotrofik lateral skleroz (ALS), multipl skleroz (MS) ve felç gibi çeşitli nörolojik hastalıklar ve bazı enfeksiyonların nörolojik komplikasyonları ile ilişkili olduğu bildirilmiştir. Bu bölümde inflamasyonun kan beyin bariyerine etkisi ve sonuçlarından bahsedilmiştir.
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