Bakteriyel Etkenler
Özet
Afet sonrası toplu yaşam; yetersiz hijyen ve beslenmeyle bağışıklığın azalması üst ve alt solunum yolu enfeksiyonlarını artırabilmektedir. Bu enfeksiyonlarda bakteriyel etkenler virüslerden sonra ikinci sırada görülür. Tsunami sinüziti en çok görülen üst solunum yolu enfeksiyonudur. Deniz kumunun sinüslerde birikmesiyle oluşur ve çoklu gram negatif bakteriler en sık görülen etkendir. Alt solunum yolu salgınlarında ise en sık sırasıyla Streptococcus pneumoniae, Haemophilus influenzae, Bordetella pertussis, Legionella spp. ve Mycobacterium tuberculosis etken olmaktadır. Tüberküloz hastalığının doğası gereği afet dönemlerinde yaşam koşullarının fiziksel değişkenliğinden dolayı daha hızlı yayılabilir. Afetzedelerin kişisel risk faktörlerinin artması ile latent tüberküloz vakalarının aktif hale geçmesinde artış gözlenir. Afet sonrasında tüberküloz dışı mikobakteri enfeksiyonlarında da bozulmuş ekosisteme bağlı olarak artış görülmektedir. Solunum yolu örneklerinin özelliklerine bağlı olarak ayırıcı tanıda zorluklar yaşanabilmektedir. Solunum yolu enfeksiyonlarının tanısında kültür halen altın standart yöntem olarak yerini korumaktadır. Ancak afet dönemlerinde tanı için hızlı boyama yöntemleri, hasta başı hızlı moleküler yöntemler ile tanı konulması ve direnç patentlerinin belirlenmesi ile vakaların tedavisi zamanında yapılmalıdır. Akut solunum yolu enfeksiyonu tanısında kullanılan sendromik panel testlerinin pratik ve maliyet etkin bir yöntem olarak kullanımı için ise biraz daha zamana ihtiyaç vardır.
Communal living after the disaster; decreased immunity due to inadequate hygiene and malnutrition can increase upper and lower respiratory tract infections. Bacterial pathogens are seen second only to viruses. Tsunami sinusitis is the most common upper respiratory tract infection. It occurs when sea sand accumulates in the sinuses and gram-negative bacteria are the most common agents. The most common pathogens in bacterial lower respiratory tract epidemics due to disasters are Streptococcus pneumoniae, Haemophilus influenzae, Bordetella pertussis, Legionella spp. and Mycobacterium tuberculosis. Due to the nature of tuberculosis disease, it can spread more rapidly during disaster periods because of the physical variability of living conditions. There is an increase in the activation of latent tuberculosis cases due to increased personal risk factors of disaster victims. There is also an increase in non-tuberculous mycobacterial infections after a disaster based on the disrupted ecosystem. Difficulties may be experienced in differential diagnosis depending on the characteristics of respiratory tract samples. Culture remains the gold standard method in the diagnosis of respiratory tract infections. However, rapid staining methods for the diagnosis in disaster periods, diagnosis with rapid molecular methods at the bedside, determination of resistance patents, and treatment of cases should be done in a timely manner. Time is needed for research of syndromic panel tests used in the diagnosis of acute respiratory tract infection to be used as a practical and cost-effective method.
Referanslar
Burdass D. Microbes and. J Sea Res. 2008;169–70.
Smith DFQ, Casadevall A. Disaster Microbiology-a New Field of Study. mBio. 2022 ;13(4).
Nawfal Dagher T, Al-Bayssari C, Diene SM, Azar E, Rolain JM. Bacterial infection during wars, conflicts and post-natural disasters in Asia and the Middle East: a narrative review. Expert Rev Anti Infect Ther. 2020;18(6):511–29.
Kouadio IK, Aljunid S, Kamigaki T, Hammad K, Oshitani H. Infectious diseases following natural disasters: Prevention and control measures. Expert Rev Anti Infect Ther. 2012;10(1):95–104.
Kim M, Kim K, Kim E. Problems and Implications of Shelter Planning Focusing on Habitability. A Case Study of a Temporary Disaster Shelter after the Pohang Earthquake in South Korea. 2021;
Charnley GEC, Kelman I, Gaythorpe KAM, Murray KA. Traits and risk factors of post-disaster infectious disease outbreaks: a systematic review. Sci Rep 2021;11(1):1–14.
Murdoch DR, Werno AM, Jennings LC. Microbiological diagnosis of respiratory illness: recent advances. Kendig’s Disorders of the Respiratory Tract in Children. 2019;396–405.
