Epilepsi ve Febril Konvülsiyonların Beyin Gelişimi Üzerindeki Etkileri

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Referanslar

Aldenkamp, A. P., Alpherts, W. C., De Bruïne-Seeder, D., & Dekker, M. J. (1990). Test-retest variability in children with epilepsy--a comparison of WISC-R profiles. Epilepsy research, 7(2), 165–172. https://doi.org/10.1016/0920-1211(90)90102-2

Austin, J. K., Smith, M. S., Risinger, M. W., & McNelis, A. M. (1994). Childhood epilepsy and asthma: comparison of quality of life. Epilepsia, 35(3), 608–615. https://doi.org/10.1111/j.1528-1157.1994.tb02481.x

Babb, T. L., Kupfer, W. R., Pretorius, J. K., Crandall, P. H., & Levesque, M. F. (1991). Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience, 42(2), 351–363. https://doi.org/10.1016/0306-4522(91)90380-7

Behar, T. N., Schaffner, A. E., Scott, C. A., O'Connell, C., & Barker, J. L. (1998). Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(16), 6378–6387. https://doi.org/10.1523/JNEUROSCI.18-16-06378.1998

Beker Acay, M., Köken, R., Ünlü, E., Kaçar, E., & Balçık, Ç. (2017). Evaluation of hippocampal infolding angle and incomplete hippocampal inversion in pediatric patients with epilepsy and febrile seizures. Diagnostic and interventional radiology (Ankara, Turkey), 23(4), 326–330. https://doi.org/10.5152/dir.2017.160077

Ben-Ari, Y., & Represa, A. (1990). Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus. Trends in neurosciences, 13(8), 312–318. https://doi.org/10.1016/0166-2236(90)90135-w

Bertelsen, E. N., Larsen, J. T., Petersen, L., Christensen, J., & Dalsgaard, S. (2016). Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD. Pediatrics, 138(2), e20154654. https://doi.org/10.1542/peds.2015-4654

Bjørnaes, H., Stabell, K., Henriksen, O., & Løyning, Y. (2001). The effects of refractory epilepsy on intellectual functioning in children and adults. A longitudinal study. Seizure, 10(4), 250–259. https://doi.org/10.1053/seiz.2000.0503

Bough, K. J., & Rho, J. M. (2007). Anticonvulsant mechanisms of the ketogenic diet. Epilepsia, 48(1), 43–58. https://doi.org/10.1111/j.1528-1167.2007.00915.x

Bourgeois B. F. (1998). Antiepileptic drugs, learning, and behavior in childhood epilepsy. Epilepsia, 39(9), 913–921. https://doi.org/10.1111/j.1528-1157.1998.tb01440.x

Braak, H., Braak, E., Yilmazer, D., & Bohl, J. (1996). Functional anatomy of human hippocampal formation and related structures. Journal of child neurology, 11(4), 265–275. https://doi.org/10.1177/088307389601100402

Brunson, K. L., Eghbal-Ahmadi, M., & Baram, T. Z. (2001). How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis. Brain & development, 23(7), 533–538. https://doi.org/10.1016/s0387-7604(01)00312-6

Buelow, J. M., Perkins, S. M., Johnson, C. S., Byars, A. W., Fastenau, P. S., Dunn, D. W., & Austin, J. K. (2012). Adaptive functioning in children with epilepsy and learning problems. Journal of child neurology, 27(10), 1241–1249. https://doi.org/10.1177/0883073811432750

Camfield, P., & Camfield, C. (2007). Long-term prognosis for symptomatic (secondarily) generalized epilepsies: a population-based study. Epilepsia, 48(6), 1128–1132. https://doi.org/10.1111/j.1528-1167.2007.01072.x

Carlson, H., Ronne-Engström, E., Ungerstedt, U., & Hillered, L. (1992). Seizure related elevations of extracellular amino acids in human focal epilepsy. Neuroscience letters, 140(1), 30–32. https://doi.org/10.1016/0304-3940(92)90674-v

Cascino G. D. (1995). Clinical correlations with hippocampal atrophy. Magnetic resonance imaging, 13(8), 1133–1136. https://doi.org/10.1016/0730-725x(95)02023-m

Cavazos, J. E., & Sutula, T. P. (1990). Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis. Brain research, 527(1), 1–6. https://doi.org/10.1016/0006-8993(90)91054-k

Chang, L. R., Liu, J. P., Zhang, N., Wang, Y. J., Gao, X. L., & Wu, Y. (2009). Different expression of NR2B and PSD-95 in rat hippocampal subregions during postnatal development. Microscopy research and technique, 72(7), 517–524. https://doi.org/10.1002/jemt.20708

Chang, Y. C., Huang, A. M., Kuo, Y. M., Wang, S. T., Chang, Y. Y., & Huang, C. C. (2003). Febrile seizures impair memory and cAMP response-element binding protein activation. Annals of neurology, 54(6), 706–718. https://doi.org/10.1002/ana.10789

Chen, K., Aradi, I., Thon, N., Eghbal-Ahmadi, M., Baram, T. Z., & Soltesz, I. (2001). Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nature medicine, 7(3), 331–337. https://doi.org/10.1038/85480

Chungath, M., & Shorvon, S. (2008). The mortality and morbidity of febrile seizures. Nature clinical practice. Neurology, 4(11), 610–621. https://doi.org/10.1038/ncpneuro0922

Clanton, R. M., Wu, G., Akabani, G., & Aramayo, R. (2017). Control of seizures by ketogenic diet-induced modulation of metabolic pathways. Amino acids, 49(1), 1–20. https://doi.org/10.1007/s00726-016-2336-7

Cronin, J., & Dudek, F. E. (1988). Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain research, 474(1), 181–184. https://doi.org/10.1016/0006-8993(88)90681-6

Dahlin, M., Elfving, A., Ungerstedt, U., & Amark, P. (2005). The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy. Epilepsy research, 64(3), 115–125. https://doi.org/10.1016/j.eplepsyres.2005.03.008

Daikhin, Y., & Yudkoff, M. (1998). Ketone bodies and brain glutamate and GABA metabolism. Developmental neuroscience, 20(4-5), 358–364. https://doi.org/10.1159/000017331

Davies, S., Heyman, I., & Goodman, R. (2003). A population survey of mental health problems in children with epilepsy. Developmental medicine and child neurology, 45(5), 292–295. https://doi.org/10.1017/s0012162203000550

Davis, B. K., Wen, H., & Ting, J. P. (2011). The inflammasome NLRs in immunity, inflammation, and associated diseases. Annual review of immunology, 29, 707–735. https://doi.org/10.1146/annurev-immunol-031210-101405

During, M. J., & Spencer, D. D. (1993). Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet (London, England), 341(8861), 1607–1610. https://doi.org/10.1016/0140-6736(93)90754-5

Dzhala, V. I., & Staley, K. J. (2003). Transition from interictal to ictal activity in limbic networks in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(21), 7873–7880. https://doi.org/10.1523/JNEUROSCI.23-21-07873.2003

Ekdahl, C. T., Mohapel, P., Weber, E., Bahr, B., Blomgren, K., & Lindvall, O. (2002). Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus. The European journal of neuroscience, 16(8), 1463–1471. https://doi.org/10.1046/j.1460-9568.2002.02202.x

