Sporcularda Kardiyak Manyetik Resonans Görüntüleme
Özet
Kardiyak manyetik resonans, sporcu çocuklarda, özellikle kardiyomiyopati ve spora bağlı gelişen adaptif değişiklikleri ayırmada ekokardiyografi sonrası tercih edilmesi önerilen bir görüntüleme yöntemidir. Kardiyak manyetik resonans, hem morfo-fonksiyonel olarak daha hassas ölçümler yapar hem de doku karakterizasyonu çalışmaları ile birlikte, özellikle geç faz gadolinyum dağılımı sayesinde prognostik bilgiler verir. Sporcu çocuklarda olası miyokardit durumunda kardiyak manyetik resonans istenmelidir. Güncel miyokardit tanı kriterlerine göre, erken dönemde miyokardiyal ödem, geç dönemde ise miyokardiyal skar değerlendirilmesi önerilmektedir. Koroner hastalık şüphesinde, kardiyak manyetik resonansın koroner bilgisayarlı tomografi ve kateter anjiografiye üstünlüğü, kontrastsız ve radyasyon maruziyeti olmaksızın üç boyutlu koroner görüntüleme yapabilmesidir. Ayrıca, olası koroner hastalığa bağlı iskemi olup olmadığını perfüzyon kardiyak manyetik resonans ile saptamak mümkün olmaktadır.
Referanslar
Szabo L, Brunetti G, Cipriani A, et al. Certainties and Uncertainties of Cardiac Magnetic Resonance Imaging in Athletes. J Cardiovasc Dev Dis. 2022 Oct 20;9(10):361. doi: 10.3390/jcdd9100361. PMID: 36286312; PMCID: PMC9604894.
Mont L, Pelliccia A, Sharma S, et al. Pre-participation cardiovascular evaluation for athletic participants to prevent sudden death: Position paper from the EHRA and the EACPR, branches of the ESC. Endorsed by APHRS, HRS, and SOLAECE. Eur J Prev Cardiol. 2017 Jan;24(1):41-69. doi: 10.1177/2047487316676042. Epub 2016 Nov 4. PMID: 27815537.
Pelliccia, A., Caselli, S., Sharma, S., et al. European Association of Preventive Cardiology (EAPC) and European Association of Cardiovascular Imaging (EACVI) joint position statement: Recommendations for the indication and interpretation of cardiovascular imaging in the evaluation of the athlete’s he. Eur. Heart J. 2018, 39, 1949–1969.
Ferrari, V. 35. Athlete’s Heart and Prevention of Sudden Cardiac Death in Athletes. In The EACVI Textbook of Cardiovascular Magnetic Resonance; Oxford University Press: Oxford, UK, 2018; pp. 1–20.
Corrado D, Perazzolo Marra M, Zorzi A, et al. Diagnosis of arrhythmogenic cardiomyopathy: the Padua criteria. Int J Cardiol. 2020;319:106–114. doi: 10.1016/j.ijcard.2020.06.005.
Cipriani A, Mattesi G, Bariani R, et al. Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives. Eur Radiol. 2023 Jan;33(1):270-282. doi: 10.1007/s00330-022-08958-2. Epub 2022 Jul 5. PMID: 35788758; PMCID: PMC9755099.
Aherne E, Chow K, Carr J. Cardiac T1 mapping: Techniques and applications. J Magn Reson Imaging. 2020 May;51(5):1336-1356. doi: 10.1002/jmri.26866. Epub 2019 Jul 23. PMID: 31334899.
Prakken NH, Velthuis BK, Teske AJ, Mosterd A, Mali WP, Cramer MJ. Cardiac MRI reference values for athletes and nonathletes corrected for body surface area, training hours/week and sex. Eur J Cardiovasc Prev Rehabil. 2010;17:198–203
Pieles, G.E.; Stuart, A.G. The adolescent athlete’s heart; A miniature adult or grown-up child? Clin. Cardiol. 2020, 43, 852–862.
Makan, J.; Sharma, S.; Firoozi, S.; et al. Physiological upper limits of ventricular cavity size in highly trained adolescent athletes. Heart 2005, 91, 495–499.
Csecs, I.; Czimbalmos, C.; Toth, A.; et al. The impact of sex, age and training on biventricular cardiac adaptation in healthy adult and adolescent athletes: Cardiac magnetic resonance imaging study. Eur. J. Prev. Cardiol. 2020, 27, 540–549.
Maestrini, V.; Birtolo, L.; Filomena, D.; et al. Gender difference in extreme cardiac remodelling in endurance olympic athletes assessed by non-contrast CMR. Eur. Heart J. Cardiovasc. Imaging 2021, 22, 297.
Ozo, U.; Sharma, S. The Impact of Ethnicity on Cardiac Adaptation. Eur. Cardiol. Rev. 2020, 15, e61.
Prakken, N.H.; Velthuis, B.K.; Teske, A.J.; et al. Cardiac MRI reference values for athletes and nonathletes corrected for body surface area, training hours/week and sex. Eur. J. Cardiovasc. Prev. Rehabil. 2010, 17, 198–203
Starekova, J.; Thottakara, T.; Lund, G.K.; et al. Increased myocardial mass and attenuation of myocardial strain in professional male soccer players and competitive male triathletes. Int. J. Cardiovasc. Imaging 2020, 36, 2187–2197.
Martinez, V.; De La Garza, M.S.; Grazioli, G.; et al. Cardiac adaptation to endurance exercise training: Differential impact of swimming and running. Eur. J. Sport Sci. 2021, 21, 844–853.