Burhan E, Mukminin U. A systematic review of respiratory infection due to air pollution during natural disasters. Med J Indones 2020;29(1):11–8.
Mavrouli M, Mavroulis S, Lekkas E, Tsakris A. Respiratory infections following earthquake-induced tsunamis: Transmission risk factors and lessons learned for disaster risk management. Int J Environ Res Public Health 2021;18(9).
Chimed-Ochir O, Yumiya Y, Taji A, Kishita E, Kondo H, Wakai A, et al. Emergency Medical Teams’ Responses during the West Japan Heavy Rain 2018: J-SPEED Data Analysis. Prehosp Disaster Med 2022;37(2):205–11.
Giri BR, Chapagain RH, Sharma S, Shrestha S, Ghimire S, Shankar PR. Effect of the 2015 earthquake on pediatric inpatient pattern at a tertiary care hospital in Nepal. BMC Pediatr 2018;18(1):1–7.
Mavrouli M, Mavroulis S, Lekkas E, Tsakris A. An Emerging Health Crisis in Turkey and Syria after the Earthquake Disaster on 6 February 2023: Risk Factors, Prevention and Management of Infectious Diseases. Healthcare (Switzerland). 2023;11(7).
Uddin KN. Nature, Our Climate and Our Health Risks. BIRDEM Medical Journal 2017;7(3):179–86.
Yorifuji T, Sato T, Yoneda T, Kishida Y, Yamamoto S, Sakai T, et al. Disease and injury trends among evacuees in a shelter located at the epicenter of the 2016 Kumamoto earthquakes, Japan. Arch Environ Occup Health 2018;73(5):284–91.
Limchawalit K, Suchato C. Tsunami Sinusitis. N Engl J Med. 2005;352(25):e23.
Maegele M, Gregor S, Yuecel N, Simanski C, Paffrath T, Rixen D, et al. One year ago not business as usual: Wound management, infection and psychoemotional control during tertiary medical care following the 2004 Tsunami disaster in southeast Asia. Crit Care 2006;10(2):1–9.
Baba S, Kondo K, Kanaya K, Suzukawa K, Sato T, Kurata H, et al. Tsunami sinusitis. The Lancet 2011;378(9796):1116.
İ KLİMUDR. Tıbbi Mikrobiyoloji Uzmanları için.
Ray CG, Ryan KJ. Sherris medical microbiology. McGraw-Hill Education/Medical New York, NY, USA; 2014.
Mavrouli M, Mavroulis S, Lekkas E, Tsakris A. Respiratory infections following earthquake-induced tsunamis: Transmission risk factors and lessons learned for disaster risk management. Int J Environ Res Public Health 2021;18(9).
Das S, Dunbar S, Tang YW. Laboratory diagnosis of respiratory tract infections in children - The state of the art. Front Microbiol 2018;9(OCT):1–9.
Leber AL. (2016). Clinical Microbiology Procedures Handbook. ASM Press. 2016.
Miller JM, Binnicker MJ, Campbell S, Carroll KC, Chapin KC, Gilligan PH, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis 2018;67(6):e1–94.
Das S, Dunbar S, Tang YW. Laboratory diagnosis of respiratory tract infections in children - The state of the art. Front Microbiol 2018;9(OCT):1–9.
Calderaro A, Buttrini M, Farina B, Montecchini S, De Conto F, Chezzi C. Respiratory tract infections and laboratory diagnostic methods: A review with a focus on syndromic panel-based assays. Microorganisms 2022;10(9):1856.
Mellinger CW, Ginzl D, Pragle A, Lolley D, Schulte J. The impact of Hurricane Ivan on the management of a pertussis outbreak. In: 39th National Immunization Conference. 2005. p. 20–4.
Lemonick DM. Epidemics after natural disasters. Am J Clin Med 2011;8(3):144–52.
Yamauchi K, Nagashima H, Nakadate T, Nakamura Y. Tsunami Lung in Great East Japan Earthquake 2011: Clinical Time Course, Feature, Pathogenesis, and Treatment. Disaster and Respiratory Diseases. 2019;23–35.
Cristovam E, Almeida D, Caldeira D, Ferreira JJ, Marques T. Accuracy of diagnostic tests for legionnaires’ disease: A systematic review. J Med Microbiology 2017; 66: 485–9.
Zanella MC, Meylan P, Kaiser L. Syndromic panels or ‘panel syndrome’? A perspective through the lens of respiratory tract infections. Clinical Microbiology and Infection. 2020;26(6):665–8.
