An Alternative Honeybee Product for the Treatment of Mastitis: Propolis
Özet
One of the most common and complicated production disorders that affect dairy animals is mastitis. Its prevalence not only lowers milk productivity and costs dairy farmers money, but it also affects the affected animals' ability to reproduce after giving birth and is linked to the infections that cause mastitis being important for public health. Subclinical mastitis and clinical mastitis are the two main types of mastitis. It is closely associated with lower milk yield, declining milk quality, and consumer health issues. Propolis is a product that can be used as a health promoter and disease preventative in cases of mastitis. Propolis is a natural and economical alternative that has a composition free from the side effects of synthetic antibiotics.
Propolis has long been used for its antiviral, antiinflammatory, antibacterial, anesthetic, antioxidant, antitumor, anticancer, antifungal, antiprotozoal, antihepatotoxic, antimutagenic, and antiseptic properties. Published research indicates that propolis and its derivatives possess a wide spectrum of natural antimicrobial compounds effective against various bacterial species and enhance the efficacy of traditional antibiotics. Propolis's synergistic effects when combined with other substances, like honey, have also been studied. These studies have shown propolis to be effective against bacteria like Staphylococcus aureus and Escherichia coli, although the compound's activity is mostly dependent on regional and seasonal variables. The potential applications of propolis and its main flavonoid components should not be overlooked, and clinical trials should evaluate their various potential uses in medicine more comprehensively. The therapeutic antibacterial activity of propolis and its application in novel medicinal biotechnology products require extensive additional research. The aim of this study is to summarize some of the most recent research on propolis's antibacterial qualities and how its constituents might be used to treat mastitis.
Referanslar
Ruegg, P. (2017). A 100-Year Review: Mastitis detection, management, and prevention. Journal of dairy science, 100 12, 10381-10397.
Sharun, K., Dhama, K., Tiwari, R., Gugjoo, M., Yatoo, M., Patel, S., Pathak, M., Karthik, K., Khurana, S., Singh, R., Puvvala, B., A., Singh, R., Singh, K., & Chaicumpa, W. (2021). Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review. The Veterinary Quarterly, 41, 107 - 136. https://doi.org/10.1080/01652176.2021.1882713.
Aqib, A., Muneer, A., Shafeeq, M., & Kirn, N. (2021). Economic Impacts of Clinical and Sub Clinical Mastitis on Dairy Farms. Veterinary Science Research. https://doi.org/10.30564/vsr.v3i2.4119.
Goulart, D. B., & Mellata, M. (2022). Escherichia coli Mastitis in Dairy Cattle: Etiology, Diagnosis, and Treatment Challenges. Frontiers in microbiology, 13, 928346. https://doi.org/10.3389/fmicb.2022.928346
Taponen S, Koort J, Björkroth J, Saloniemi H, Pyörälä S. 2007. Bovine intramammary infections caused by coagulase-negative staphylococci may persist throughout lactation according to amplified fragment length polymorphism-based analysis. Journal of Dairy Science, 90: 3301-3307.
Green, MJ., Bradley, AJ., Medley, GF., W. J. Browne, WJ. 2007. Cow, Farm, and Management Factors During the Dry Period that Determine the Rate of Clinical Mastitis After Calving. J. Dairy Sci. 90:3764–3776.
7. Hamid S, Bhat MA, Mir IA, Taku, A., Badroo, GA., Salik Nazki, Malik, A. 2017. Phenotypic and genotypic characterization of methicillin-resistant Staphylococcus aureus from bovine mastitis. Vet World. 2017; 10:363–7. doi: 10.14202/vetworld.2017.363-367.
Gupta S, Kundabala M, Acharya SR, Ballal V. 2007. A comparative evaluation of the antibacterial efficacy of propolis 30% sodium hypochlorite and 02% chlorhexidine gluconate against enterococcus faecalis-An in vitro study. Endodontology. 2007;19(2):31–8.
Marcucci MC. 1995. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26(2):83–99.
Aga H, Shibuya T, Hamada S, Iritani S, Miyake T. 1999. Propolis extract with improved water Solubility1999. Available from: https://patents.google.com/patent/US5922324A/en.
Diarra, MS, Block G, Rempel H, Oomah, BD., Harrison, J., McCallum, J., Boulanger,S., Brouillette, E., Gattuso, M., Malouin, F. 2013. In vitro and in vivo antibacterial activities of cranberry press cake extracts alone or in combination with β-lactams against Staphylococcus aureus. BMC Complement Altern Med. 2013; 13:90.
Wang, K., Jin, X., Shen, X., Sun, L., Wu, L., Wei, J., Marcucci, M., Hu, F., & Liu, J. (2016). Effects of Chinese Propolis in Protecting Bovine Mammary Epithelial Cells against Mastitis Pathogens-Induced Cell Damage. Mediators of Inflammation, 2016.
Ashraf A, Imran M. 2018. Diagnosis of bovine mastitis: from laboratory to farm. Trop Anim Health Prod. 50:1193–202. doi: 10.1007/s11250-018-1629-0.
Bhutia, PS., Bansal, BK., Gupta, DK., Singh, RS., Uppal, SK. 2019. Bacterial isolation of milk samples submitted from clinical mastitis buffaloes during 2007 to 2016. Tropical Animal Health and Production (2019) 51:1551–1557.
Oliveira M, Bexiga R, Nunes SF, Vilela CL. 2011. Invasive potential of biofilm-forming Staphylococci bovine subclinical mastitis isolates. J Vet Sci. 12:95–7. doi: 10.4142/jvs.2011.12.1.95.
Quinn, P. J. Carter, M.E., Markey, B. K. and Carter, G. R. 2002. Veterinary microbiology microbial diseases, bacterial causes of bovine mastitis, 8th Edition,Mosby International Limited, London, pp 465–475.
Lakew BT, Fayera T, Ali YM. 2019. Risk factors for bovine mastitis with the isolation and identification of Streptococcus agalactiae from farms in and around Haramaya district, eastern Ethiopia. Trop Anim Health Prod. 2019;51:1507–13. doi: 10.1007/s11250-019-01838-w.
Mendes, LB., Coppa, M., Rouel, J., Martin, B., Dumont, B. 2021. Profiles of dairy cows with different productive lifespan emerge together from multiple traits assessed at f irst lactation: the case of a grassland-based dairy system. Livestock Science, 2021, pp.104443.
Ranjan, R., Swarup, D., Patra, R. C., & Nandi, D. 2006. Bovine protothecal mastitis: a review. Perspectives in Agriculture, Veterinary Sciences, Nutrition and Natural Resources, 1(17), 1-7. doi: 10.1079/PAVSNNR20061017.
Schlegelova, J., Dendis, M., Benedık, J., Babak, V., Ryšánek, D. 2003. Staphylococcus aureus isolates dairy cows and humans on a farm differ in coagulase genotype. Veterinary Microbiology, 92(4), 327-334.
Cheng, W.N., Han, S.G. 2020. Bovine mastitis: risk factors, therapeutic strategies, and alternative treatments A review. Asian-Australas J Anim Sci. 2020 Nov; 33(11): 1699–1713.
Klaas IC, Zadoks RN. 2018. An update on environmental mastitis: Challenging perceptions. Transbound Emerg Dis. 2018;65(Suppl 1):166–85. doi: 10.1111/tbed.12704.
Özenç E. 2019. Determination of Risk Factors Associated with Subclinical Mastitis as Detected by California Mastitis Test in Smallholder Dairy Farms in Afyonkarahisar. Kocatepe Vet J 12:1-1. DOI: 10.30607/kvj.579928 .
Samad, M.A. 2022. Review on Mastitis in Dairy Lactating Animals and their Public Health Importance: The 56 Years Bangladesh Perspective, J. Vet. Med. OH Res. 4(2): 33-114
Schreiner D, Ruegg P. 2002. Effects of tail docking on milk quality and cow cleanliness. J Dairy Sci. 85:2503–11. doi: 10.3168/jds.S0022-0302(02)74333-6.
Kibebew K. 2017. Bovine mastitis: A review of causes and epidemiological point of view. J Biol Agric Healthc. 2017;7:1–14.
Sharma N, Singh N, Bhadwal M. 2011. Relationship of somatic cell count and mastitis: An overview. Asian-Australas J Anim Sci. 24:429–38. doi: 10.5713/ajas.2011.10233.
Smith KL, Hogan JS. 1993. Environmental mastitis. Vet Clin North Am Food Anim Pract., 9:489–98. doi: 10.1016/S0749-0720(15)30616-2.
Vasudevan P, Nair MKM, Annamalai T, Venkitanarayanan KS. 2003. Phenotypic and genotypic characterization of bovine mastitis isolates of Staphylococcus aureus for biofilm formation. Vet Microbiol. 92:179–85. doi: 10.1016/S0378-1135(02)00360-7.
Rainard P, Foucras G, Fitzgerald JR, Watts, JL, Koop, G., Middleton, JR. 2018. Knowledge gaps and research priorities in Staphylococcus aureus mastitis control. Transbound Emerg Dis. 65(Suppl 1):149–65. doi: 10.1111/tbed.12698.
