İskemik Serebrovasküler Hastalık ve İntraserebral Kanama Olgusunda Yoğun Bakım Yönetimi
Özet
55 yaşında erkek hasta; sol kol ve bacakta kuvvet kaybı şikayetiyle acil servise getirilmiş. Glasgow Koma Skoru (GKS):12 (Göz:3 Motor:6 Sözel:3), bilinci açık, kısmi koopere, dizartrik, kas gücü sol üstte ve altta 1/5, Babinsky -/+. Bilgisayarlı Tomografi (BT) Anjio’da sağ internal karotid arter (İCA) oklüzyonu görüldü ve anjio ile sağ İCA’ya balon anjioplasti ve stent; sol İCA ve orta serebral arter (MCA) oklüzyonuna mekanik trombektomi uygulandı. Yoğun bakım ünitesinde (YBÜ) takip edilen hastanın işlem sonrası 12. saatte GKS:13’e (G:4, M:6, S:3) geriledi; kontrol beyin BT’de hemorajik transformasyon, sağ MCA alanında ödem ve orta hatta sola itilme izlendi. Dekompresyon cerrahisi uygulandı. Postoperatif dördüncü saatte ekstübe edildi, GKS:15, koopere, oryante idi. Mannitol %20 4X100 mL İV infüzyon tedavisi başlandı. YBÜ takibinin dördüncü gününde Enoksaparin sodyum 60 mg 1X0,6 mL Subkutan ve Klopidogrel 75 mg tablet 1X1 Peroral tedavisine eklendi. Postoperatif 4. günde kas gücü sol üstte 3/5, sol altta 4/5 olan hasta fizyoterapi programına dahil edildi. YBÜ’de takibinin 11. gününde bilinç açık, oryante, koopere, oda havasında spontan soluyan, fizyoterapi programı devam eden hasta nöroloji servisine devredildi.
55-year-old male patient was brought to the emergency room complaining of loss of strength in his left arm and leg. Glasgow Coma Score (GCS):12 (Eye:3 Motor:6 Verbal:3), conscious, partially cooperative, dysarthric, muscle strength 1/5 in the upper and lower left, Babinsky -/+. Computerized Tomography (CT) Angiography revealed right internal carotid artery (ICA) occlusion, and angiography performed balloon angioplasty and stent to the right ICA; mechanical thrombectomy was performed for left ICA and middle cerebral artery (MCA) occlusion. The GCS of the patient, who was followed up in the intensive care unit (ICU), decreased to 13 (E:4, M:6, V:3) at the 12th hour after the procedure; control brain CT showed hemorrhagic transformation, edema in the right MCA area, and a shift to the left in the midline. Decompression surgery was performed. He was extubated at the fourth postoperative hour, GCS:15, cooperative and oriented. Mannitol 20% 4X100 mL IV infusion treatment was started. On the fourth day of ICU follow-up, Enoxaparin sodium 60 mg 1X0.6 mL Subcutaneous and Clopidogrel 75 mg tablet 1X1 Peroral were added to the treatment. On the 4th postoperative day, the patient, whose muscle strength was 3/5 in the upper left and 4/5 in the lower left, was included in the physiotherapy program. On the 11th day of his follow-up in the ICU, the patient, who was conscious, oriented, cooperative, breathing spontaneously on room air, and whose physiotherapy program was continuing, was transferred to the neurology service.
Referanslar
Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics —2015 update. Circulation. 2015;131:e29.
Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease – The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke. 2009;40(6):2276-2293.
Rothwell PM, Coull AJ, Silver LE, et al. Population-based study of event- rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet. 2005;366(9499):1773- 1783.
4.Jauch EC, Saver JL, Adams HP, Jr, et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(3):870-947.
Cerebrovascular diseases. In: Ropper AH, Samuels MA, Klein JP, eds. Adams and Victor’s Principles of Neurology. 10th ed. McGraw-Hill; 2014:778-885.
Sacco S, Marini C, Totaro R, Russo T, Cerone D, Carolei A. A population- based study of the incidence and prognosis of lacunar stroke. Neurology. 2006;66(9):1335-1338.
Moonis M, Fisher M. Imaging of acute stroke. Cerebrovasc Dis. 2001;11(3):143-150.
Rivers CS, Wardlaw JM, Armitage PA, et al. Do acute diffusion-and perfusion-weighted MRI lesions identify final infarct volüme in ischemic stroke? Stroke. 2006;37(1):98-104.
Sondergaard L, Kasner SE, Rhodes JF, et al. Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke. N Engl J Med. 2017;377(11):1033-1042.
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581.
Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with Alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317-1329.
North American Symptomatic Carotid Endarterectomy Trial Collaborators; Barnett HJM, Taylor DW, Haynes RB, et al. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325(7):445-453.