Engel, J., Jr, & International League Against Epilepsy (ILAE) (2001). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia, 42(6), 796–803. https://doi.org/10.1046/j.1528-1157.2001.10401.x

Erecińska, M., Nelson, D., Daikhin, Y., & Yudkoff, M. (1996). Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. Journal of neurochemistry, 67(6), 2325–2334. https://doi.org/10.1046/j.1471-4159.1996.67062325.x

Falconer M. A. (1974). Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention. Lancet (London, England), 2(7883), 767–770. https://doi.org/10.1016/s0140-6736(74)90956-8

Fetveit A. (2008). Assessment of febrile seizures in children. European journal of pediatrics, 167(1), 17–27. https://doi.org/10.1007/s00431-007-0577-x

French, J. A., Williamson, P. D., Thadani, V. M., Darcey, T. M., Mattson, R. H., Spencer, S. S., & Spencer, D. D. (1993). Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Annals of neurology, 34(6), 774–780. https://doi.org/10.1002/ana.410340604

Forsgren, L., Beghi, E., Oun, A., & Sillanpää, M. (2005). The epidemiology of epilepsy in Europe - a systematic review. European journal of neurology, 12(4), 245–253. https://doi.org/10.1111/j.1468-1331.2004.00992.x

Gillberg, C., Lundström, S., Fernell, E., Nilsson, G., & Neville, B. (2017). Febrile Seizures and Epilepsy: Association With Autism and Other Neurodevelopmental Disorders in the Child and Adolescent Twin Study in Sweden. Pediatric neurology, 74, 80–86.e2. https://doi.org/10.1016/j.pediatrneurol.2017.05.027

Glass, H. C., Glidden, D., Jeremy, R. J., Barkovich, A. J., Ferriero, D. M., & Miller, S. P. (2009). Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury. The Journal of pediatrics, 155(3), 318–323. https://doi.org/10.1016/j.jpeds.2009.03.040

Hattiangady, B., Rao, M. S., & Shetty, A. K. (2004). Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus. Neurobiology of disease, 17(3), 473–490. https://doi.org/10.1016/j.nbd.2004.08.008

Hauser W. A. (1992). Seizure disorders: the changes with age. Epilepsia, 33 Suppl 4, S6–S14. https://doi.org/10.1111/j.1528-1157.1992.tb06222.x

Hauser W. A. (1994). The prevalence and incidence of convulsive disorders in children. Epilepsia, 35 Suppl 2, S1–S6. https://doi.org/10.1111/j.1528-1157.1994.tb05932.x

Hesdorffer, D. C., Beck, V., Begley, C. E., Bishop, M. L., Cushner-Weinstein, S., Holmes, G. L., Shafer, P. O., Sirven, J. I., & Austin, J. K. (2013). Research implications of the Institute of Medicine Report, Epilepsy Across the Spectrum: Promoting Health and Understanding. Epilepsia, 54(2), 207–216. https://doi.org/10.1111/epi.12056

Hollmann, M., & Heinemann, S. (1994). Cloned glutamate receptors. Annual review of neuroscience, 17, 31–108. https://doi.org/10.1146/annurev.ne.17.030194.000335

Holmes G. L. (2004). Effects of early seizures on later behavior and epileptogenicity. Mental retardation and developmental disabilities research reviews, 10(2), 101–105. https://doi.org/10.1002/mrdd.20019

Holmes G. L. (2014). What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data?. Epileptic disorders : international epilepsy journal with videotape, 16 Spec No 1(Spec No 1), S12–S22. https://doi.org/10.1684/epd.2014.0686

Holmes G. L. (2015). Cognitive impairment in epilepsy: the role of network abnormalities. Epileptic disorders : international epilepsy journal with videotape, 17(2), 101–116. https://doi.org/10.1684/epd.2015.0739

Holmes, G. L., Milh, M. D., & Dulac, O. (2012). Maturation of the human brain and epilepsy. Handbook of clinical neurology, 107, 135–143. https://doi.org/10.1016/B978-0-444-52898-8.00007-0

Holopainen I. E. (2008). Seizures in the developing brain: cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization. Neurochemistry international, 52(6), 935–947. https://doi.org/10.1016/j.neuint.2007.10.021

Huang, L., Cilio, M. R., Silveira, D. C., McCabe, B. K., Sogawa, Y., Stafstrom, C. E., & Holmes, G. L. (1999). Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study. Brain research. Developmental brain research, 118(1-2), 99–107. https://doi.org/10.1016/s0165-3806(99)00135-2

Huttenlocher P. R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28(6), 517–527. https://doi.org/10.1016/0028-3932(90)90031-i

Isaeva, E., Isaev, D., Khazipov, R., & Holmes, G. L. (2006). Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. The European journal of neuroscience, 23(6), 1559–1566. https://doi.org/10.1111/j.1460-9568.2006.04693.x

Jensen, F. E., Applegate, C. D., Holtzman, D., Belin, T. R., & Burchfiel, J. L. (1991). Epileptogenic effect of hypoxia in the immature rodent brain. Annals of neurology, 29(6), 629–637. https://doi.org/10.1002/ana.410290610

Jung, K. H., Chu, K., Lee, S. T., Kim, J. H., Kang, K. M., Song, E. C., Kim, S. J., Park, H. K., Kim, M., Lee, S. K., & Roh, J. K. (2009). Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. Epilepsia, 50(3), 537–549. https://doi.org/10.1111/j.1528-1167.2008.01718.x

Kanemura, H., Sano, F., Mizorogi, S., Tando, T., Sugita, K., & Aihara, M. (2013). Parental thoughts and actions regarding their child's first febrile seizure. Pediatrics international : official journal of the Japan Pediatric Society, 55(3), 315–319. https://doi.org/10.1111/ped.12058

Khalilov, I., Holmes, G. L., & Ben-Ari, Y. (2003). In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nature neuroscience, 6(10), 1079–1085. https://doi.org/10.1038/nn1125

Khazipov, R., Esclapez, M., Caillard, O., Bernard, C., Khalilov, I., Tyzio, R., Hirsch, J., Dzhala, V., Berger, B., & Ben-Ari, Y. (2001). Early development of neuronal activity in the primate hippocampus in utero. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(24), 9770–9781. https://doi.org/10.1523/JNEUROSCI.21-24-09770.2001

Khazipov, R., Khalilov, I., Tyzio, R., Morozova, E., Ben-Ari, Y., & Holmes, G. L. (2004). Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. The European journal of neuroscience, 19(3), 590–600. https://doi.org/10.1111/j.0953-816x.2003.03152.x

Kim, D. Y., Simeone, K. A., Simeone, T. A., Pandya, J. D., Wilke, J. C., Ahn, Y., Geddes, J. W., Sullivan, P. G., & Rho, J. M. (2015). Ketone bodies mediate antiseizure effects through mitochondrial permeability transition. Annals of neurology, 78(1), 77–87. https://doi.org/10.1002/ana.24424

Korman, B., Krsek, P., Duchowny, M., Maton, B., Pacheco-Jacome, E., & Rey, G. (2013). Early seizure onset and dysplastic lesion extent independently disrupt cognitive networks. Neurology, 81(8), 745–751. https://doi.org/10.1212/WNL.0b013e3182a1aa2a