Gilbert FB, Cunha P, Jensen K, Glass, EJ., Foucras, G., Robert-Granié, C., Rupp, R. Pascal Rainard, P. 2013. Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system. Vet Res. 2013;44:40. doi: 10.1186/1297-9716-44-40.
Oliveira, L., Hulland, C. and Ruegg, P.L., 2013. Characterization of clinical mastitis occurring in cows on 50 large dairy herds in Wisconsin, Journal of Dairy Science, 96, 7538–7549.
Scali F, Camussone C, Calvinho LF, Cipolla M, Zecconi A. 2015. Which are important targets in the development of S. aureus mastitis vaccine? Res Vet Sci. 100:88–99. doi: 10.1016/j.rvsc.2015.03.019.
Rosini R., Margarit I. 2015. Biofilm formation by Streptococcus agalactiae: influence of environmental conditions and implicated virulence factors. Front Cell Infect Microbiol. 2015;5:6. doi: 10.3389/fcimb.2015.00006.
Samuel Mohammed Chekabab, Judith Paquin-Veillette, Charles M. Dozois, Josée Harel, The ecological habitat and transmission of Escherichia coli O157:H7, FEMS Microbiology Letters, Volume 341, Issue 1, April 2013, Pages 1–12.
Fernandes JBC, Zanardo LG, Galvão NN, Carvalho IA, Nero LA, Moreira MAS. 2011. Escherichia coli from clinical mastitis: serotypes and virulence factors. J Vet Diagn Invest. 2011; 23:1146–52. doi: 10.1177/1040638711425581.
Zhang, T., Niu, G., Boonyayatra, S., Pichpol, D. 2021. Antimicrobial Resistance Profiles and Genes in Streptococcus uberis Associated With Bovine Mastitis in Thailand. Frontiers in Veterinary Science, 8:705338
Halasa T, Huijps K, Østerås O, Hogeveen H. 2007.Economic effects of bovine mastitis and mastitis management: a review. Vet Q. 29:18–31. doi: 10.1080/01652176.2007.9695224
Ajose, DJ., Oluwarinde, BO., Abolarinwa, TO., Fri, J., Montso, KP., Fayemi, OE., Aremu, AO., Ateba, CN. 2022. Combating Bovine Mastitis in the Dairy Sector in an Era of Antimicrobial Resistance: Ethno-veterinary Medicinal Option as a Viable Alternative Approach Frontiers in Veterinary Science | www.frontiersin.org, April 2022 | Volume 9 | Article 800322.
Rossi R, Amarante A, Correia L, Guerra S, Nobrega D, Latosinski G, Rossi, BF., Rall, VLM., Pantoja, JCF., 2018. Diagnostic accuracy of Somaticell, California Mastitis Test, and microbiological examination of composite milk to detect Streptococcus agalactiae intramammary infections. J Dairy Sci., 101:10220–9. doi: 10.3168/jds.2018-14753.
Kour, S., Sharma, N., Balaji N, B., Kumar, P., Soodan, JS., dos Santos, MV., Son, Young-Ok. 2023. Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis. Vet. Sci. 2023, 10, 449.
Souza FN, Cunha AF, Rosa DL, Brito MAV, Guimarães AS, Mendonça LC, Souza, GN., Lage, AL., Blagitz, MG., Della Libera, Alice M.M.P.Heinemann, MB., Cerqueira, Mônica M.O.P. 2016. Somatic cell count and mastitis pathogen detection in composite and single or duplicate quarter milk samples. Pesquisa Veterinária Brasileira, 36:811–8. doi: 10.1590/S0100-736X2016000900004.
Sargeant, J., Leslie, K., Shirley, J., Pulkrabek, B., & Lim, G. (2001). Sensitivity and specificity of somatic cell count and California Mastitis Test for identifying intramammary infection in early lactation.. Journal of dairy science, 84 9, 2018-24 .
Green, M., Green, L., Schukken, Y., Bradley, A., Peeler, E., Barkema, H., Haas, Y., Collis, V., & Medley, G. (2004). Somatic cell count distributions during lactation predict clinical mastitis.. Journal of dairy science, 87 5, 1256-64.
Ali, A.; Maqbool, I.; Ayaz, A.; Mir, M.R.; Ganie, S.A. 2021. Ability of Diagnostic Tests to Predict Subclinical Mastitis and Intramammary Infections in Quarters from Lactating Dairy Cows. Res. J. Agril. Sci. 12:1982–1986.
Ferronatto JA, Ferronatto TC, Schneider M, Pessoa LF, Blagitz MG, Heinemann MB. 2018. Diagnosing mastitis in early lactation: use of SomaticellR , California mastitis test and somatic cell count. Ital J Anim Sci. (2018) 17:723–9. doi: 10.1080/1828051X.2018.1426394
Godden S, Royster E, Timmerman J, Rapnicki P, Green H. Evaluation of an automated milk leukocyte differential test and the CaliforniaMastitis Test for detecting intramammary infection in early-and late-lactation quarters and cows. J Dairy Sci. (2017) 100:6527–44. doi: 10.3168/jds.2017-12548.
Ryskaliyeva A, Henry C, Miranda G, Faye B, Konuspayeva G, Martin P. 2018. Combining different proteomic approaches to resolve complexity of the milk protein fraction of dromedary, Bactrian camels and hybrids, from different regions of Kazakhstan. PLoS ONE (2018) 13:e0197026. doi: 10.1371/journal.pone.0197026
Gomes F, Henriques M. 2016. Control of bovine mastitis: old and recent therapeutic approaches. Curr Microbiol. 72:377–82. doi: 10.1007/s00284-015-0958.
Holland, J.K., Hadrich, J.C., Wolf, C.A., Lombard, J. (2015) Economics of Measuring Costs Due to Mastitis-Related Milk Loss. 2015 Presentation at the 2015 AAEA & WAEA Joint Annual Meeting, San Francisco, California, July 26-28, 2015.
Hogeveen H, Steeneveld W, Wolf CA. 2019. Production diseases reduce the efficiency of dairy production: A review of the results, methods, and approaches regarding the economics of mastitis. Annu Rev Resour Economics. 11:289–312. doi: 10.1146/annurev-resource-100518-093954.
Zhao X, Lacasse P. 2008. Mammary tissue damage during bovine mastitis: causes and control. J Anim Sci. 86:57–65. doi: 10.2527/jas.2007-0302.
Singh AK, Bhakat C, Kumari T, Mandal DK, Chatterjee A, Karunakaran, M. 2020a. Influence of pre and postpartum alpha-tocopherol supplementation on milk yield, milk quality and udder health of Jersey crossbred cows at tropical lower Gangetic region. Veterinary World, 13(9):2006–11. DOI: 10.14202/vetworld.2020.2006-2011
Singh AK, Bhakat C, Mandal DK, Mandal A, Rai S, Chatterjee A. 2020b. Effect of reducing energy intake during dry period on milk production, udder health and body condition score of Jersey crossbred cows at tropical lower Gangetic region. Tropical Animal Health and Production 2020;52:1759–67. DOI: 10.1007/s11250-019-02191-8
Bhakat C, Singh AK, Mandal A, Karunakaran M, Mohammad A, Mandal DK, 2022. Udder health maintenance to augment milk production in dairy cattle: A review. Indian Journal of Animal Research 2022. DOI:10.18805/IJAR.B-4816.
Kansal G, Yadav DK, Singh AK, Rajput MS. 2020. Advances in the management of bovine mastitis. International Journal of Advances in Agricultural Science and Technology 2020;7(2):10–22.
Kumari T, Bhakat C, Choudhary RK. 2018. A review on sub clinical mastitis in dairy cattle. International Journal of Pure and Applied Biosciences, 6(2):1291–9.
Rathod, P.; Shivamurty, V.; Desai, A.R. 2017. Economic Losses Due to Subclinical Mastitis in Dairy Animals: A Study in Bidar District of Karnataka. Indian J. Vet. Sci. Biotechnol. 13:37–41.
Richardet, M.; Solari, H.G.; Cabrera, V.E.; Vissio, C.; Agüero, D.; Bartolomé, J.A.; Bó, G.A.; Bogni, C.I.; Larriestra, A.J. 2023. The Economic Evaluation of Mastitis Control Strategies in Holstein-Friesian Dairy Herds. Animals, 13: 1701.
Bayram, NE., Gerçek, YC. 2017. Major Constituents of Different Propolis SamplesHacettepe J. Biol. & Chem., 2017, 45 (4), 581-584.
Anjum, S., Ullah, A., Khan, K., Attaullah, M., Khan, H., Ali, H., Bashir, M., Tahir, M., Ansari, M., Ghramh, H., Adgaba, N., & Dash, C. (2018). Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences, 26, 1695 - 1703.
Huang, S., Zhang, C., Wang, K., Li, G., & Hu, F. (2014). Recent Advances in the Chemical Composition of Propolis. Molecules, 19, 19610 - 19632.
Becerra, T.B., Calla-Poma, R.D., Requena-Mendizabal, M.F., Millones-Gomez, P.A., 2019. Antibacterial effect of Peruvian propolis collected during different seasons on the growth of streptococcus mutans. Open Dent. J. 13 (1).