Hanson KE, Azar MM, Banerjee R, Chou A, Colgrove RC, Ginocchio CC, et al. Molecular testing for acute respiratory tract infections: Clinical and diagnostic recommendations from the IDSA’s diagnostics committee. Vol. 71, Clinical Infectious Diseases. Oxford University Press; 2020. p. 2744–51.
Lee SH, Ruan SY, Pan SC, Lee TF, Chien JY, Hsueh PR. Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units. Journal of Microbiology, Immunology and Infection. 2019 Dec 1;52(6):920–8.
Brendish NJ, Mills S, Ewings S, Clark TW. Impact of point-of-care testing for respiratory viruses on antibiotic use in adults with exacerbation of airways disease. J Infect. 2019 Oct 1;79(4):357–62.
Ramanan P, Bryson AL, Binnicker MJ, Pritt BS, Patel R. Syndromic panel-based testing in clinical microbiology. Clin Microbiol Rev. 2018;31(1).
https://www.fda.gov/medical-devices/in-vitro-diagnostics/nucleic-acid-based-tests.
Klompas M. Clinical evaluation and diagnostic testing for community-acquired pneumonia in adults. Wolters Kluwer. https://www. uptodate. com/contents/clinical-evaluation-and …;
Murray KO, Castillo-Carandang NT, Mandalakas AM, Cruz AT, Leining LM, Gatchalian SR, et al. Prevalence of tuberculosis in children after natural disasters, Bohol, Philippines. Emerg Infect Dis. 2019;25(10):1884.
Organization WH. Moving beyond the tsunami-The WHO story. WHO Regional Office for South-East Asia; 2005.
Bagcchi S. WHO’s Global Tuberculosis Report 2022. Lancet Microbe. 2023;4(1):e20.
Coleman M, Martinez L, Theron G, Wood R, Marais B. Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights. Pathogens. 2022;11(11):1228.
Robinson B, Alatas MF, Robertson A, Steer H. Natural disasters and the lung. Respirology. 2011;16(3):386–95.
Shears P. Epidemiology and infection in famine and disasters. Epidemiol Infect. 1991;107(2):241–51.
Centers for Disease Control and Prevention. (2023, March 22). Tuberculosis information for emergencies and Disasters. Centers for Disease Control and Prevention. https://www.cdc.gov/tb/education/emergencies-and-disasters.htm [Internet].
Kanamori H, Hatakeyama T, Uchiyama B, Weber DJ, Takeuchi M, Endo S, et al. Clinical and molecular epidemiological features of tuberculosis after the 2011 Japan earthquake and tsunami. Int J Tuberc Lung Dıs. 2016;20(4):505–14.
Sakurai M, Takahashi T, Ohuchi M, Terui Y, Kiryu K, Shikano K. Increasing incidence of tuberculosis infection in the coastal region of Northern Miyagi after the Great East Japan Earthquake. Tohoku J Exp Med. 2016;238(3):187–95.
Othman N, Ismail IH, Yip R, Zainuddin Z, Kasim SM, Isa R, et al. Infections in post-tsunami victims. Pediatr Infect Dis J. 2007;26(10):960–1.
Kendall BA, Winthrop KL. Update on the epidemiology of pulmonary nontuberculous mycobacterial infections. In: Seminars in respiratory and critical care medicine. Thieme Medical Publishers; 2013. p. 87–94.
Honda JR, Bernhard JN, Chan ED. Natural disasters and nontuberculous mycobacteria: a recipe for increased disease? Chest. 2015;147(2):304–8.
Ben Salah I, Drancourt M. Surviving within the amoebal exocyst: the Mycobacterium avium complex paradigm. BMC Microbiol. 2010;10(1):1–8.
Heemskerk D, Caws M, Marais B, Farrar J. Tuberculosis in adults and children. 2015;
Abacıoğlu YH, Sönmez C. Ulusal Mikrobiyoloji Standartları Laboratuvar Güvenliği Rehberi. TC Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Başkanlığı, Ankara, 345s. 2014;
Referanslar
Burdass D. Microbes and. J Sea Res. 2008;169–70.
Smith DFQ, Casadevall A. Disaster Microbiology-a New Field of Study. mBio. 2022 ;13(4).
Nawfal Dagher T, Al-Bayssari C, Diene SM, Azar E, Rolain JM. Bacterial infection during wars, conflicts and post-natural disasters in Asia and the Middle East: a narrative review. Expert Rev Anti Infect Ther. 2020;18(6):511–29.
Kouadio IK, Aljunid S, Kamigaki T, Hammad K, Oshitani H. Infectious diseases following natural disasters: Prevention and control measures. Expert Rev Anti Infect Ther. 2012;10(1):95–104.