Kossoff, E. H., Bosarge, J. L., Miranda, M. J., Wiemer-Kruel, A., Kang, H. C., & Kim, H. D. (2010). Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?. Epilepsia, 51(12), 2496–2499. https://doi.org/10.1111/j.1528-1167.2010.02774.x

Kumar, S. S., Bacci, A., Kharazia, V., & Huguenard, J. R. (2002). A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(8), 3005–3015. https://doi.org/10.1523/JNEUROSCI.22-08-03005.2002

Lado, F. A., Sankar, R., Lowenstein, D., & Moshé, S. L. (2000). Age-dependent consequences of seizures: relationship to seizure frequency, brain damage, and circuitry reorganization. Mental retardation and developmental disabilities research reviews, 6(4), 242–252. https://doi.org/10.1002/1098-2779(2000)6:4<242::AID-MRDD3>3.0.CO;2-W

Lavigne, J. V., & Faier-Routman, J. (1992). Psychological adjustment to pediatric physical disorders: a meta-analytic review. Journal of pediatric psychology, 17(2), 133–157. https://doi.org/10.1093/jpepsy/17.2.133

Leaffer, E. B., Hinton, V. J., & Hesdorffer, D. C. (2013). Longitudinal assessment of skill development in children with first febrile seizure. Epilepsy & behavior : E&B, 28(1), 83–87. https://doi.org/10.1016/j.yebeh.2013.03.034

Lee, C. L., Hannay, J., Hrachovy, R., Rashid, S., Antalffy, B., & Swann, J. W. (2001). Spatial learning deficits without hippocampal neuronal loss in a model of early-onset epilepsy. Neuroscience, 107(1), 71–84. https://doi.org/10.1016/s0306-4522(01)00327-x

Lewis, D. L., DeCamillis, M., & Bennett, R. L. (2000). Distinct roles of the homeotic genes Ubx and abd-A in beetle embryonic abdominal appendage development. Proceedings of the National Academy of Sciences of the United States of America, 97(9), 4504–4509. https://doi.org/10.1073/pnas.97.9.4504

Li, Z., & Heber, D. (2020). Ketogenic Diets. JAMA, 323(4), 386. https://doi.org/10.1001/jama.2019.18408

Margerison, J. H., & Corsellis, J. A. (1966). Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain : a journal of neurology, 89(3), 499–530. https://doi.org/10.1093/brain/89.3.499

Mathern, G. W., Adelson, P. D., Cahan, L. D., & Leite, J. P. (2002). Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Progress in brain research, 135, 237–251. https://doi.org/10.1016/s0079-6123(02)35023-4

Mathieson G. (1975). Pathology of temporal lobe foci. Advances in neurology, 11, 163–185.

Mewasingh, L. D., Chin, R. F. M., & Scott, R. C. (2020). Current understanding of febrile seizures and their long-term outcomes. Developmental medicine and child neurology, 62(11), 1245–1249. https://doi.org/10.1111/dmcn.14642

McDonald, J. W., Johnston, M. V., & Young, A. B. (1990). Differential ontogenic development of three receptors comprising the NMDA receptor/channel complex in the rat hippocampus. Experimental neurology, 110(3), 237–247. https://doi.org/10.1016/0014-4886(90)90035-q

McLean, H. A., Caillard, O., Khazipov, R., Ben-Ari, Y., & Gaiarsa, J. L. (1996). Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus. Journal of neurophysiology, 76(2), 1036–1046. https://doi.org/10.1152/jn.1996.76.2.1036

McNally, M. A., & Hartman, A. L. (2012). Ketone bodies in epilepsy. Journal of neurochemistry, 121(1), 28–35. https://doi.org/10.1111/j.1471-4159.2012.07670.x

Millan, M. H., Chapman, A. G., & Meldrum, B. S. (1993). Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. Epilepsy research, 14(2), 139–148. https://doi.org/10.1016/0920-1211(93)90018-3

Minamoto, Y., Itano, T., Tokuda, M., Matsui, H., Janjua, N. A., Hosokawa, K., Okada, Y., Murakami, T. H., Negi, T., & Hatase, O. (1992). In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat. Brain research, 573(2), 345–348. https://doi.org/10.1016/0006-8993(92)90786-9

Minlebaev, M., Ben-Ari, Y., & Khazipov, R. (2009). NMDA receptors pattern early activity in the developing barrel cortex in vivo. Cerebral cortex (New York, N.Y. : 1991), 19(3), 688–696. https://doi.org/10.1093/cercor/bhn115

Monfries, N., & Goldman, R. D. (2017). Prophylactic antipyretics for prevention of febrile seizures following vaccination. Canadian family physician Medecin de famille canadien, 63(2), 128–130.

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994). Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron, 12(3), 529–540. https://doi.org/10.1016/0896-6273(94)90210-0

Murugan, M., & Boison, D. (2020). Ketogenic diet, neuroprotection, and antiepileptogenesis. Epilepsy research, 167, 106444. https://doi.org/10.1016/j.eplepsyres.2020.106444

Musto, A. E., Gjorstrup, P., & Bazan, N. G. (2011). The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia, 52(9), 1601–1608. https://doi.org/10.1111/j.1528-1167.2011.03081.x

Musto, A. E., Rosencrans, R. F., Walker, C. P., Bhattacharjee, S., Raulji, C. M., Belayev, L., Fang, Z., Gordon, W. C., & Bazan, N. G. (2016). Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism. Scientific reports, 6, 30298. https://doi.org/10.1038/srep30298

Nassau, J. H., & Drotar, D. (1997). Social competence among children with central nervous system-related chronic health conditions: a review. Journal of pediatric psychology, 22(6), 771–793. https://doi.org/10.1093/jpepsy/22.6.771

Neyens, L. G., Aldenkamp, A. P., & Meinardi, H. M. (1999). Prospective follow-up of intellectual development in children with a recent onset of epilepsy. Epilepsy research, 34(2-3), 85–90. https://doi.org/10.1016/s0920-1211(98)00118-1

Lallement, G., Carpentier, P., Collet, A., Pernot-Marino, I., Baubichon, D., & Blanchet, G. (1991). Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain research, 563(1-2), 234–240. https://doi.org/10.1016/0006-8993(91)91539-d

Leung, A. K., & Robson, W. L. (1991). Febrile convulsions. How dangerous are they?. Postgraduate medicine, 89(5), 217–224. https://doi.org/10.1080/00325481.1991.11700905

Miller, L. P., Johnson, A. E., Gelhard, R. E., & Insel, T. R. (1990). The ontogeny of excitatory amino acid receptors in the rat forebrain--II. Kainic acid receptors. Neuroscience, 35(1), 45–51. https://doi.org/10.1016/0306-4522(90)90118-n

McDermott, S., Coker, A. L., Mani, S., Krishnaswami, S., Nagle, R. J., Barnett-Queen, L. L., & Wuori, D. F. (1996). A population-based analysis of behavior problems in children with cerebral palsy. Journal of pediatric psychology, 21(3), 447–463. https://doi.org/10.1093/jpepsy/21.3.447

Pujar, S. S., Seunarine, K. K., Martinos, M. M., Neville, B. G. R., Scott, R. C., Chin, R. F. M., & Clark, C. A. (2017). Long-term white matter tract reorganization following prolonged febrile seizures. Epilepsia, 58(5), 772–780. https://doi.org/10.1111/epi.13724

Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Müller-Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., Okun, J. G., Offermanns, S., & Schwaninger, M. (2014). The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nature communications, 5, 3944. https://doi.org/10.1038/ncomms4944

Sadleir, L. G., & Scheffer, I. E. (2007). Febrile seizures. BMJ (Clinical research ed.), 334(7588), 307–311. https://doi.org/10.1136/bmj.39087.691817.AE

Sagar, H. J., & Oxbury, J. M. (1987). Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions. Annals of neurology, 22(3), 334–340. https://doi.org/10.1002/ana.410220309

Salehi, B., Yousefichaijan, P., Safi Arian, S., Ebrahimi, S., & Naziri, M. (2016). Comparison of Relation between Attention Deficit Hyperactivity Disorder in Children with and without Simple Febrile Seizure Admitted in Arak Central Iran. Iranian journal of child neurology, 10(4), 56–61.