Ristivojevic´ , P., Trifkovic´ , J., Andric´ , F., Milojkovic´-Opsenica, D., 2015. Poplar-type Propolis: Chemical Composition, Botanical Origin and Biological Activity. Nat. Prod. Commun. 10 (11).
Bankova, V. d. C., S. L., Marcucci, M.C. 2000. ‘‘Propolis: recent advances in chemistry and plant origin.” Apidologie 31(1): 3-15.
Drescher, N., Klein, A.M., Schmitt, T., Leonhardt, S.D., 2019. A clue on bee glue: New insight into the sources and factors driving resin intake in honeybees (Apis mellifera). PLoS ONE 14 (2).
Freires, I. A., S. M. de Alencar and P. L. Rosalen 2016. ‘‘A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases.” European journal of medicinal chemistry 110.
Hossain, S., Yousaf, M., Liu, Y., Chang, D., & Zhou, X. (2022). An Overview of the Evidence and Mechanism of Drug–Herb Interactions Between Propolis and Pharmaceutical Drugs. Frontiers in Pharmacology, 13.
Nasir, N.F.; Kannan, T.P.; Sulaiman, S.A.; Shamsuddin, S.; Azlina, A.; Stangaciu, S. The relationship between telomere length and beekeeping among Malaysians. Age 2015, 37, 9797.
Cogulu, O., Biray, C., Gündüz, C., Karaca, E., Aksoylar, S., Sorkun, K., Salih, B., & Ozkinay, F. (2009). Effects of Manisa propolis on telomerase activity in leukemia cells obtained from the bone marrow of leukemia patients. International Journal of Food Sciences and Nutrition, 60, 601 - 605.
Nichitoi, M., Josceanu, A., Isopescu, R., Isopencu, G., geană, E., Ciucure, C., & Lavric, V. (2021). Polyphenolics profile effects upon the antioxidant and antimicrobial activity of propolis extracts. Scientific Reports, 11.
Farag, M., Abdelnour, S., Patra, A., Dhama, K., Dawood, M., Elnesr, S., & Alagawany, M. (2021). Propolis: properties and composition, health benefits and applications in fish nutrition. Fish & shellfish immunology.
Şahinler, N., & Kaftanoğlu, O. (2005). Natural product propolis: chemical composition. Natural Product Research, 19, 183 - 188.
Wozniak, M. M., L.; Waskiexicz; A.; Rogozinski, T.; Ratajczak; I. 2019. ‘‘The role of seasonality on the chemical composition, antioxidant activity and cytotoxicity of Polish propolis in human erythrocytes.” Revista Brasileira de Farmacognosia 29(3): 301-308.
Afrouzan, H., Tahghighi, A., Zakeri, S. and Es-haghi, A. 2018. Chemical Composition and Antimicrobial Activities of Iranian Propolis. Iranian Biomedical Journal, 22, 1, 50-65
Cushnie, T.P., Lamb, A.J., 2005. Detection of galanin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss. J. Ethnopharmacol. 101 (1–3).
Seibert, J., Bautista-Silva, J., Amparo, T., Petit, A., Pervier, P., Almeida, J., Azevedo, M., Silveira, B., Brandão, G., Souza, G., Teixeira, L., & Santos, O. (2019). Development of propolis nanoemulsion with antioxidant and antimicrobial activity for use as a potential natural preservative.. Food chemistry, 287, 61-67.
Meccatti, V., Martins, K., Ramos, L., Pereira, T., Menezes, R., Marcucci, M., Hasna, A., & Oliveira, L. (2023). Synergistic Antibiofilm Action of Cinnamomum verum and Brazilian Green Propolis Hydroethanolic Extracts against Multidrug-Resistant Strains of Acinetobacter baumannii and Pseudomonas aeruginosa and Their Biocompatibility on Human Keratinocytes. Molecules, 28.
Al-Ani, I., Zimmermann, S., Reichling, J., Wink, M., 2018. Antimicrobial Activities of European Propolis Collected from Various Geographic Origins Alone and in Combination with Antibiotics. Medicines (Basel, Switzerland) 5 (1).
Regueira, M., Tintino, S., Silva, A., Costa, M., Boligon, A., Matias, E., Balbino, V., Menezes, I., & Coutinho, H. (2017). Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 107 Pt B, 572-580 .
Orsi, R., Sforcin, J., Funari, S., Júnior, A., & Bankova, V. (2006). Synergistic effect of propolis and antibiotics on the Salmonella Typhi. Brazilian Journal of Microbiology, 37, 108-112.
Galeotti, F., Maccari, F., Fachini, A., Volpi, N., 2018. Chemical Composition and Antioxidant Activity of Propolis Prepared in Different Forms and in Different Solvents Useful for Finished Products. Foods (Basel, Switzerland) 7 (3).
Veloz, J. J., M. Alvear and L. A. Salazar 2019. ‘‘Antimicrobial and Antibiofilm Activity against Streptococcus mutans of Individual and Mixtures of the Main Polyphenolic Compounds Found in Chilean Propolis.” BioMed research international, 2:7602343.
Akilandeswari, K., Ruckmani, K., 2016. ‘‘Synergistic antibacterial effect of apigenin with b-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin-resistant Staphylococcus aureus.” Cellular and molecular biology (Noisy-le-Grand . France) 62 (14).
Eumkeb, G., Chukrathok, S., 2013. Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae. Phytomedicine: international journal of phytotherapy and phytopharmacology 20 (3–4).
Przybyłek, I., Karpinski, TM. 2019. Antibacterial Properties of Propolis. Molecules 2019, 24, 2047.
Talas, Z., & Gulhan, M. (2009). Effects of various propolis concentrations on biochemical and hematological parameters of rainbow trout (Oncorhynchus mykiss).. Ecotoxicology and environmental safety, 72 7, 1994-8 .
Mani, F., Damasceno, H., Novelli, E., Martins, E., & Sforcin, J. (2006). Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables.. Journal of ethnopharmacology, 105 1-2, 95-8 .
Mirzoeva, O. K., Grishanin, R. N., & Calder, P. C. (1997). Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria. Microbiological research, 152(3), 239–246.
Kashkooli, O., Dorcheh, E., Mahboobi-Soofiani, N., & Samie, A. (2011). Long-term effects of propolis on serum biochemical parameters of rainbow trout (Oncorhynchus mykiss).. Ecotoxicology and environmental safety, 74 3, 315-8 .
Kalafova, A., Haščík, P., Kacaniova, M., Petruska, P., Capcarova, M. (2016). The effect of propolis on biochemical parameters and antioxidant status of the blood of broiler chickens. Journal of Apicultural Research. 54. 1-6.
Yılmaz, S., Sova, M., Ergün, S., 2018. Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates. J. Appl. Microbiol, 125(6):1714-1727.
Zhang, W., Margarita, G., Wu, D., Yuan, W., Yan, S., Qi, S., Xue, X., Wang, K., & Wu, L. (2022). Antibacterial Activity of Chinese Red Propolis against Staphylococcus aureus and MRSA. Molecules, 27.
Scazzocchio, F., D'Auria, F., Alessandrini, D., & Pantanella, F. (2006). Multifactorial aspects of antimicrobial activity of propolis.. Microbiological research, 161 4, 327-33 .
Almuhayawi, M.S., 2020. Propolis as a novel antibacterial agent, Saudi Journal of Biological Sciences 27 (2020) 3079–3086.
Zhang-jun, Z. (2009). Preliminary study on antibacterial activity and mechanism of propolis. Food Science and Technology International.
Orsi, R.O., Fernandes, A., Bankova, V., Sforcin, J.M., 2012. The effects of Brazilian and Bulgarian propolis in vitro against Salmonella Typhi and their synergism with antibiotics acting on the ribosome. Nat. Prod. Res. 26 (5): 430-7.
Williams, R.J., Spencer, J.P., Rice-Evans, C., 2004. Flavonoids: antioxidants or signalling molecules?. Free Radical Biol. Med. 1;36(7):838-49.
Youn, H.S., Lee, J.Y., Saitoh, S.I., Miyake, K., Kang, K.W., Choi, Y.J., Hwang, D.H., 2006. Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem. Pharmacol. 72(7):850-9.
Leitner G., Yadlin N., Lubashevsy E., Ezra E., Glickman A., Chaffer M., Winkler M., Saran A., and Trainin Z. 2003. Development of a Staphylococcus aureus vaccine against mastitis in dairy cows. II. Field trial. Veterinay Immunology and Immunopathology 93: 153–158
Yücel, B., Onenc, A., Kaya, A., and Altan, O., 2015. Efects of Propolis Administration on Growth Performance and Neonatal Diarrhea of Calves, Symbiosis Journal of Veterinary Science, 1(1): 102.
Slanzon, G.S., Toledo, A.F., Silva, A.P., Coelho, M.G., da Silva, M.D., Cezar, A.M. , Bittar, M.M., 2019. Red propolis as an additive for preweaned dairy calves: Effect on growth performance, health, and selected blood parameters. Journal of Dairy Science, 102(10):8952–8962
Shedeed, H. A., Farrag, B., Elwakeel, E. A., Abd El-Hamid, I. S., & El-Rayes, M. A. H. 2019. Propolis supplementation improved productivity, oxidative status, and immune response of Barki ewes and lambs. Veterinary world, 12(6): 834.
