Akut Pankreatit
Özet
Son 20 yılda akut pankreatit (AP) insidansı artmıştır ve ABD'de yılda 300,000'den fazla hastaneye yatışa neden olmaktadır. Hastaların çoğu hafif seyir izlerken, %10-20'sinde ciddi inflamatuar yanıt nedeniyle önemli morbidite ve mortalite gelişir. Akut pankreatitin patofizyolojisi, asiner hücrelerdeki anormal pankreatik enzim aktivasyonuna dayanır. Safra taşları ve alkol, en yaygın risk faktörleridir. AP'nin ciddiyeti, çeşitli klinik skorlamalar ve biyokimyasal belirteçler kullanılarak değerlendirilir. Tedavi, sıvı resüsitasyonu, ağrı kontrolü ve erken beslenme üzerine odaklanır.
The incidence of acute pancreatitis (AP) has increased over the past 20 years, leading to more than 300,000 hospital admissions annually in the United States. While most patients have a mild course, 10-20% experience severe inflammation, resulting in significant morbidity and mortality. The pathophysiology of AP involves abnormal pancreatic enzyme activation in acinar cells. Gallstones and alcohol abuse are the most common risk factors. The severity of AP is assessed using various clinical scoring systems and biochemical markers. Treatment focuses on fluid resuscitation, pain management, and early nutrition.
Referanslar
Forsmark CE, Gardner TB. Diagnosis and management of acute pancreatitis. Surg Clin North Am. 2019;99(2):229-244.
Andersen DK, Jafari MD. Acute pancreatitis: update and review. Ann Surg. 2013;257(2):193-197.
Becerra CA, Olsen DO. Treatment of severe acute pancreatitis: a surgical perspective. Surg Clin North Am. 2015;95(2):335-350.
Bennett AL, Yeo CJ. Acute pancreatitis: a review. JAMA. 2016;316(20):2104-2115.
Craig WL, Rozycki GS. Early management of severe acute pancreatitis. Surg Clin North Am. 2017;97(6):1323-1334.
McFadden DW, Cameron JL. Management of acute pancreatitis. Surg Clin North Am. 2001;81(6):1377-1401.
Silvis WB, Dolan JP. Surgical treatment of acute pancreatitis: a review. Dig Dis Sci. 2010;55(6):1653-1663.
Referanslar
Forsmark CE, Gardner TB. Diagnosis and management of acute pancreatitis. Surg Clin North Am. 2019;99(2):229-244.
Andersen DK, Jafari MD. Acute pancreatitis: update and review. Ann Surg. 2013;257(2):193-197.
Becerra CA, Olsen DO. Treatment of severe acute pancreatitis: a surgical perspective. Surg Clin North Am. 2015;95(2):335-350.
Bennett AL, Yeo CJ. Acute pancreatitis: a review. JAMA. 2016;316(20):2104-2115.
Craig WL, Rozycki GS. Early management of severe acute pancreatitis. Surg Clin North Am. 2017;97(6):1323-1334.
McFadden DW, Cameron JL. Management of acute pancreatitis. Surg Clin North Am. 2001;81(6):1377-1401.
Silvis WB, Dolan JP. Surgical treatment of acute pancreatitis: a review. Dig Dis Sci. 2010;55(6):1653-1663.