Cerqueira MD, Weissman NJ, Dilsizian V, et al. American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002 Jan 29;105(4):539-42. doi: 10.1161/hc0402.102975. PMID: 11815441.
Grigoratos, C.; Pantan, A.; Meschisi, M.; et al. Clinical importance of late gadolinium enhancement at right ventricular insertion points in otherwise normal hearts. Int. J. Cardiovasc. Imaging 2020, 36, 913–920.
Domenech-Ximenos, B.; La Garza, M.S.-D.; Prat-González, S.; et al. Prevalence and pattern of cardiovascular magnetic resonance late gadolinium enhancement in highly trained endurance athletes. J. Cardiovasc. Magn. Reson. 2020, 22, 62.
Małek, Ł.A.; Barczuk-Fale ̨cka, M.; Werys, K.; et al. Cardiovascular magnetic resonance with parametric mapping in long-term ultra-marathon runners. Eur. J. Radiol. 2019, 117, 89–94.
Miller CA, Naish J, Bishop P, et al. Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of 18 Journal of Magnetic Resonance Imaging myocardial extracellular volume. Circ Cardiovasc Imaging 2013;6: 373–383. 35.
Rosimini S, Bulluck H, Captur G, et al. Myocardial native T1 and extracellular volume with healthy aging and gender. Eur Heart J Cardiovasc Imaging 2019;9:615–621.
Ridouani F, Damy T, Tacher V, et al. Myocardial native T2 measurement to differentiate light‐chain and transthyretin cardiac amyloidosis and assess prognosis. J Cardiovasc Magn Reson. 2018; 20:58.
Windecker S, Kolh P, Alfonso F, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2014 Oct 1;35(37):2541-619. doi: 10.1093/eurheartj/ehu278. Epub 2014 Aug 29. PMID: 25173339.
Petersen SE, Khanji MY, Plein S, et al. European Association of Cardiovascular Imaging expert consensus paper: a comprehensive review of cardiovascular magnetic resonance normal values of cardiac chamber size and aortic root in adults and recommendations for grading severity. Eur Heart J Cardiovasc Imaging. 2019; 20:1321–1331. doi: 10.1093/ehjci/jez232.
Perazzolo Marra M, Cipriani A, Rizzo S, et al. Myocardial tissue characterization in arrhythmogenic cardiomyopathy: comparison between endomyocardial biopsy and cardiac magnetic resonance. JACC Cardiovasc Imaging. 2021;14:1675–1678. doi: 10.1016/j.jcmg.2021.02.015.
Zghaib T, Te Riele ASJM, James CA, et al. Left ventricular fibro-fatty replacement in arrhythmogenic right ventricular dysplasia/cardiomyopathy: prevalence, patterns, and association with arrhythmias. J Cardiovasc Magn Reson. 2021;23:58. doi: 10.1186/s12968-020-00702-3.
Aquaro GD, De Luca A, Cappelletto C, et al. Prognostic value of magnetic resonance phenotype in patients with arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol. 2020;75:2753–2765. doi: 10.1016/j.jacc.2020.04.023.
Bryde RE, Cooper LT Jr, Fairweather D, et al. Exercise After Acute Myocarditis: When and How to Return to Sports. Cardiol Clin. 2023 Feb;41(1):107-115. doi: 10.1016/j.ccl.2022.08.009. PMID: 36368807.
Lurz P, Luecke C, Eitel I, et al. Comprehensive cardiac magnetic resonance imaging in patients with suspected myocarditis: the MyoRacer-Trial. J Am Coll Cardiol. 2016;67(15):1800–1811. doi: 10.1016/j.jacc.2016.02.013
Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations. J Am Coll Cardiol. 2018 Dec 18;72(24):3158-3176. doi: 10.1016/j.jacc.2018.09.072. PMID: 30545455.
Hurwitz B, Issa O. Management and Treatment of Myocarditis in Athletes. Curr Treat Options Cardiovasc Med. 2020;22(12):65. doi: 10.1007/s11936-020-00875-1. Epub 2020 Nov 4. PMID: 33169059; PMCID: PMC7609375.
Zorzi A, Perazzolo Marra M, Rigato I, et al. Nonischemic left ventricular scar as a substrate of life-threatening ventricular arrhythmias and sudden cardiac death in competitive athletes. Circ Arrhythm Electrophysiol. 2016;9(7):e004229. doi: 10.1161/CIRCEP.116.004229.
Aquaro GD, Perfetti M, Camastra G, et al. Cardiac MR with late gadolinium enhancement in acute myocarditis with preserved systolic function. J Am Coll Cardiol. 2017;70(16):1977–1987. doi: 10.1016/j.jacc.2017.08.044.
Di Gioia, C.R.T.; Giordano, C.; Cerbelli, B.; Pisano, A.; Perli, E.; de Dominicis, E.; Poscolieri, B.; Palmieri, V.; Ciallella, C.; Zeppilli, P.; et al. Nonischemic left ventricular scar and cardiac sudden death in the young. Hum.Pathol. 2016, 58, 78–89.
Muser,D.;Nucifora,G.;Muser,D.;Nucifora,G.;Pieroni,M.;Castro,S.A.;Arroyo,R.C.; Maeda,S.;Benhayon,D.A.;Liuba,I.;etal. Prognostic value of nonischemic ringlike left ventricular scar in patients with apparently idiopathic nonsustained ventricular arrhythmias. Circulation 2021, 143, 1359–1373.
DiBella,G.; Gentile,G.; Irsuti,F.; Giuseppe,R.;Clemenza,F.; Mamone,G.; Donato,R.; DeLuca,A.; Bogaert,J.; Aquaro,G.D. Prognostic Role of Left Ventricular Intramyocardial Fatty Metaplasia in Patients With Previous Myocarditis (MYOFAT Study). Am. J. Cardiol. 2021, 143, 135–144.