Kabiloglu, A., Kocabağlı, N., Ilgın Kekeç, A. 2023. Effect of propolis extract on growth performance and health conditions of dairy calves. Tropical Animal Health and Production, 55(115).
Morsy, A.S., Soltan, Y.A., El-Zaiat, H.M., Alencar, S.M.,Abdalla, A.L. 2021. Bee propolis extract as a phytogenic feed additive to enhance diet digestibility, rumen microbial biosynthesis, mitigating methane formation and health status of late pregnant ewes. Animal Feed Science and Technology 273 (2021) 114834.
Cecere, B.G.O., da Silva, A.S., Molosse, V.L., Alba, D.F., Leal, K.W., da Rosa, G,. Pereira, W.A.B., da Silva,A.D., Schetinger, M.R.C., Kempka, A.P., Nunes, A., Maraschin, M., Araujo, D.N., Deolindo, G.L. & Vedovatto, M., 2021. Addition of propolis to milk improves lactating lamb’s growth: effect on Antimicrobial, Antioxidant and Immune Responses in Animals, Small Ruminant Research, 194: 106265.
Dezmirean DS, Paşca C, Moise AR, Bobiş O. Plant Sources Responsible for the Chemical Composition and Main Bioactive Properties of Poplar-Type Propolis. Plants. 2021; 10(1):22.
Bacic, G., Macesic, N., Radin, L., Aladrovic, J., Matanovic, K., Masek, T., Brozic, D., Benic, M., Radic, B., Bacic, I., Suran, J. 2016. Intramammary propolis formulation for subclinical mastitis prevention and treatment in dairy cows. J Dairy Vet Anim Res. 2016;3(5):159.
Voitenko, L & Voitenko, O. (2021). Zootechnical and veterinary methods of high-producing dairy cows treatment. IOP Conference Series: Earth and Environmental Science. 640. 032053.
Mukherjee, R., Dash, P. K. and Ram, G. C. 2005. Immunotherapeutic potential of Ocimum sanctum (L) in bovine subclinical mastitis. Research in veterinary science, 79(1): 37-43.
Santana, H. F., Barbosa, A. A. T., Ferreira, S. D., & Mantovani, H. C. 2012. Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows. World Journal of Microbiology & Biotechnology, 28(2):485-491. http://dx.doi. org/10.1007/s11274-011-0839-7. PMid:22806843.
Silva J.C., Rodrigues S., Feás X. & Estevinho L.M. 2012. Antimicrobial activity, phenolic profile and role in the inflammation of propolis. Food Chem. Toxicol. 50(5):1790-1795.
František, Z., Zigová Martin, Z., Milan, V. 2019. Distribution of Bacterial Pathogens Causing Mastitis in Dairy Cows,‖ International Research Journal of Pharmacy and Medical Sciences (IRJPMS), 3(1): 49-52.
Wei, W., L. Dejie, S. Xiaojing, W. Tiancheng, C. Yongguo, T. Zhengtao, Z. Naisheng. 2015. Magnolol inhibits the inflammatory response in mouse mammary epithelial cells and mouse mastitis model. Inflammation 38:16–26.
Romvary, A., G. Szita, G. Csiko, Z. Gaspar, and I. Gaspar. 1993. Effectiveness of an intramammary infusion with no antibiotics. IV. Innocuity test of new intramammary infusion. Magyar Allatorvosok Lapja 48:493–497.
Wagh, V.D. 2013. Propolis: A Wonder Bees Product and ItsPharmacological Potentials. Advances in Pharmacological Sciences, Article ID 308249, 11 pages
Deolindo, G. L. .; Molosse, V. L. .; Dilda, A.; Girardini, L. K. .; Vedovatto, M.; Silva, A. S. Da; Araujo, D. N. . Lacaune ewes with subclinical mastitis: effects of intramammary application of própolis. Research, Society and Development, [S. l.], v. 10, n. 2, p. e18210211709, 2021.
Langoni H., Araújo W.N., Silva A.V., Souza L.C. 2000. Tratamento da mastite bovina com amoxicilina e enrofloxacina bem como a sua associação. Arq. Inst. Biológico, São Paulo, 67:177-180.
Hegazi AG, El-Houssiny AS, Sadek WMA, Al-Guthami FM, Al-Gethami AFM, Sadik AMA, Farag T.K. 2021. Egyptian propolis 13: Influence of propolis and alginate-propolis NPs on Egyptian Nubian goats serum immunoglobulins and cytokines level. Advances in Animal and Veterinary Sciences, 9(2): 280-288.
Kawakami, Y., Yanagawa, A., Mizushima, Y., & Narikawa, S. (1997). Antimicrobial activity of propolis.. , 17, 573-576.
Santos, H., Vieira, D., Yamamoto, S., Costa, M., Sá, M., Silva, E., & Silva, T. (2019). Antimicrobial activity of propolis extract fractions against Staphylococcus spp. isolated from goat mastitis. Pesquisa Veterinária Brasileira.
Karslı, M.A. & Evci, Ş., 2018. The Importance of Cattle and Calf Nutrition in Preventing Calf Losses. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 58:23–34.
Nascimento, T. S., Silva, I. S. M., Alves, M. C. M. A., Gouveia, B. B., Barbosa, L. M. R., Macedo, T. J. S., Santos, J. M. S., Monte, A. P. O., Matos, M. H. T., Padilha, F. F., & Lima-Verde, I. B. (2019). Effect of red propolis extract isolated or encapsulated in nanoparticles on the in vitro culture of sheep preantral follicle: Impacts on antrum formation, mitochondrial activity and glutathione levels. Reproduction in domestic animals = Zuchthygiene, 54(1), 31–38.
Machado, G., Veleirinho, M., Mazzarino, L., Filho, L., Maraschin, M., Cerri, R., & Kuhnen, S. (2019). Development of propolis nanoparticles for the treatment of bovine mastitis: in vitro studies on antimicrobial and cytotoxic activities. Canadian Journal of Animal Science, 99, 713 - 723.
Skliarov, P. M., Fedorenko, S. Y., Onyshchenko, O. V., PasternakА. М., Lieshchova, M. A., Bilyi, D. D., Vakulyk, V. V., Antonenko, P. P., & Mylostyvyi, R. V. (2021). The effectiveness of ozone therapy in goats with mastitis. Theoretical and Applied Veterinary Medicine, 9(1), 24-29.
Sinha, M.K.; Thombare, N.N.; Mondal, B. 2104. Subclinical Mastitis in Dairy Animals: Incidence, Economics, and Predisposing Factors. Sci. World J. 523984.
Singh, A.K. 2022. A comprehensive review on subclinical mastitis in dairy animals: Pathogenesis, factors associated, prevalence, economic losses and management strategies. CABI Reviews (2022) 17, No. 057
Armağan Aydın, T. 2021. İneklerde Subklinik Mastitis Tanısında Akut Faz Proteinlerinden Amiloid A ve C-Reaktif Protein’in Belirlenmesi. T.C. Harran Üniversitesi Sağlik Bilimleri Enstitüsü Doğum ve Jinekoloji Anabilim Dalı, Yüksek Lisans Tezi, Şanlı Urfa.
Riollet, C., Rainard, P., Poutrel, B. 2001. Cell Subpopulations and Cytokine Expression in Cow Milk in Response to Chronic Staphylococcus aureus infection. J.DairySci., 84:1077–1084
Gómez, P., Jon, L., Torres, D., Amaranto, R., Díaz, I., & Medina, C. (2021). Antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro oral biofilm. F1000Research, 10, 1093.
Popova, M., Silici, S., Kaftanoglu, O., Bankova, V. Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition, Phytomedicine, Volume 12, Issue 3, 2005, Pages 221-228, ISSN 0944-7113.
Nedji, N., & Loucif-Ayad, W. (2014). Antimicrobial activity of Algerian propolis in foodborne pathogens and its quantitative chemical composition. Asian Pacific Journal of Tropical Disease, 4, 433-437.
Airen B., Sarkar P.A., Tomar U., Bishen K.A. Antibacterial effect of propolis derived from tribal region on. J Indian Soc Pedod Prev Dent. 2018;36(1):48–52.
Muli, E., & Maingi, J. (2007). Antibacterial activity of Apis mellifera L. propolis collected in three regions of Kenya. Journal of Venomous Animals and Toxins Including Tropical Diseases, 13, 655-663.
Nina, N., Quispe, C., Jiménez-Aspee, F., Theoduloz, C., Feresin, G., Lima, B., Leiva, E., & Schmeda-Hirschmann, G. (2015). Antibacterial Activity, Antioxidant Effect and Chemical Composition of Propolis from the Región del Maule, Central Chile. Molecules, 20, 18144 - 18167.
