Koenzim Q10’Un Etki Mekanizması ve Hastalıklarla İlişkisi
Özet
Koenzim Q10; benzokinon yapısında olan, her hücrede bulunan, mitokondriyal enerji sisteminde kritik rollere sahip insan sağlığı üzerine rolleri araştırılan önemli bir bileşiktir. Mitokondrideki elektron taşıma sistemi üzerinde elektron taşıyıcılığı rolü, antioksidan rolü ve yaşlanma karşıtı (anti-aging) rolü bulunan Koenzim Q10’un birçok hastalıkta eksikliğinin kilit bir fonksiyonu olduğu düşünülmektedir. Bu bölümün amacı Koenzim Q10’un etki mekanizmasının incelemek ve çeşitli hastalıklardaki etkisini belirlemektir. Koenzim Q10’un hipertansiyon, dislipidemi, kalp yetmezliği, parkinson, demans ve diyabet gibi hastalıklarda eksikliğine dair bulgulara rastlanmıştır. İnsan vücudunda Koenzim Q10’un çeşitli hastalıklarda tedavi aşamasında olmasa da takviye açısından yararlı olduğu bulunmuş, bununla birlikte etki mekanizması net olarak aydınlatılamamıştır. Bu nedenle Koenzim Q10’un hastalıkların tedavisinde güvenli bir şekilde kullanılması için bu konu ile ilgili daha fazla araştırmaya ihtiyaç vardır.
Coenzyme Q10; It is an important compound with a benzoquinone structure, found in every cell, and has critical roles in the mitochondrial energy system, and its roles in human health are being investigated. Coenzyme Q10, which has an electron transport role on the electron transport system in mitochondria, an antioxidant role, and an anti-aging role, is thought to have a key function in many diseases. The aim of this chapter is to examine the mechanism of action of Coenzyme Q10 and determine its effect on various diseases. Findings of Coenzyme Q10 deficiency have been found in diseases such as hypertension, dyslipidemia, heart failure, Parkinson's, dementia, and diabetes. It has been found that Coenzyme Q10 is useful in terms of supplementation in the human body, although not in the treatment phase, in various diseases, however, its mechanism of action has not been clearly elucidated. Therefore, more research is needed on this subject for the safe use of Coenzyme Q10 in the treatment of diseases.
Referanslar
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Crane FL. Discovery of ubiquinone (coenzyme Q) and an overview of function. Mitochondrion. 2007;7 Suppl:S2-7. doi: 10.1016/j.mito.2007.02.011.
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Referanslar
Varela-López A, Giampieri F, Battino M, Quiles JL. Coenzyme Q and its role in the dietary therapy against aging. Molecules.2016;18:21(3):373. https://doi.org/10.3390/molecules21030373
Ercan P, El S. Koenzim Q10’un beslenme ve sağlık açısından önemi ve biyoyararlılığı. TÜBAV Bilim Dergisi. 2010;3(2):192-200.
Overvad K, Diamant B, Holm L, Holmer G, Mortensen SA, Stender S. Coenzyme Q10 in health and disease. European journal of clinical nutrition. 1999;53(10):764-70. doi: 10.1038/sj.ejcn.1600880.
Åberg F, Appelkvist E-L , Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Archives of Biochemistry and Biophysics. 1992;295(2):230-4. doi: 10.1016/0003-9861(92)90511-t.
Stefely JA, Pagliarin DJ. Biochemistry of mitochondrial coenzyme Q biosynthesis. Trends in biochemical sciences. 2017;42(10):824-843. doi: 10.1016/j.tibs.2017.06.008.
Campisi L, La Motta C. The use of the coenzyme Q10 as a food supplement in the management of fibromyalgia: A critical review. Coenzyme Q10 in fibromyalgia. Antioxidants. 2022;11(10), 1969. https://doi.org/10.3390/antiox11101969
Crane FL. Biochemical functions of coenzyme Q10. Journal of the American College of Nutrition. 2001;20(6):591-8. doi: 10.1080/07315724.2001.10719063.
Hoppe Professor Dr U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D, Sauermann G, Schreiner V, Stäb F, Steckel F. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8. doi: 10.1002/biof.5520090238.
