Antijen Sunumu ve Doku Uygunluk Antijenleri
Özet
Antijen işleme ve sunumu bağışık yanıtın temel taşlarıdır. Yüksek afiniteli antikorlar üretebilmek için Dendritik hücreler, T hücreleri ve B hücrelerinin işbirliği içinde bir arada çalışması gereklidir. Bu hücreler antijene özgü yüzey reseptörleri ve bağlantı kurdukları peptid-MHC komplexlerini kullanarak sürece yardımcı olurlar. Virüsle enfekte hücrelerle mücadele genellikle sitotoksik CD8+ T hücrelerine bağlıdır ve bu hücreler de peptit-MHC kompleksleri aracılığıyla bu süreci yönetir. Hem CD8+ T hücreleri hemde CD4+ T hücreleri antijenik peptitleri sunan MHC sınıf I ve sınıf II moleküllerinin antijen sunumu ile bağışık yanıta katılır. Bu bölümde antijen işleme ve sunumunun temelleri ve bu sürece katkıda bulunan hücre içi ve dışı mekanizmalara kısaca değinilecektir.
Antigen processing and presentation are the cornerstones of the immune response. Dendritic cells, T cells and B cells must work together in cooperation to produce high-affinity antibodies. These cells help the process by utilizing antigen-specific surface receptors and the peptide-MHC complexes they bind to. The fight against virus-infected cells is often dependent on cytotoxic CD8+ T cells, which manage the process through peptide-MHC complexes. Both CD8+ T cells and CD4+ T cells participate in the immune response through antigen presentation of MHC class I and class II molecules that present antigenic peptides. This chapter will briefly review the basics of antigen processing and presentation and the intracellular and extracellular mechanisms that contribute to this process.
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