Postoperatif Serotonin Sendromu Gelişen Hastanın Yoğun Bakım Yönetimi
Özet
41 yaşında erkek hasta, artroskopik menisküs ve ön çapraz bağ rekonstrüksiyonu için spinal anestezi altında ameliyata alındı. Hastanın operasyon sırasında huzursuzluğu nedeniyle genel anesteziye geçildi. Operasyon sonrası hipertansiyon, taşikardi, takipne, ajitasyon ve myoklonik kasılmalar gelişti. Postoperatif yoğun bakıma alınan hastanın santral görüntülemelerinin normal olması, tedaviye dirençli devam eden klinik bulgular serotonin sendromu şüphesini doğurdu. Hastanın preoperatif değerlendirmede bilgi vermediği ek ilaç ve madde kullanımları tespit edildi. SS tanısı konularak uygun tedavi uygulandı ve hasta 24 saat içinde stabil hale getirildi ve yoğun bakımdan servise devredildi.
A 41-year-old male patient underwent arthroscopic meniscus and anterior cruciate ligament reconstruction surgery under spinal anesthesia. Due to the patient's restlessness during the operation, general anesthesia was administered. Postoperatively, the patient developed hypertension, tachycardia, tachypnea, agitation, and myoclonic jerks. Due to the patient’s, who was taken to intensive care postoperatively, normal central imaging and the persistence of clinical symptoms resistant to treatment serotonin syndrome was supected. It was discovered that the patient had not disclosed the use of additional medications and drugs during the preoperative evaluation. The patient was diagnosed with SS, appropriate treatment was administered, and he stabilized within 24 hours, after which he was transferred from the intensive care unit to orthopedic clinic.
Referanslar
Maitland S, Baker MJD, bulletin t. Serotonin syndrome. 2022;60(6):88-91.
Mikkelsen N, Damkier P, Pedersen SAJB, et al. Serotonin syndrome—a focused review. 2023;133(2):124-129.
Spadaro A, Scott KR, Koyfman A, et al. High risk and low prevalence diseases: Serotonin syndrome. 2022;61:90-97.
Foong A-L, Grindrod KA, Patel T, et al. Demystifying serotonin syndrome (or serotonin toxicity). 2018;64(10):720-727.
Francescangeli J, Karamchandani K, Powell M, et al. The serotonin syndrome: from molecular mechanisms to clinical practice. 2019;20(9):2288.
Dunkley E, Isbister G, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. 2003;96(9):635-642.
Scotton WJ, Hill LJ, Williams AC, et al. Serotonin syndrome: pathophysiology, clinical features, management, and potential future directions. 2019;12:1178646919873925.
Volpi-Abadie J, Kaye AM, Kaye ADJOJ. Serotonin syndrome. 2013;13(4):533-540.