Gaweł S, Wardas M, Niedworok E, Wardas P. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiadomości lekarskie. 2004;57(9-10):453-5.
Akan M. Yaşlanma ile koenzim Q10 ve antioksidanların ilişkisi. Yüksek lisans tezi, Gaziantep, 2011.
Crane FL. Discovery of ubiquinone (coenzyme Q) and an overview of function. Mitochondrion. 2007;7 Suppl:S2-7. doi: 10.1016/j.mito.2007.02.011.
Green DE, Loomıs WF, Auerbach VH. Studies on the cyclophorase system; the complete oxidation of pyruvic acid to carbondioxide and water. Journal of Biological Chemistry 1948;172(2):389-403.
Abdul-Rasheed OF, Farid YY. Development of a new high performance liquid chromatography method for measurement of coenzyme Q10 in healthy blood plasma. Saudi Medical Journal 2009;30(9):1138-43.
Bentinger M, Brismar K, Dallner G. The antioxidant role of coenzyme Q. Mitochondrion. 2007;7: S41-S50. doi: 10.1016/j.mito.2007.02.006.
Ersnter L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et biophysica açta. 1995;1271(1):195-204. doi: 10.1016/0925-4439(95)00028-3.
Gutierrez-Mariscal FM, Yubero-Serrano EM, Villalba JM, Lopez-Miranda J. Coenzyme Q10: from bench to clinic in aging diseases, a translational review. Critical reviews in food science and nutrition. 2019;59(14):2240-2257. doi: 10.1080/10408398.2018.1442316.
Nakamura T, Ohno T, Hamamura K, Sato T. Metabolism of coenzyme Q10: biliary and urinary excretion study in guinea pigs. Biofactors. 1999;9(2-4):111-9. doi: 10.1002/biof.5520090205. PMID: 10416022.
Bentinger M, Dallner G, Chojnaki T, Swiezewska E. Distribution and breakdown of labeled coenzyme Q10 in rat. Free Radical Biology and Medicine. 2003;34 (5):563-575. doi: 10.1016/s0891-5849(02)01357-6.
Rauchova H. Coenzyme Q10 effects in neurological diseases. Physiological reviews. 2021; 70(Suppl 4): 683–714. doi: 10.33549/physiolres.934712.
Aaseth J, Alexander J, Alegahen U. Coenzyme Q10 supplementation – In ageing and disease. Mechanisms of Ageing and Development. 2021;7:111521. doi: 10.1016/j.mad.2021.111521.
Oparil S, Czarina Acelajado M, Bakris G. L., Berlowitz DR, Cífková R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, Whelton PK. Hypertension. Nature Reviews Disease Primers. 2018; 4, 18014. doi: 10.1038/nrdp.2018.14.
Digiesi V, Cantini F, Oradei A, Bisi G, Guarino GC, Brocchi A, Bellandi F, Mancini M, Littarru GP. Coenzyme Q10 in essential hypertension. Molecular Aspects of Medicine. 1994;15 (Supplement 1):257-263. doi: 10.1016/0098-2997(94)90036-1.
Rabanal-Ruiz Y, Llanos-González E, Alcain FJ. The Use of Coenzyme Q10 in cardiovascular diseases. Antioxidants. 2021;10(5):755. doi: 10.3390/antiox10050755.
Kimura I, Kimura M, Tsuneki H, Sasaoka T, Koya S. Can Coenzyme Q10 lead to improvement of essential hypertension?: a long-term case study. Journal of Health Science. 2008;54(5): 571-575. Doi: 10.1248/jhs.54.571
Mthembu SXH, Orlando P , Silvestri S, Ziqubu K, Mazibuko-Mbeje SE, Mabhida SE, Nyambuya TM, Nkambule BB, Muller CJF, Basson AK, Tiano L, Dludla PV. Impact of dyslipidemia in the development of cardiovascular complications: Delineating the potential therapeutic role of coenzyme Q10. Biochimie. 2023;204:33-40. doi: 10.1016/j.biochi.2022.08.018.
Bentinger M, Tekle M, Dallner G. Coenzyme Q--biosynthesis and functions. Biochemical and biophysical research communications. 2010; 21:396(1):74-9. doi: 10.1016/j.bbrc.2010.02.147.
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