Pelliccia, A.;Solberg, E.E.; Papadakis ,M.;Adami, P.E.; Biffi, A.;Caselli, S.;LaGerche,A.; Niebauer, J.; Pressler, A.;Schmied,C.M.; et al. Recommendations for participation in competitive and leisure time sport in athletes with cardiomyopathies, myocarditis, and pericarditis: Position statement of the Sport Cardiology Section of the European Association of Preventive Cardiology (EAPC). Eur. Heart J. 2019, 40, 19–33.
Maron,B.J.;Zipes,D.P.;Kovacs,R.J.Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Preamble, Principles, and General Considerations: A Scientific Statement from the American Heart Association and American College of Cardiology. Circulation 2015, 132, e256–e261.
Eichhorn C, Bière L, Schnell F, et al. Myocarditis in athletes is a challenge: diagnosis, risk stratification, and uncertainties. JACC Cardiovasc Imaging. 2020;13(2 Pt 1):494–507. 10.1016/j.jcmg.2019.01.039..
Maron B.J., Haas T.S., Doerer J.J., et al. Comparison of US and Italian experiences with sudden cardiac deaths in young competitive athletes and implications for preparticipation screening strategies. Am. J. Cardiol. 2009;104:276–280. doi: 10.1016/j.amjcard.2009.03.037.
Caselli S., Maron M.S., Urbano-Moral J.A., et al. Differentiating left ventricular hypertrophy in athletes from that in patients with hypertrophic cardiomyopathy. Am. J. Cardiol. 2014;114:1383–1389. doi: 10.1016/j.amjcard.2014.07.070.
Augustine DX, Howard L. Left ventricular hypertrophy in athletes: differentiating physiology from pathology. Curr Treat Options Cardiovasc Med. 2018;20(12):96. doi: 10.1007/s11936-018-0691-2
Palmisano A, Darvizeh F, Cundari G, et al. Advanced cardiac imaging in athlete's heart: unravelling the grey zone between physiologic adaptation and pathology. Radiol Med. 2021 Dec;126(12):1518-1531. doi: 10.1007/s11547-021-01411-2. Epub 2021 Aug 22. PMID: 34420142; PMCID: PMC8380417.
Schnell F, Claessen G, La Gerche A, et al. Subepicardial delayed gadolinium enhancement in asymptomatic athletes: Let sleeping dogs lie? Br J Sports Med. 2016;50:111–117. doi: 10.1136/bjsports-2014-094546.
Swoboda P.P., McDiarmid A.K., Erhayiem B., et al. Assessing Myocardial Extracellular Volume by T1 Mapping to Distinguish Hypertrophic Cardiomyopathy from Athlete’s Heart. J. Am. Coll. Cardiol. 2016;67:2189–2190. doi: 10.1016/j.jacc.2016.02.054.
Gastl M., Lachmann V., Christidi A., et al. Cardiac magnetic resonance T2 mapping and feature tracking in athlete’s heart and HCM. Eur. Radiol. 2021;31:2768–2777. doi: 10.1007/s00330-020-07289-4.
Haaf P., Garg P., Messroghli D.R., et al. Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: A comprehensive review. J. Cardiovasc. Magn. Reson. 2017;18:89. doi: 10.1186/s12968-016-0308-4.
Chan RH, Maron BJ, Olivotto I, et al. Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy. Circulation. 2014;130:484–495. doi: 10.1161/CIRCULATIONAHA.113.007094.
Weng Z, Yao J, Chan RH, He J, Yang X, Zhou Y, He Y. Prognostic Value of LGE-CMR in HCM: A Meta-Analysis. JACC Cardiovasc Imaging. 2016 Dec;9(12):1392-1402. doi: 10.1016/j.jcmg.2016.02.031. Epub 2016 Jul 20. PMID: 27450876.
Maron,B.J.Distinguishing hypertrophic cardiomyopathy from athlete’sheart physiological remodelling: Clinicalsignificance, diagnostic strategies and implications for preparticipation screening. Br. J. Sports Med. 2009, 43, 649–656.
Abergel,E.;Chatellier,G.;Hagege,A.; Oblak,A.; Linhart,A.; Ducardonnet,A.; Menard, J.Serialleft ventricular adaptations in world-class professional cyclists: Implications for disease screening and follow-up. J. Am. Coll. Cardiol. 2004, 44, 144–149.
Finocchiaro, G.; Papadakis, M.; Robertus, J.-L.; Dhutia, H.; Steriotis, A.K.; Tome, M.; Mellor, G.; Merghani, A.; Malhotr, A.; Behr, E.; et al. Etiology of sudden death in sports: Insights from a United Kingdom regional registry. J. Am. Coll. Cardiol. 2016, 67, 2108–2115
Małek, Ł.A.; Mazurkiewicz, Ł.; Marszałek, M.; Barczuk-Fale ̨cka, M.; Simon, J.; Grzybowski, J.; Miłosz-Wieczorek, B.; Postuła, M.; Marczak, M. Deformation Parameters of the Heart in Endurance Athletes and in Patients with Dilated Cardiomyopathy—A Cardiac Magnetic Resonance Study. Diagnostics 2021, 11, 374.
Mordi, I.; Carrick, D.; Bezerra, H.; Tzemos, N. T 1 and T 2 mapping for early diagnosis of dilated non-ischaemic cardiomyopathy in middle-aged patients and differentiation from normal physiological adaptation. Eur. Heart J. Cardiovasc. Imaging 2016, 17, 797–803.