Paciaroni M, Agnelli G, Falocci N, et al. Early recurrence and cerebral bleeding in patients with acute ischemic stroke and atrial fibrillation: effect of anticoagulation and its timing – the RAF study. Stroke. 2015;46:26130094.
Saver JL, Carroll JD, Thaler DE, et al. Long-term outcomes of patent foramen ovale closure or medical therapy after stroke. N Engl J Med. 2017;377(11):1022-1032.
Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018;378(1):11-21.
Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011;365(11):993-1003.
Moonis M, Fisher M. HMG CoA reductase inhibitors (statins): use in stroke prevention and outcome after stroke. Expert Rev Neurother. 2004;4(2):241- 247.
Moonis M, Fisher M. Considering the role of heparin and low-molecular- weight heparins in acute ischemic stroke. Stroke. 2002;33(7):1927-1933.
Moonis M, Wingard E, Selveraj N, et al. Factors predisposing to secondary hemorrhagic conversion in acute ischemic stroke. Ann Neurol. 2000;48:497.
Hankey GJ. Clopidogrel and thrombotic thrombocytopenic purpura. Lancet. 2000;356(9226):269-270.
The European Stroke Prevention Study (ESPS): principal endpoints. The ESPS Group. Lancet. 1987;2:1351.
Gent M, Blakely JA, Easton JD, et al. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet. 1989;1(8649):1215-1220.
Pan Y, Elm JJ, Li H, et al. Outcomes Associated with clopidogrel-aspirin use in minor stroke or transient ischemic attack: a pooled analysis of clopidogrel in high-risk patients with acute non-disabling cerebrovascular events (CHANCE) and Platelet-Oriented Inhibition in New TIA and minor Ischemic Stroke (POINT) Trials. JAMA Neurol. 2019;76(12):1466-1473.
Mimatsu K, Yamaguchi T. Management of intracerebral hemorrhage. In: Fisher M, ed. Stroke Therapy. Butterworth Heinemann; 2001:287.
Logallo N, Novotny V, Assmus J, et al. Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial. Lancet Neurol. 2017;16(10):781-788.
Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology. 2001;56(4):537-539.
Berger AR, Lipton RB, Lesser ML, Lantos G, Portenoy RK. Early seizures following intracerebral hemorrhage: implications for therapy. Neurology. 1988;38(9): 1363-1365.
Fisher CM. Clinical syndromes in cerebral hemorrhage. In: Fields WS, ed. Pathogenesis and Treatment of Cerebrovascular Disease. Charles C Thomas; 1961:318.
Chen ST, Chen SD, Hsu CY, Hogan EL. Progression of hypertensive intracerebral hemorrhage. Neurology. 1989;39(11):1509-1514.
Vernooij MW, van der Lugt A, Ikram MA, et al. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology. 2008;70(14):1208-1214.
Radberg JA, Olsson JE, Radberg CT. Prognostic parameters in spontaneous intracerebral hematomas with special reference to anticoagulant treatment. Stroke. 1991;22(5):571-576.
Moonis M. Intraarterial thrombolysis within the first three hours after acute ischemic stroke in selected patients. Stroke. 2009;40(7):2611-2612.
Toffol GJ, Biller J, Adams HP. Nontraumatic intracerebral hemorrhage in young adults. Arch Neurol. 1987;44(5):483-485.
Topcuoglu MA, Singhal AB. Hemorrhagic reversible cerebral vasoconstriction syndrome: features and mechanisms. Stroke. 2016;47(7):1742-1747.
Darby DG, Donnan GA, Saling MA, Walsh KW, Bladin PF. Primary intraventricular hemorrhage: clinical and neuropsychological findings in a prospective stroke series. Neurology. 1988;38(1):68-75.
Poungvarin N, Bhoopat W, Viriyavejakul A, et al. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage. N Engl J Med. 1987;316(20): 1229-1233.
Faught E, Peters D, Bartolucci A, Moore L, Miller PC. Seizures after primary intracerebral hemorrhage. Neurology. 1989;39(8):1089-1093.
Cerebral Embolism Task Force. Cardiogenic brain embolism. The second report of the cerebral embolism task force. Arch Neurol. 1989;46(7):727. [published erratum appears in Arch Neurol 46(10):1079, 1989] [see comments].
Dewitt LD, Wechsler LR. Transcranial Doppler. Stroke. 1988;19(7):915- 921.
Albers GW, Marks MP, Kemp S, et al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378(8):708- 718.
Borges LF. Management of nontraumatic brain hemorrhage. In: Ropper AM, Kennedy SF, eds. Neurological and Neurosurgical Intensive Care. Aspen; 1988:209.