Özgül (Edinsel) Bağışıklık Sistemi: Tanıma, Efektör Mekanizmalar, Düzenlenme ve Aktivasyon
Özet
Özgül (edinsel-kazanılmış) bağışıklık sistemi patojenlere karşı hedefe yönelik, etkili, uzun süreli bir yanıt geliştirmesini sağlarlar. Ayrıca aynı patojenle yeniden karşılaşma durumunda daha hızlı ve güçlü bir koruma sunar. Özgül bağışıklığın temel hücreleri T ve B lenfositlerdir. Makrofajlar ve dentritik hücreler hem doğal bağışıklık ve özgül bağışıklık arasında köprü rolü oynarlar. Bu bölümde özgül bağışıklık sistemi tartışılmıştır.
Referanslar
Abbas AK, Lichtman AH, Pillai S. (2023). Basic Immunology, Functions and Disorders of the Immune System (Seventh Edit). Philadelphia: Elsevier Health Sciences.
Abbas AK, Lichtman AH, Pillai S (2021). Cellular and Molecular Immunology (Tenth Edit). Philadelphia: Elsevier Health Sciences.
Punt J, Stranford S, Jones P, Owen J. (2023).Kuby Immunology (Eighth Edit). New York: Macmillan Learning.
Burmester GR, Pezzutto A, Ulrichs T, Aicher A. (2003). Color atlas of immunology. Vol. 18. New York: Thieme.
Delves PJ, Martin SJ, Burton DR, Roitt IM. (2017). Roitt's Essential Immunology (13th Edit). London: Wiley Blackwell.
Janeway CA, Travers P, Walport M, Shlomchik M. (2001). Immunobiology: the immune system in health and disease (Vol. 2). New York: Garland Pub.
Mackay IR, Rosen, FS, Delves PJ, Roitt IM. (2000). The immune system. N Engl J Med, 343(1), 37-49.
Lam N, Lee Y, Farber DL. (2024). A guide to adaptive immune memory. Nature Reviews Immunology, 1-20.
Cancro MP, Tomayko MM. (2021). Memory B cells and plasma cells: The differentiative continuum of humoral immunity. Immunological reviews, 303(1), 72-82.
Muroyama Y, Wherry EJ. (2021). Memory T-cell heterogeneity and terminology. Cold Spring Harbor Perspectives in Biology, 13(10), a037929.
Schijns V, Majhen D, Van Der Ley P, Thakur A, Summerfield A, Berisio R, et al. (2021). Rational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation. Pharmaceutics, 13(4), 501.
Stavnezer J, Schrader CE. (2014). IgH chain class switch recombination: mechanism and regulation. The Journal of Immunology, 193(11), 5370-5378.
Bonilla FA, Oettgen HC. (2010). Adaptive immunity. Journal of Allergy and Clinical Immunology, 125(2), S33-S40.
Tokoyoda K, Hauser AE, Nakayama T, Radbruch A. (2010). Organization of immunological memory by bone marrow stroma. Nature Reviews Immunology, 10(3), 193-200.
Gutzeit C, Chen K, Cerutti A. (2018). The enigmatic function of IgD: some answers at last. European journal of immunology, 48(7), 1101-1113.