Applications of Blue Biotechnology in Human Health
Özet
Blue biotechnology is a branch of biotechnology that uses biological resources of aquatic environments to provide innovative solutions in areas such as health, environment and industry. In the field of human health, blue biotechnology makes significant contributions, especially in drug development, disease treatment, diagnostic methods and nutrition. Bioactive components possessed by marine organisms offer a unique potential for the discovery of new drugs that can be used in the treatment of diseases such as cancer, infection and inflammation. For example, some molecules obtained from marine sponges show effects that inhibit tumor growth or strengthen the immune system. In addition, omega-3 fatty acids and other beneficial nutritional supplements produced through blue biotechnology support cardiovascular health and reduce the risk of heart disease. In addition, diagnostic tests developed using marine microorganisms offer new opportunities for early diagnosis of diseases and more effective treatment processes. The contributions of blue biotechnology to human health encourage the sustainable use of natural resources while also supporting the protection of marine biodiversity. Advances in this field both improve human health and support biotechnological innovations.
Referanslar
Zhao L, Lu L, Wang A, Zhang H, Huang M, Wu H, et al. Nano-Biotechnology in Agriculture: Use of Nanomaterials to Promote Plant Growth and Stress Tolerance. J Agric Food Chem. 2020;68(7):1935–47.
The Bioeconomy to 2030. The Bioeconomy to 2030. 2009.
Arı Yuka S, Akpek A, Özarslan A, Vural A, Koçer AT, Aslan A, et al. Recent advances in health biotechnology during pandemic. Sigma J Eng Nat Sci. 2023;41(3):625–55.
Hodgson J. The pandemic pipeline. Nat Biotechnol [Internet]. 2020;38(5):523–32. Available from: http://dx.doi.org/10.1038/d41587-020-00005-z
Tesfahun W. RETRACTED ARTICLE: Climate change mitigation and adaptation through biotechnology approaches: A review. Cogent Food Agric [Internet]. 2018;4(1):1512837. Available from: https://doi.org/10.1080/23311932.2018.1512837
Seid A, Andualem B. The Role of Green Biotechnology through Genetic Engineering for Climate Change Mitigation and Adaptation, and for Food Security: Current Challenges and Future Perspectives. J Adv Biol Biotechnol. 2021;24(1):1–11.
Bentahar S, Abada R, Ykhlef N, Soumia B, Rofia A, Ykhlef N. Biotechnology: Definitions, Types and Main Applications. YAMER Digit [Internet]. 2023;22(1):563–75. Available from: https://doi.org/10.37896/YMER22.04/49.
Prajapat R, Jain S. Advancement in Medical Biotechnology: A Review. Med Rev . 2022;9(1):217–26.
Mika N, Zorn H, Rühl M. Yellow Biotechnology II [Internet]. Vol. 136, Advances in biochemical engineering/biotechnology. 2013. 1–17 p. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23881056
Vilcinskas A. Biotechnology I Insect Biotechnologie in Drug Discovery. 2013. 201 p.
Gupta V, Sengupta M, Prakash J, Charan B. VarshaaGupta ManjisthaaSengupta JayaaPrakash BaishnabbCharannTripathy Basic and Applied Aspects of Biotechnology.
Rad F, Sen İ. Biyo - Ekonomi ve Su Ürünleri : Mavi Ekonomi ve Fırsatlar. Tarımsal Araştırmalar ve Polit Genel Müdürlüğü Biyo-ekonomi Çalıştayı. 2014;
Gao K, Gao G, Wang Y, Dupont S. Impacts of ocean acidification under multiple stressors on typical organisms and ecological processes. Mar Life Sci Technol [Internet]. 2020;2(3):279–91. Available from: https://doi.org/10.1007/s42995-020-00048-w
Mayer AMS, Rodríguez AD, Berlinck RGS, Fusetani N. Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; Affecting the immune and nervous system, and other miscellaneous mec. Comp Biochem Physiol - C Toxicol Pharmacol. 2011;153(2):191–222.
Özkaya FC, Erdoğan C, Altunok M. Denizel biyoaktif bileşikler. Ege J Fish Aquat Sci. 2013;30(2):85–92.