Al-Waili N., Al-Ghamdi A., Ansari M.J., Al-Attal Y., Salom K. Synergistic effects of honey and propolis toward drug multi-resistant Staphylococcus aureus, Escherichia coli and Candida albicans isolates in single and polymicrobial cultures. International J. Medical Sci. 2012;9(9)
Mohammadzadeh, S., Shariatpanahi, M., Hamedi, M., Ahmadkhaniha, R., Samadi, N., & Ostad, S. (2007). Chemical composition, oral toxicity and antimicrobial activity of Iranian propolis. Food Chemistry, 103, 1097-1103. https://doi.org/10.1016/J.FOODCHEM.2006.10.006.
Referanslar
Ruegg, P. (2017). A 100-Year Review: Mastitis detection, management, and prevention. Journal of dairy science, 100 12, 10381-10397.
Sharun, K., Dhama, K., Tiwari, R., Gugjoo, M., Yatoo, M., Patel, S., Pathak, M., Karthik, K., Khurana, S., Singh, R., Puvvala, B., A., Singh, R., Singh, K., & Chaicumpa, W. (2021). Advances in therapeutic and managemental approaches of bovine mastitis: a comprehensive review. The Veterinary Quarterly, 41, 107 - 136. https://doi.org/10.1080/01652176.2021.1882713.
Aqib, A., Muneer, A., Shafeeq, M., & Kirn, N. (2021). Economic Impacts of Clinical and Sub Clinical Mastitis on Dairy Farms. Veterinary Science Research. https://doi.org/10.30564/vsr.v3i2.4119.
Goulart, D. B., & Mellata, M. (2022). Escherichia coli Mastitis in Dairy Cattle: Etiology, Diagnosis, and Treatment Challenges. Frontiers in microbiology, 13, 928346. https://doi.org/10.3389/fmicb.2022.928346
Taponen S, Koort J, Björkroth J, Saloniemi H, Pyörälä S. 2007. Bovine intramammary infections caused by coagulase-negative staphylococci may persist throughout lactation according to amplified fragment length polymorphism-based analysis. Journal of Dairy Science, 90: 3301-3307.
Green, MJ., Bradley, AJ., Medley, GF., W. J. Browne, WJ. 2007. Cow, Farm, and Management Factors During the Dry Period that Determine the Rate of Clinical Mastitis After Calving. J. Dairy Sci. 90:3764–3776.
7. Hamid S, Bhat MA, Mir IA, Taku, A., Badroo, GA., Salik Nazki, Malik, A. 2017. Phenotypic and genotypic characterization of methicillin-resistant Staphylococcus aureus from bovine mastitis. Vet World. 2017; 10:363–7. doi: 10.14202/vetworld.2017.363-367.
Gupta S, Kundabala M, Acharya SR, Ballal V. 2007. A comparative evaluation of the antibacterial efficacy of propolis 30% sodium hypochlorite and 02% chlorhexidine gluconate against enterococcus faecalis-An in vitro study. Endodontology. 2007;19(2):31–8.
Marcucci MC. 1995. Propolis: chemical composition, biological properties and therapeutic activity. Apidologie. 1995;26(2):83–99.
Aga H, Shibuya T, Hamada S, Iritani S, Miyake T. 1999. Propolis extract with improved water Solubility1999. Available from: https://patents.google.com/patent/US5922324A/en.
Diarra, MS, Block G, Rempel H, Oomah, BD., Harrison, J., McCallum, J., Boulanger,S., Brouillette, E., Gattuso, M., Malouin, F. 2013. In vitro and in vivo antibacterial activities of cranberry press cake extracts alone or in combination with β-lactams against Staphylococcus aureus. BMC Complement Altern Med. 2013; 13:90.
Wang, K., Jin, X., Shen, X., Sun, L., Wu, L., Wei, J., Marcucci, M., Hu, F., & Liu, J. (2016). Effects of Chinese Propolis in Protecting Bovine Mammary Epithelial Cells against Mastitis Pathogens-Induced Cell Damage. Mediators of Inflammation, 2016.
Ashraf A, Imran M. 2018. Diagnosis of bovine mastitis: from laboratory to farm. Trop Anim Health Prod. 50:1193–202. doi: 10.1007/s11250-018-1629-0.
Bhutia, PS., Bansal, BK., Gupta, DK., Singh, RS., Uppal, SK. 2019. Bacterial isolation of milk samples submitted from clinical mastitis buffaloes during 2007 to 2016. Tropical Animal Health and Production (2019) 51:1551–1557.
Oliveira M, Bexiga R, Nunes SF, Vilela CL. 2011. Invasive potential of biofilm-forming Staphylococci bovine subclinical mastitis isolates. J Vet Sci. 12:95–7. doi: 10.4142/jvs.2011.12.1.95.
Quinn, P. J. Carter, M.E., Markey, B. K. and Carter, G. R. 2002. Veterinary microbiology microbial diseases, bacterial causes of bovine mastitis, 8th Edition,Mosby International Limited, London, pp 465–475.
Lakew BT, Fayera T, Ali YM. 2019. Risk factors for bovine mastitis with the isolation and identification of Streptococcus agalactiae from farms in and around Haramaya district, eastern Ethiopia. Trop Anim Health Prod. 2019;51:1507–13. doi: 10.1007/s11250-019-01838-w.
Mendes, LB., Coppa, M., Rouel, J., Martin, B., Dumont, B. 2021. Profiles of dairy cows with different productive lifespan emerge together from multiple traits assessed at f irst lactation: the case of a grassland-based dairy system. Livestock Science, 2021, pp.104443.
Ranjan, R., Swarup, D., Patra, R. C., & Nandi, D. 2006. Bovine protothecal mastitis: a review. Perspectives in Agriculture, Veterinary Sciences, Nutrition and Natural Resources, 1(17), 1-7. doi: 10.1079/PAVSNNR20061017.
Schlegelova, J., Dendis, M., Benedık, J., Babak, V., Ryšánek, D. 2003. Staphylococcus aureus isolates dairy cows and humans on a farm differ in coagulase genotype. Veterinary Microbiology, 92(4), 327-334.
Cheng, W.N., Han, S.G. 2020. Bovine mastitis: risk factors, therapeutic strategies, and alternative treatments A review. Asian-Australas J Anim Sci. 2020 Nov; 33(11): 1699–1713.
Klaas IC, Zadoks RN. 2018. An update on environmental mastitis: Challenging perceptions. Transbound Emerg Dis. 2018;65(Suppl 1):166–85. doi: 10.1111/tbed.12704.
Özenç E. 2019. Determination of Risk Factors Associated with Subclinical Mastitis as Detected by California Mastitis Test in Smallholder Dairy Farms in Afyonkarahisar. Kocatepe Vet J 12:1-1. DOI: 10.30607/kvj.579928 .
Samad, M.A. 2022. Review on Mastitis in Dairy Lactating Animals and their Public Health Importance: The 56 Years Bangladesh Perspective, J. Vet. Med. OH Res. 4(2): 33-114
Schreiner D, Ruegg P. 2002. Effects of tail docking on milk quality and cow cleanliness. J Dairy Sci. 85:2503–11. doi: 10.3168/jds.S0022-0302(02)74333-6.
Kibebew K. 2017. Bovine mastitis: A review of causes and epidemiological point of view. J Biol Agric Healthc. 2017;7:1–14.
Sharma N, Singh N, Bhadwal M. 2011. Relationship of somatic cell count and mastitis: An overview. Asian-Australas J Anim Sci. 24:429–38. doi: 10.5713/ajas.2011.10233.
Smith KL, Hogan JS. 1993. Environmental mastitis. Vet Clin North Am Food Anim Pract., 9:489–98. doi: 10.1016/S0749-0720(15)30616-2.
Vasudevan P, Nair MKM, Annamalai T, Venkitanarayanan KS. 2003. Phenotypic and genotypic characterization of bovine mastitis isolates of Staphylococcus aureus for biofilm formation. Vet Microbiol. 92:179–85. doi: 10.1016/S0378-1135(02)00360-7.
Rainard P, Foucras G, Fitzgerald JR, Watts, JL, Koop, G., Middleton, JR. 2018. Knowledge gaps and research priorities in Staphylococcus aureus mastitis control. Transbound Emerg Dis. 65(Suppl 1):149–65. doi: 10.1111/tbed.12698.
Gilbert FB, Cunha P, Jensen K, Glass, EJ., Foucras, G., Robert-Granié, C., Rupp, R. Pascal Rainard, P. 2013. Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system. Vet Res. 2013;44:40. doi: 10.1186/1297-9716-44-40.
Oliveira, L., Hulland, C. and Ruegg, P.L., 2013. Characterization of clinical mastitis occurring in cows on 50 large dairy herds in Wisconsin, Journal of Dairy Science, 96, 7538–7549.
Scali F, Camussone C, Calvinho LF, Cipolla M, Zecconi A. 2015. Which are important targets in the development of S. aureus mastitis vaccine? Res Vet Sci. 100:88–99. doi: 10.1016/j.rvsc.2015.03.019.
Rosini R., Margarit I. 2015. Biofilm formation by Streptococcus agalactiae: influence of environmental conditions and implicated virulence factors. Front Cell Infect Microbiol. 2015;5:6. doi: 10.3389/fcimb.2015.00006.