Millar, L.M.; Fanton, Z.; Finocchiaro, G.; Sanchez-Fernandez, G.; Dhutia, H.; Malhotra, A.; Merghani, A.; Papadakis, M.; Behr, E.R.; Bunce, N.; et al. Differentiation between athlete’s heart and dilated cardiomyopathy in athletic individuals. Heart 2020, 106, 1059–1065.
Di Marco, A.; Anguera, I.; Schmitt, M.; Klem, I.; Neilan, T.G.; White, J.A.; Sramko, M.; Masci, P.G.; Barison, A.; Mckenna, P.; et al. Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis. JACC Heart Fail. 2017, 5, 28–38.
Barison, A.; Aimo, A.; Mirizzi, G.; Castiglione, V.; Ripoli, A.; Panchetti, L.; Rossi, A.; Giannoni, A.; Startari, U.; Aquaro, G.D.; et al. The extent and location of late gadolinium enhancement predict defibrillator shock and cardiac mortality in patients with non-ischaemic dilated cardiomyopathy. Int. J. Cardiol. 2020, 307, 180–186.
Galderisi M, Cardim N, D'Andrea A, Bruder O, Cosyns B, Davin L, Donal E, Edvardsen T, Freitas A, Habib G, Kitsiou A, Plein S, Petersen SE, Popescu BA, Schroeder S, Burgstahler C, Lancellotti P. The multi-modality cardiac imaging approach to the Athlete's heart: an expert consensus of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015 Apr;16(4):353. doi: 10.1093/ehjci/jeu323. PMID: 25681828.
Petersen S.E., Selvanayagam J.B., Wiesmann F., Robson M.D., Francis J.M., Anderson R.H., Watkins H., Neubauer S. Left Ventricular Non-Compaction: Insights From Cardiovascular Magnetic Resonance Imaging. J. Am. Coll. Cardiol. 2005;46:101–105. doi: 10.1016/j.jacc.2005.03.045.
Stacey R.B., Andersen M.M., St Clair M., Hundley W.G., Thohan V. Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc. Imaging. 2013;6:931–940. doi: 10.1016/j.jcmg.2013.01.014.
Jacquier A., Thuny F., Jop B., Giorgi R., Cohen F., Gaubert J.-Y., Vidal V., Bartoli J.M., Habib G., Moulin G. Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction. Eur. Heart J. 2010;31:1098–1104. doi: 10.1093/eurheartj/ehp595.
Caselli, S.; Ferreira, D.; Kanawati, E.; Di Paolo, F.; Pisicchio, C.; Jost, C.A.; Spataro, A.; Jenni, R.; Pelliccia, A. Prominent left ventricular trabeculations in competitive athletes: A proposal for risk stratification and management. Int. J. Cardiol. 2016, 223, 590–595.
Nucifora,G.;Aquaro,G.D.;Pingitore,A.;Masci,P.G.;Lombardi,M.Myocardial fibrosisin isolated left ventricular non compaction and its relation to disease severity. Eur. J. Heart Fail. 2011, 13, 170–176.
Casas,G.; Limeres,J.; Oristrell,G.; Gutierrez-Garcia,L.; Andreini,D.; Borregan,M.; Larrañaga-Moreira,J.M.; Lopez-Sainz, A.; Codina-Solà, M.; Teixido-Tura, G.; et al. Clinical risk prediction in patients with left ventricular myocardial noncompaction. J. Am. Coll. Cardiol. 2021, 78, 643–662.
Ramchand, J.; Podugu, P.; Obuchowski, N.; Harb, S.C.; Chetrit, M.; Milinovich, A.; Griffin, B.; Burrell, L.M.; Tang, W.H.W.; Kwon, D.H.; et al. Novel Approach to Risk Stratification in Left Ventricular Non-Compaction Using ACombined Cardiac Imaging and Plasma Biomarker Approach. J. Am. Heart Assoc. 2021, 10, e019209.
Araujo-Filho, J.A.B.; Assuncao, A.N.; De Melo, M.D.T.; Bière, L.; Lima, C.R.; Dantas, R.N.; Nomura, C.H.; Salemi, V.M.C.; Jerosch-Herold, M.; Parga, J. Myocardial T1 mapping and extracellular volume quantification in patients with left ventricular non-compaction cardiomyopathy. Eur. Heart J. Cardiovasc. Imaging 2018,19,888–895.
Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, Caselli S, Collet JP, Corrado D, Drezner JA, Halle M, Hansen D, Heidbuchel H, Myers J, Niebauer J, Papadakis M, Piepoli MF, Prescott E, Roos-Hesselink JW, Graham Stuart A, Taylor RS, Thompson PD, Tiberi M, Vanhees L, Wilhelm M; ESC Scientific Document Group. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J. 2021 Jan 1;42(1):17-96. doi: 10.1093/eurheartj/ehaa605. Erratum in: Eur Heart J. 2021 Feb 1;42(5):548-549. PMID: 32860412.
Prakken, N.H.; Cramer,M.J.; Olimulder, M.A.; Agostoni,P.; Mali,W.P.; Velthuis,B.K. Screening for proximal coronary artery anomalies with 3-dimensional MR coronary angiography. Int. J. Cardiovasc. Imaging 2010, 26, 701–710.
Angelini, P.; Cheong, B.Y.; De Rosen, V.V.L.; Lopez, A.; Uribe, C.; Masso, A.H.; Ali, S.W.; Davis, B.R.; Muthupillai, R.; Willerson, J.T. High-risk cardiovascular conditions in sports-related sudden death: Prevalence in 5169school children screened via cardiac magnetic resonance. Texas Heart Inst. J. 2018, 45, 205–213.