Kim M, Kim K, Kim E. Problems and Implications of Shelter Planning Focusing on Habitability. A Case Study of a Temporary Disaster Shelter after the Pohang Earthquake in South Korea. 2021;
Charnley GEC, Kelman I, Gaythorpe KAM, Murray KA. Traits and risk factors of post-disaster infectious disease outbreaks: a systematic review. Sci Rep 2021;11(1):1–14.
Murdoch DR, Werno AM, Jennings LC. Microbiological diagnosis of respiratory illness: recent advances. Kendig’s Disorders of the Respiratory Tract in Children. 2019;396–405.
Burhan E, Mukminin U. A systematic review of respiratory infection due to air pollution during natural disasters. Med J Indones 2020;29(1):11–8.
Mavrouli M, Mavroulis S, Lekkas E, Tsakris A. Respiratory infections following earthquake-induced tsunamis: Transmission risk factors and lessons learned for disaster risk management. Int J Environ Res Public Health 2021;18(9).
Chimed-Ochir O, Yumiya Y, Taji A, Kishita E, Kondo H, Wakai A, et al. Emergency Medical Teams’ Responses during the West Japan Heavy Rain 2018: J-SPEED Data Analysis. Prehosp Disaster Med 2022;37(2):205–11.
Giri BR, Chapagain RH, Sharma S, Shrestha S, Ghimire S, Shankar PR. Effect of the 2015 earthquake on pediatric inpatient pattern at a tertiary care hospital in Nepal. BMC Pediatr 2018;18(1):1–7.
Mavrouli M, Mavroulis S, Lekkas E, Tsakris A. An Emerging Health Crisis in Turkey and Syria after the Earthquake Disaster on 6 February 2023: Risk Factors, Prevention and Management of Infectious Diseases. Healthcare (Switzerland). 2023;11(7).
Uddin KN. Nature, Our Climate and Our Health Risks. BIRDEM Medical Journal 2017;7(3):179–86.
Yorifuji T, Sato T, Yoneda T, Kishida Y, Yamamoto S, Sakai T, et al. Disease and injury trends among evacuees in a shelter located at the epicenter of the 2016 Kumamoto earthquakes, Japan. Arch Environ Occup Health 2018;73(5):284–91.
Limchawalit K, Suchato C. Tsunami Sinusitis. N Engl J Med. 2005;352(25):e23.
Maegele M, Gregor S, Yuecel N, Simanski C, Paffrath T, Rixen D, et al. One year ago not business as usual: Wound management, infection and psychoemotional control during tertiary medical care following the 2004 Tsunami disaster in southeast Asia. Crit Care 2006;10(2):1–9.
Baba S, Kondo K, Kanaya K, Suzukawa K, Sato T, Kurata H, et al. Tsunami sinusitis. The Lancet 2011;378(9796):1116.
İ KLİMUDR. Tıbbi Mikrobiyoloji Uzmanları için.
Ray CG, Ryan KJ. Sherris medical microbiology. McGraw-Hill Education/Medical New York, NY, USA; 2014.
Mavrouli M, Mavroulis S, Lekkas E, Tsakris A. Respiratory infections following earthquake-induced tsunamis: Transmission risk factors and lessons learned for disaster risk management. Int J Environ Res Public Health 2021;18(9).
Das S, Dunbar S, Tang YW. Laboratory diagnosis of respiratory tract infections in children - The state of the art. Front Microbiol 2018;9(OCT):1–9.
Leber AL. (2016). Clinical Microbiology Procedures Handbook. ASM Press. 2016.
Miller JM, Binnicker MJ, Campbell S, Carroll KC, Chapin KC, Gilligan PH, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis 2018;67(6):e1–94.
Das S, Dunbar S, Tang YW. Laboratory diagnosis of respiratory tract infections in children - The state of the art. Front Microbiol 2018;9(OCT):1–9.
Calderaro A, Buttrini M, Farina B, Montecchini S, De Conto F, Chezzi C. Respiratory tract infections and laboratory diagnostic methods: A review with a focus on syndromic panel-based assays. Microorganisms 2022;10(9):1856.
Mellinger CW, Ginzl D, Pragle A, Lolley D, Schulte J. The impact of Hurricane Ivan on the management of a pertussis outbreak. In: 39th National Immunization Conference. 2005. p. 20–4.
Lemonick DM. Epidemics after natural disasters. Am J Clin Med 2011;8(3):144–52.