Samuel Mohammed Chekabab, Judith Paquin-Veillette, Charles M. Dozois, Josée Harel, The ecological habitat and transmission of Escherichia coli O157:H7, FEMS Microbiology Letters, Volume 341, Issue 1, April 2013, Pages 1–12.
Fernandes JBC, Zanardo LG, Galvão NN, Carvalho IA, Nero LA, Moreira MAS. 2011. Escherichia coli from clinical mastitis: serotypes and virulence factors. J Vet Diagn Invest. 2011; 23:1146–52. doi: 10.1177/1040638711425581.
Zhang, T., Niu, G., Boonyayatra, S., Pichpol, D. 2021. Antimicrobial Resistance Profiles and Genes in Streptococcus uberis Associated With Bovine Mastitis in Thailand. Frontiers in Veterinary Science, 8:705338
Halasa T, Huijps K, Østerås O, Hogeveen H. 2007.Economic effects of bovine mastitis and mastitis management: a review. Vet Q. 29:18–31. doi: 10.1080/01652176.2007.9695224
Ajose, DJ., Oluwarinde, BO., Abolarinwa, TO., Fri, J., Montso, KP., Fayemi, OE., Aremu, AO., Ateba, CN. 2022. Combating Bovine Mastitis in the Dairy Sector in an Era of Antimicrobial Resistance: Ethno-veterinary Medicinal Option as a Viable Alternative Approach Frontiers in Veterinary Science | www.frontiersin.org, April 2022 | Volume 9 | Article 800322.
Rossi R, Amarante A, Correia L, Guerra S, Nobrega D, Latosinski G, Rossi, BF., Rall, VLM., Pantoja, JCF., 2018. Diagnostic accuracy of Somaticell, California Mastitis Test, and microbiological examination of composite milk to detect Streptococcus agalactiae intramammary infections. J Dairy Sci., 101:10220–9. doi: 10.3168/jds.2018-14753.
Kour, S., Sharma, N., Balaji N, B., Kumar, P., Soodan, JS., dos Santos, MV., Son, Young-Ok. 2023. Advances in Diagnostic Approaches and Therapeutic Management in Bovine Mastitis. Vet. Sci. 2023, 10, 449.
Souza FN, Cunha AF, Rosa DL, Brito MAV, Guimarães AS, Mendonça LC, Souza, GN., Lage, AL., Blagitz, MG., Della Libera, Alice M.M.P.Heinemann, MB., Cerqueira, Mônica M.O.P. 2016. Somatic cell count and mastitis pathogen detection in composite and single or duplicate quarter milk samples. Pesquisa Veterinária Brasileira, 36:811–8. doi: 10.1590/S0100-736X2016000900004.
Sargeant, J., Leslie, K., Shirley, J., Pulkrabek, B., & Lim, G. (2001). Sensitivity and specificity of somatic cell count and California Mastitis Test for identifying intramammary infection in early lactation.. Journal of dairy science, 84 9, 2018-24 .
Green, M., Green, L., Schukken, Y., Bradley, A., Peeler, E., Barkema, H., Haas, Y., Collis, V., & Medley, G. (2004). Somatic cell count distributions during lactation predict clinical mastitis.. Journal of dairy science, 87 5, 1256-64.
Ali, A.; Maqbool, I.; Ayaz, A.; Mir, M.R.; Ganie, S.A. 2021. Ability of Diagnostic Tests to Predict Subclinical Mastitis and Intramammary Infections in Quarters from Lactating Dairy Cows. Res. J. Agril. Sci. 12:1982–1986.
Ferronatto JA, Ferronatto TC, Schneider M, Pessoa LF, Blagitz MG, Heinemann MB. 2018. Diagnosing mastitis in early lactation: use of SomaticellR , California mastitis test and somatic cell count. Ital J Anim Sci. (2018) 17:723–9. doi: 10.1080/1828051X.2018.1426394
Godden S, Royster E, Timmerman J, Rapnicki P, Green H. Evaluation of an automated milk leukocyte differential test and the CaliforniaMastitis Test for detecting intramammary infection in early-and late-lactation quarters and cows. J Dairy Sci. (2017) 100:6527–44. doi: 10.3168/jds.2017-12548.
Ryskaliyeva A, Henry C, Miranda G, Faye B, Konuspayeva G, Martin P. 2018. Combining different proteomic approaches to resolve complexity of the milk protein fraction of dromedary, Bactrian camels and hybrids, from different regions of Kazakhstan. PLoS ONE (2018) 13:e0197026. doi: 10.1371/journal.pone.0197026
Gomes F, Henriques M. 2016. Control of bovine mastitis: old and recent therapeutic approaches. Curr Microbiol. 72:377–82. doi: 10.1007/s00284-015-0958.
Holland, J.K., Hadrich, J.C., Wolf, C.A., Lombard, J. (2015) Economics of Measuring Costs Due to Mastitis-Related Milk Loss. 2015 Presentation at the 2015 AAEA & WAEA Joint Annual Meeting, San Francisco, California, July 26-28, 2015.
Hogeveen H, Steeneveld W, Wolf CA. 2019. Production diseases reduce the efficiency of dairy production: A review of the results, methods, and approaches regarding the economics of mastitis. Annu Rev Resour Economics. 11:289–312. doi: 10.1146/annurev-resource-100518-093954.
Zhao X, Lacasse P. 2008. Mammary tissue damage during bovine mastitis: causes and control. J Anim Sci. 86:57–65. doi: 10.2527/jas.2007-0302.
Singh AK, Bhakat C, Kumari T, Mandal DK, Chatterjee A, Karunakaran, M. 2020a. Influence of pre and postpartum alpha-tocopherol supplementation on milk yield, milk quality and udder health of Jersey crossbred cows at tropical lower Gangetic region. Veterinary World, 13(9):2006–11. DOI: 10.14202/vetworld.2020.2006-2011
Singh AK, Bhakat C, Mandal DK, Mandal A, Rai S, Chatterjee A. 2020b. Effect of reducing energy intake during dry period on milk production, udder health and body condition score of Jersey crossbred cows at tropical lower Gangetic region. Tropical Animal Health and Production 2020;52:1759–67. DOI: 10.1007/s11250-019-02191-8
Bhakat C, Singh AK, Mandal A, Karunakaran M, Mohammad A, Mandal DK, 2022. Udder health maintenance to augment milk production in dairy cattle: A review. Indian Journal of Animal Research 2022. DOI:10.18805/IJAR.B-4816.
Kansal G, Yadav DK, Singh AK, Rajput MS. 2020. Advances in the management of bovine mastitis. International Journal of Advances in Agricultural Science and Technology 2020;7(2):10–22.
Kumari T, Bhakat C, Choudhary RK. 2018. A review on sub clinical mastitis in dairy cattle. International Journal of Pure and Applied Biosciences, 6(2):1291–9.
Rathod, P.; Shivamurty, V.; Desai, A.R. 2017. Economic Losses Due to Subclinical Mastitis in Dairy Animals: A Study in Bidar District of Karnataka. Indian J. Vet. Sci. Biotechnol. 13:37–41.
Richardet, M.; Solari, H.G.; Cabrera, V.E.; Vissio, C.; Agüero, D.; Bartolomé, J.A.; Bó, G.A.; Bogni, C.I.; Larriestra, A.J. 2023. The Economic Evaluation of Mastitis Control Strategies in Holstein-Friesian Dairy Herds. Animals, 13: 1701.
Bayram, NE., Gerçek, YC. 2017. Major Constituents of Different Propolis SamplesHacettepe J. Biol. & Chem., 2017, 45 (4), 581-584.
Anjum, S., Ullah, A., Khan, K., Attaullah, M., Khan, H., Ali, H., Bashir, M., Tahir, M., Ansari, M., Ghramh, H., Adgaba, N., & Dash, C. (2018). Composition and functional properties of propolis (bee glue): A review. Saudi Journal of Biological Sciences, 26, 1695 - 1703.
Huang, S., Zhang, C., Wang, K., Li, G., & Hu, F. (2014). Recent Advances in the Chemical Composition of Propolis. Molecules, 19, 19610 - 19632.
Becerra, T.B., Calla-Poma, R.D., Requena-Mendizabal, M.F., Millones-Gomez, P.A., 2019. Antibacterial effect of Peruvian propolis collected during different seasons on the growth of streptococcus mutans. Open Dent. J. 13 (1).
Ristivojevic´ , P., Trifkovic´ , J., Andric´ , F., Milojkovic´-Opsenica, D., 2015. Poplar-type Propolis: Chemical Composition, Botanical Origin and Biological Activity. Nat. Prod. Commun. 10 (11).
Bankova, V. d. C., S. L., Marcucci, M.C. 2000. ‘‘Propolis: recent advances in chemistry and plant origin.” Apidologie 31(1): 3-15.
Drescher, N., Klein, A.M., Schmitt, T., Leonhardt, S.D., 2019. A clue on bee glue: New insight into the sources and factors driving resin intake in honeybees (Apis mellifera). PLoS ONE 14 (2).
Freires, I. A., S. M. de Alencar and P. L. Rosalen 2016. ‘‘A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases.” European journal of medicinal chemistry 110.