Agrawal, H.; Wilkinson, J.C.; Noel, C.V.; Qureshi, A.M.; Masand, P.M.; Mery, C.M.; Sexson-Tejtel, S.K.; Molossi, S. Impaired myocardial perfusion on stress CMR correlates with invasive FFR in children with coronary anomalies. J. Invasive Cardiol. 2021, 33, E45–E51.
Referanslar
Szabo L, Brunetti G, Cipriani A, et al. Certainties and Uncertainties of Cardiac Magnetic Resonance Imaging in Athletes. J Cardiovasc Dev Dis. 2022 Oct 20;9(10):361. doi: 10.3390/jcdd9100361. PMID: 36286312; PMCID: PMC9604894.
Mont L, Pelliccia A, Sharma S, et al. Pre-participation cardiovascular evaluation for athletic participants to prevent sudden death: Position paper from the EHRA and the EACPR, branches of the ESC. Endorsed by APHRS, HRS, and SOLAECE. Eur J Prev Cardiol. 2017 Jan;24(1):41-69. doi: 10.1177/2047487316676042. Epub 2016 Nov 4. PMID: 27815537.
Pelliccia, A., Caselli, S., Sharma, S., et al. European Association of Preventive Cardiology (EAPC) and European Association of Cardiovascular Imaging (EACVI) joint position statement: Recommendations for the indication and interpretation of cardiovascular imaging in the evaluation of the athlete’s he. Eur. Heart J. 2018, 39, 1949–1969.
Ferrari, V. 35. Athlete’s Heart and Prevention of Sudden Cardiac Death in Athletes. In The EACVI Textbook of Cardiovascular Magnetic Resonance; Oxford University Press: Oxford, UK, 2018; pp. 1–20.
Corrado D, Perazzolo Marra M, Zorzi A, et al. Diagnosis of arrhythmogenic cardiomyopathy: the Padua criteria. Int J Cardiol. 2020;319:106–114. doi: 10.1016/j.ijcard.2020.06.005.
Cipriani A, Mattesi G, Bariani R, et al. Cardiac magnetic resonance imaging of arrhythmogenic cardiomyopathy: evolving diagnostic perspectives. Eur Radiol. 2023 Jan;33(1):270-282. doi: 10.1007/s00330-022-08958-2. Epub 2022 Jul 5. PMID: 35788758; PMCID: PMC9755099.
Aherne E, Chow K, Carr J. Cardiac T1 mapping: Techniques and applications. J Magn Reson Imaging. 2020 May;51(5):1336-1356. doi: 10.1002/jmri.26866. Epub 2019 Jul 23. PMID: 31334899.
Prakken NH, Velthuis BK, Teske AJ, Mosterd A, Mali WP, Cramer MJ. Cardiac MRI reference values for athletes and nonathletes corrected for body surface area, training hours/week and sex. Eur J Cardiovasc Prev Rehabil. 2010;17:198–203
Pieles, G.E.; Stuart, A.G. The adolescent athlete’s heart; A miniature adult or grown-up child? Clin. Cardiol. 2020, 43, 852–862.
Makan, J.; Sharma, S.; Firoozi, S.; et al. Physiological upper limits of ventricular cavity size in highly trained adolescent athletes. Heart 2005, 91, 495–499.
Csecs, I.; Czimbalmos, C.; Toth, A.; et al. The impact of sex, age and training on biventricular cardiac adaptation in healthy adult and adolescent athletes: Cardiac magnetic resonance imaging study. Eur. J. Prev. Cardiol. 2020, 27, 540–549.
Maestrini, V.; Birtolo, L.; Filomena, D.; et al. Gender difference in extreme cardiac remodelling in endurance olympic athletes assessed by non-contrast CMR. Eur. Heart J. Cardiovasc. Imaging 2021, 22, 297.
Ozo, U.; Sharma, S. The Impact of Ethnicity on Cardiac Adaptation. Eur. Cardiol. Rev. 2020, 15, e61.
Prakken, N.H.; Velthuis, B.K.; Teske, A.J.; et al. Cardiac MRI reference values for athletes and nonathletes corrected for body surface area, training hours/week and sex. Eur. J. Cardiovasc. Prev. Rehabil. 2010, 17, 198–203
Starekova, J.; Thottakara, T.; Lund, G.K.; et al. Increased myocardial mass and attenuation of myocardial strain in professional male soccer players and competitive male triathletes. Int. J. Cardiovasc. Imaging 2020, 36, 2187–2197.
Martinez, V.; De La Garza, M.S.; Grazioli, G.; et al. Cardiac adaptation to endurance exercise training: Differential impact of swimming and running. Eur. J. Sport Sci. 2021, 21, 844–853.
Cerqueira MD, Weissman NJ, Dilsizian V, et al. American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002 Jan 29;105(4):539-42. doi: 10.1161/hc0402.102975. PMID: 11815441.
Grigoratos, C.; Pantan, A.; Meschisi, M.; et al. Clinical importance of late gadolinium enhancement at right ventricular insertion points in otherwise normal hearts. Int. J. Cardiovasc. Imaging 2020, 36, 913–920.
Domenech-Ximenos, B.; La Garza, M.S.-D.; Prat-González, S.; et al. Prevalence and pattern of cardiovascular magnetic resonance late gadolinium enhancement in highly trained endurance athletes. J. Cardiovasc. Magn. Reson. 2020, 22, 62.
Małek, Ł.A.; Barczuk-Fale ̨cka, M.; Werys, K.; et al. Cardiovascular magnetic resonance with parametric mapping in long-term ultra-marathon runners. Eur. J. Radiol. 2019, 117, 89–94.