Yamauchi K, Nagashima H, Nakadate T, Nakamura Y. Tsunami Lung in Great East Japan Earthquake 2011: Clinical Time Course, Feature, Pathogenesis, and Treatment. Disaster and Respiratory Diseases. 2019;23–35.
Cristovam E, Almeida D, Caldeira D, Ferreira JJ, Marques T. Accuracy of diagnostic tests for legionnaires’ disease: A systematic review. J Med Microbiology 2017; 66: 485–9.
Zanella MC, Meylan P, Kaiser L. Syndromic panels or ‘panel syndrome’? A perspective through the lens of respiratory tract infections. Clinical Microbiology and Infection. 2020;26(6):665–8.
Hanson KE, Azar MM, Banerjee R, Chou A, Colgrove RC, Ginocchio CC, et al. Molecular testing for acute respiratory tract infections: Clinical and diagnostic recommendations from the IDSA’s diagnostics committee. Vol. 71, Clinical Infectious Diseases. Oxford University Press; 2020. p. 2744–51.
Lee SH, Ruan SY, Pan SC, Lee TF, Chien JY, Hsueh PR. Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units. Journal of Microbiology, Immunology and Infection. 2019 Dec 1;52(6):920–8.
Brendish NJ, Mills S, Ewings S, Clark TW. Impact of point-of-care testing for respiratory viruses on antibiotic use in adults with exacerbation of airways disease. J Infect. 2019 Oct 1;79(4):357–62.
Ramanan P, Bryson AL, Binnicker MJ, Pritt BS, Patel R. Syndromic panel-based testing in clinical microbiology. Clin Microbiol Rev. 2018;31(1).
https://www.fda.gov/medical-devices/in-vitro-diagnostics/nucleic-acid-based-tests.
Klompas M. Clinical evaluation and diagnostic testing for community-acquired pneumonia in adults. Wolters Kluwer. https://www. uptodate. com/contents/clinical-evaluation-and …;
Murray KO, Castillo-Carandang NT, Mandalakas AM, Cruz AT, Leining LM, Gatchalian SR, et al. Prevalence of tuberculosis in children after natural disasters, Bohol, Philippines. Emerg Infect Dis. 2019;25(10):1884.
Organization WH. Moving beyond the tsunami-The WHO story. WHO Regional Office for South-East Asia; 2005.
Bagcchi S. WHO’s Global Tuberculosis Report 2022. Lancet Microbe. 2023;4(1):e20.
Coleman M, Martinez L, Theron G, Wood R, Marais B. Mycobacterium tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights. Pathogens. 2022;11(11):1228.
Robinson B, Alatas MF, Robertson A, Steer H. Natural disasters and the lung. Respirology. 2011;16(3):386–95.
Shears P. Epidemiology and infection in famine and disasters. Epidemiol Infect. 1991;107(2):241–51.
Centers for Disease Control and Prevention. (2023, March 22). Tuberculosis information for emergencies and Disasters. Centers for Disease Control and Prevention. https://www.cdc.gov/tb/education/emergencies-and-disasters.htm [Internet].
Kanamori H, Hatakeyama T, Uchiyama B, Weber DJ, Takeuchi M, Endo S, et al. Clinical and molecular epidemiological features of tuberculosis after the 2011 Japan earthquake and tsunami. Int J Tuberc Lung Dıs. 2016;20(4):505–14.
Sakurai M, Takahashi T, Ohuchi M, Terui Y, Kiryu K, Shikano K. Increasing incidence of tuberculosis infection in the coastal region of Northern Miyagi after the Great East Japan Earthquake. Tohoku J Exp Med. 2016;238(3):187–95.
Othman N, Ismail IH, Yip R, Zainuddin Z, Kasim SM, Isa R, et al. Infections in post-tsunami victims. Pediatr Infect Dis J. 2007;26(10):960–1.
Kendall BA, Winthrop KL. Update on the epidemiology of pulmonary nontuberculous mycobacterial infections. In: Seminars in respiratory and critical care medicine. Thieme Medical Publishers; 2013. p. 87–94.
Honda JR, Bernhard JN, Chan ED. Natural disasters and nontuberculous mycobacteria: a recipe for increased disease? Chest. 2015;147(2):304–8.
Ben Salah I, Drancourt M. Surviving within the amoebal exocyst: the Mycobacterium avium complex paradigm. BMC Microbiol. 2010;10(1):1–8.
Heemskerk D, Caws M, Marais B, Farrar J. Tuberculosis in adults and children. 2015;
Abacıoğlu YH, Sönmez C. Ulusal Mikrobiyoloji Standartları Laboratuvar Güvenliği Rehberi. TC Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu Başkanlığı, Ankara, 345s. 2014;