Ahmed I, Asgher M, Sher F, Hussain SM, Nazish N, Joshi N, et al. Exploring Marine as a Rich Source of Bioactive Peptides: Challenges and Opportunities from Marine Pharmacology. Mar Drugs. 2022;20(3).
Anestopoulos I, Kiousi DE, Klavaris A, Maijo M, Serpico A, Suarez A, et al. Marine‐derived surface active agents: Health‐ promoting properties and blue biotechnology‐based applications. Biomolecules. 2020;10(6):1–28.
Supriya J S and Yogesh S. Marine: the Ultimate Source of Bioactives and Drug Metabolites. Ijrap. 2010;2(4):907–23.
Cappello E, Nieri P. From Life in the Sea to the Clinic: The Marine Drugs Approved and under Clinical Trial. Life. 2021;11(12):1–19.
Wu L, Ye K, Jiang S, Zhou G. Marine power on cancer: Drugs, lead compounds, and mechanisms. Mar Drugs. 2021;19(9).
Querellou J. Marine Biotechnology : A New Vision and Strategy for Europe. Eur Sci Found. 2010;(September):1–91.
Barreca M, Spanò V, Montalbano A, Cueto M, Díaz Marrero AR, Deniz I, et al. Marine anticancer agents: An overview with a particular focus on their chemical classes. Mar Drugs. 2020;18(12).
Mayer AMS, Hamann MT. Marine Pharmacology in 2000 : Marine Compounds Antituberculosis , and Antiviral Activities ; Affecting the Cardiovascular , Immune , and Nervous Systems and Other Miscellaneous Mechanisms of Action. Mar Biotechnol. 2024;6:37–52.
Ahmad M, Zhang B, Manzoor K, Ahmad S, Ikram S. Chitin and chitosan-based bionanocomposites. Bionanocomposites Green Synth Appl. 2020;145–56.
Lange KW. Omega-3 fatty acids and mental health. Glob Heal J [Internet]. 2020;4(1):18–30. Available from: https://doi.org/10.1016/j.glohj.2020.01.004
Nair A, Ahirwar A, Singh S, Lodhi R, Lodhi A, Rai A, et al. Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties. Mar Drugs. 2023;21(3).
Tekin E, Aslan Karakelle N, Dinçer S. Effects of taurine on metal cations, transthyretin and LRP-1 in a rat model of Alzheimer’s disease. J Trace Elem Med Biol [Internet]. 2023;79(May):127219. Available from: https://doi.org/10.1016/j.jtemb.2023.127219
AliAkbari R, Ghasemi MH, Neekzad N, Kowsari E, Ramakrishna S, Mehrali M, et al. High value add bio-based low-carbon materials: Conversion processes and circular economy. J Clean Prod [Internet]. 2021;293:126101. Available from: https://doi.org/10.1016/j.jclepro.2021.126101
Samalens F, Thomas M, Claverie M, Castejon N, Zhang Y, Pigot T, et al. Progresses and future prospects in biodegradation of marine biopolymers and emerging biopolymer-based materials for sustainable marine ecosystems†. Green Chem. 2022;24(5):1762–79.
Rivki M, Bachtiar AM, Informatika T, Teknik F, Indonesia UK. Industrial Applications of Marine Biopolymers.
Moriya H, Takita Y, Matsumoto A, Yamahata Y, Nishimukai M, Miyazaki M, et al. Cobetia sp. Bacteria, Which Are Capable of Utilizing Alginate or Waste Laminaria sp. for Poly(3-Hydroxybutyrate) Synthesis, Isolated From a Marine Environment. Front Bioeng Biotechnol. 2020;8(August).
Yudiati E, Nugroho AA, Sedjati S, Arifin Z, Ridlo A. The Agar Production, Pigment and Nutrient Content in Gracilaria sp. Grown in Two Habitats with Varying Salinity and Nutrient Levels. Jordan J Biol Sci. 2021;14(4):755–61.
Hurtado A, Aljabali AAA, Mishra V, Tambuwala MM, Serrano-Aroca Á. Alginate: Enhancement Strategies for Advanced Applications. Int J Mol Sci. 2022;23(9).