Miller CA, Naish J, Bishop P, et al. Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of 18 Journal of Magnetic Resonance Imaging myocardial extracellular volume. Circ Cardiovasc Imaging 2013;6: 373–383. 35.
Rosimini S, Bulluck H, Captur G, et al. Myocardial native T1 and extracellular volume with healthy aging and gender. Eur Heart J Cardiovasc Imaging 2019;9:615–621.
Ridouani F, Damy T, Tacher V, et al. Myocardial native T2 measurement to differentiate light‐chain and transthyretin cardiac amyloidosis and assess prognosis. J Cardiovasc Magn Reson. 2018; 20:58.
Windecker S, Kolh P, Alfonso F, et al. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur Heart J. 2014 Oct 1;35(37):2541-619. doi: 10.1093/eurheartj/ehu278. Epub 2014 Aug 29. PMID: 25173339.
Petersen SE, Khanji MY, Plein S, et al. European Association of Cardiovascular Imaging expert consensus paper: a comprehensive review of cardiovascular magnetic resonance normal values of cardiac chamber size and aortic root in adults and recommendations for grading severity. Eur Heart J Cardiovasc Imaging. 2019; 20:1321–1331. doi: 10.1093/ehjci/jez232.
Perazzolo Marra M, Cipriani A, Rizzo S, et al. Myocardial tissue characterization in arrhythmogenic cardiomyopathy: comparison between endomyocardial biopsy and cardiac magnetic resonance. JACC Cardiovasc Imaging. 2021;14:1675–1678. doi: 10.1016/j.jcmg.2021.02.015.
Zghaib T, Te Riele ASJM, James CA, et al. Left ventricular fibro-fatty replacement in arrhythmogenic right ventricular dysplasia/cardiomyopathy: prevalence, patterns, and association with arrhythmias. J Cardiovasc Magn Reson. 2021;23:58. doi: 10.1186/s12968-020-00702-3.
Aquaro GD, De Luca A, Cappelletto C, et al. Prognostic value of magnetic resonance phenotype in patients with arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol. 2020;75:2753–2765. doi: 10.1016/j.jacc.2020.04.023.
Bryde RE, Cooper LT Jr, Fairweather D, et al. Exercise After Acute Myocarditis: When and How to Return to Sports. Cardiol Clin. 2023 Feb;41(1):107-115. doi: 10.1016/j.ccl.2022.08.009. PMID: 36368807.
Lurz P, Luecke C, Eitel I, et al. Comprehensive cardiac magnetic resonance imaging in patients with suspected myocarditis: the MyoRacer-Trial. J Am Coll Cardiol. 2016;67(15):1800–1811. doi: 10.1016/j.jacc.2016.02.013
Ferreira VM, Schulz-Menger J, Holmvang G, et al. Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations. J Am Coll Cardiol. 2018 Dec 18;72(24):3158-3176. doi: 10.1016/j.jacc.2018.09.072. PMID: 30545455.
Hurwitz B, Issa O. Management and Treatment of Myocarditis in Athletes. Curr Treat Options Cardiovasc Med. 2020;22(12):65. doi: 10.1007/s11936-020-00875-1. Epub 2020 Nov 4. PMID: 33169059; PMCID: PMC7609375.
Zorzi A, Perazzolo Marra M, Rigato I, et al. Nonischemic left ventricular scar as a substrate of life-threatening ventricular arrhythmias and sudden cardiac death in competitive athletes. Circ Arrhythm Electrophysiol. 2016;9(7):e004229. doi: 10.1161/CIRCEP.116.004229.
Aquaro GD, Perfetti M, Camastra G, et al. Cardiac MR with late gadolinium enhancement in acute myocarditis with preserved systolic function. J Am Coll Cardiol. 2017;70(16):1977–1987. doi: 10.1016/j.jacc.2017.08.044.
Di Gioia, C.R.T.; Giordano, C.; Cerbelli, B.; Pisano, A.; Perli, E.; de Dominicis, E.; Poscolieri, B.; Palmieri, V.; Ciallella, C.; Zeppilli, P.; et al. Nonischemic left ventricular scar and cardiac sudden death in the young. Hum.Pathol. 2016, 58, 78–89.
Muser,D.;Nucifora,G.;Muser,D.;Nucifora,G.;Pieroni,M.;Castro,S.A.;Arroyo,R.C.; Maeda,S.;Benhayon,D.A.;Liuba,I.;etal. Prognostic value of nonischemic ringlike left ventricular scar in patients with apparently idiopathic nonsustained ventricular arrhythmias. Circulation 2021, 143, 1359–1373.
DiBella,G.; Gentile,G.; Irsuti,F.; Giuseppe,R.;Clemenza,F.; Mamone,G.; Donato,R.; DeLuca,A.; Bogaert,J.; Aquaro,G.D. Prognostic Role of Left Ventricular Intramyocardial Fatty Metaplasia in Patients With Previous Myocarditis (MYOFAT Study). Am. J. Cardiol. 2021, 143, 135–144.
Pelliccia, A.;Solberg, E.E.; Papadakis ,M.;Adami, P.E.; Biffi, A.;Caselli, S.;LaGerche,A.; Niebauer, J.; Pressler, A.;Schmied,C.M.; et al. Recommendations for participation in competitive and leisure time sport in athletes with cardiomyopathies, myocarditis, and pericarditis: Position statement of the Sport Cardiology Section of the European Association of Preventive Cardiology (EAPC). Eur. Heart J. 2019, 40, 19–33.