Sans, N., Petralia, R. S., Wang, Y. X., Blahos, J., 2nd, Hell, J. W., & Wenthold, R. J. (2000). A developmental change in NMDA receptor-associated proteins at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(3), 1260–1271. https://doi.org/10.1523/JNEUROSCI.20-03-01260.2000

Scheffer, I. E., & Berkovic, S. F. (1997). Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain : a journal of neurology, 120 ( Pt 3), 479–490. https://doi.org/10.1093/brain/120.3.479

Schoenfeld, J., Seidenberg, M., Woodard, A., Hecox, K., Inglese, C., Mack, K., & Hermann, B. (1999). Neuropsychological and behavioral status of children with complex partial seizures. Developmental medicine and child neurology, 41(11), 724–731. https://doi.org/10.1017/s0012162299001486

Scott R. C. (2014). Consequences of febrile seizures in childhood. Current opinion in pediatrics, 26(6), 662–667. https://doi.org/10.1097/MOP.0000000000000153

Shahrokhi, A., Zare-Shahabadi, A., Soltani, S., Ashrafi, M. R., Zoghi, S., Hosseini, S. A., Heidari, M., Yaghmaei, B., Pourakbari, B., & Rezaei, N. (2014). Association of IL6 single nucleotide polymorphisms with febrile seizures. Journal of the neurological sciences, 342(1-2), 25–28. https://doi.org/10.1016/j.jns.2014.04.003

Sillanpää M. (2004). Learning disability: occurrence and long-term consequences in childhood-onset epilepsy. Epilepsy & behavior : E&B, 5(6), 937–944. https://doi.org/10.1016/j.yebeh.2004.08.008

Sutula, T. P., & Hermann, B. (1999). Progression in mesial temporal lobe epilepsy. Annals of neurology, 45(5), 553–556.

Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics (2008). Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics, 121(6), 1281–1286. https://doi.org/10.1542/peds.2008-0939

Stores, G., Williams, P. L., Styles, E., & Zaiwalla, Z. (1992). Psychological effects of sodium valproate and carbamazepine in epilepsy. Archives of disease in childhood, 67(11), 1330–1337. https://doi.org/10.1136/adc.67.11.1330

Stafstrom C. E. (2002). Assessing the behavioral and cognitive effects of seizures on the developing brain. Progress in brain research, 135, 377–390. https://doi.org/10.1016/S0079-6123(02)35034-9

Swann, J. W., Smith, K. L., & Brady, R. J. (1991). Age-dependent alterations in the operations of hippocampal neural networks. Annals of the New York Academy of Sciences, 627, 264–276. https://doi.org/10.1111/j.1749-6632.1991.tb25930.x

Thavendiranathan, P., Chow, C., Cunnane, S., & McIntyre Burnham, W. (2003). The effect of the 'classic' ketogenic diet on animal seizure models. Brain research, 959(2), 206–213. https://doi.org/10.1016/s0006-8993(02)03744-7

Titre-Johnson, S., Schoeler, N., Eltze, C., Williams, R., Vezyroglou, K., McCullagh, H., Freemantle, N., Heales, S., Kneen, R., Marston, L., Martland, T., Nazareth, I., Neal, E., Lux, A., Parker, A., Agrawal, S., Fallon, P., & Cross, J. H. (2017). Ketogenic diet in the treatment of epilepsy in children under the age of 2 years: study protocol for a randomised controlled trial. Trials, 18(1), 195. https://doi.org/10.1186/s13063-017-1918-3

Van Paesschen, W., Revesz, T., Duncan, J. S., King, M. D., & Connelly, A. (1997). Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy. Annals of neurology, 42(5), 756–766. https://doi.org/10.1002/ana.410420512

Velísek, L., & Moshé, S. L. (2002). Effects of brief seizures during development. Progress in brain research, 135, 355–364. https://doi.org/10.1016/S0079-6123(02)35032-5

Visser, A. M., Jaddoe, V. W., Ghassabian, A., Schenk, J. J., Verhulst, F. C., Hofman, A., Tiemeier, H., Moll, H. A., & Arts, W. F. (2012). Febrile seizures and behavioural and cognitive outcomes in preschool children: the Generation R study. Developmental medicine and child neurology, 54(11), 1006–1011. https://doi.org/10.1111/j.1469-8749.2012.04405.x

Wheless J. W. (2008). History of the ketogenic diet. Epilepsia, 49 Suppl 8, 3–5. https://doi.org/10.1111/j.1528-1167.2008.01821.x

Wibisono, C., Rowe, N., Beavis, E., Kepreotes, H., Mackie, F. E., Lawson, J. A., & Cardamone, M. (2015). Ten-year single-center experience of the ketogenic diet: factors influencing efficacy, tolerability, and compliance. The Journal of pediatrics, 166(4), 1030–6.e1. https://doi.org/10.1016/j.jpeds.2014.12.018

Ye, G. L., Yi, S., Gamkrelidze, G., Pasternak, J. F., & Trommer, B. L. (2005). AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells. Brain research. Developmental brain research, 155(1), 26–32. https://doi.org/10.1016/j.devbrainres.2004.12.002

Youm, Y. H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., Kang, S., Horvath, T. L., Fahmy, T. M., Crawford, P. A., Biragyn, A., Alnemri, E., & Dixit, V. D. (2015). The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature medicine, 21(3), 263–269. https://doi.org/10.1038/nm.3804

Yu, Y. H., Lee, K., Sin, D. S., Park, K. H., Park, D. K., & Kim, D. S. (2017). Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures. Brain research bulletin, 131, 25–38. https://doi.org/10.1016/j.brainresbull.2017.02.009

Yudkoff, M., Daikhin, Y., Nissim, I., Grunstein, R., & Nissim, I. (1997). Effects of ketone bodies on astrocyte amino acid metabolism. Journal of neurochemistry, 69(2), 682–692. https://doi.org/10.1046/j.1471-4159.1997.69020682.x

Referanslar

Aldenkamp, A. P., Alpherts, W. C., De Bruïne-Seeder, D., & Dekker, M. J. (1990). Test-retest variability in children with epilepsy--a comparison of WISC-R profiles. Epilepsy research, 7(2), 165–172. https://doi.org/10.1016/0920-1211(90)90102-2