Ahmad Raus R, Wan Nawawi WMF, Nasaruddin RR. Alginate and alginate composites for biomedical applications. Asian J Pharm Sci [Internet]. 2021;16(3):280–306. Available from: https://doi.org/10.1016/j.ajps.2020.10.001
Zdiri K, Cayla A, Elamri A, Erard A, Salaun F. Alginate-Based Bio-Composites and Their Potential Applications. J Funct Biomater. 2022;13(3).
Hu C, Lu W, Mata A, Nishinari K, Fang Y. Ions-induced gelation of alginate: Mechanisms and applications. Int J Biol Macromol [Internet]. 2021;177:578–88. Available from: https://doi.org/10.1016/j.ijbiomac.2021.02.086
Chen X, Fu X, Huang L, Xu J, Gao X. Agar oligosaccharides: A review of preparation, structures, bioactivities and application. Carbohydr Polym [Internet]. 2021;265(April):118076. Available from: https://doi.org/10.1016/j.carbpol.2021.118076
Olatunji O. Aquatic Biopolymers. 2020. 169–188 p.
Akkurt MD. Kitin , Kitosan ve Diş Hekimliğindeki Kullanım Alanları : Kısa Derleme Chitin , Chitosan and Their Application Areas in Dentistry : Short Review. ADO Klin Bilim Derg. 2012;6(2):1206–11.
Kozma M, Acharya B, Bissessur R. Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications. Polymers (Basel). 2022;14(19):1–28.
Baharlouei P, Rahman A. Chitin and Chitosan : Prospective Biomedical Applications in. Mar Drugs. 2022;20(7):460.
Ding J, Wu B, Chen L. Application of Marine Microbial Natural Products in Cosmetics. Front Microbiol. 2022;13(May).
Draghici-Popa AM, Buliga DI, Popa I, Tomas ST, Stan R, Boscornea AC. Cosmetic Products with Potential Photoprotective Effects Based on Natural Compounds Extracted from Waste of the Winemaking Industry. Molecules. 2024;29(12).
Fonseca S, Amaral MN, Reis CP, Custódio L. Marine Natural Products as Innovative Cosmetic Ingredients. Mar Drugs. 2023;21(3):1–23.
De Luca M, Pappalardo I, Limongi AR, Viviano E, Radice RP, Todisco S, et al. Lipids from microalgae for cosmetic applications. Cosmetics. 2021;8(2).
Kalaycı MZ, Gödekmerdan A. Tıbbi Sülük Uygulamalarına İmmünolojik Açıdan Yaklaşım. Bütünleyıcı ve Anadolu Tıbbı Derg. 2020;1(3):36–42.
Ayhan H, Mollahaliloğlu S. Medicinal Leech Therapy: Hirudotherapy. Ankara Med J. 2018;18(1).
Referanslar
Zhao L, Lu L, Wang A, Zhang H, Huang M, Wu H, et al. Nano-Biotechnology in Agriculture: Use of Nanomaterials to Promote Plant Growth and Stress Tolerance. J Agric Food Chem. 2020;68(7):1935–47.
The Bioeconomy to 2030. The Bioeconomy to 2030. 2009.
Arı Yuka S, Akpek A, Özarslan A, Vural A, Koçer AT, Aslan A, et al. Recent advances in health biotechnology during pandemic. Sigma J Eng Nat Sci. 2023;41(3):625–55.
Hodgson J. The pandemic pipeline. Nat Biotechnol [Internet]. 2020;38(5):523–32. Available from: http://dx.doi.org/10.1038/d41587-020-00005-z
Tesfahun W. RETRACTED ARTICLE: Climate change mitigation and adaptation through biotechnology approaches: A review. Cogent Food Agric [Internet]. 2018;4(1):1512837. Available from: https://doi.org/10.1080/23311932.2018.1512837
Seid A, Andualem B. The Role of Green Biotechnology through Genetic Engineering for Climate Change Mitigation and Adaptation, and for Food Security: Current Challenges and Future Perspectives. J Adv Biol Biotechnol. 2021;24(1):1–11.
Bentahar S, Abada R, Ykhlef N, Soumia B, Rofia A, Ykhlef N. Biotechnology: Definitions, Types and Main Applications. YAMER Digit [Internet]. 2023;22(1):563–75. Available from: https://doi.org/10.37896/YMER22.04/49.
Prajapat R, Jain S. Advancement in Medical Biotechnology: A Review. Med Rev . 2022;9(1):217–26.