Maron,B.J.;Zipes,D.P.;Kovacs,R.J.Eligibility and Disqualification Recommendations for Competitive Athletes with Cardiovascular Abnormalities: Preamble, Principles, and General Considerations: A Scientific Statement from the American Heart Association and American College of Cardiology. Circulation 2015, 132, e256–e261.
Eichhorn C, Bière L, Schnell F, et al. Myocarditis in athletes is a challenge: diagnosis, risk stratification, and uncertainties. JACC Cardiovasc Imaging. 2020;13(2 Pt 1):494–507. 10.1016/j.jcmg.2019.01.039..
Maron B.J., Haas T.S., Doerer J.J., et al. Comparison of US and Italian experiences with sudden cardiac deaths in young competitive athletes and implications for preparticipation screening strategies. Am. J. Cardiol. 2009;104:276–280. doi: 10.1016/j.amjcard.2009.03.037.
Caselli S., Maron M.S., Urbano-Moral J.A., et al. Differentiating left ventricular hypertrophy in athletes from that in patients with hypertrophic cardiomyopathy. Am. J. Cardiol. 2014;114:1383–1389. doi: 10.1016/j.amjcard.2014.07.070.
Augustine DX, Howard L. Left ventricular hypertrophy in athletes: differentiating physiology from pathology. Curr Treat Options Cardiovasc Med. 2018;20(12):96. doi: 10.1007/s11936-018-0691-2
Palmisano A, Darvizeh F, Cundari G, et al. Advanced cardiac imaging in athlete's heart: unravelling the grey zone between physiologic adaptation and pathology. Radiol Med. 2021 Dec;126(12):1518-1531. doi: 10.1007/s11547-021-01411-2. Epub 2021 Aug 22. PMID: 34420142; PMCID: PMC8380417.
Schnell F, Claessen G, La Gerche A, et al. Subepicardial delayed gadolinium enhancement in asymptomatic athletes: Let sleeping dogs lie? Br J Sports Med. 2016;50:111–117. doi: 10.1136/bjsports-2014-094546.
Swoboda P.P., McDiarmid A.K., Erhayiem B., et al. Assessing Myocardial Extracellular Volume by T1 Mapping to Distinguish Hypertrophic Cardiomyopathy from Athlete’s Heart. J. Am. Coll. Cardiol. 2016;67:2189–2190. doi: 10.1016/j.jacc.2016.02.054.
Gastl M., Lachmann V., Christidi A., et al. Cardiac magnetic resonance T2 mapping and feature tracking in athlete’s heart and HCM. Eur. Radiol. 2021;31:2768–2777. doi: 10.1007/s00330-020-07289-4.
Haaf P., Garg P., Messroghli D.R., et al. Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: A comprehensive review. J. Cardiovasc. Magn. Reson. 2017;18:89. doi: 10.1186/s12968-016-0308-4.
Chan RH, Maron BJ, Olivotto I, et al. Prognostic value of quantitative contrast-enhanced cardiovascular magnetic resonance for the evaluation of sudden death risk in patients with hypertrophic cardiomyopathy. Circulation. 2014;130:484–495. doi: 10.1161/CIRCULATIONAHA.113.007094.
Weng Z, Yao J, Chan RH, He J, Yang X, Zhou Y, He Y. Prognostic Value of LGE-CMR in HCM: A Meta-Analysis. JACC Cardiovasc Imaging. 2016 Dec;9(12):1392-1402. doi: 10.1016/j.jcmg.2016.02.031. Epub 2016 Jul 20. PMID: 27450876.
Maron,B.J.Distinguishing hypertrophic cardiomyopathy from athlete’sheart physiological remodelling: Clinicalsignificance, diagnostic strategies and implications for preparticipation screening. Br. J. Sports Med. 2009, 43, 649–656.
Abergel,E.;Chatellier,G.;Hagege,A.; Oblak,A.; Linhart,A.; Ducardonnet,A.; Menard, J.Serialleft ventricular adaptations in world-class professional cyclists: Implications for disease screening and follow-up. J. Am. Coll. Cardiol. 2004, 44, 144–149.
Finocchiaro, G.; Papadakis, M.; Robertus, J.-L.; Dhutia, H.; Steriotis, A.K.; Tome, M.; Mellor, G.; Merghani, A.; Malhotr, A.; Behr, E.; et al. Etiology of sudden death in sports: Insights from a United Kingdom regional registry. J. Am. Coll. Cardiol. 2016, 67, 2108–2115
Małek, Ł.A.; Mazurkiewicz, Ł.; Marszałek, M.; Barczuk-Fale ̨cka, M.; Simon, J.; Grzybowski, J.; Miłosz-Wieczorek, B.; Postuła, M.; Marczak, M. Deformation Parameters of the Heart in Endurance Athletes and in Patients with Dilated Cardiomyopathy—A Cardiac Magnetic Resonance Study. Diagnostics 2021, 11, 374.
Mordi, I.; Carrick, D.; Bezerra, H.; Tzemos, N. T 1 and T 2 mapping for early diagnosis of dilated non-ischaemic cardiomyopathy in middle-aged patients and differentiation from normal physiological adaptation. Eur. Heart J. Cardiovasc. Imaging 2016, 17, 797–803.
Millar, L.M.; Fanton, Z.; Finocchiaro, G.; Sanchez-Fernandez, G.; Dhutia, H.; Malhotra, A.; Merghani, A.; Papadakis, M.; Behr, E.R.; Bunce, N.; et al. Differentiation between athlete’s heart and dilated cardiomyopathy in athletic individuals. Heart 2020, 106, 1059–1065.