Austin, J. K., Smith, M. S., Risinger, M. W., & McNelis, A. M. (1994). Childhood epilepsy and asthma: comparison of quality of life. Epilepsia, 35(3), 608–615. https://doi.org/10.1111/j.1528-1157.1994.tb02481.x

Babb, T. L., Kupfer, W. R., Pretorius, J. K., Crandall, P. H., & Levesque, M. F. (1991). Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience, 42(2), 351–363. https://doi.org/10.1016/0306-4522(91)90380-7

Behar, T. N., Schaffner, A. E., Scott, C. A., O'Connell, C., & Barker, J. L. (1998). Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(16), 6378–6387. https://doi.org/10.1523/JNEUROSCI.18-16-06378.1998

Beker Acay, M., Köken, R., Ünlü, E., Kaçar, E., & Balçık, Ç. (2017). Evaluation of hippocampal infolding angle and incomplete hippocampal inversion in pediatric patients with epilepsy and febrile seizures. Diagnostic and interventional radiology (Ankara, Turkey), 23(4), 326–330. https://doi.org/10.5152/dir.2017.160077

Ben-Ari, Y., & Represa, A. (1990). Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus. Trends in neurosciences, 13(8), 312–318. https://doi.org/10.1016/0166-2236(90)90135-w

Bertelsen, E. N., Larsen, J. T., Petersen, L., Christensen, J., & Dalsgaard, S. (2016). Childhood Epilepsy, Febrile Seizures, and Subsequent Risk of ADHD. Pediatrics, 138(2), e20154654. https://doi.org/10.1542/peds.2015-4654

Bjørnaes, H., Stabell, K., Henriksen, O., & Løyning, Y. (2001). The effects of refractory epilepsy on intellectual functioning in children and adults. A longitudinal study. Seizure, 10(4), 250–259. https://doi.org/10.1053/seiz.2000.0503

Bough, K. J., & Rho, J. M. (2007). Anticonvulsant mechanisms of the ketogenic diet. Epilepsia, 48(1), 43–58. https://doi.org/10.1111/j.1528-1167.2007.00915.x

Bourgeois B. F. (1998). Antiepileptic drugs, learning, and behavior in childhood epilepsy. Epilepsia, 39(9), 913–921. https://doi.org/10.1111/j.1528-1157.1998.tb01440.x

Braak, H., Braak, E., Yilmazer, D., & Bohl, J. (1996). Functional anatomy of human hippocampal formation and related structures. Journal of child neurology, 11(4), 265–275. https://doi.org/10.1177/088307389601100402

Brunson, K. L., Eghbal-Ahmadi, M., & Baram, T. Z. (2001). How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis. Brain & development, 23(7), 533–538. https://doi.org/10.1016/s0387-7604(01)00312-6

Buelow, J. M., Perkins, S. M., Johnson, C. S., Byars, A. W., Fastenau, P. S., Dunn, D. W., & Austin, J. K. (2012). Adaptive functioning in children with epilepsy and learning problems. Journal of child neurology, 27(10), 1241–1249. https://doi.org/10.1177/0883073811432750

Camfield, P., & Camfield, C. (2007). Long-term prognosis for symptomatic (secondarily) generalized epilepsies: a population-based study. Epilepsia, 48(6), 1128–1132. https://doi.org/10.1111/j.1528-1167.2007.01072.x

Carlson, H., Ronne-Engström, E., Ungerstedt, U., & Hillered, L. (1992). Seizure related elevations of extracellular amino acids in human focal epilepsy. Neuroscience letters, 140(1), 30–32. https://doi.org/10.1016/0304-3940(92)90674-v

Cascino G. D. (1995). Clinical correlations with hippocampal atrophy. Magnetic resonance imaging, 13(8), 1133–1136. https://doi.org/10.1016/0730-725x(95)02023-m

Cavazos, J. E., & Sutula, T. P. (1990). Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis. Brain research, 527(1), 1–6. https://doi.org/10.1016/0006-8993(90)91054-k

Chang, L. R., Liu, J. P., Zhang, N., Wang, Y. J., Gao, X. L., & Wu, Y. (2009). Different expression of NR2B and PSD-95 in rat hippocampal subregions during postnatal development. Microscopy research and technique, 72(7), 517–524. https://doi.org/10.1002/jemt.20708

Chang, Y. C., Huang, A. M., Kuo, Y. M., Wang, S. T., Chang, Y. Y., & Huang, C. C. (2003). Febrile seizures impair memory and cAMP response-element binding protein activation. Annals of neurology, 54(6), 706–718. https://doi.org/10.1002/ana.10789

Chen, K., Aradi, I., Thon, N., Eghbal-Ahmadi, M., Baram, T. Z., & Soltesz, I. (2001). Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nature medicine, 7(3), 331–337. https://doi.org/10.1038/85480

Chungath, M., & Shorvon, S. (2008). The mortality and morbidity of febrile seizures. Nature clinical practice. Neurology, 4(11), 610–621. https://doi.org/10.1038/ncpneuro0922

Clanton, R. M., Wu, G., Akabani, G., & Aramayo, R. (2017). Control of seizures by ketogenic diet-induced modulation of metabolic pathways. Amino acids, 49(1), 1–20. https://doi.org/10.1007/s00726-016-2336-7

Cronin, J., & Dudek, F. E. (1988). Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain research, 474(1), 181–184. https://doi.org/10.1016/0006-8993(88)90681-6

Dahlin, M., Elfving, A., Ungerstedt, U., & Amark, P. (2005). The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy. Epilepsy research, 64(3), 115–125. https://doi.org/10.1016/j.eplepsyres.2005.03.008

Daikhin, Y., & Yudkoff, M. (1998). Ketone bodies and brain glutamate and GABA metabolism. Developmental neuroscience, 20(4-5), 358–364. https://doi.org/10.1159/000017331

Davies, S., Heyman, I., & Goodman, R. (2003). A population survey of mental health problems in children with epilepsy. Developmental medicine and child neurology, 45(5), 292–295. https://doi.org/10.1017/s0012162203000550

Davis, B. K., Wen, H., & Ting, J. P. (2011). The inflammasome NLRs in immunity, inflammation, and associated diseases. Annual review of immunology, 29, 707–735. https://doi.org/10.1146/annurev-immunol-031210-101405

During, M. J., & Spencer, D. D. (1993). Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet (London, England), 341(8861), 1607–1610. https://doi.org/10.1016/0140-6736(93)90754-5

Dzhala, V. I., & Staley, K. J. (2003). Transition from interictal to ictal activity in limbic networks in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(21), 7873–7880. https://doi.org/10.1523/JNEUROSCI.23-21-07873.2003

Ekdahl, C. T., Mohapel, P., Weber, E., Bahr, B., Blomgren, K., & Lindvall, O. (2002). Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus. The European journal of neuroscience, 16(8), 1463–1471. https://doi.org/10.1046/j.1460-9568.2002.02202.x

Engel, J., Jr, & International League Against Epilepsy (ILAE) (2001). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia, 42(6), 796–803. https://doi.org/10.1046/j.1528-1157.2001.10401.x

Erecińska, M., Nelson, D., Daikhin, Y., & Yudkoff, M. (1996). Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. Journal of neurochemistry, 67(6), 2325–2334. https://doi.org/10.1046/j.1471-4159.1996.67062325.x

Falconer M. A. (1974). Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention. Lancet (London, England), 2(7883), 767–770. https://doi.org/10.1016/s0140-6736(74)90956-8