Mika N, Zorn H, Rühl M. Yellow Biotechnology II [Internet]. Vol. 136, Advances in biochemical engineering/biotechnology. 2013. 1–17 p. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23881056
Vilcinskas A. Biotechnology I Insect Biotechnologie in Drug Discovery. 2013. 201 p.
Gupta V, Sengupta M, Prakash J, Charan B. VarshaaGupta ManjisthaaSengupta JayaaPrakash BaishnabbCharannTripathy Basic and Applied Aspects of Biotechnology.
Rad F, Sen İ. Biyo - Ekonomi ve Su Ürünleri : Mavi Ekonomi ve Fırsatlar. Tarımsal Araştırmalar ve Polit Genel Müdürlüğü Biyo-ekonomi Çalıştayı. 2014;
Gao K, Gao G, Wang Y, Dupont S. Impacts of ocean acidification under multiple stressors on typical organisms and ecological processes. Mar Life Sci Technol [Internet]. 2020;2(3):279–91. Available from: https://doi.org/10.1007/s42995-020-00048-w
Mayer AMS, Rodríguez AD, Berlinck RGS, Fusetani N. Marine pharmacology in 2007-8: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiprotozoal, antituberculosis, and antiviral activities; Affecting the immune and nervous system, and other miscellaneous mec. Comp Biochem Physiol - C Toxicol Pharmacol. 2011;153(2):191–222.
Özkaya FC, Erdoğan C, Altunok M. Denizel biyoaktif bileşikler. Ege J Fish Aquat Sci. 2013;30(2):85–92.
Ahmed I, Asgher M, Sher F, Hussain SM, Nazish N, Joshi N, et al. Exploring Marine as a Rich Source of Bioactive Peptides: Challenges and Opportunities from Marine Pharmacology. Mar Drugs. 2022;20(3).
Anestopoulos I, Kiousi DE, Klavaris A, Maijo M, Serpico A, Suarez A, et al. Marine‐derived surface active agents: Health‐ promoting properties and blue biotechnology‐based applications. Biomolecules. 2020;10(6):1–28.
Supriya J S and Yogesh S. Marine: the Ultimate Source of Bioactives and Drug Metabolites. Ijrap. 2010;2(4):907–23.
Cappello E, Nieri P. From Life in the Sea to the Clinic: The Marine Drugs Approved and under Clinical Trial. Life. 2021;11(12):1–19.
Wu L, Ye K, Jiang S, Zhou G. Marine power on cancer: Drugs, lead compounds, and mechanisms. Mar Drugs. 2021;19(9).
Querellou J. Marine Biotechnology : A New Vision and Strategy for Europe. Eur Sci Found. 2010;(September):1–91.
Barreca M, Spanò V, Montalbano A, Cueto M, Díaz Marrero AR, Deniz I, et al. Marine anticancer agents: An overview with a particular focus on their chemical classes. Mar Drugs. 2020;18(12).
Mayer AMS, Hamann MT. Marine Pharmacology in 2000 : Marine Compounds Antituberculosis , and Antiviral Activities ; Affecting the Cardiovascular , Immune , and Nervous Systems and Other Miscellaneous Mechanisms of Action. Mar Biotechnol. 2024;6:37–52.
Ahmad M, Zhang B, Manzoor K, Ahmad S, Ikram S. Chitin and chitosan-based bionanocomposites. Bionanocomposites Green Synth Appl. 2020;145–56.
Lange KW. Omega-3 fatty acids and mental health. Glob Heal J [Internet]. 2020;4(1):18–30. Available from: https://doi.org/10.1016/j.glohj.2020.01.004
Nair A, Ahirwar A, Singh S, Lodhi R, Lodhi A, Rai A, et al. Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties. Mar Drugs. 2023;21(3).
Tekin E, Aslan Karakelle N, Dinçer S. Effects of taurine on metal cations, transthyretin and LRP-1 in a rat model of Alzheimer’s disease. J Trace Elem Med Biol [Internet]. 2023;79(May):127219. Available from: https://doi.org/10.1016/j.jtemb.2023.127219
AliAkbari R, Ghasemi MH, Neekzad N, Kowsari E, Ramakrishna S, Mehrali M, et al. High value add bio-based low-carbon materials: Conversion processes and circular economy. J Clean Prod [Internet]. 2021;293:126101. Available from: https://doi.org/10.1016/j.jclepro.2021.126101
Samalens F, Thomas M, Claverie M, Castejon N, Zhang Y, Pigot T, et al. Progresses and future prospects in biodegradation of marine biopolymers and emerging biopolymer-based materials for sustainable marine ecosystems†. Green Chem. 2022;24(5):1762–79.