Di Marco, A.; Anguera, I.; Schmitt, M.; Klem, I.; Neilan, T.G.; White, J.A.; Sramko, M.; Masci, P.G.; Barison, A.; Mckenna, P.; et al. Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis. JACC Heart Fail. 2017, 5, 28–38.
Barison, A.; Aimo, A.; Mirizzi, G.; Castiglione, V.; Ripoli, A.; Panchetti, L.; Rossi, A.; Giannoni, A.; Startari, U.; Aquaro, G.D.; et al. The extent and location of late gadolinium enhancement predict defibrillator shock and cardiac mortality in patients with non-ischaemic dilated cardiomyopathy. Int. J. Cardiol. 2020, 307, 180–186.
Galderisi M, Cardim N, D'Andrea A, Bruder O, Cosyns B, Davin L, Donal E, Edvardsen T, Freitas A, Habib G, Kitsiou A, Plein S, Petersen SE, Popescu BA, Schroeder S, Burgstahler C, Lancellotti P. The multi-modality cardiac imaging approach to the Athlete's heart: an expert consensus of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015 Apr;16(4):353. doi: 10.1093/ehjci/jeu323. PMID: 25681828.
Petersen S.E., Selvanayagam J.B., Wiesmann F., Robson M.D., Francis J.M., Anderson R.H., Watkins H., Neubauer S. Left Ventricular Non-Compaction: Insights From Cardiovascular Magnetic Resonance Imaging. J. Am. Coll. Cardiol. 2005;46:101–105. doi: 10.1016/j.jacc.2005.03.045.
Stacey R.B., Andersen M.M., St Clair M., Hundley W.G., Thohan V. Comparison of systolic and diastolic criteria for isolated LV noncompaction in CMR. JACC Cardiovasc. Imaging. 2013;6:931–940. doi: 10.1016/j.jcmg.2013.01.014.
Jacquier A., Thuny F., Jop B., Giorgi R., Cohen F., Gaubert J.-Y., Vidal V., Bartoli J.M., Habib G., Moulin G. Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction. Eur. Heart J. 2010;31:1098–1104. doi: 10.1093/eurheartj/ehp595.
Caselli, S.; Ferreira, D.; Kanawati, E.; Di Paolo, F.; Pisicchio, C.; Jost, C.A.; Spataro, A.; Jenni, R.; Pelliccia, A. Prominent left ventricular trabeculations in competitive athletes: A proposal for risk stratification and management. Int. J. Cardiol. 2016, 223, 590–595.
Nucifora,G.;Aquaro,G.D.;Pingitore,A.;Masci,P.G.;Lombardi,M.Myocardial fibrosisin isolated left ventricular non compaction and its relation to disease severity. Eur. J. Heart Fail. 2011, 13, 170–176.
Casas,G.; Limeres,J.; Oristrell,G.; Gutierrez-Garcia,L.; Andreini,D.; Borregan,M.; Larrañaga-Moreira,J.M.; Lopez-Sainz, A.; Codina-Solà, M.; Teixido-Tura, G.; et al. Clinical risk prediction in patients with left ventricular myocardial noncompaction. J. Am. Coll. Cardiol. 2021, 78, 643–662.
Ramchand, J.; Podugu, P.; Obuchowski, N.; Harb, S.C.; Chetrit, M.; Milinovich, A.; Griffin, B.; Burrell, L.M.; Tang, W.H.W.; Kwon, D.H.; et al. Novel Approach to Risk Stratification in Left Ventricular Non-Compaction Using ACombined Cardiac Imaging and Plasma Biomarker Approach. J. Am. Heart Assoc. 2021, 10, e019209.
Araujo-Filho, J.A.B.; Assuncao, A.N.; De Melo, M.D.T.; Bière, L.; Lima, C.R.; Dantas, R.N.; Nomura, C.H.; Salemi, V.M.C.; Jerosch-Herold, M.; Parga, J. Myocardial T1 mapping and extracellular volume quantification in patients with left ventricular non-compaction cardiomyopathy. Eur. Heart J. Cardiovasc. Imaging 2018,19,888–895.
Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, Caselli S, Collet JP, Corrado D, Drezner JA, Halle M, Hansen D, Heidbuchel H, Myers J, Niebauer J, Papadakis M, Piepoli MF, Prescott E, Roos-Hesselink JW, Graham Stuart A, Taylor RS, Thompson PD, Tiberi M, Vanhees L, Wilhelm M; ESC Scientific Document Group. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J. 2021 Jan 1;42(1):17-96. doi: 10.1093/eurheartj/ehaa605. Erratum in: Eur Heart J. 2021 Feb 1;42(5):548-549. PMID: 32860412.
Prakken, N.H.; Cramer,M.J.; Olimulder, M.A.; Agostoni,P.; Mali,W.P.; Velthuis,B.K. Screening for proximal coronary artery anomalies with 3-dimensional MR coronary angiography. Int. J. Cardiovasc. Imaging 2010, 26, 701–710.
Angelini, P.; Cheong, B.Y.; De Rosen, V.V.L.; Lopez, A.; Uribe, C.; Masso, A.H.; Ali, S.W.; Davis, B.R.; Muthupillai, R.; Willerson, J.T. High-risk cardiovascular conditions in sports-related sudden death: Prevalence in 5169school children screened via cardiac magnetic resonance. Texas Heart Inst. J. 2018, 45, 205–213.
Agrawal, H.; Wilkinson, J.C.; Noel, C.V.; Qureshi, A.M.; Masand, P.M.; Mery, C.M.; Sexson-Tejtel, S.K.; Molossi, S. Impaired myocardial perfusion on stress CMR correlates with invasive FFR in children with coronary anomalies. J. Invasive Cardiol. 2021, 33, E45–E51.