Fetveit A. (2008). Assessment of febrile seizures in children. European journal of pediatrics, 167(1), 17–27. https://doi.org/10.1007/s00431-007-0577-x

French, J. A., Williamson, P. D., Thadani, V. M., Darcey, T. M., Mattson, R. H., Spencer, S. S., & Spencer, D. D. (1993). Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Annals of neurology, 34(6), 774–780. https://doi.org/10.1002/ana.410340604

Forsgren, L., Beghi, E., Oun, A., & Sillanpää, M. (2005). The epidemiology of epilepsy in Europe - a systematic review. European journal of neurology, 12(4), 245–253. https://doi.org/10.1111/j.1468-1331.2004.00992.x

Gillberg, C., Lundström, S., Fernell, E., Nilsson, G., & Neville, B. (2017). Febrile Seizures and Epilepsy: Association With Autism and Other Neurodevelopmental Disorders in the Child and Adolescent Twin Study in Sweden. Pediatric neurology, 74, 80–86.e2. https://doi.org/10.1016/j.pediatrneurol.2017.05.027

Glass, H. C., Glidden, D., Jeremy, R. J., Barkovich, A. J., Ferriero, D. M., & Miller, S. P. (2009). Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury. The Journal of pediatrics, 155(3), 318–323. https://doi.org/10.1016/j.jpeds.2009.03.040

Hattiangady, B., Rao, M. S., & Shetty, A. K. (2004). Chronic temporal lobe epilepsy is associated with severely declined dentate neurogenesis in the adult hippocampus. Neurobiology of disease, 17(3), 473–490. https://doi.org/10.1016/j.nbd.2004.08.008

Hauser W. A. (1992). Seizure disorders: the changes with age. Epilepsia, 33 Suppl 4, S6–S14. https://doi.org/10.1111/j.1528-1157.1992.tb06222.x

Hauser W. A. (1994). The prevalence and incidence of convulsive disorders in children. Epilepsia, 35 Suppl 2, S1–S6. https://doi.org/10.1111/j.1528-1157.1994.tb05932.x

Hesdorffer, D. C., Beck, V., Begley, C. E., Bishop, M. L., Cushner-Weinstein, S., Holmes, G. L., Shafer, P. O., Sirven, J. I., & Austin, J. K. (2013). Research implications of the Institute of Medicine Report, Epilepsy Across the Spectrum: Promoting Health and Understanding. Epilepsia, 54(2), 207–216. https://doi.org/10.1111/epi.12056

Hollmann, M., & Heinemann, S. (1994). Cloned glutamate receptors. Annual review of neuroscience, 17, 31–108. https://doi.org/10.1146/annurev.ne.17.030194.000335

Holmes G. L. (2004). Effects of early seizures on later behavior and epileptogenicity. Mental retardation and developmental disabilities research reviews, 10(2), 101–105. https://doi.org/10.1002/mrdd.20019

Holmes G. L. (2014). What is more harmful, seizures or epileptic EEG abnormalities? Is there any clinical data?. Epileptic disorders : international epilepsy journal with videotape, 16 Spec No 1(Spec No 1), S12–S22. https://doi.org/10.1684/epd.2014.0686

Holmes G. L. (2015). Cognitive impairment in epilepsy: the role of network abnormalities. Epileptic disorders : international epilepsy journal with videotape, 17(2), 101–116. https://doi.org/10.1684/epd.2015.0739

Holmes, G. L., Milh, M. D., & Dulac, O. (2012). Maturation of the human brain and epilepsy. Handbook of clinical neurology, 107, 135–143. https://doi.org/10.1016/B978-0-444-52898-8.00007-0

Holopainen I. E. (2008). Seizures in the developing brain: cellular and molecular mechanisms of neuronal damage, neurogenesis and cellular reorganization. Neurochemistry international, 52(6), 935–947. https://doi.org/10.1016/j.neuint.2007.10.021

Huang, L., Cilio, M. R., Silveira, D. C., McCabe, B. K., Sogawa, Y., Stafstrom, C. E., & Holmes, G. L. (1999). Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study. Brain research. Developmental brain research, 118(1-2), 99–107. https://doi.org/10.1016/s0165-3806(99)00135-2

Huttenlocher P. R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28(6), 517–527. https://doi.org/10.1016/0028-3932(90)90031-i

Isaeva, E., Isaev, D., Khazipov, R., & Holmes, G. L. (2006). Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. The European journal of neuroscience, 23(6), 1559–1566. https://doi.org/10.1111/j.1460-9568.2006.04693.x

Jensen, F. E., Applegate, C. D., Holtzman, D., Belin, T. R., & Burchfiel, J. L. (1991). Epileptogenic effect of hypoxia in the immature rodent brain. Annals of neurology, 29(6), 629–637. https://doi.org/10.1002/ana.410290610

Jung, K. H., Chu, K., Lee, S. T., Kim, J. H., Kang, K. M., Song, E. C., Kim, S. J., Park, H. K., Kim, M., Lee, S. K., & Roh, J. K. (2009). Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis. Epilepsia, 50(3), 537–549. https://doi.org/10.1111/j.1528-1167.2008.01718.x

Kanemura, H., Sano, F., Mizorogi, S., Tando, T., Sugita, K., & Aihara, M. (2013). Parental thoughts and actions regarding their child's first febrile seizure. Pediatrics international : official journal of the Japan Pediatric Society, 55(3), 315–319. https://doi.org/10.1111/ped.12058

Khalilov, I., Holmes, G. L., & Ben-Ari, Y. (2003). In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nature neuroscience, 6(10), 1079–1085. https://doi.org/10.1038/nn1125

Khazipov, R., Esclapez, M., Caillard, O., Bernard, C., Khalilov, I., Tyzio, R., Hirsch, J., Dzhala, V., Berger, B., & Ben-Ari, Y. (2001). Early development of neuronal activity in the primate hippocampus in utero. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(24), 9770–9781. https://doi.org/10.1523/JNEUROSCI.21-24-09770.2001

Khazipov, R., Khalilov, I., Tyzio, R., Morozova, E., Ben-Ari, Y., & Holmes, G. L. (2004). Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. The European journal of neuroscience, 19(3), 590–600. https://doi.org/10.1111/j.0953-816x.2003.03152.x

Kim, D. Y., Simeone, K. A., Simeone, T. A., Pandya, J. D., Wilke, J. C., Ahn, Y., Geddes, J. W., Sullivan, P. G., & Rho, J. M. (2015). Ketone bodies mediate antiseizure effects through mitochondrial permeability transition. Annals of neurology, 78(1), 77–87. https://doi.org/10.1002/ana.24424

Korman, B., Krsek, P., Duchowny, M., Maton, B., Pacheco-Jacome, E., & Rey, G. (2013). Early seizure onset and dysplastic lesion extent independently disrupt cognitive networks. Neurology, 81(8), 745–751. https://doi.org/10.1212/WNL.0b013e3182a1aa2a

Kossoff, E. H., Bosarge, J. L., Miranda, M. J., Wiemer-Kruel, A., Kang, H. C., & Kim, H. D. (2010). Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?. Epilepsia, 51(12), 2496–2499. https://doi.org/10.1111/j.1528-1167.2010.02774.x

