Status Epileptikus
Özet
Epilepsi, beyindeki anormal artmış nöron aktivitesinin neden olduğu, tekrarlayan nöbetlerle seyreden, genetik kökenli de olabilen kronik nörolojik bir hastalıktır. Status epileptikus ise 5 dakikadan uzun süren tek bir nöbet veya nöbetler arasında bilincin düzelmediği iki veya daha fazla nöbet aktivitesi olarak tanımlanabilir. Genelde epilepsi hikayesi veya nöbet öyküsü olan hastalarda görülürken acil servislere ilk nöbet hikayesi ile beraber de gelebilir. Mortalite oranı oldukça yüksek bir tablo olup tedavinin esası hızlı müdahale ile beyinin oksijenizasyonunun sağlanması ve nöronal hasarı önlemek için nöbetin bir an önce sonlandırılması üzerinedir. Hızlı ve etkin müdahaleyi vurgulamak için ‘time is brain’ sloganı son yıllarda status epileptikus (SE) tedavisi ile özdeşleşmiştir.
Referanslar
Lowenstein DH, Bleck T, Macdonald RL. It’s time to revise the definition of status epilepticus. Epilepsia. 1999 Jan;40(1):120–2.
Smith MD, Sampson CS, Wall SP, et al. Clinical Policy: Critical Issues in the Management of Adult Patients Presenting to the Emergency Department With Seizures: Approved by the ACEP Board of Directors, April 17, 2024. Vol. 84, Annals of Emergency Medicine. Elsevier Inc.; 2024. p. e1–12.
Shorvon S, Baulac M, Cross H, et al. TaskForce on Status Epilepticus of the ILAE Commission for European Affairs. The drug treatment of status epilepticus in Europe: consensus document from a workshop at the first London Colloquium on Status Epilepticus. Epilepsia. 2008 Jul;49(7):1277–85.
Chen JWY, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol. 2006 Mar;5(3):246–56.
Hocker SE. Status Epilepticus. Continuum (Minneap Minn). 2015 Oct;21(5 Neurocritical Care):1362–83.
Glauser T, Shinnar S, Gloss D, et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016;16(1):48–61.
Dham BS, Hunter K, Rincon F. The epidemiology of status epilepticus in the United States. Neurocrit Care. 2014 Jun;20(3):476–83.
Betjemann JP, Lowenstein DH. Status epilepticus in adults. Lancet Neurol. 2015 Jun;14(6):615–24.
Kornegay J. Seizures and Status Epilepticus in Adults. In: Tintinalli JE (eds.) Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, Ninth Ed. United States: McGraw-Hill Education; 2020. p. 1153-1159.
Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus--Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015 Oct;56(10):1515–23.
Leitinger M, Beniczky S, Rohracher A, et al. Salzburg Consensus Criteria for Non-Convulsive Status Epilepticus--approach to clinical application. Epilepsy Behav. 2015 Aug;49:158–63.
Leitinger M, Trinka E, Zimmermann G, et al. Epidemiology of status epilepticus in adults: Apples, pears, and oranges - A critical review. Epilepsy Behav. 2020 Feb;103(Pt A):106720.
Smith KR, Kittler JT. The cell biology of synaptic inhibition in health and disease. Curr Opin Neurobiol. 2010 Oct;20(5):550–6.
Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011 Oct;134(Pt 10):2802–18.
Lipka K, Bülow HH. Lactic acidosis following convulsions. Acta Anaesthesiol Scand. 2003 May;47(5):616–8.
Shah AM, Vashi A, Jagoda A. Review article: Convulsive and non-convulsive status epilepticus: an emergency medicine perspective. Emerg Med Australas. 2009 Oct;21(5):352–66.
Altındağ E, Kamışlı Ö. Epilepsi Tanı ve Tedavi Rehberi [Internet]. 2021 [cited 2024 Dec 15]. Available from: https://noroloji.org.tr/TNDData/Uploads/files/epilepsi-tani-ve-tedavi-rehberi.pdf
Friedman A. Blood-brain barrier dysfunction, status epilepticus, seizures, and epilepsy: a puzzle of a chicken and egg? Epilepsia. 2011 Oct;52 Suppl 8(Suppl 8):19–20.