Hossain, S., Yousaf, M., Liu, Y., Chang, D., & Zhou, X. (2022). An Overview of the Evidence and Mechanism of Drug–Herb Interactions Between Propolis and Pharmaceutical Drugs. Frontiers in Pharmacology, 13.
Nasir, N.F.; Kannan, T.P.; Sulaiman, S.A.; Shamsuddin, S.; Azlina, A.; Stangaciu, S. The relationship between telomere length and beekeeping among Malaysians. Age 2015, 37, 9797.
Cogulu, O., Biray, C., Gündüz, C., Karaca, E., Aksoylar, S., Sorkun, K., Salih, B., & Ozkinay, F. (2009). Effects of Manisa propolis on telomerase activity in leukemia cells obtained from the bone marrow of leukemia patients. International Journal of Food Sciences and Nutrition, 60, 601 - 605.
Nichitoi, M., Josceanu, A., Isopescu, R., Isopencu, G., geană, E., Ciucure, C., & Lavric, V. (2021). Polyphenolics profile effects upon the antioxidant and antimicrobial activity of propolis extracts. Scientific Reports, 11.
Farag, M., Abdelnour, S., Patra, A., Dhama, K., Dawood, M., Elnesr, S., & Alagawany, M. (2021). Propolis: properties and composition, health benefits and applications in fish nutrition. Fish & shellfish immunology.
Şahinler, N., & Kaftanoğlu, O. (2005). Natural product propolis: chemical composition. Natural Product Research, 19, 183 - 188.
Wozniak, M. M., L.; Waskiexicz; A.; Rogozinski, T.; Ratajczak; I. 2019. ‘‘The role of seasonality on the chemical composition, antioxidant activity and cytotoxicity of Polish propolis in human erythrocytes.” Revista Brasileira de Farmacognosia 29(3): 301-308.
Afrouzan, H., Tahghighi, A., Zakeri, S. and Es-haghi, A. 2018. Chemical Composition and Antimicrobial Activities of Iranian Propolis. Iranian Biomedical Journal, 22, 1, 50-65
Cushnie, T.P., Lamb, A.J., 2005. Detection of galanin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss. J. Ethnopharmacol. 101 (1–3).
Seibert, J., Bautista-Silva, J., Amparo, T., Petit, A., Pervier, P., Almeida, J., Azevedo, M., Silveira, B., Brandão, G., Souza, G., Teixeira, L., & Santos, O. (2019). Development of propolis nanoemulsion with antioxidant and antimicrobial activity for use as a potential natural preservative.. Food chemistry, 287, 61-67.
Meccatti, V., Martins, K., Ramos, L., Pereira, T., Menezes, R., Marcucci, M., Hasna, A., & Oliveira, L. (2023). Synergistic Antibiofilm Action of Cinnamomum verum and Brazilian Green Propolis Hydroethanolic Extracts against Multidrug-Resistant Strains of Acinetobacter baumannii and Pseudomonas aeruginosa and Their Biocompatibility on Human Keratinocytes. Molecules, 28.
Al-Ani, I., Zimmermann, S., Reichling, J., Wink, M., 2018. Antimicrobial Activities of European Propolis Collected from Various Geographic Origins Alone and in Combination with Antibiotics. Medicines (Basel, Switzerland) 5 (1).
Regueira, M., Tintino, S., Silva, A., Costa, M., Boligon, A., Matias, E., Balbino, V., Menezes, I., & Coutinho, H. (2017). Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 107 Pt B, 572-580 .
Orsi, R., Sforcin, J., Funari, S., Júnior, A., & Bankova, V. (2006). Synergistic effect of propolis and antibiotics on the Salmonella Typhi. Brazilian Journal of Microbiology, 37, 108-112.
Galeotti, F., Maccari, F., Fachini, A., Volpi, N., 2018. Chemical Composition and Antioxidant Activity of Propolis Prepared in Different Forms and in Different Solvents Useful for Finished Products. Foods (Basel, Switzerland) 7 (3).
Veloz, J. J., M. Alvear and L. A. Salazar 2019. ‘‘Antimicrobial and Antibiofilm Activity against Streptococcus mutans of Individual and Mixtures of the Main Polyphenolic Compounds Found in Chilean Propolis.” BioMed research international, 2:7602343.
Akilandeswari, K., Ruckmani, K., 2016. ‘‘Synergistic antibacterial effect of apigenin with b-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin-resistant Staphylococcus aureus.” Cellular and molecular biology (Noisy-le-Grand . France) 62 (14).
Eumkeb, G., Chukrathok, S., 2013. Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae. Phytomedicine: international journal of phytotherapy and phytopharmacology 20 (3–4).
Przybyłek, I., Karpinski, TM. 2019. Antibacterial Properties of Propolis. Molecules 2019, 24, 2047.
Talas, Z., & Gulhan, M. (2009). Effects of various propolis concentrations on biochemical and hematological parameters of rainbow trout (Oncorhynchus mykiss).. Ecotoxicology and environmental safety, 72 7, 1994-8 .
Mani, F., Damasceno, H., Novelli, E., Martins, E., & Sforcin, J. (2006). Propolis: Effect of different concentrations, extracts and intake period on seric biochemical variables.. Journal of ethnopharmacology, 105 1-2, 95-8 .
Mirzoeva, O. K., Grishanin, R. N., & Calder, P. C. (1997). Antimicrobial action of propolis and some of its components: the effects on growth, membrane potential and motility of bacteria. Microbiological research, 152(3), 239–246.
Kashkooli, O., Dorcheh, E., Mahboobi-Soofiani, N., & Samie, A. (2011). Long-term effects of propolis on serum biochemical parameters of rainbow trout (Oncorhynchus mykiss).. Ecotoxicology and environmental safety, 74 3, 315-8 .
Kalafova, A., Haščík, P., Kacaniova, M., Petruska, P., Capcarova, M. (2016). The effect of propolis on biochemical parameters and antioxidant status of the blood of broiler chickens. Journal of Apicultural Research. 54. 1-6.
Yılmaz, S., Sova, M., Ergün, S., 2018. Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates. J. Appl. Microbiol, 125(6):1714-1727.
Zhang, W., Margarita, G., Wu, D., Yuan, W., Yan, S., Qi, S., Xue, X., Wang, K., & Wu, L. (2022). Antibacterial Activity of Chinese Red Propolis against Staphylococcus aureus and MRSA. Molecules, 27.
Scazzocchio, F., D'Auria, F., Alessandrini, D., & Pantanella, F. (2006). Multifactorial aspects of antimicrobial activity of propolis.. Microbiological research, 161 4, 327-33 .
Almuhayawi, M.S., 2020. Propolis as a novel antibacterial agent, Saudi Journal of Biological Sciences 27 (2020) 3079–3086.
Zhang-jun, Z. (2009). Preliminary study on antibacterial activity and mechanism of propolis. Food Science and Technology International.
Orsi, R.O., Fernandes, A., Bankova, V., Sforcin, J.M., 2012. The effects of Brazilian and Bulgarian propolis in vitro against Salmonella Typhi and their synergism with antibiotics acting on the ribosome. Nat. Prod. Res. 26 (5): 430-7.
Williams, R.J., Spencer, J.P., Rice-Evans, C., 2004. Flavonoids: antioxidants or signalling molecules?. Free Radical Biol. Med. 1;36(7):838-49.
Youn, H.S., Lee, J.Y., Saitoh, S.I., Miyake, K., Kang, K.W., Choi, Y.J., Hwang, D.H., 2006. Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem. Pharmacol. 72(7):850-9.
Leitner G., Yadlin N., Lubashevsy E., Ezra E., Glickman A., Chaffer M., Winkler M., Saran A., and Trainin Z. 2003. Development of a Staphylococcus aureus vaccine against mastitis in dairy cows. II. Field trial. Veterinay Immunology and Immunopathology 93: 153–158
Yücel, B., Onenc, A., Kaya, A., and Altan, O., 2015. Efects of Propolis Administration on Growth Performance and Neonatal Diarrhea of Calves, Symbiosis Journal of Veterinary Science, 1(1): 102.
Slanzon, G.S., Toledo, A.F., Silva, A.P., Coelho, M.G., da Silva, M.D., Cezar, A.M. , Bittar, M.M., 2019. Red propolis as an additive for preweaned dairy calves: Effect on growth performance, health, and selected blood parameters. Journal of Dairy Science, 102(10):8952–8962
Shedeed, H. A., Farrag, B., Elwakeel, E. A., Abd El-Hamid, I. S., & El-Rayes, M. A. H. 2019. Propolis supplementation improved productivity, oxidative status, and immune response of Barki ewes and lambs. Veterinary world, 12(6): 834.
Kabiloglu, A., Kocabağlı, N., Ilgın Kekeç, A. 2023. Effect of propolis extract on growth performance and health conditions of dairy calves. Tropical Animal Health and Production, 55(115).
Morsy, A.S., Soltan, Y.A., El-Zaiat, H.M., Alencar, S.M.,Abdalla, A.L. 2021. Bee propolis extract as a phytogenic feed additive to enhance diet digestibility, rumen microbial biosynthesis, mitigating methane formation and health status of late pregnant ewes. Animal Feed Science and Technology 273 (2021) 114834.