Kumar, S. S., Bacci, A., Kharazia, V., & Huguenard, J. R. (2002). A developmental switch of AMPA receptor subunits in neocortical pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(8), 3005–3015. https://doi.org/10.1523/JNEUROSCI.22-08-03005.2002

Lado, F. A., Sankar, R., Lowenstein, D., & Moshé, S. L. (2000). Age-dependent consequences of seizures: relationship to seizure frequency, brain damage, and circuitry reorganization. Mental retardation and developmental disabilities research reviews, 6(4), 242–252. https://doi.org/10.1002/1098-2779(2000)6:4<242::AID-MRDD3>3.0.CO;2-W

Lavigne, J. V., & Faier-Routman, J. (1992). Psychological adjustment to pediatric physical disorders: a meta-analytic review. Journal of pediatric psychology, 17(2), 133–157. https://doi.org/10.1093/jpepsy/17.2.133

Leaffer, E. B., Hinton, V. J., & Hesdorffer, D. C. (2013). Longitudinal assessment of skill development in children with first febrile seizure. Epilepsy & behavior : E&B, 28(1), 83–87. https://doi.org/10.1016/j.yebeh.2013.03.034

Lee, C. L., Hannay, J., Hrachovy, R., Rashid, S., Antalffy, B., & Swann, J. W. (2001). Spatial learning deficits without hippocampal neuronal loss in a model of early-onset epilepsy. Neuroscience, 107(1), 71–84. https://doi.org/10.1016/s0306-4522(01)00327-x

Lewis, D. L., DeCamillis, M., & Bennett, R. L. (2000). Distinct roles of the homeotic genes Ubx and abd-A in beetle embryonic abdominal appendage development. Proceedings of the National Academy of Sciences of the United States of America, 97(9), 4504–4509. https://doi.org/10.1073/pnas.97.9.4504

Li, Z., & Heber, D. (2020). Ketogenic Diets. JAMA, 323(4), 386. https://doi.org/10.1001/jama.2019.18408

Margerison, J. H., & Corsellis, J. A. (1966). Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain : a journal of neurology, 89(3), 499–530. https://doi.org/10.1093/brain/89.3.499

Mathern, G. W., Adelson, P. D., Cahan, L. D., & Leite, J. P. (2002). Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Progress in brain research, 135, 237–251. https://doi.org/10.1016/s0079-6123(02)35023-4

Mathieson G. (1975). Pathology of temporal lobe foci. Advances in neurology, 11, 163–185.

Mewasingh, L. D., Chin, R. F. M., & Scott, R. C. (2020). Current understanding of febrile seizures and their long-term outcomes. Developmental medicine and child neurology, 62(11), 1245–1249. https://doi.org/10.1111/dmcn.14642

McDonald, J. W., Johnston, M. V., & Young, A. B. (1990). Differential ontogenic development of three receptors comprising the NMDA receptor/channel complex in the rat hippocampus. Experimental neurology, 110(3), 237–247. https://doi.org/10.1016/0014-4886(90)90035-q

McLean, H. A., Caillard, O., Khazipov, R., Ben-Ari, Y., & Gaiarsa, J. L. (1996). Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus. Journal of neurophysiology, 76(2), 1036–1046. https://doi.org/10.1152/jn.1996.76.2.1036

McNally, M. A., & Hartman, A. L. (2012). Ketone bodies in epilepsy. Journal of neurochemistry, 121(1), 28–35. https://doi.org/10.1111/j.1471-4159.2012.07670.x

Millan, M. H., Chapman, A. G., & Meldrum, B. S. (1993). Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures. Epilepsy research, 14(2), 139–148. https://doi.org/10.1016/0920-1211(93)90018-3

Minamoto, Y., Itano, T., Tokuda, M., Matsui, H., Janjua, N. A., Hosokawa, K., Okada, Y., Murakami, T. H., Negi, T., & Hatase, O. (1992). In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat. Brain research, 573(2), 345–348. https://doi.org/10.1016/0006-8993(92)90786-9

Minlebaev, M., Ben-Ari, Y., & Khazipov, R. (2009). NMDA receptors pattern early activity in the developing barrel cortex in vivo. Cerebral cortex (New York, N.Y. : 1991), 19(3), 688–696. https://doi.org/10.1093/cercor/bhn115

Monfries, N., & Goldman, R. D. (2017). Prophylactic antipyretics for prevention of febrile seizures following vaccination. Canadian family physician Medecin de famille canadien, 63(2), 128–130.

Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994). Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron, 12(3), 529–540. https://doi.org/10.1016/0896-6273(94)90210-0

Murugan, M., & Boison, D. (2020). Ketogenic diet, neuroprotection, and antiepileptogenesis. Epilepsy research, 167, 106444. https://doi.org/10.1016/j.eplepsyres.2020.106444

Musto, A. E., Gjorstrup, P., & Bazan, N. G. (2011). The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia, 52(9), 1601–1608. https://doi.org/10.1111/j.1528-1167.2011.03081.x

Musto, A. E., Rosencrans, R. F., Walker, C. P., Bhattacharjee, S., Raulji, C. M., Belayev, L., Fang, Z., Gordon, W. C., & Bazan, N. G. (2016). Dysfunctional epileptic neuronal circuits and dysmorphic dendritic spines are mitigated by platelet-activating factor receptor antagonism. Scientific reports, 6, 30298. https://doi.org/10.1038/srep30298

Nassau, J. H., & Drotar, D. (1997). Social competence among children with central nervous system-related chronic health conditions: a review. Journal of pediatric psychology, 22(6), 771–793. https://doi.org/10.1093/jpepsy/22.6.771

Neyens, L. G., Aldenkamp, A. P., & Meinardi, H. M. (1999). Prospective follow-up of intellectual development in children with a recent onset of epilepsy. Epilepsy research, 34(2-3), 85–90. https://doi.org/10.1016/s0920-1211(98)00118-1

Lallement, G., Carpentier, P., Collet, A., Pernot-Marino, I., Baubichon, D., & Blanchet, G. (1991). Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain research, 563(1-2), 234–240. https://doi.org/10.1016/0006-8993(91)91539-d

Leung, A. K., & Robson, W. L. (1991). Febrile convulsions. How dangerous are they?. Postgraduate medicine, 89(5), 217–224. https://doi.org/10.1080/00325481.1991.11700905

Miller, L. P., Johnson, A. E., Gelhard, R. E., & Insel, T. R. (1990). The ontogeny of excitatory amino acid receptors in the rat forebrain--II. Kainic acid receptors. Neuroscience, 35(1), 45–51. https://doi.org/10.1016/0306-4522(90)90118-n

McDermott, S., Coker, A. L., Mani, S., Krishnaswami, S., Nagle, R. J., Barnett-Queen, L. L., & Wuori, D. F. (1996). A population-based analysis of behavior problems in children with cerebral palsy. Journal of pediatric psychology, 21(3), 447–463. https://doi.org/10.1093/jpepsy/21.3.447

Pujar, S. S., Seunarine, K. K., Martinos, M. M., Neville, B. G. R., Scott, R. C., Chin, R. F. M., & Clark, C. A. (2017). Long-term white matter tract reorganization following prolonged febrile seizures. Epilepsia, 58(5), 772–780. https://doi.org/10.1111/epi.13724