Rivki M, Bachtiar AM, Informatika T, Teknik F, Indonesia UK. Industrial Applications of Marine Biopolymers.
Moriya H, Takita Y, Matsumoto A, Yamahata Y, Nishimukai M, Miyazaki M, et al. Cobetia sp. Bacteria, Which Are Capable of Utilizing Alginate or Waste Laminaria sp. for Poly(3-Hydroxybutyrate) Synthesis, Isolated From a Marine Environment. Front Bioeng Biotechnol. 2020;8(August).
Yudiati E, Nugroho AA, Sedjati S, Arifin Z, Ridlo A. The Agar Production, Pigment and Nutrient Content in Gracilaria sp. Grown in Two Habitats with Varying Salinity and Nutrient Levels. Jordan J Biol Sci. 2021;14(4):755–61.
Hurtado A, Aljabali AAA, Mishra V, Tambuwala MM, Serrano-Aroca Á. Alginate: Enhancement Strategies for Advanced Applications. Int J Mol Sci. 2022;23(9).
Ahmad Raus R, Wan Nawawi WMF, Nasaruddin RR. Alginate and alginate composites for biomedical applications. Asian J Pharm Sci [Internet]. 2021;16(3):280–306. Available from: https://doi.org/10.1016/j.ajps.2020.10.001
Zdiri K, Cayla A, Elamri A, Erard A, Salaun F. Alginate-Based Bio-Composites and Their Potential Applications. J Funct Biomater. 2022;13(3).
Hu C, Lu W, Mata A, Nishinari K, Fang Y. Ions-induced gelation of alginate: Mechanisms and applications. Int J Biol Macromol [Internet]. 2021;177:578–88. Available from: https://doi.org/10.1016/j.ijbiomac.2021.02.086
Chen X, Fu X, Huang L, Xu J, Gao X. Agar oligosaccharides: A review of preparation, structures, bioactivities and application. Carbohydr Polym [Internet]. 2021;265(April):118076. Available from: https://doi.org/10.1016/j.carbpol.2021.118076
Olatunji O. Aquatic Biopolymers. 2020. 169–188 p.
Akkurt MD. Kitin , Kitosan ve Diş Hekimliğindeki Kullanım Alanları : Kısa Derleme Chitin , Chitosan and Their Application Areas in Dentistry : Short Review. ADO Klin Bilim Derg. 2012;6(2):1206–11.
Kozma M, Acharya B, Bissessur R. Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications. Polymers (Basel). 2022;14(19):1–28.
Baharlouei P, Rahman A. Chitin and Chitosan : Prospective Biomedical Applications in. Mar Drugs. 2022;20(7):460.
Ding J, Wu B, Chen L. Application of Marine Microbial Natural Products in Cosmetics. Front Microbiol. 2022;13(May).
Draghici-Popa AM, Buliga DI, Popa I, Tomas ST, Stan R, Boscornea AC. Cosmetic Products with Potential Photoprotective Effects Based on Natural Compounds Extracted from Waste of the Winemaking Industry. Molecules. 2024;29(12).
Fonseca S, Amaral MN, Reis CP, Custódio L. Marine Natural Products as Innovative Cosmetic Ingredients. Mar Drugs. 2023;21(3):1–23.
De Luca M, Pappalardo I, Limongi AR, Viviano E, Radice RP, Todisco S, et al. Lipids from microalgae for cosmetic applications. Cosmetics. 2021;8(2).
Kalaycı MZ, Gödekmerdan A. Tıbbi Sülük Uygulamalarına İmmünolojik Açıdan Yaklaşım. Bütünleyıcı ve Anadolu Tıbbı Derg. 2020;1(3):36–42.
Ayhan H, Mollahaliloğlu S. Medicinal Leech Therapy: Hirudotherapy. Ankara Med J. 2018;18(1).