Silbergleit R, Lowenstein D, Durkalski V, et al. Neurological Emergency Treatment Trials (NETT) Investigators. RAMPART (Rapid Anticonvulsant Medication Prior to Arrival Trial): a double-blind randomized clinical trial of the efficacy of intramuscular midazolam versus intravenous lorazepam in the prehospital treatment of status epilepticus by paramedics. Epilepsia. 2011 Oct;52 Suppl 8(Suppl 8):45–7.
Semmlack S, Yeginsoy D, Spiegel R, et al. Emergency response to out-of-hospital status epilepticus: A 10-year observational cohort study. Neurology. 2017 Jul 25;89(4):376–84.
Glauser T, Shinnar S, Gloss D, et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016;16(1):48–61.
Huff JS, Melnick ER, Tomaszewski CA, et al. Correction: Correction to “Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Seizures” [Annals of Emergency Medicine 63 (2014) 437-447.e15]. Ann Emerg Med. 2017 Nov;70(5):758.
Silbergleit R, Durkalski V, Lowenstein D, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012 Feb 16;366(7):591–600.
Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998 Sep 17;339(12):792–8.
McIntyre J, Robertson S, Norris E, et al. Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet. 366(9481):205–10.
Finkel R, Clark MA, Cubeddu LX. Lippincott’s Illustrated Reviews: Pharmacology, 4th Edition.
Trinka E, Höfler J, Leitinger M, et al. Pharmacotherapy for Status Epilepticus. Drugs. 2015 Sep;75(13):1499–521.
Cock HR, ESETT Group. Established status epilepticus treatment trial (ESETT). Epilepsia. 2011 Oct;52 Suppl 8:50–2.
Meek PD, Davis SN, Collins DM, et al. Guidelines for nonemergency use of parenteral phenytoin products: proceedings of an expert panel consensus process. Panel on Nonemergency Use of Parenteral Phenytoin Products. Arch Intern Med. 159(22):2639–44.
Schmidt D, Schachter SC. Drug treatment of epilepsy in adults. BMJ. 2014 Feb 28;348:g254.
Wheless JW, Treiman DM. The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus. Epilepsia. 2008 Dec;49 Suppl 9:74–8.
Gámez-Leyva G, Aristín JL, Fernández E, et al. Experience with intravenous levetiracetam in status epilepticus: a retrospective case series. CNS Drugs. 2009 Nov;23(11):983–7.
Aiguabella M, Falip M, Villanueva V, et al. Efficacy of intravenous levetiracetam as an add-on treatment in status epilepticus: a multicentric observational study. Seizure. 2011 Jan;20(1):60–4.
Sinha S, Naritoku DK. Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology. 2000 Sep 12;55(5):722–4.
Trinka E, Höfler J, Zerbs A, et al. Efficacy and safety of intravenous valproate for status epilepticus: a systematic review. CNS Drugs. 2014 Jul;28(7):623–39.
Agarwal P, Kumar N, Chandra R, et al. Randomized study of intravenous valproate and phenytoin in status epilepticus. Seizure. 2007 Sep;16(6):527–32.
Mayer SA, Claassen J, Lokin J, et al. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol. 2002 Feb;59(2):205–10.
Synowiec AS, Singh DS, Yenugadhati V, et al. Ketamine use in the treatment of refractory status epilepticus. Epilepsy Res. 2013 Jul;105(1–2):183–8.
Yasiry Z, Shorvon SD. The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: a meta-analysis of published studies. Seizure. 2014 Mar;23(3):167–74.
Dionisio S, Brown H, Boyle R, et al. Managing the generalised tonic-clonic seizure and preventing progress to status epilepticus: a stepwise approach. Intern Med J. 2013 Jul;43(7):739–46.
Stecker MM, Kramer TH, Raps EC, et al. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia. 1998 Jan;39(1):18–26.
Prasad A, Worrall BB, Bertram EH, et al. Propofol and midazolam in the treatment of refractory status epilepticus. Epilepsia. 2001 Mar;42(3):380–6.
Claassen J, Hirsch LJ, Emerson RG, et al. Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia. 2002 Feb;43(2):146–53.
Kramer AH. Early ketamine to treat refractory status epilepticus. Neurocrit Care. 2012 Apr;16(2):299–305.
Synowiec AS, Singh DS, Yenugadhati V, et al. Ketamine use in the treatment of refractory status epilepticus. Epilepsy Res. 2013 Jul;105(1–2):183–8.