Rahman, M., Muhammad, S., Khan, M. A., Chen, H., Ridder, D. A., Müller-Fielitz, H., Pokorná, B., Vollbrandt, T., Stölting, I., Nadrowitz, R., Okun, J. G., Offermanns, S., & Schwaninger, M. (2014). The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages. Nature communications, 5, 3944. https://doi.org/10.1038/ncomms4944

Sadleir, L. G., & Scheffer, I. E. (2007). Febrile seizures. BMJ (Clinical research ed.), 334(7588), 307–311. https://doi.org/10.1136/bmj.39087.691817.AE

Sagar, H. J., & Oxbury, J. M. (1987). Hippocampal neuron loss in temporal lobe epilepsy: correlation with early childhood convulsions. Annals of neurology, 22(3), 334–340. https://doi.org/10.1002/ana.410220309

Salehi, B., Yousefichaijan, P., Safi Arian, S., Ebrahimi, S., & Naziri, M. (2016). Comparison of Relation between Attention Deficit Hyperactivity Disorder in Children with and without Simple Febrile Seizure Admitted in Arak Central Iran. Iranian journal of child neurology, 10(4), 56–61.

Sans, N., Petralia, R. S., Wang, Y. X., Blahos, J., 2nd, Hell, J. W., & Wenthold, R. J. (2000). A developmental change in NMDA receptor-associated proteins at hippocampal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20(3), 1260–1271. https://doi.org/10.1523/JNEUROSCI.20-03-01260.2000

Scheffer, I. E., & Berkovic, S. F. (1997). Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain : a journal of neurology, 120 ( Pt 3), 479–490. https://doi.org/10.1093/brain/120.3.479

Schoenfeld, J., Seidenberg, M., Woodard, A., Hecox, K., Inglese, C., Mack, K., & Hermann, B. (1999). Neuropsychological and behavioral status of children with complex partial seizures. Developmental medicine and child neurology, 41(11), 724–731. https://doi.org/10.1017/s0012162299001486

Scott R. C. (2014). Consequences of febrile seizures in childhood. Current opinion in pediatrics, 26(6), 662–667. https://doi.org/10.1097/MOP.0000000000000153

Shahrokhi, A., Zare-Shahabadi, A., Soltani, S., Ashrafi, M. R., Zoghi, S., Hosseini, S. A., Heidari, M., Yaghmaei, B., Pourakbari, B., & Rezaei, N. (2014). Association of IL6 single nucleotide polymorphisms with febrile seizures. Journal of the neurological sciences, 342(1-2), 25–28. https://doi.org/10.1016/j.jns.2014.04.003

Sillanpää M. (2004). Learning disability: occurrence and long-term consequences in childhood-onset epilepsy. Epilepsy & behavior : E&B, 5(6), 937–944. https://doi.org/10.1016/j.yebeh.2004.08.008

Sutula, T. P., & Hermann, B. (1999). Progression in mesial temporal lobe epilepsy. Annals of neurology, 45(5), 553–556.

Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics (2008). Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics, 121(6), 1281–1286. https://doi.org/10.1542/peds.2008-0939

Stores, G., Williams, P. L., Styles, E., & Zaiwalla, Z. (1992). Psychological effects of sodium valproate and carbamazepine in epilepsy. Archives of disease in childhood, 67(11), 1330–1337. https://doi.org/10.1136/adc.67.11.1330

Stafstrom C. E. (2002). Assessing the behavioral and cognitive effects of seizures on the developing brain. Progress in brain research, 135, 377–390. https://doi.org/10.1016/S0079-6123(02)35034-9

Swann, J. W., Smith, K. L., & Brady, R. J. (1991). Age-dependent alterations in the operations of hippocampal neural networks. Annals of the New York Academy of Sciences, 627, 264–276. https://doi.org/10.1111/j.1749-6632.1991.tb25930.x

Thavendiranathan, P., Chow, C., Cunnane, S., & McIntyre Burnham, W. (2003). The effect of the 'classic' ketogenic diet on animal seizure models. Brain research, 959(2), 206–213. https://doi.org/10.1016/s0006-8993(02)03744-7

Titre-Johnson, S., Schoeler, N., Eltze, C., Williams, R., Vezyroglou, K., McCullagh, H., Freemantle, N., Heales, S., Kneen, R., Marston, L., Martland, T., Nazareth, I., Neal, E., Lux, A., Parker, A., Agrawal, S., Fallon, P., & Cross, J. H. (2017). Ketogenic diet in the treatment of epilepsy in children under the age of 2 years: study protocol for a randomised controlled trial. Trials, 18(1), 195. https://doi.org/10.1186/s13063-017-1918-3

Van Paesschen, W., Revesz, T., Duncan, J. S., King, M. D., & Connelly, A. (1997). Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy. Annals of neurology, 42(5), 756–766. https://doi.org/10.1002/ana.410420512

Velísek, L., & Moshé, S. L. (2002). Effects of brief seizures during development. Progress in brain research, 135, 355–364. https://doi.org/10.1016/S0079-6123(02)35032-5

Visser, A. M., Jaddoe, V. W., Ghassabian, A., Schenk, J. J., Verhulst, F. C., Hofman, A., Tiemeier, H., Moll, H. A., & Arts, W. F. (2012). Febrile seizures and behavioural and cognitive outcomes in preschool children: the Generation R study. Developmental medicine and child neurology, 54(11), 1006–1011. https://doi.org/10.1111/j.1469-8749.2012.04405.x

Wheless J. W. (2008). History of the ketogenic diet. Epilepsia, 49 Suppl 8, 3–5. https://doi.org/10.1111/j.1528-1167.2008.01821.x

Wibisono, C., Rowe, N., Beavis, E., Kepreotes, H., Mackie, F. E., Lawson, J. A., & Cardamone, M. (2015). Ten-year single-center experience of the ketogenic diet: factors influencing efficacy, tolerability, and compliance. The Journal of pediatrics, 166(4), 1030–6.e1. https://doi.org/10.1016/j.jpeds.2014.12.018

Ye, G. L., Yi, S., Gamkrelidze, G., Pasternak, J. F., & Trommer, B. L. (2005). AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells. Brain research. Developmental brain research, 155(1), 26–32. https://doi.org/10.1016/j.devbrainres.2004.12.002

Youm, Y. H., Nguyen, K. Y., Grant, R. W., Goldberg, E. L., Bodogai, M., Kim, D., D'Agostino, D., Planavsky, N., Lupfer, C., Kanneganti, T. D., Kang, S., Horvath, T. L., Fahmy, T. M., Crawford, P. A., Biragyn, A., Alnemri, E., & Dixit, V. D. (2015). The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature medicine, 21(3), 263–269. https://doi.org/10.1038/nm.3804

Yu, Y. H., Lee, K., Sin, D. S., Park, K. H., Park, D. K., & Kim, D. S. (2017). Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures. Brain research bulletin, 131, 25–38. https://doi.org/10.1016/j.brainresbull.2017.02.009

Yudkoff, M., Daikhin, Y., Nissim, I., Grunstein, R., & Nissim, I. (1997). Effects of ketone bodies on astrocyte amino acid metabolism. Journal of neurochemistry, 69(2), 682–692. https://doi.org/10.1046/j.1471-4159.1997.69020682.x

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