Cecere, B.G.O., da Silva, A.S., Molosse, V.L., Alba, D.F., Leal, K.W., da Rosa, G,. Pereira, W.A.B., da Silva,A.D., Schetinger, M.R.C., Kempka, A.P., Nunes, A., Maraschin, M., Araujo, D.N., Deolindo, G.L. & Vedovatto, M., 2021. Addition of propolis to milk improves lactating lamb’s growth: effect on Antimicrobial, Antioxidant and Immune Responses in Animals, Small Ruminant Research, 194: 106265.
Dezmirean DS, Paşca C, Moise AR, Bobiş O. Plant Sources Responsible for the Chemical Composition and Main Bioactive Properties of Poplar-Type Propolis. Plants. 2021; 10(1):22.
Bacic, G., Macesic, N., Radin, L., Aladrovic, J., Matanovic, K., Masek, T., Brozic, D., Benic, M., Radic, B., Bacic, I., Suran, J. 2016. Intramammary propolis formulation for subclinical mastitis prevention and treatment in dairy cows. J Dairy Vet Anim Res. 2016;3(5):159.
Voitenko, L & Voitenko, O. (2021). Zootechnical and veterinary methods of high-producing dairy cows treatment. IOP Conference Series: Earth and Environmental Science. 640. 032053.
Mukherjee, R., Dash, P. K. and Ram, G. C. 2005. Immunotherapeutic potential of Ocimum sanctum (L) in bovine subclinical mastitis. Research in veterinary science, 79(1): 37-43.
Santana, H. F., Barbosa, A. A. T., Ferreira, S. D., & Mantovani, H. C. 2012. Bactericidal activity of ethanolic extracts of propolis against Staphylococcus aureus isolated from mastitic cows. World Journal of Microbiology & Biotechnology, 28(2):485-491. http://dx.doi. org/10.1007/s11274-011-0839-7. PMid:22806843.
Silva J.C., Rodrigues S., Feás X. & Estevinho L.M. 2012. Antimicrobial activity, phenolic profile and role in the inflammation of propolis. Food Chem. Toxicol. 50(5):1790-1795.
František, Z., Zigová Martin, Z., Milan, V. 2019. Distribution of Bacterial Pathogens Causing Mastitis in Dairy Cows,‖ International Research Journal of Pharmacy and Medical Sciences (IRJPMS), 3(1): 49-52.
Wei, W., L. Dejie, S. Xiaojing, W. Tiancheng, C. Yongguo, T. Zhengtao, Z. Naisheng. 2015. Magnolol inhibits the inflammatory response in mouse mammary epithelial cells and mouse mastitis model. Inflammation 38:16–26.
Romvary, A., G. Szita, G. Csiko, Z. Gaspar, and I. Gaspar. 1993. Effectiveness of an intramammary infusion with no antibiotics. IV. Innocuity test of new intramammary infusion. Magyar Allatorvosok Lapja 48:493–497.
Wagh, V.D. 2013. Propolis: A Wonder Bees Product and ItsPharmacological Potentials. Advances in Pharmacological Sciences, Article ID 308249, 11 pages
Deolindo, G. L. .; Molosse, V. L. .; Dilda, A.; Girardini, L. K. .; Vedovatto, M.; Silva, A. S. Da; Araujo, D. N. . Lacaune ewes with subclinical mastitis: effects of intramammary application of própolis. Research, Society and Development, [S. l.], v. 10, n. 2, p. e18210211709, 2021.
Langoni H., Araújo W.N., Silva A.V., Souza L.C. 2000. Tratamento da mastite bovina com amoxicilina e enrofloxacina bem como a sua associação. Arq. Inst. Biológico, São Paulo, 67:177-180.
Hegazi AG, El-Houssiny AS, Sadek WMA, Al-Guthami FM, Al-Gethami AFM, Sadik AMA, Farag T.K. 2021. Egyptian propolis 13: Influence of propolis and alginate-propolis NPs on Egyptian Nubian goats serum immunoglobulins and cytokines level. Advances in Animal and Veterinary Sciences, 9(2): 280-288.
Kawakami, Y., Yanagawa, A., Mizushima, Y., & Narikawa, S. (1997). Antimicrobial activity of propolis.. , 17, 573-576.
Santos, H., Vieira, D., Yamamoto, S., Costa, M., Sá, M., Silva, E., & Silva, T. (2019). Antimicrobial activity of propolis extract fractions against Staphylococcus spp. isolated from goat mastitis. Pesquisa Veterinária Brasileira.
Karslı, M.A. & Evci, Ş., 2018. The Importance of Cattle and Calf Nutrition in Preventing Calf Losses. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 58:23–34.
Nascimento, T. S., Silva, I. S. M., Alves, M. C. M. A., Gouveia, B. B., Barbosa, L. M. R., Macedo, T. J. S., Santos, J. M. S., Monte, A. P. O., Matos, M. H. T., Padilha, F. F., & Lima-Verde, I. B. (2019). Effect of red propolis extract isolated or encapsulated in nanoparticles on the in vitro culture of sheep preantral follicle: Impacts on antrum formation, mitochondrial activity and glutathione levels. Reproduction in domestic animals = Zuchthygiene, 54(1), 31–38.
Machado, G., Veleirinho, M., Mazzarino, L., Filho, L., Maraschin, M., Cerri, R., & Kuhnen, S. (2019). Development of propolis nanoparticles for the treatment of bovine mastitis: in vitro studies on antimicrobial and cytotoxic activities. Canadian Journal of Animal Science, 99, 713 - 723.
Skliarov, P. M., Fedorenko, S. Y., Onyshchenko, O. V., PasternakА. М., Lieshchova, M. A., Bilyi, D. D., Vakulyk, V. V., Antonenko, P. P., & Mylostyvyi, R. V. (2021). The effectiveness of ozone therapy in goats with mastitis. Theoretical and Applied Veterinary Medicine, 9(1), 24-29.
Sinha, M.K.; Thombare, N.N.; Mondal, B. 2104. Subclinical Mastitis in Dairy Animals: Incidence, Economics, and Predisposing Factors. Sci. World J. 523984.
Singh, A.K. 2022. A comprehensive review on subclinical mastitis in dairy animals: Pathogenesis, factors associated, prevalence, economic losses and management strategies. CABI Reviews (2022) 17, No. 057
Armağan Aydın, T. 2021. İneklerde Subklinik Mastitis Tanısında Akut Faz Proteinlerinden Amiloid A ve C-Reaktif Protein’in Belirlenmesi. T.C. Harran Üniversitesi Sağlik Bilimleri Enstitüsü Doğum ve Jinekoloji Anabilim Dalı, Yüksek Lisans Tezi, Şanlı Urfa.
Riollet, C., Rainard, P., Poutrel, B. 2001. Cell Subpopulations and Cytokine Expression in Cow Milk in Response to Chronic Staphylococcus aureus infection. J.DairySci., 84:1077–1084
Gómez, P., Jon, L., Torres, D., Amaranto, R., Díaz, I., & Medina, C. (2021). Antibacterial, antibiofilm, and cytotoxic activities and chemical compositions of Peruvian propolis in an in vitro oral biofilm. F1000Research, 10, 1093.
Popova, M., Silici, S., Kaftanoglu, O., Bankova, V. Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition, Phytomedicine, Volume 12, Issue 3, 2005, Pages 221-228, ISSN 0944-7113.
Nedji, N., & Loucif-Ayad, W. (2014). Antimicrobial activity of Algerian propolis in foodborne pathogens and its quantitative chemical composition. Asian Pacific Journal of Tropical Disease, 4, 433-437.
Airen B., Sarkar P.A., Tomar U., Bishen K.A. Antibacterial effect of propolis derived from tribal region on. J Indian Soc Pedod Prev Dent. 2018;36(1):48–52.
Muli, E., & Maingi, J. (2007). Antibacterial activity of Apis mellifera L. propolis collected in three regions of Kenya. Journal of Venomous Animals and Toxins Including Tropical Diseases, 13, 655-663.
Nina, N., Quispe, C., Jiménez-Aspee, F., Theoduloz, C., Feresin, G., Lima, B., Leiva, E., & Schmeda-Hirschmann, G. (2015). Antibacterial Activity, Antioxidant Effect and Chemical Composition of Propolis from the Región del Maule, Central Chile. Molecules, 20, 18144 - 18167.
Al-Waili N., Al-Ghamdi A., Ansari M.J., Al-Attal Y., Salom K. Synergistic effects of honey and propolis toward drug multi-resistant Staphylococcus aureus, Escherichia coli and Candida albicans isolates in single and polymicrobial cultures. International J. Medical Sci. 2012;9(9)
Mohammadzadeh, S., Shariatpanahi, M., Hamedi, M., Ahmadkhaniha, R., Samadi, N., & Ostad, S. (2007). Chemical composition, oral toxicity and antimicrobial activity of Iranian propolis. Food Chemistry, 103, 1097-1103. https://doi.org/10.1016/J.FOODCHEM.2006.10.006.
